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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tamsulosin
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Accession:CHEBI:9398 term browser browse the term
Definition:A 5-(2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzenesulfonamide that has (R)-configuration. A specific alpha1 adrenoceptor antagonist used (generally as its hydrochloride salt, tamsulosin hydrochloride) in the treatment of prostatic hyperplasia, chronic prostatitis, urinary retention, and help with the passage of kidney stones.
Synonyms:exact_synonym: 5-[(2R)-2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl]-2-methoxybenzenesulfonamide
 related_synonym: (R)-(-)-tamsulosin;   (R)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide;   Formula=C20H28N2O5S;   InChI=1S/C20H28N2O5S/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24)/t15-/m1/s1;   InChIKey=DRHKJLXJIQTDTD-OAHLLOKOSA-N;   SMILES=C=1C=C(OCCN[C@@H](CC2=CC=C(C(=C2)S(N)(=O)=O)OC)C)C(=CC1)OCC;   tamsulosina;   tamsulosine;   tamsulosinum
 xref: Beilstein:6896059;   CAS:106133-20-4;   DrugBank:DB00706;   Drug_Central:2562;   KEGG:C07124;   KEGG:D08560
 xref_mesh: MESH:C088482
 xref: PMID:2891044;   PMID:29728928;   PMID:29737501;   PMID:29913020;   PMID:29971698;   PMID:29974124;   PMID:30174141;   PMID:30360332;   Patent:EP34432;   Patent:US4703063;   Reaxys:6896059;   Wikipedia:Tamsulosin
 cyclic_relationship: is_conjugate_base_of CHEBI:142544;   is_enantiomer_of CHEBI:142548


show annotations for term's descendants           Sort by:
tamsulosin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO tamsulosin results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Adra1a adrenoceptor alpha 1A affects binding ISO
EXP		 tamsulosin binds to ADRA1A protein CTD PMID:7536677 PMID:21544540 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Adra1d adrenoceptor alpha 1D affects binding EXP tamsulosin binds to ADRA1D protein CTD PMID:9294627 NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19740
    role 19713
      application 19546
        pharmaceutical 19425
          drug 19425
            antineoplastic agent 17627
              tamsulosin 3
                rac-tamsulosin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    p-block element atom 19686
                      chalcogen 19482
                        oxygen atom 19459
                          oxygen molecular entity 19459
                            hydroxides 19255
                              oxoacid 18635
                                chalcogen oxoacid 11751
                                  sulfur oxoacid 11375
                                    sulfonic acid 7667
                                      sulfonic acid derivative 7667
                                        sulfonamide 3222
                                          5-(2-\{[2-(2-ethoxyphenoxy)ethyl]amino\}propyl)-2-methoxybenzenesulfonamide 3
                                            tamsulosin 3
                                              rac-tamsulosin 0
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