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ONTOLOGY REPORT - ANNOTATIONS


Term:tazobactam
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Accession:CHEBI:9421 term browser browse the term
Definition:A member of the class of penicillanic acids that is sulbactam in which one of the exocyclic methyl hydrogens is replaced by a 1,2,3-triazol-1-yl group; used (in the form of its sodium salt) in combination with ceftolozane sulfate for treatment of complicated intra-abdominal infections and complicated urinary tract infections.
Synonyms:exact_synonym: (2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[(1H-1,2,3-triazol-1-yl)methyl]-4lambda(6)-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
 related_synonym: (2S,3S,5S)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide;   Formula=C10H12N4O5S;   InChI=1S/C10H12N4O5S/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19/h2-3,7-8H,4-5H2,1H3,(H,16,17)/t7-,8+,10+/m1/s1;   InChIKey=LPQZKKCYTLCDGQ-WEDXCCLWSA-N;   SMILES=C[C@]1(Cn2ccnn2)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O;   tazobactamum
 alt_id: CHEBI:45973
 xref: CAS:89786-04-9;   DrugBank:DB01606;   Drug_Central:2572;   KEGG:C07771;   KEGG:D00660;   LINCS:LSM-5323
 xref_mesh: MESH:C043265
 xref: PDBeChem:TAZ;   PMID:25098503;   PMID:25512410;   PMID:25529765;   PMID:25609660;   PMID:25662788;   PMID:25670823;   Reaxys:4787944;   Wikipedia:Tazobactam
 cyclic_relationship: is_conjugate_acid_of CHEBI:85193


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tazobactam term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19778
    role 19725
      biological role 19724
        antimicrobial agent 17271
          tazobactam 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19778
    subatomic particle 19776
      composite particle 19776
        hadron 19776
          baryon 19776
            nucleon 19776
              atomic nucleus 19776
                atom 19776
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19556
                        carbon atom 19545
                          organic molecular entity 19545
                            organic group 18459
                              organic divalent group 18453
                                organodiyl group 18453
                                  carbonyl group 18354
                                    carbonyl compound 18354
                                      carboxylic acid 18027
                                        carboacyl group 17185
                                          univalent carboacyl group 17185
                                            carbamoyl group 16923
                                              carboxamide 16923
                                                lactam 7826
                                                  beta-lactam 793
                                                    beta-lactam antibiotic 781
                                                      penams 262
                                                        penicillanic acids 262
                                                          sulbactam 3
                                                            tazobactam 2
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