Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Ro 25-6981
go back to main search page
Accession:CHEBI:92897 term browser browse the term
Definition:A member of the class of piperidines that is 4-benzylpiperidine substituted by a 3-hydroxy-3-(4-hydroxyphenyl)-2-methylpropyl group at position 1 (the 1R,2S-stereoisomer). It is a potent antagonist of the GluN2B subunit of the N-methyl-D-aspartate (NMDA) receptor.
Synonyms:exact_synonym: 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol
 related_synonym: (alphaR,betaS)-alpha-(4-Hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidinepropanol;   4-[(1R,2S)-1-hydroxy-2-methyl-3-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol;   Formula=C22H29NO2;   InChI=1S/C22H29NO2/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18/h2-10,17,19,22,24-25H,11-16H2,1H3/t17-,22+/m0/s1;   InChIKey=WVZSEUPGUDIELE-HTAPYJJXSA-N;   Ro 25-6981 free base;   Ro25-6981;   SMILES=C[C@@H](CN1CCC(CC2=CC=CC=C2)CC1)[C@@H](O)C1=CC=C(O)C=C1
 xref: CAS:169274-78-6;   Chemspider:5037146;   LINCS:LSM-3140
 xref_mesh: MESH:C109643
 xref: PDBeChem:QEM;   PMID:11290368;   PMID:12498913;   PMID:14534359;   PMID:15081591;   PMID:15256539;   PMID:17970830;   PMID:18809426;   PMID:21598675;   PMID:21677647;   PMID:23113280;   PMID:24076088;   PMID:24893066;   PMID:25008524;   PMID:25446739;   PMID:27062927;   PMID:27456026;   PMID:27871866;   PMID:28802646;   PMID:29777135;   PMID:29790100;   PMID:29800545;   PMID:29862605;   PMID:32640759;   PMID:32925228;   PMID:34363521;   PMID:34453973;   PMID:34575558;   PMID:9400004;   PMID:9572302
 cyclic_relationship: is_conjugate_base_of CHEBI:183314



show annotations for term's descendants           Sort by:
 
Ro 25-6981 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B decreases activity EXP Ro 25-6981 results in decreased activity of GRIN2B protein CTD PMID:29982505 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20057
    role 20023
      application 19770
        refrigerant 18117
          ammonia 17541
            organic amino compound 17541
              tertiary amino compound 9084
                Ro 25-6981 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20057
    subatomic particle 20056
      composite particle 20068
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19971
                    main group molecular entity 19959
                      s-block molecular entity 19758
                        hydrogen molecular entity 19764
                          hydrides 19134
                            inorganic hydride 17935
                              pnictogen hydride 17901
                                nitrogen hydride 17789
                                  azane 17542
                                    ammonia 17541
                                      organic amino compound 17541
                                        tertiary amino compound 9084
                                          Ro 25-6981 1
paths to the root