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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tubastatin A
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Accession:CHEBI:94186 term browser browse the term
Definition:A pyridoindole that is 1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indole which is substituted on the tetrahydropyridine nitrogen by a methyl group and on the indole nitrogen by a p-[N-(hydroxy)aminocarbonyl]benzyl group. It is a histone deacetylase 6 (HDAC6) inhibitor that is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold).
Synonyms:exact_synonym: N-hydroxy-4-[(2-methyl-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide
 related_synonym: Formula=C20H21N3O2;   InChI=1S/C20H21N3O2/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25/h2-9,25H,10-13H2,1H3,(H,21,24);   InChIKey=GOVYBPLHWIEHEJ-UHFFFAOYSA-N;   N-hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide;   SMILES=CN1CCC2=C(C1)C3=CC=CC=C3N2CC4=CC=C(C=C4)C(=O)NO
 xref: CAS:1252003-15-8;   LINCS:LSM-4806
 xref_mesh: MESH:C553587
 xref: PMID:20614936;   PMID:23541634;   PMID:24844691;   PMID:24909686;   PMID:25108326;   PMID:25921924;   PMID:26647018;   PMID:26790818;   Reaxys:20796421



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tubastatin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd274 CD274 molecule decreases expression ISO tubastatin A results in decreased expression of CD274 protein CTD PMID:26775640 NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450
JBrowse link
G Hdac6 histone deacetylase 6 multiple interactions
decreases activity
ISO tubastatin A inhibits the reaction [[bisphenol A co-treated with mono-(2-ethylhexyl)phthalate] results in increased expression of HDAC6 protein]; tubastatin A inhibits the reaction [bisphenol A results in increased expression of HDAC6 protein]
tubastatin A results in decreased activity of HDAC6 protein
CTD PMID:26775640 PMID:34910997 NCBI chr  X:14,550,645...14,572,445
Ensembl chr  X:14,551,044...14,572,441
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO tubastatin A inhibits the reaction [[bisphenol A co-treated with mono-(2-ethylhexyl)phthalate] results in increased expression of MYC protein]; tubastatin A inhibits the reaction [bisphenol A results in increased expression of MYC protein] CTD PMID:34910997 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO tubastatin A inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 protein] CTD PMID:22367689 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions ISO tubastatin A affects the reaction [PDK1 protein affects the abundance of Cyclic AMP] CTD PMID:28887310 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
JBrowse link
G Pten phosphatase and tensin homolog increases expression
multiple interactions
ISO tubastatin A results in increased expression of PTEN mRNA
[bisphenol A co-treated with tubastatin A] results in increased expression of PTEN mRNA; [mono-(2-ethylhexyl)phthalate co-treated with bisphenol A co-treated with tubastatin A] results in increased expression of PTEN mRNA; [mono-(2-ethylhexyl)phthalate co-treated with tubastatin A] results in increased expression of PTEN mRNA
CTD PMID:34910997 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO tubastatin A results in decreased phosphorylation of STAT3 protein CTD PMID:26775640 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19876
    role 19851
      application 19687
        refrigerant 18241
          ammonia 17794
            organic amino compound 17794
              tertiary amino compound 10125
                tubastatin A 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19876
    subatomic particle 19874
      composite particle 19874
        hadron 19874
          baryon 19874
            nucleon 19874
              atomic nucleus 19905
                atom 19905
                  main group element atom 19821
                    p-block element atom 19821
                      carbon group element atom 19768
                        carbon atom 19764
                          organic molecular entity 19764
                            organic group 18962
                              organic divalent group 18943
                                organodiyl group 18915
                                  carbonyl group 18869
                                    carbonyl compound 18869
                                      carboxylic acid 18618
                                        carboacyl group 17678
                                          univalent carboacyl group 17678
                                            carbamoyl group 17546
                                              carboxamide 17522
                                                hydroxamic acid 6329
                                                  tubastatin A 7
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