Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sulfamethoxazole
go back to main search page
Accession:CHEBI:9332 term browser browse the term
Definition:An isoxazole (1,2-oxazole) compound having a methyl substituent at the 5-position and a 4-aminobenzenesulfonamido group at the 3-position.
Synonyms:exact_synonym: 4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide
 related_synonym: 3-(p-Aminophenylsulfonamido)-5-methylisoxazole;   3-Sulfanilamido-5-methylisoxazole;   4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide;   Formula=C10H11N3O3S;   Gantanol (TN);   InChI=1S/C10H11N3O3S/c1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h2-6H,11H2,1H3,(H,12,13);   InChIKey=JLKIGFTWXXRPMT-UHFFFAOYSA-N;   SMILES=C=1(C=CC(=CC1)N)S(NC=2C=C(ON2)C)(=O)=O;   SMX;   sulphamethoxazole
 alt_id: CHEBI:102247
 xref: CAS:723-46-6;   DrugBank:DB01015;   Drug_Central:2514;   Gmelin:226453;   HMDB:HMDB0015150;   KEGG:C07315;   KEGG:D00447;   LINCS:LSM-5422
 xref_mesh: MESH:D013420
 xref: PMID:10843725;   PMID:10891117;   PMID:10969989;   PMID:11350866;   PMID:11431418;   PMID:12019187;   PMID:15497867;   PMID:15588915;   PMID:15967282;   PMID:15984773;   PMID:17095123;   PMID:17110110;   PMID:17158933;   PMID:17311370;   PMID:17442935;   PMID:17573190;   PMID:18334600;   PMID:18958736;   PMID:19436870;   PMID:20564608;   PMID:22534821;   PMID:226453;   PMID:23611245;   PMID:23649399;   PMID:23742687;   PMID:25851465;   PMID:313909;   PMID:3906132;   PMID:6864729;   PMID:7486915;   PMID:7490723;   PMID:7534104;   PMID:7602118;   PMID:7731020;   PMID:7798534;   PMID:8208693;   PMID:8632413;   Reaxys:226453;   Wikipedia:Sulfamethoxazole


show annotations for term's descendants           Sort by:
sulfamethoxazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 decreases activity
multiple interactions		 ISO Sulfamethoxazole results in decreased activity of ABCB11 protein
Sulfamethoxazole inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]		 CTD PMID:24014644 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958 		JBrowse link
G Acan aggrecan decreases expression ISO Sulfamethoxazole results in decreased expression of ACAN mRNA CTD PMID:26107568 NCBI chr 7:78,702,974...78,764,847
Ensembl chr 7:78,703,231...78,764,847 		JBrowse link
G Alb albumin multiple interactions ISO Sulfamethoxazole metabolite binds to and results in increased metabolism of ALB protein CTD PMID:19358516 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Col2a1 collagen, type II, alpha 1 decreases expression ISO Sulfamethoxazole results in decreased expression of COL2A1 mRNA CTD PMID:26107568 NCBI chr15:97,873,483...97,902,525
Ensembl chr15:97,873,483...97,902,576 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 increases secretion ISO Sulfamethoxazole results in increased secretion of CXCL8 protein CTD PMID:22609641 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions ISO Sulfamethoxazole metabolite binds to and results in increased metabolism of GSTP1 protein CTD PMID:19358516 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
G H2-M3 histocompatibility 2, M region locus 3 affects expression ISO Sulfamethoxazole affects the expression of HLA-G mRNA CTD PMID:25811541 NCBI chr17:37,581,094...37,585,380
Ensembl chr17:37,581,111...37,585,375 		JBrowse link
G Ifng interferon gamma increases secretion EXP Sulfamethoxazole analog results in increased secretion of IFNG protein CTD PMID:15588915 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Il5 interleukin 5 increases secretion EXP Sulfamethoxazole analog results in increased secretion of IL5 protein CTD PMID:15588915 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933 		JBrowse link
G Mir155 microRNA 155 increases expression ISO Sulfamethoxazole results in increased expression of MIR155 mRNA CTD PMID:29644860 NCBI chr16:84,511,028...84,511,092
Ensembl chr16:84,511,028...84,511,092 		JBrowse link
G Mir18 microRNA 18 increases expression ISO Sulfamethoxazole results in increased expression of MIR18A mRNA CTD PMID:29644860 NCBI chr14:115,281,283...115,281,378
Ensembl chr14:115,281,283...115,281,378 		JBrowse link
G Mir21a microRNA 21a increases expression ISO Sulfamethoxazole results in increased expression of MIR21 mRNA CTD PMID:29644860 NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Sulfamethoxazole] which results in increased chemical synthesis of 4-nitrososulfamethoxazole; [MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Sulfamethoxazole CTD PMID:25531135 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Nat2 N-acetyltransferase 2 (arylamine N-acetyltransferase) increases metabolic processing ISO NAT2 protein results in increased metabolism of Sulfamethoxazole CTD PMID:16847467 NCBI chr 8:67,947,527...67,955,296
Ensembl chr 8:67,947,510...67,955,236 		JBrowse link
G Phyh phytanoyl-CoA hydroxylase decreases expression ISO Sulfamethoxazole results in decreased expression of PHYH mRNA CTD PMID:15342952 NCBI chr 2:4,923,807...4,943,554
Ensembl chr 2:4,923,830...4,943,541 		JBrowse link
G Pir pirin increases expression ISO Sulfamethoxazole results in increased expression of PIR mRNA CTD PMID:22609641 NCBI chr  X:163,052,427...163,156,009
Ensembl chr  X:163,052,367...163,156,007 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions ISO [SOD2 co-treated with CYP3A4] affects the susceptibility to Sulfamethoxazole CTD PMID:19501153 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Sox9 SRY (sex determining region Y)-box 9 decreases expression ISO Sulfamethoxazole results in decreased expression of SOX9 mRNA CTD PMID:26107568 NCBI chr11:112,673,036...112,678,583
Ensembl chr11:112,673,050...112,678,586 		JBrowse link
