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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:taurodeoxycholic acid
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Accession:CHEBI:9410 term browser browse the term
Definition:A bile acid taurine conjugate of deoxycholic acid.
Synonyms:exact_synonym: 2-[(3alpha,12alpha-dihydroxy-24-oxo-5beta-cholan-24-yl)amino]ethanesulfonic acid
 related_synonym: Formula=C26H45NO6S;   InChI=1S/C26H45NO6S/c1-16(4-9-24(30)27-12-13-34(31,32)33)20-7-8-21-19-6-5-17-14-18(28)10-11-25(17,2)22(19)15-23(29)26(20,21)3/h16-23,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17-,18-,19+,20-,21+,22+,23+,25+,26-/m1/s1;   InChIKey=AWDRATDZQPNJFN-VAYUFCLWSA-N;   SMILES=[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@]([H])([C@H](C)CCC(=O)NCCS(O)(=O)=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2;   Taurodeoxycholate
 xref: Beilstein:3228310;   CAS:516-50-7;   HMDB:HMDB0000896;   KEGG:C05463;   LINCS:LSM-5477;   LIPID_MAPS_instance:LMST05040013
 xref_mesh: MESH:D013657
 xref: Reaxys:3228310;   Wikipedia:Taurodeoxycholic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:36261

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taurodeoxycholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
increases abundance		 ISO
EXP		 [Glyburide results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; [Ketoconazole results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; [troglitazone results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid
ABCB11 protein results in increased abundance of Taurodeoxycholic Acid
[Cyclosporine results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; [Glyburide results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; [troglitazone results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid		 CTD PMID:14570929 PMID:20147439 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO Taurodeoxycholic Acid inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein] CTD PMID:16101123 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases secretion		 ISO AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in decreased secretion of Taurodeoxycholic Acid]
AHR gene mutant form results in increased secretion of Taurodeoxycholic Acid		 CTD PMID:29452137 PMID:32679164 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO Taurodeoxycholic Acid results in increased activity of CASP3 protein
tauroursodeoxycholic acid inhibits the reaction [Taurodeoxycholic Acid results in increased activity of CASP3 protein]		 CTD PMID:12773247 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions		 ISO Taurodeoxycholic Acid results in increased activity of CASP9 protein
tauroursodeoxycholic acid inhibits the reaction [Taurodeoxycholic Acid results in increased activity of CASP9 protein]		 CTD PMID:12773247 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 increases response to substance
increases activity		 ISO CHRM3 protein results in increased susceptibility to Taurodeoxycholic Acid
Taurodeoxycholic Acid results in increased activity of CHRM3 protein		 CTD PMID:15964566 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169 		JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases activity
decreases expression		 EXP Taurodeoxycholic Acid results in decreased activity of CYP7B1 protein
Taurodeoxycholic Acid results in decreased expression of CYP7B1 mRNA		 CTD PMID:12029625 NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257 		JBrowse link
G Il10 interleukin 10 multiple interactions
increases abundance		 ISO Taurodeoxycholic Acid promotes the reaction [irinotecan results in decreased secretion of IL10 protein]
IL10 gene mutant form results in increased abundance of Taurodeoxycholic Acid		 CTD PMID:26706406 PMID:27580383 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases activity ISO Taurodeoxycholic Acid results in increased activity of MAPK14 protein CTD PMID:14762791 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases activity ISO Taurodeoxycholic Acid results in increased activity of NR1H4 protein CTD PMID:17567710 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056 		JBrowse link
G Pnlip pancreatic lipase affects folding ISO Taurodeoxycholic Acid affects the folding of PNLIP protein CTD PMID:19346257 NCBI chr 1:279,798,187...279,811,372
Ensembl chr 1:279,798,187...279,811,372 		JBrowse link
G Por cytochrome p450 oxidoreductase affects abundance ISO POR gene mutant form affects the abundance of Taurodeoxycholic Acid CTD PMID:25034404 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814 		JBrowse link
G Stim1 stromal interaction molecule 1 multiple interactions
affects localization		 EXP STIM1 protein promotes the reaction [Taurodeoxycholic Acid results in increased abundance of Calcium]
Taurodeoxycholic Acid affects the localization of STIM1 protein		 CTD PMID:18342630 NCBI chr 1:167,373,894...167,533,412
Ensembl chr 1:167,373,678...167,533,420 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      chemical role 19309
        antioxidant 14234
          taurine 411
            bile acid taurine conjugate 280
              taurodeoxycholic acid 13
                7-oxotaurodeoxycholic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic molecule 19556
                              organic cyclic compound 19365
                                organic polycyclic compound 16408
                                  steroid 12810
                                    steroid fundamental parent 12426
                                      cholane 939
                                        cholanoid 939
                                          cholanic acids 923
                                            cholanic acid 923
                                              5beta-cholanic acid 923
                                                hydroxy-5beta-cholanic acid 923
                                                  dihydroxy-5beta-cholanic acid 770
                                                    deoxycholic acid 230
                                                      taurodeoxycholic acid 13
                                                        7-oxotaurodeoxycholic acid 0
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