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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Swertiamarin
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Accession:CHEBI:9370 term browser browse the term
Definition:A glycoside that has formula C16H22O10.
Synonyms:related_synonym: Formula=C16H22O10;   InChI=1S/C16H22O10/c1-2-7-14(24-6-8-13(21)23-4-3-16(7,8)22)26-15-12(20)11(19)10(18)9(5-17)25-15/h2,6-7,9-12,14-15,17-20,22H,1,3-5H2/t7-,9+,10+,11-,12+,14-,15-,16+/m0/s1;   InChIKey=HEYZWPRKKUGDCR-QBXMEVCASA-N;   SMILES=OC[C@H]1O[C@@H](O[C@@H]2OC=C3C(=O)OCC[C@@]3(O)[C@H]2C=C)[C@H](O)[C@@H](O)[C@@H]1O
 xref: CAS:17388-39-5;   KEGG:C09800;   KNApSAcK:C00003100
 xref_mesh: MESH:C013270


show annotations for term's descendants           Sort by:
Swertiamarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp3 acid phosphatase 3 multiple interactions EXP swertiamarin inhibits the reaction [Testosterone results in increased secretion of ACP3 protein] CTD PMID:27866977 NCBI chr 8:104,905,570...104,956,146
Ensembl chr 8:113,785,032...113,833,033 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP swertiamarin inhibits the reaction [Testosterone results in increased expression of ACTA2 mRNA] CTD PMID:27866977 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Ar androgen receptor multiple interactions EXP swertiamarin inhibits the reaction [Testosterone results in increased expression of AR protein] CTD PMID:27866977 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression 		EXP
ISO 		swertiamarin inhibits the reaction [Testosterone results in decreased expression of BAX protein]
swertiamarin results in increased expression of BAX protein 		CTD PMID:27866977 PMID:38852899 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression 		EXP
ISO 		swertiamarin inhibits the reaction [Testosterone results in increased expression of BCL2 protein]
swertiamarin results in increased expression of BCL2 protein 		CTD PMID:27866977 PMID:38852899 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Casp3 caspase 3 increases cleavage ISO swertiamarin results in increased cleavage of CASP3 protein CTD PMID:38852899 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cdh1 cadherin 1 multiple interactions EXP swertiamarin inhibits the reaction [Testosterone results in decreased expression of CDH1 mRNA] CTD PMID:27866977 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565 		JBrowse link
G Egf epidermal growth factor multiple interactions EXP swertiamarin inhibits the reaction [Testosterone results in increased expression of EGF protein] CTD PMID:27866977 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions EXP swertiamarin inhibits the reaction [Testosterone results in increased expression of ESR1 protein] CTD PMID:27866977 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions EXP swertiamarin inhibits the reaction [Testosterone results in increased expression of FGF2 protein] CTD PMID:27866977 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions EXP swertiamarin inhibits the reaction [Testosterone results in increased expression of HIF1A protein] CTD PMID:27866977 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO swertiamarin results in increased phosphorylation of MAPK1 protein CTD PMID:38852899 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO swertiamarin results in increased phosphorylation of MAPK3 protein CTD PMID:38852899 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase increases phosphorylation ISO swertiamarin results in increased phosphorylation of MLKL protein CTD PMID:38852899 NCBI chr19:39,277,526...39,304,555
Ensembl chr19:56,186,860...56,213,858 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression
multiple interactions 		ISO swertiamarin results in increased expression of PARP1 mRNA
swertiamarin results in increased expression of and results in increased cleavage of PARP1 protein 		CTD PMID:38852899 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP swertiamarin inhibits the reaction [Testosterone results in increased expression of PCNA protein] CTD PMID:27866977 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP swertiamarin inhibits the reaction [Testosterone results in increased expression of PTGS2 protein] CTD PMID:27866977 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 multiple interactions EXP swertiamarin inhibits the reaction [Testosterone results in increased expression of TWIST1 mRNA] CTD PMID:27866977 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:56,398,061...56,404,965 		JBrowse link
G Vim vimentin multiple interactions EXP swertiamarin inhibits the reaction [Testosterone results in increased expression of VIM mRNA] CTD PMID:27866977 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    chemical entity 20860
      atom 20860
        nonmetal atom 20766
          oxygen atom 20457
            oxygen molecular entity 20457
              organooxygen compound 19806
                carbohydrates and carbohydrate derivatives 15487
                  carbohydrate derivative 14459
                    glycosyl compound 13167
                      glycoside 11941
                        Swertiamarin 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organooxygen compound 19806
                                  carbohydrates and carbohydrate derivatives 15487
                                    carbohydrate 15487
                                      carbohydrate derivative 14459
                                        glycosyl compound 13167
                                          glycoside 11941
                                            Swertiamarin 19
paths to the root