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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide
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Accession:CHEBI:93310 term browser browse the term
Definition:A benzamide that has formula C15H8ClF6NO2.
Synonyms:related_synonym: Formula=C15H8ClF6NO2;   InChI=1S/C15H8ClF6NO2/c16-9-1-2-12(24)11(6-9)13(25)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6,24H,(H,23,25);   InChIKey=CHILCFMQWMQVAL-UHFFFAOYSA-N;   SMILES=C1=CC(=C(C=C1Cl)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)O
 xref: LINCS:LSM-3667
 xref_mesh: MESH:C492919



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N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acly ATP citrate lyase multiple interactions ISO N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Particulate Matter results in increased expression of ACLY protein] CTD PMID:29635361 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Particulate Matter results in decreased phosphorylation of and results in decreased expression of AKT1 protein] CTD PMID:29635361 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [TNF protein results in increased phosphorylation of CHUK protein] CTD PMID:22207076 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Smoke results in increased expression of EDNRB protein]; N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [TNF protein results in increased expression of EDNRB mRNA]; N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [TNF protein results in increased expression of EDNRB protein] CTD PMID:18718921 PMID:22207076 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
JBrowse link
G F11r F11 receptor multiple interactions ISO N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Poly I-C results in decreased expression of F11R protein] CTD PMID:20932985 NCBI chr13:83,873,797...83,897,388
Ensembl chr13:83,873,797...83,897,402
JBrowse link
G Fbp1 fructose-bisphosphatase 1 multiple interactions ISO N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Particulate Matter results in increased expression of FBP1 protein] CTD PMID:29635361 NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Particulate Matter results in increased expression of G6PC protein] CTD PMID:29635361 NCBI chr10:86,307,400...86,318,766 JBrowse link
G Gck glucokinase multiple interactions ISO N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Particulate Matter results in increased expression of GCK mRNA] CTD PMID:29635361 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Copper results in increased expression of GCLC mRNA] CTD PMID:19747488 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Copper results in increased expression of HMOX1 mRNA] CTD PMID:19747488 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Ier3 immediate early response 3 multiple interactions ISO N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Copper results in increased expression of IER3 mRNA] CTD PMID:19747488 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO [N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide results in decreased activity of IKBKB protein] which results in decreased susceptibility to Copper
N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of IKBKB mRNA]
CTD PMID:19747488 PMID:25358444 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Il6 interleukin 6 multiple interactions ISO N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of IL6 mRNA] CTD PMID:25358444 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [TNF results in increased expression of MMP9 mRNA] CTD PMID:17560598 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO
EXP
N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Poly I-C results in increased phosphorylation of NFKBIA protein]
N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
CTD PMID:20932985 PMID:22207076 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Pklr pyruvate kinase L/R multiple interactions ISO N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Particulate Matter results in increased expression of PKLR mRNA] CTD PMID:29635361 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [TNF protein results in increased expression of RELA protein] CTD PMID:22207076 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Particulate Matter results in increased expression of SCD1 protein] CTD PMID:29635361 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Srxn1 sulfiredoxin 1 multiple interactions ISO N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Copper results in increased expression of SRXN1 mRNA] CTD PMID:19747488 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [TNF protein results in increased expression of EDNRB mRNA]; N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [TNF protein results in increased expression of EDNRB protein]; N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [TNF protein results in increased expression of RELA protein]; N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [TNF protein results in increased phosphorylation of CHUK protein]; N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [TNF results in increased expression of MMP9 mRNA]
CTD PMID:17560598 PMID:20932985 PMID:22207076 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Zfand2a zinc finger AN1-type containing 2A multiple interactions ISO N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Copper results in increased expression of ZFAND2A mRNA] CTD PMID:19747488 NCBI chr12:15,161,601...15,172,679
Ensembl chr12:15,161,639...15,172,677
JBrowse link

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  CHEBI ontology 19823
    chemical entity 19823
      atom 19821
        nonmetal atom 19709
          nitrogen atom 18778
            nitrogen molecular entity 18778
              amide 17593
                aromatic amide 7459
                  arenecarboxamide 7267
                    benzamides 7267
                      N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide 21
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  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic group 18739
                              organic divalent group 18730
                                organodiyl group 18730
                                  carbonyl group 18678
                                    carbonyl compound 18678
                                      carboxylic acid 18376
                                        carboacyl group 17490
                                          univalent carboacyl group 17490
                                            carbamoyl group 17304
                                              carboxamide 17304
                                                monocarboxylic acid amide 15012
                                                  arenecarboxamide 7267
                                                    benzamides 7267
                                                      N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide 21
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