co-trimoxazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ins2 insulin II increases secretion ISO Trimethoprim, Sulfamethoxazole Drug Combination results in increased secretion of INS protein modified form CTD PMID:14714756 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118 		JBrowse link
nitrososulfamethoxazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b10 aldo-keto reductase family 1, member B10 increases expression ISO 4-nitrososulfamethoxazole results in increased expression of AKR1B10 mRNA CTD PMID:28444390 NCBI chr 6:34,361,182...34,373,884
Ensembl chr 6:34,361,153...34,373,885 		JBrowse link
G Hmgb1 high mobility group box 1 increases secretion ISO 4-nitrososulfamethoxazole results in increased secretion of HMGB1 protein CTD PMID:28444390 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299 		JBrowse link
G Ifng interferon gamma increases secretion ISO 4-nitrososulfamethoxazole results in increased secretion of IFNG protein CTD PMID:22331489 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Il13 interleukin 13 increases secretion ISO 4-nitrososulfamethoxazole results in increased secretion of IL13 protein CTD PMID:22331489 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529 		JBrowse link
G Il1a interleukin 1 alpha increases secretion ISO 4-nitrososulfamethoxazole results in increased secretion of IL1A protein CTD PMID:28444390 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892 		JBrowse link
G Il1b interleukin 1 beta increases secretion ISO 4-nitrososulfamethoxazole results in increased secretion of IL1B protein CTD PMID:28444390 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il5 interleukin 5 increases secretion ISO 4-nitrososulfamethoxazole results in increased secretion of IL5 protein CTD PMID:22331489 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933 		JBrowse link
G Il6 interleukin 6 increases secretion ISO 4-nitrososulfamethoxazole results in increased secretion of IL6 protein CTD PMID:28444390 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Mpo myeloperoxidase affects binding
multiple interactions		 ISO 4-nitrososulfamethoxazole binds to MPO protein
[[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Sulfamethoxazole] which results in increased chemical synthesis of 4-nitrososulfamethoxazole		 CTD PMID:25531135 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression ISO 4-nitrososulfamethoxazole results in increased expression of NQO1 mRNA CTD PMID:28444390 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Srxn1 sulfiredoxin 1 homolog (S. cerevisiae) increases expression ISO 4-nitrososulfamethoxazole results in increased expression of SRXN1 mRNA CTD PMID:28444390 NCBI chr 2:151,946,738...151,953,296
Ensembl chr 2:151,947,436...151,953,296 		JBrowse link
G Tnf tumor necrosis factor increases secretion ISO 4-nitrososulfamethoxazole results in increased secretion of TNF protein CTD PMID:28444390 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO 4-nitrososulfamethoxazole results in increased expression of TXNRD1 mRNA CTD PMID:28444390 NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546 		JBrowse link
sulfamethoxazole hydroxylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyb5b cytochrome b5 type B multiple interactions ISO [MTARC1 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine; [MTARC2 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine CTD PMID:25170804 NCBI chr 8:107,877,293...107,914,102
Ensembl chr 8:107,877,272...107,914,103 		JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 multiple interactions ISO [MTARC1 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine; [MTARC2 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine CTD PMID:25170804 NCBI chr15:83,037,696...83,060,641
Ensembl chr15:83,037,695...83,056,793 		JBrowse link
G Mtarc1 mitochondrial amidoxime reducing component 1 multiple interactions ISO [MTARC1 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine CTD PMID:25170804 NCBI chr 1:184,518,964...184,543,622
Ensembl chr 1:184,518,964...184,543,394 		JBrowse link
G Mtarc2 mitochondrial amidoxime reducing component 2 multiple interactions ISO [MTARC2 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine CTD PMID:25170804 NCBI chr 1:184,545,263...184,579,266
Ensembl chr 1:184,545,265...184,578,648 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22194
    role 22179
      biological role 22178
        antimicrobial agent 19567
          sulfamethoxazole 33
            N-acetylsulfamethoxazole 0
            co-trimoxazole 1
            nitrososulfamethoxazole 13
            sulfamethoxazole hydroxylamine 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    main group molecular entity 22120
                      s-block molecular entity 21717
                        hydrogen molecular entity 21634
                          hydrides 20777
                            inorganic hydride 18692
                              pnictogen hydride 18672
                                nitrogen hydride 18540
                                  azane 18447
                                    ammonia 18446
                                      organic amino compound 18446
                                        aromatic amine 15737
                                          anilines 14580
                                            substituted aniline 14212
                                              sulfanilamide 2892
                                                sulfamethoxazole 33
                                                  N-acetylsulfamethoxazole 0
                                                  co-trimoxazole 1
                                                  nitrososulfamethoxazole 13
                                                  sulfamethoxazole hydroxylamine 4
paths to the root