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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:5-(2-chloroethyl)-4-methylthiazole
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Accession:CHEBI:92875 term browser browse the term
Definition:A thiazole that has formula C6H8ClNS.
Synonyms:related_synonym: Formula=C6H8ClNS;   InChI=1S/C6H8ClNS/c1-5-6(2-3-7)9-4-8-5/h4H,2-3H2,1H3;   InChIKey=PCLITLDOTJTVDJ-UHFFFAOYSA-N;   SMILES=CC1=C(SC=N1)CCCl;   chlorethiazol;   chlorethiazole;   chlormethiazol;   chlormethiazole;   chlormethiazole HCl;   chlormethiazole hydrochloride;   clomethiazole edisilate;   clomethiazolum;   distraneurin;   emineurina
 xref: CAS:533-45-9;   Drug_Central:602;   LINCS:LSM-3110
 xref_mesh: MESH:D002719


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5-(2-chloroethyl)-4-methylthiazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO Chlormethiazole inhibits the reaction [Ethanol results in decreased phosphorylation of and results in decreased expression of ACACA protein] CTD PMID:24892905 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO Chlormethiazole inhibits the reaction [Ethanol results in decreased expression of ADIPOQ] CTD PMID:25162931 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Chlormethiazole inhibits the reaction [Ethanol results in decreased phosphorylation of AKT1 protein] CTD PMID:24892905 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions EXP Chlormethiazole inhibits the reaction [Acetaminophen results in increased degradation of CDKN1A protein] CTD PMID:16330492 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression EXP Chlormethiazole results in decreased expression of CYP1A1 protein CTD PMID:10751552 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression EXP Chlormethiazole results in decreased expression of CYP1A2 mRNA CTD PMID:10751552 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 multiple interactions ISO Chlormethiazole inhibits the reaction [Ethanol results in increased activity of CYP2A5 protein] CTD PMID:22552773 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity
decreases expression
ISO
EXP
Chlormethiazole inhibits the reaction [cyanoginosin LR results in increased expression of CYP2E1 mRNA]; Chlormethiazole inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]; Chlormethiazole inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]
Chlormethiazole results in decreased activity of CYP2E1 protein
[Chlormethiazole results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; Chlormethiazole inhibits the reaction [Docosahexaenoic Acids results in increased expression of CYP2E1 protein]
Chlormethiazole results in decreased expression of CYP2E1 protein
Chlormethiazole results in decreased expression of CYP2E1 mRNA; Chlormethiazole results in decreased expression of CYP2E1 protein
Chlormethiazole inhibits the reaction [CYP2E1 protein results in increased metabolism of 4-nitrophenol]; Chlormethiazole inhibits the reaction [CYP2E1 protein results in increased metabolism of Carbon Tetrachloride]
CTD PMID:7601153 PMID:10751552 PMID:16330492 PMID:16963249 PMID:21684301 PMID:22552773 PMID:24892905 PMID:26599973 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp2g1 cytochrome P450, family 2, subfamily g, polypeptide 1 decreases expression EXP Chlormethiazole results in decreased expression of CYP2G1 protein CTD PMID:10751552 NCBI chr 1:83,626,639...83,638,154
Ensembl chr 1:83,626,639...83,637,780
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions ISO Chlormethiazole promotes the reaction [Ethanol results in increased expression of DGAT2 protein] CTD PMID:24892905 NCBI chr 1:164,113,459...164,143,818
Ensembl chr 1:164,113,459...164,143,818
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO Chlormethiazole inhibits the reaction [Ethanol results in decreased expression of EP300 protein] CTD PMID:24892905 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO Chlormethiazole inhibits the reaction [Ethanol results in decreased expression of FASN protein] CTD PMID:24892905 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO Chlormethiazole inhibits the reaction [Ethanol results in decreased phosphorylation of GSK3B protein] CTD PMID:24892905 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Chlormethiazole inhibits the reaction [Ethanol results in decreased phosphorylation of MAPK1 protein] CTD PMID:24892905 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Chlormethiazole inhibits the reaction [Ethanol results in decreased phosphorylation of MAPK3 protein] CTD PMID:24892905 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO Chlormethiazole inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA]; Chlormethiazole inhibits the reaction [Ethanol results in decreased expression of PPARA protein]; Chlormethiazole inhibits the reaction [Ethanol results in increased expression of PPARA protein] CTD PMID:24892905 PMID:25162931 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO Chlormethiazole affects the reaction [Ethanol results in decreased expression of PPARGC1A mRNA]; Chlormethiazole inhibits the reaction [Ethanol results in decreased acetylation of PPARGC1A protein] CTD PMID:24892905 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO Chlormethiazole affects the reaction [Ethanol affects the expression of RXRA mRNA] CTD PMID:24892905 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Sirt1 sirtuin 1 decreases expression
multiple interactions
ISO Chlormethiazole results in decreased expression of SIRT1 protein
Chlormethiazole inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein]
CTD PMID:24892905 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO Chlormethiazole inhibits the reaction [Methamphetamine results in decreased activity of TH protein] CTD PMID:1381816 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Chlormethiazole inhibits the reaction [Ethanol results in increased expression of TNF protein] CTD PMID:24892905 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Chlormethiazole inhibits the reaction [Acetaminophen results in increased degradation of TP53 protein] CTD PMID:16330492 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

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  CHEBI ontology 19767
    chemical entity 19767
      atom 19766
        nonmetal atom 19645
          sulfur atom 16298
            sulfur molecular entity 16298
              organosulfur compound 15238
                organosulfur heterocyclic compound 5855
                  thiazoles 1255
                    5-(2-chloroethyl)-4-methylthiazole 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19767
    subatomic particle 19766
      composite particle 19766
        hadron 19766
          baryon 19766
            nucleon 19766
              atomic nucleus 19766
                atom 19766
                  main group element atom 19657
                    p-block element atom 19657
                      carbon group element atom 19573
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19496
                              organic cyclic compound 19322
                                organic heterocyclic compound 18510
                                  heteroarene 16522
                                    monocyclic heteroarene 13364
                                      azole 12537
                                        thiazoles 1255
                                          5-(2-chloroethyl)-4-methylthiazole 22
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