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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:taurodeoxycholic acid
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Accession:CHEBI:9410 term browser browse the term
Definition:A bile acid taurine conjugate of deoxycholic acid.
Synonyms:exact_synonym: 2-[(3alpha,12alpha-dihydroxy-24-oxo-5beta-cholan-24-yl)amino]ethanesulfonic acid
 related_synonym: Formula=C26H45NO6S;   InChI=1S/C26H45NO6S/c1-16(4-9-24(30)27-12-13-34(31,32)33)20-7-8-21-19-6-5-17-14-18(28)10-11-25(17,2)22(19)15-23(29)26(20,21)3/h16-23,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17-,18-,19+,20-,21+,22+,23+,25+,26-/m1/s1;   InChIKey=AWDRATDZQPNJFN-VAYUFCLWSA-N;   SMILES=[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@]([H])([C@H](C)CCC(=O)NCCS(O)(=O)=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2;   Taurodeoxycholate
 xref: Beilstein:3228310;   CAS:516-50-7;   HMDB:HMDB0000896;   KEGG:C05463;   LINCS:LSM-5477;   LIPID_MAPS_instance:LMST05040013
 xref_mesh: MESH:D013657
 xref: Reaxys:3228310;   Wikipedia:Taurodeoxycholic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:36261



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taurodeoxycholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 multiple interactions
increases abundance
increases transport
ISO
EXP
[Glyburide results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; [Ketoconazole results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; [NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate] promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of diosbulbin B] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; [NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate] promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of saikogenin A analog] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; [NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate] promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of saikogenin A] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; [Troglitazone results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; Aconitine inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; aurantio-obtusin inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; carboxyatractyloside inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; celastrol inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; cryptotanshinone inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; Cyclosporine inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; dihydrotanshinone I inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; diosbulbin B metabolite inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; diosbulbin B promotes the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; Enzymes and Coenzymes inhibits the reaction [celastrol inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; Enzymes and Coenzymes inhibits the reaction [diosbulbin B promotes the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; Enzymes and Coenzymes inhibits the reaction [isobavachalcone inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; Enzymes and Coenzymes inhibits the reaction [rhein promotes the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; Enzymes and Coenzymes inhibits the reaction [saikosaponin D analog inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; Enzymes and Coenzymes inhibits the reaction [saikosaponin D inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; Enzymes and Coenzymes promotes the reaction [saikogenin A analog inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; Enzymes and Coenzymes promotes the reaction [saikogenin A inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; Enzymes and Coenzymes promotes the reaction [Troglitazone inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; isobavachalcone inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; kansuinin A inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; kansuinin B inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; mesaconitine inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; NADP promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of diosbulbin B] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; NADP promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of saikogenin A analog] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; NADP promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of saikogenin A] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; rhein metabolite inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; rhein promotes the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; saikogenin A analog inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; saikogenin A inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; saikogenin F inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; saikosaponin D analog inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; saikosaponin D inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; tanshinone inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; toosendanin inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; Troglitazone inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]
ABCB11 protein results in increased abundance of Taurodeoxycholic Acid
[Cyclosporine results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; [Glyburide results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; [troglitazone results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid
CTD PMID:14570929 PMID:20147439 PMID:35101544 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958
JBrowse link
G Abcc1 ATP-binding cassette, sub-family C member 1 multiple interactions ISO Taurodeoxycholic Acid inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein] CTD PMID:16101123 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601
JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions
increases secretion
EXP AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in decreased secretion of Taurodeoxycholic Acid]
AHR gene mutant form results in increased secretion of Taurodeoxycholic Acid
CTD PMID:29452137 PMID:32679164 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO Taurodeoxycholic Acid results in increased activity of CASP3 protein
ursodoxicoltaurine inhibits the reaction [Taurodeoxycholic Acid results in increased activity of CASP3 protein]
CTD PMID:12773247 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO Taurodeoxycholic Acid results in increased activity of CASP9 protein
ursodoxicoltaurine inhibits the reaction [Taurodeoxycholic Acid results in increased activity of CASP9 protein]
CTD PMID:12773247 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3, cardiac increases response to substance
increases activity
EXP CHRM3 protein results in increased susceptibility to Taurodeoxycholic Acid
Taurodeoxycholic Acid results in increased activity of CHRM3 protein
CTD PMID:15964566 NCBI chr13:9,925,522...10,411,131
Ensembl chr13:9,925,522...10,410,883
JBrowse link
G Cyp7b1 cytochrome P450, family 7, subfamily b, polypeptide 1 decreases activity
decreases expression
ISO Taurodeoxycholic Acid results in decreased activity of CYP7B1 protein
Taurodeoxycholic Acid results in decreased expression of CYP7B1 mRNA
CTD PMID:12029625 NCBI chr 3:18,126,108...18,298,054
Ensembl chr 3:18,126,114...18,297,502
JBrowse link
G Il10 interleukin 10 multiple interactions
increases abundance
EXP Taurodeoxycholic Acid promotes the reaction [irinotecan results in decreased secretion of IL10 protein]
IL10 gene mutant form results in increased abundance of Taurodeoxycholic Acid
CTD PMID:26706406 PMID:27580383 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
JBrowse link
G Mapk14 mitogen-activated protein kinase 14 increases activity ISO Taurodeoxycholic Acid results in increased activity of MAPK14 protein CTD PMID:14762791 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases activity ISO Taurodeoxycholic Acid results in increased activity of NR1H4 protein CTD PMID:17567710 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447
JBrowse link
G Pnlip pancreatic lipase affects folding ISO Taurodeoxycholic Acid affects the folding of PNLIP protein CTD PMID:19346257 NCBI chr19:58,658,797...58,670,231
Ensembl chr19:58,640,930...58,670,220
JBrowse link
G Por cytochrome p450 oxidoreductase affects abundance EXP POR gene mutant form affects the abundance of Taurodeoxycholic Acid CTD PMID:25034404 NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180
JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 affects abundance
multiple interactions
EXP SLCO1A1 protein affects the abundance of Taurodeoxycholic Acid
SLCO1A1 protein affects the susceptibility to [Deoxycholic Acid results in increased abundance of Taurodeoxycholic Acid]
CTD PMID:21914718 NCBI chr 6:141,853,007...141,892,688
Ensembl chr 6:141,853,008...141,892,688
JBrowse link
G Stim1 stromal interaction molecule 1 multiple interactions
affects localization
ISO STIM1 protein promotes the reaction [Taurodeoxycholic Acid results in increased abundance of Calcium]
Taurodeoxycholic Acid affects the localization of STIM1 protein
CTD PMID:18342630 NCBI chr 7:101,909,279...102,086,525
Ensembl chr 7:101,917,013...102,086,526
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22194
    role 22179
      chemical role 21424
        antioxidant 16412
          taurine 415
            bile acid taurine conjugate 282
              taurodeoxycholic acid 14
                7-oxotaurodeoxycholic acid 0
                Sodium taurodeoxycholate hydrate 0
                taurodeoxycholic acid-d4 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    p-block element atom 22120
                      carbon group element atom 21920
                        carbon atom 21846
                          organic molecular entity 21846
                            organic molecule 21662
                              organic cyclic compound 21269
                                organic polycyclic compound 17934
                                  steroid 14888
                                    steroid fundamental parent 14672
                                      cholane 1015
                                        cholanoid 1015
                                          cholanic acids 999
                                            cholanic acid 999
                                              5beta-cholanic acid 999
                                                hydroxy-5beta-cholanic acid 999
                                                  dihydroxy-5beta-cholanic acid 838
                                                    deoxycholic acid 313
                                                      taurodeoxycholic acid 14
                                                        7-oxotaurodeoxycholic acid 0
                                                        Sodium taurodeoxycholate hydrate 0
                                                        taurodeoxycholic acid-d4 0
paths to the root