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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:taurodeoxycholic acid
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Accession:CHEBI:9410 term browser browse the term
Definition:A bile acid taurine conjugate of deoxycholic acid.
Synonyms:exact_synonym: 2-[(3alpha,12alpha-dihydroxy-24-oxo-5beta-cholan-24-yl)amino]ethanesulfonic acid
 related_synonym: Formula=C26H45NO6S;   InChI=1S/C26H45NO6S/c1-16(4-9-24(30)27-12-13-34(31,32)33)20-7-8-21-19-6-5-17-14-18(28)10-11-25(17,2)22(19)15-23(29)26(20,21)3/h16-23,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17-,18-,19+,20-,21+,22+,23+,25+,26-/m1/s1;   InChIKey=AWDRATDZQPNJFN-VAYUFCLWSA-N;   SMILES=[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@]([H])([C@H](C)CCC(=O)NCCS(O)(=O)=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2;   Taurodeoxycholate
 xref: Beilstein:3228310;   CAS:516-50-7;   HMDB:HMDB0000896;   KEGG:C05463;   LINCS:LSM-5477;   LIPID_MAPS_instance:LMST05040013
 xref_mesh: MESH:D013657
 xref: Reaxys:3228310;   Wikipedia:Taurodeoxycholic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:36261


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taurodeoxycholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
increases abundance		 ISO
EXP		 [Glyburide results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; [Ketoconazole results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; [troglitazone results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid
ABCB11 protein results in increased abundance of Taurodeoxycholic Acid
[Cyclosporine results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; [Glyburide results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; [troglitazone results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid		 CTD PMID:14570929 PMID:20147439 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO Taurodeoxycholic Acid inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein] CTD PMID:16101123 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases secretion		 ISO AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in decreased secretion of Taurodeoxycholic Acid]
AHR gene mutant form results in increased secretion of Taurodeoxycholic Acid		 CTD PMID:29452137 PMID:32679164 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO Taurodeoxycholic Acid results in increased activity of CASP3 protein
ursodoxicoltaurine inhibits the reaction [Taurodeoxycholic Acid results in increased activity of CASP3 protein]		 CTD PMID:12773247 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions		 ISO Taurodeoxycholic Acid results in increased activity of CASP9 protein
ursodoxicoltaurine inhibits the reaction [Taurodeoxycholic Acid results in increased activity of CASP9 protein]		 CTD PMID:12773247 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 increases response to substance
increases activity		 ISO CHRM3 protein results in increased susceptibility to Taurodeoxycholic Acid
Taurodeoxycholic Acid results in increased activity of CHRM3 protein		 CTD PMID:15964566 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases activity
decreases expression		 EXP Taurodeoxycholic Acid results in decreased activity of CYP7B1 protein
Taurodeoxycholic Acid results in decreased expression of CYP7B1 mRNA		 CTD PMID:12029625 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698 		JBrowse link
G Il10 interleukin 10 multiple interactions
increases abundance		 ISO Taurodeoxycholic Acid promotes the reaction [irinotecan results in decreased secretion of IL10 protein]
IL10 gene mutant form results in increased abundance of Taurodeoxycholic Acid		 CTD PMID:26706406 PMID:27580383 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases activity ISO Taurodeoxycholic Acid results in increased activity of MAPK14 protein CTD PMID:14762791 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases activity ISO Taurodeoxycholic Acid results in increased activity of NR1H4 protein CTD PMID:17567710 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Pnlip pancreatic lipase affects folding ISO Taurodeoxycholic Acid affects the folding of PNLIP protein CTD PMID:19346257 NCBI chr 1:257,774,012...257,811,656
Ensembl chr 1:257,798,581...257,811,654 		JBrowse link
G Por cytochrome p450 oxidoreductase affects abundance ISO POR gene mutant form affects the abundance of Taurodeoxycholic Acid CTD PMID:25034404 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Stim1 stromal interaction molecule 1 multiple interactions
affects localization		 EXP STIM1 protein promotes the reaction [Taurodeoxycholic Acid results in increased abundance of Calcium]
Taurodeoxycholic Acid affects the localization of STIM1 protein		 CTD PMID:18342630 NCBI chr 1:156,656,246...156,818,777
Ensembl chr 1:156,656,013...156,818,363 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      chemical role 19320
        antioxidant 14438
          taurine 415
            bile acid taurine conjugate 284
              taurodeoxycholic acid 13
                7-oxotaurodeoxycholic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic polycyclic compound 16570
                                  steroid 13347
                                    steroid fundamental parent 13017
                                      cholane 989
                                        cholanoid 989
                                          cholanic acids 974
                                            cholanic acid 974
                                              5beta-cholanic acid 974
                                                hydroxy-5beta-cholanic acid 974
                                                  dihydroxy-5beta-cholanic acid 827
                                                    deoxycholic acid 313
                                                      taurodeoxycholic acid 13
                                                        7-oxotaurodeoxycholic acid 0
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