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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tamsulosin
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Accession:CHEBI:9398 term browser browse the term
Definition:A 5-(2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzenesulfonamide that has (R)-configuration. A specific alpha1 adrenoceptor antagonist used (generally as its hydrochloride salt, tamsulosin hydrochloride) in the treatment of prostatic hyperplasia, chronic prostatitis, urinary retention, and help with the passage of kidney stones.
Synonyms:exact_synonym: 5-[(2R)-2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl]-2-methoxybenzenesulfonamide
 related_synonym: (R)-(-)-tamsulosin;   (R)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide;   Formula=C20H28N2O5S;   InChI=1S/C20H28N2O5S/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24)/t15-/m1/s1;   InChIKey=DRHKJLXJIQTDTD-OAHLLOKOSA-N;   SMILES=C=1C=C(OCCN[C@@H](CC2=CC=C(C(=C2)S(N)(=O)=O)OC)C)C(=CC1)OCC;   tamsulosina;   tamsulosine;   tamsulosinum
 xref: Beilstein:6896059;   CAS:106133-20-4;   DrugBank:DB00706;   Drug_Central:2562;   KEGG:C07124;   KEGG:D08560
 xref_mesh: MESH:C088482
 xref: PMID:2891044;   PMID:29728928;   PMID:29737501;   PMID:29913020;   PMID:29971698;   PMID:29974124;   PMID:30174141;   PMID:30360332;   Patent:EP34432;   Patent:US4703063;   Reaxys:6896059;   Wikipedia:Tamsulosin
 cyclic_relationship: is_conjugate_base_of CHEBI:142544;   is_enantiomer_of CHEBI:142548


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tamsulosin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO tamsulosin results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Adra1a adrenoceptor alpha 1A affects binding ISO
EXP
tamsulosin binds to ADRA1A protein CTD PMID:7536677 PMID:21544540 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Adra1d adrenoceptor alpha 1D affects binding EXP tamsulosin binds to ADRA1D protein CTD PMID:9294627 NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    role 19804
      application 19477
        pharmaceutical 19350
          drug 19350
            antineoplastic agent 17010
              tamsulosin 3
                rac-tamsulosin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    p-block element atom 19744
                      chalcogen 19438
                        oxygen atom 19400
                          oxygen molecular entity 19400
                            hydroxides 19123
                              oxoacid 18256
                                chalcogen oxoacid 11493
                                  sulfur oxoacid 11097
                                    sulfonic acid 7345
                                      sulfonic acid derivative 7345
                                        sulfonamide 3178
                                          5-(2-\{[2-(2-ethoxyphenoxy)ethyl]amino\}propyl)-2-methoxybenzenesulfonamide 3
                                            tamsulosin 3
                                              rac-tamsulosin 0
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