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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sulfadiazine
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Accession:CHEBI:9328 term browser browse the term
Definition:A sulfonamide consisting of pyrimidine with a 4-aminobenzenesulfonamido group at the 2-position.
Synonyms:exact_synonym: 4-amino-N-(pyrimidin-2-yl)benzenesulfonamide
 related_synonym: 2-sulfanilamidopyrimidine;   2-sulfanilylaminopyrimidine;   4-amino-N-2-pyrimidinylbenzenesulfonamide;   Formula=C10H10N4O2S;   InChI=1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14);   InChIKey=SEEPANYCNGTZFQ-UHFFFAOYSA-N;   N(1)-2-pyrimidinylsulfanilamide;   N(1)-2-pyrimidylsulfanilamide;   SMILES=Nc1ccc(cc1)S(=O)(=O)Nc1ncccn1;   sulfadiazin;   sulfadiazina;   sulfadiazinum;   sulfapyrimidine;   sulphadiazine
 xref: Beilstein:235192;   CAS:68-35-9;   DrugBank:DB00359;   Drug_Central:2500;   Gmelin:219136;   HMDB:HMDB0014503;   KEGG:C07658;   KEGG:D00587;   LINCS:LSM-5457
 xref_mesh: MESH:D013411
 xref: PMID:11431418;   PMID:12811231;   PMID:13037579;   PMID:15907564;   PMID:18706672;   PMID:20244050;   PMID:23206954;   PMID:23245764;   PMID:23270807;   PMID:23322489;   PMID:23396336;   PMID:23411088;   PMID:23411170;   PMID:23704574;   PMID:23707894;   PMID:7378112;   PMID:8429812;   Patent:GB557055;   Patent:US2407966;   Patent:US2410793;   Reaxys:235192;   VSDB:1740;   Wikipedia:Sulfadiazine
 cyclic_relationship: is_conjugate_acid_of CHEBI:33127

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sulfadiazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G M Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 increases hydroxylation ISO CYP2C8 protein results in increased hydroxylation of Sulfadiazine CTD PMID:15843491 NCBI chr19:39,275,488...39,319,157
Ensembl chr19:39,257,849...39,319,157 		JBrowse link
G M Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 increases hydroxylation ISO CYP2C9 protein results in increased hydroxylation of Sulfadiazine CTD PMID:15843491 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388 		JBrowse link
G M Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 increases hydroxylation ISO CYP2C9 protein results in increased hydroxylation of Sulfadiazine CTD PMID:15843491 NCBI chr19:39,102,342...39,175,200
Ensembl chr19:39,102,342...39,175,516 		JBrowse link
G R Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases hydroxylation ISO CYP2C8 protein results in increased hydroxylation of Sulfadiazine CTD PMID:15843491
G H CYP2C8 cytochrome P450 family 2 subfamily C member 8 increases hydroxylation EXP CYP2C8 protein results in increased hydroxylation of Sulfadiazine CTD PMID:15843491 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497 		JBrowse link
G H CYP2C9 cytochrome P450 family 2 subfamily C member 9 increases hydroxylation EXP CYP2C9 protein results in increased hydroxylation of Sulfadiazine CTD PMID:15843491 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091 		JBrowse link
G R Grin1 glutamate ionotropic receptor NMDA type subunit 1 decreases expression ISO Sulfadiazine results in decreased expression of GRIN1 mRNA CTD PMID:34748853 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G M Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) decreases expression ISO Sulfadiazine results in decreased expression of GRIN1 mRNA CTD PMID:34748853 NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199 		JBrowse link
G H GRIN1 glutamate ionotropic receptor NMDA type subunit 1 decreases expression EXP Sulfadiazine results in decreased expression of GRIN1 mRNA CTD PMID:34748853 NCBI chr 9:137,139,154...137,168,756
Ensembl chr 9:137,139,154...137,168,756 		JBrowse link
G R Hmbs hydroxymethylbilane synthase decreases activity EXP Sulfadiazine decreases activity of purified Hmbs protein RGD PMID:6893114 RGD:26923963 NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957 		JBrowse link
G M Hmbs hydroxymethylbilane synthase decreases activity ISO Sulfadiazine decreases activity of purified Hmbs protein RGD PMID:6893114 RGD:26923963 NCBI chr 9:44,247,645...44,255,525
Ensembl chr 9:44,247,636...44,255,525 		JBrowse link
G H HMBS hydroxymethylbilane synthase decreases activity ISO Sulfadiazine decreases activity of purified Hmbs protein RGD PMID:6893114 RGD:26923963 NCBI chr11:119,084,881...119,093,549
Ensembl chr11:119,084,866...119,093,834 		JBrowse link
G R Il6 interleukin 6 multiple interactions ISO [Trimethoprim co-treated with Sulfadiazine] results in increased expression of IL6 protein CTD PMID:10888991 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G M Il6 interleukin 6 multiple interactions ISO [Trimethoprim co-treated with Sulfadiazine] results in increased expression of IL6 protein CTD PMID:10888991 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G H IL6 interleukin 6 multiple interactions EXP [Trimethoprim co-treated with Sulfadiazine] results in increased expression of IL6 protein CTD PMID:10888991 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G R Lpo lactoperoxidase decreases expression ISO Sulfadiazine results in decreased expression of LPO mRNA CTD PMID:34748853 NCBI chr10:72,606,944...72,626,535
Ensembl chr10:72,606,944...72,626,535 		JBrowse link
