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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tubastatin A
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Accession:CHEBI:94186 term browser browse the term
Definition:A pyridoindole that is 1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indole which is substituted on the tetrahydropyridine nitrogen by a methyl group and on the indole nitrogen by a p-[N-(hydroxy)aminocarbonyl]benzyl group. It is a histone deacetylase 6 (HDAC6) inhibitor that is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold).
Synonyms:exact_synonym: N-hydroxy-4-[(2-methyl-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide
 related_synonym: Formula=C20H21N3O2;   InChI=1S/C20H21N3O2/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25/h2-9,25H,10-13H2,1H3,(H,21,24);   InChIKey=GOVYBPLHWIEHEJ-UHFFFAOYSA-N;   N-hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide;   SMILES=CN1CCC2=C(C1)C3=CC=CC=C3N2CC4=CC=C(C=C4)C(=O)NO
 xref: CAS:1252003-15-8;   LINCS:LSM-4806
 xref_mesh: MESH:C553587
 xref: PMID:20614936;   PMID:23541634;   PMID:24844691;   PMID:24909686;   PMID:25108326;   PMID:25921924;   PMID:26647018;   PMID:26790818;   Reaxys:20796421


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tubastatin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd274 CD274 molecule decreases expression ISO tubastatin A results in decreased expression of CD274 protein CTD PMID:26775640 NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450 		JBrowse link
G Hdac6 histone deacetylase 6 multiple interactions
decreases activity		 ISO tubastatin A inhibits the reaction [[bisphenol A co-treated with mono-(2-ethylhexyl)phthalate] results in increased expression of HDAC6 protein]; tubastatin A inhibits the reaction [bisphenol A results in increased expression of HDAC6 protein]
tubastatin A results in decreased activity of HDAC6 protein		 CTD PMID:26775640 PMID:34910997 NCBI chr  X:14,550,645...14,572,445
Ensembl chr  X:14,551,044...14,572,441 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO tubastatin A inhibits the reaction [[bisphenol A co-treated with mono-(2-ethylhexyl)phthalate] results in increased expression of MYC protein]; tubastatin A inhibits the reaction [bisphenol A results in increased expression of MYC protein] CTD PMID:34910997 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO tubastatin A inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 protein] CTD PMID:22367689 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions ISO tubastatin A affects the reaction [PDK1 protein affects the abundance of Cyclic AMP] CTD PMID:28887310 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038 		JBrowse link
G Pten phosphatase and tensin homolog increases expression
multiple interactions		 ISO tubastatin A results in increased expression of PTEN mRNA
[bisphenol A co-treated with tubastatin A] results in increased expression of PTEN mRNA; [mono-(2-ethylhexyl)phthalate co-treated with bisphenol A co-treated with tubastatin A] results in increased expression of PTEN mRNA; [mono-(2-ethylhexyl)phthalate co-treated with tubastatin A] results in increased expression of PTEN mRNA		 CTD PMID:34910997 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO tubastatin A results in decreased phosphorylation of STAT3 protein CTD PMID:26775640 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      application 19650
        NMR chemical shift reference compound 17958
          ammonia 17818
            organic amino compound 17818
              tertiary amino compound 10134
                tubastatin A 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            heteroorganic entity 19477
                              organochalcogen compound 19240
                                organooxygen compound 19155
                                  carbon oxoacid 18613
                                    carboxylic acid 18610
                                      carboacyl group 17699
                                        univalent carboacyl group 17699
                                          carbamoyl group 17549
                                            carboxamide 17549
                                              hydroxamic acid 6330
                                                tubastatin A 7
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