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ONTOLOGY REPORT - ANNOTATIONS


Term:tazobactam
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Accession:CHEBI:9421 term browser browse the term
Definition:A member of the class of penicillanic acids that is sulbactam in which one of the exocyclic methyl hydrogens is replaced by a 1,2,3-triazol-1-yl group; used (in the form of its sodium salt) in combination with ceftolozane sulfate for treatment of complicated intra-abdominal infections and complicated urinary tract infections.
Synonyms:exact_synonym: (2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[(1H-1,2,3-triazol-1-yl)methyl]-4lambda(6)-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
 related_synonym: (2S,3S,5S)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide;   Formula=C10H12N4O5S;   InChI=1S/C10H12N4O5S/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19/h2-3,7-8H,4-5H2,1H3,(H,16,17)/t7-,8+,10+/m1/s1;   InChIKey=LPQZKKCYTLCDGQ-WEDXCCLWSA-N;   SMILES=C[C@]1(Cn2ccnn2)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O;   tazobactamum
 alt_id: CHEBI:45973
 xref: CAS:89786-04-9;   DrugBank:DB01606;   Drug_Central:2572;   KEGG:C07771;   KEGG:D00660;   LINCS:LSM-5323
 xref_mesh: MESH:C043265
 xref: PDBeChem:TAZ;   PMID:25098503;   PMID:25512410;   PMID:25529765;   PMID:25609660;   PMID:25662788;   PMID:25670823;   Reaxys:4787944;   Wikipedia:Tazobactam
 cyclic_relationship: is_conjugate_acid_of CHEBI:85193


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tazobactam term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il1b interleukin 1 beta JBrowse link 2 129,364,569 129,371,164 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 17 35,199,367 35,202,007 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21260
    role 21244
      biological role 21242
        antimicrobial agent 18124
          tazobactam 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 21260
    subatomic particle 21256
      composite particle 21256
        hadron 21256
          baryon 21256
            nucleon 21256
              atomic nucleus 21256
                atom 21256
                  main group element atom 21125
                    p-block element atom 21125
                      carbon group element atom 20894
                        carbon atom 20785
                          organic molecular entity 20785
                            organic group 19179
                              organic divalent group 19169
                                organodiyl group 19169
                                  carbonyl group 19143
                                    carbonyl compound 19143
                                      carboxylic acid 18827
                                        carboacyl group 17518
                                          univalent carboacyl group 17518
                                            carbamoyl group 17226
                                              carboxamide 17226
                                                lactam 7873
                                                  beta-lactam 771
                                                    beta-lactam antibiotic 759
                                                      penams 260
                                                        penicillanic acids 260
                                                          sulbactam 3
                                                            tazobactam 2
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