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ONTOLOGY REPORT - ANNOTATIONS


Term:tamsulosin
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Accession:CHEBI:9398 term browser browse the term
Definition:A 5-(2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzenesulfonamide that has (R)-configuration. A specific alpha1 adrenoceptor antagonist used (generally as its hydrochloride salt, tamsulosin hydrochloride) in the treatment of prostatic hyperplasia, chronic prostatitis, urinary retention, and help with the passage of kidney stones.
Synonyms:exact_synonym: 5-[(2R)-2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl]-2-methoxybenzenesulfonamide
 related_synonym: (R)-(-)-tamsulosin;   (R)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide;   Formula=C20H28N2O5S;   InChI=1S/C20H28N2O5S/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24)/t15-/m1/s1;   InChIKey=DRHKJLXJIQTDTD-OAHLLOKOSA-N;   SMILES=C=1C=C(OCCN[C@@H](CC2=CC=C(C(=C2)S(N)(=O)=O)OC)C)C(=CC1)OCC;   tamsulosina;   tamsulosine;   tamsulosinum
 xref: Beilstein:6896059 "Beilstein";   CAS:106133-20-4 "ChemIDplus";   CAS:106133-20-4 "KEGG COMPOUND";   DrugBank:DB00706;   Drug_Central:2562 "DrugCentral";   KEGG:C07124;   KEGG:D08560
 xref_mesh: MESH:C088482
 xref: PMID:2891044 "Europe PMC";   PMID:29728928 "Europe PMC";   PMID:29737501 "Europe PMC";   PMID:29913020 "Europe PMC";   PMID:29971698 "Europe PMC";   PMID:29974124 "Europe PMC";   PMID:30174141 "Europe PMC";   PMID:30360332 "Europe PMC";   Patent:EP34432;   Patent:US4703063;   Reaxys:6896059 "Reaxys";   Wikipedia:Tamsulosin
 cyclic_relationship: is_conjugate_base_of CHEBI:142544;   is_enantiomer_of CHEBI:142548


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tamsulosin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb4 ATP binding cassette subfamily B member 4 JBrowse link 4 22,133,984 22,192,687 RGD:6480464
G Adra1a adrenoceptor alpha 1A JBrowse link 15 43,296,997 43,398,314 RGD:6480464
G Adra1d adrenoceptor alpha 1D JBrowse link 3 124,129,558 124,145,566 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        pharmaceutical 19097
          drug 19097
            antineoplastic agent 16555
              tamsulosin 3
                rac-tamsulosin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      chalcogen 19233
                        oxygen atom 19188
                          oxygen molecular entity 19188
                            hydroxides 18965
                              oxoacid 18076
                                chalcogen oxoacid 11397
                                  sulfur oxoacid 10987
                                    sulfonic acid 7240
                                      sulfonic acid derivative 7240
                                        sulfonamide 3125
                                          5-(2-\{[2-(2-ethoxyphenoxy)ethyl]amino\}propyl)-2-methoxybenzenesulfonamide 3
                                            tamsulosin 3
                                              rac-tamsulosin 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.