G M Lpo lactoperoxidase decreases expression ISO Sulfadiazine results in decreased expression of LPO mRNA CTD PMID:34748853 NCBI chr11:87,697,254...87,716,940
Ensembl chr11:87,697,254...87,719,115 		JBrowse link
G H LPO lactoperoxidase decreases expression EXP Sulfadiazine results in decreased expression of LPO mRNA CTD PMID:34748853 NCBI chr17:58,238,584...58,268,518
Ensembl chr17:58,218,548...58,268,518 		JBrowse link
G R Mtor mechanistic target of rapamycin kinase decreases expression ISO Sulfadiazine results in decreased expression of MTOR mRNA CTD PMID:34748853 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G M Mtor mechanistic target of rapamycin kinase decreases expression ISO Sulfadiazine results in decreased expression of MTOR mRNA CTD PMID:34748853 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G H MTOR mechanistic target of rapamycin kinase decreases expression EXP Sulfadiazine results in decreased expression of MTOR mRNA CTD PMID:34748853 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556 		JBrowse link
G R Nat2 N-acetyltransferase 2 increases acetylation ISO NAT2 protein results in increased acetylation of Sulfadiazine CTD PMID:15843491 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G M Nat2 N-acetyltransferase 2 (arylamine N-acetyltransferase) increases acetylation ISO NAT2 protein results in increased acetylation of Sulfadiazine CTD PMID:15843491 NCBI chr 8:67,947,527...67,955,296
Ensembl chr 8:67,947,510...67,955,236 		JBrowse link
G H NAT2 N-acetyltransferase 2 increases acetylation EXP NAT2 protein results in increased acetylation of Sulfadiazine CTD PMID:15843491 NCBI chr 8:18,386,301...18,401,218
Ensembl chr 8:18,391,282...18,401,218 		JBrowse link
G R Olig2 oligodendrocyte transcription factor 2 decreases expression ISO Sulfadiazine results in decreased expression of OLIG2 mRNA CTD PMID:34748853 NCBI chr11:30,475,510...30,478,886
Ensembl chr11:30,475,398...30,480,152 		JBrowse link
G M Olig2 oligodendrocyte transcription factor 2 decreases expression ISO Sulfadiazine results in decreased expression of OLIG2 mRNA CTD PMID:34748853 NCBI chr16:91,016,745...91,025,567
Ensembl chr16:91,022,345...91,025,565 		JBrowse link
G H OLIG2 oligodendrocyte transcription factor 2 decreases expression EXP Sulfadiazine results in decreased expression of OLIG2 mRNA CTD PMID:34748853 NCBI chr21:33,025,935...33,029,185
Ensembl chr21:33,025,935...33,029,196 		JBrowse link
G R Shank2 SH3 and multiple ankyrin repeat domains 2 decreases expression ISO Sulfadiazine results in decreased expression of SHANK2 mRNA CTD PMID:34748853 NCBI chr 1:199,146,210...199,590,962
Ensembl chr 1:199,169,429...199,589,394 		JBrowse link
G M Shank2 SH3 and multiple ankyrin repeat domains 2 decreases expression ISO Sulfadiazine results in decreased expression of SHANK2 mRNA CTD PMID:34748853 NCBI chr 7:143,531,819...143,979,780
Ensembl chr 7:143,555,665...143,978,231 		JBrowse link
G H SHANK2 SH3 and multiple ankyrin repeat domains 2 decreases expression EXP Sulfadiazine results in decreased expression of SHANK2 mRNA CTD PMID:34748853 NCBI chr11:70,467,854...71,253,228
Ensembl chr11:70,467,854...71,252,577 		JBrowse link
G R Slc6a4 solute carrier family 6 member 4 decreases expression ISO Sulfadiazine results in decreased expression of SLC6A4 mRNA CTD PMID:34748853 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
G M Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 decreases expression ISO Sulfadiazine results in decreased expression of SLC6A4 mRNA CTD PMID:34748853 NCBI chr11:76,889,423...76,923,169
Ensembl chr11:76,889,429...76,923,166 		JBrowse link
G H SLC6A4 solute carrier family 6 member 4 decreases expression EXP Sulfadiazine results in decreased expression of SLC6A4 mRNA CTD PMID:34748853 NCBI chr17:30,194,319...30,235,697
Ensembl chr17:30,194,319...30,236,002 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 73050
    role 72883
      biological role 72856
        antimicrobial agent 59000
          sulfadiazine 33
Path 2
Term Annotations click to browse term
  CHEBI ontology 73050
    subatomic particle 73003
      composite particle 73003
        hadron 73003
          baryon 73003
            nucleon 73003
              atomic nucleus 73003
                atom 73003
                  main group element atom 72655
                    main group molecular entity 72654
                      s-block molecular entity 71286
                        hydrogen molecular entity 70807
                          hydrides 67375
                            inorganic hydride 57422
                              pnictogen hydride 57318
                                nitrogen hydride 56851
                                  azane 56242
                                    ammonia 56239
                                      organic amino compound 56130
                                        aromatic amine 46196
                                          anilines 42782
                                            substituted aniline 41714
                                              sulfanilamide 809
                                                sulfadiazine 33
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