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Term:tubastatin A
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Accession:CHEBI:94186 term browser browse the term
Definition:A pyridoindole that is 1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indole which is substituted on the tetrahydropyridine nitrogen by a methyl group and on the indole nitrogen by a p-[N-(hydroxy)aminocarbonyl]benzyl group. It is a histone deacetylase 6 (HDAC6) inhibitor that is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold).
Synonyms:exact_synonym: N-hydroxy-4-[(2-methyl-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide
 related_synonym: Formula=C20H21N3O2;   InChI=1S/C20H21N3O2/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25/h2-9,25H,10-13H2,1H3,(H,21,24);   InChIKey=GOVYBPLHWIEHEJ-UHFFFAOYSA-N;   N-hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide;   SMILES=CN1CCC2=C(C1)C3=CC=CC=C3N2CC4=CC=C(C=C4)C(=O)NO
 xref: CAS:1252003-15-8 "ChEBI";   LINCS:LSM-4806
 xref_mesh: MESH:C553587
 xref: PMID:20614936 "Europe PMC";   PMID:23541634 "Europe PMC";   PMID:24844691 "Europe PMC";   PMID:24909686 "Europe PMC";   PMID:25108326 "Europe PMC";   PMID:25921924 "Europe PMC";   PMID:26647018 "Europe PMC";   PMID:26790818 "Europe PMC";   Reaxys:20796421 "Reaxys"

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tubastatin A term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Pdk1 pyruvate dehydrogenase kinase 1 JBrowse link 3 58,530,870 58,561,494 RGD:6480464

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Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        refrigerant 16994
          ammonia 16561
            organic amino compound 16560
              tertiary amino compound 8521
                tubastatin A 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        carboacyl group 16943
                                          univalent carboacyl group 16943
                                            carbamoyl group 16622
                                              carboxamide 16622
                                                hydroxamic acid 6230
                                                  tubastatin A 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.