CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: Swertiamarin
Accession: CHEBI:9370
browse the term
Definition: A glycoside that has formula C16H22O10.
Synonyms: related_synonym: Formula=C16H22O10; InChI=1S/C16H22O10/c1-2-7-14(24-6-8-13(21)23-4-3-16(7,8)22)26-15-12(20)11(19)10(18)9(5-17)25-15/h2,6-7,9-12,14-15,17-20,22H,1,3-5H2/t7-,9+,10+,11-,12+,14-,15-,16+/m0/s1; InChIKey=HEYZWPRKKUGDCR-QBXMEVCASA-N; SMILES=OC[C@H]1O[C@@H](O[C@@H]2OC=C3C(=O)OCC[C@@]3(O)[C@H]2C=C)[C@H](O)[C@@H](O)[C@@H]1O
xref: CAS:17388-39-5; KEGG:C09800; KNApSAcK:C00003100
xref_mesh: MESH:C013270
G
Acp3
acid phosphatase 3
multiple interactions
EXP
swertiamarin inhibits the reaction [Testosterone results in increased secretion of ACP3 protein]
CTD
PMID:27866977
NCBI chr 8:104,905,570...104,956,146
Ensembl chr 8:113,785,032...113,833,033
G
Acta2
actin alpha 2, smooth muscle
multiple interactions
EXP
swertiamarin inhibits the reaction [Testosterone results in increased expression of ACTA2 mRNA]
CTD
PMID:27866977
NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503
G
Ar
androgen receptor
multiple interactions
EXP
swertiamarin inhibits the reaction [Testosterone results in increased expression of AR protein]
CTD
PMID:27866977
NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467
G
Bax
BCL2 associated X, apoptosis regulator
multiple interactions increases expression
EXP ISO
swertiamarin inhibits the reaction [Testosterone results in decreased expression of BAX protein] swertiamarin results in increased expression of BAX protein
CTD
PMID:27866977 PMID:38852899
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
G
Bcl2
BCL2, apoptosis regulator
multiple interactions increases expression
EXP ISO
swertiamarin inhibits the reaction [Testosterone results in increased expression of BCL2 protein] swertiamarin results in increased expression of BCL2 protein
CTD
PMID:27866977 PMID:38852899
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
G
Casp3
caspase 3
increases cleavage
ISO
swertiamarin results in increased cleavage of CASP3 protein
CTD
PMID:38852899
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
G
Cdh1
cadherin 1
multiple interactions
EXP
swertiamarin inhibits the reaction [Testosterone results in decreased expression of CDH1 mRNA]
CTD
PMID:27866977
NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565
G
Egf
epidermal growth factor
multiple interactions
EXP
swertiamarin inhibits the reaction [Testosterone results in increased expression of EGF protein]
CTD
PMID:27866977
NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297
G
Esr1
estrogen receptor 1
multiple interactions
EXP
swertiamarin inhibits the reaction [Testosterone results in increased expression of ESR1 protein]
CTD
PMID:27866977
NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354
G
Fgf2
fibroblast growth factor 2
multiple interactions
EXP
swertiamarin inhibits the reaction [Testosterone results in increased expression of FGF2 protein]
CTD
PMID:27866977
NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493
G
Hif1a
hypoxia inducible factor 1 subunit alpha
multiple interactions
EXP
swertiamarin inhibits the reaction [Testosterone results in increased expression of HIF1A protein]
CTD
PMID:27866977
NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323
G
Mapk1
mitogen activated protein kinase 1
increases phosphorylation
ISO
swertiamarin results in increased phosphorylation of MAPK1 protein
CTD
PMID:38852899
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
G
Mapk3
mitogen activated protein kinase 3
increases phosphorylation
ISO
swertiamarin results in increased phosphorylation of MAPK3 protein
CTD
PMID:38852899
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
G
Mlkl
mixed lineage kinase domain like pseudokinase
increases phosphorylation
ISO
swertiamarin results in increased phosphorylation of MLKL protein
CTD
PMID:38852899
NCBI chr19:39,277,526...39,304,555
Ensembl chr19:56,186,860...56,213,858
G
Parp1
poly (ADP-ribose) polymerase 1
increases expression multiple interactions
ISO
swertiamarin results in increased expression of PARP1 mRNA swertiamarin results in increased expression of and results in increased cleavage of PARP1 protein
CTD
PMID:38852899
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567
G
Pcna
proliferating cell nuclear antigen
multiple interactions
EXP
swertiamarin inhibits the reaction [Testosterone results in increased expression of PCNA protein]
CTD
PMID:27866977
NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
EXP
swertiamarin inhibits the reaction [Testosterone results in increased expression of PTGS2 protein]
CTD
PMID:27866977
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
G
Twist1
twist family bHLH transcription factor 1
multiple interactions
EXP
swertiamarin inhibits the reaction [Testosterone results in increased expression of TWIST1 mRNA]
CTD
PMID:27866977
NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:56,398,061...56,404,965
G
Vim
vimentin
multiple interactions
EXP
swertiamarin inhibits the reaction [Testosterone results in increased expression of VIM mRNA]
CTD
PMID:27866977
NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all