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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5-(2-chloroethyl)-4-methylthiazole
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Accession:CHEBI:92875 term browser browse the term
Definition:A thiazole that has formula C6H8ClNS.
Synonyms:related_synonym: Formula=C6H8ClNS;   InChI=1S/C6H8ClNS/c1-5-6(2-3-7)9-4-8-5/h4H,2-3H2,1H3;   InChIKey=PCLITLDOTJTVDJ-UHFFFAOYSA-N;   SMILES=CC1=C(SC=N1)CCCl;   chlorethiazol;   chlorethiazole;   chlormethiazol;   chlormethiazole;   chlormethiazole HCl;   chlormethiazole hydrochloride;   clomethiazole edisilate;   clomethiazolum;   distraneurin;   emineurina
 xref: CAS:533-45-9;   Drug_Central:602;   LINCS:LSM-3110
 xref_mesh: MESH:D002719


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5-(2-chloroethyl)-4-methylthiazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO Chlormethiazole inhibits the reaction [Ethanol results in decreased phosphorylation of and results in decreased expression of ACACA protein] CTD PMID:24892905 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO Chlormethiazole inhibits the reaction [Ethanol results in decreased expression of ADIPOQ] CTD PMID:25162931 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Chlormethiazole inhibits the reaction [Ethanol results in decreased phosphorylation of AKT1 protein] CTD PMID:24892905 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions EXP Chlormethiazole inhibits the reaction [Acetaminophen results in increased degradation of CDKN1A protein] CTD PMID:16330492 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression EXP Chlormethiazole results in decreased expression of CYP1A1 protein CTD PMID:10751552 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression EXP Chlormethiazole results in decreased expression of CYP1A2 mRNA CTD PMID:10751552 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity
decreases expression		 ISO
EXP		 Chlormethiazole inhibits the reaction [cyanoginosin LR results in increased expression of CYP2E1 mRNA]; Chlormethiazole inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]; Chlormethiazole inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]
Chlormethiazole inhibits the reaction [CYP2E1 protein results in increased metabolism of 4-nitrophenol]; Chlormethiazole inhibits the reaction [CYP2E1 protein results in increased metabolism of Carbon Tetrachloride]
Chlormethiazole results in decreased activity of CYP2E1 protein
Chlormethiazole results in decreased expression of CYP2E1 mRNA; Chlormethiazole results in decreased expression of CYP2E1 protein
[Chlormethiazole results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; Chlormethiazole inhibits the reaction [Docosahexaenoic Acids results in increased expression of CYP2E1 protein]		 CTD PMID:7601153 PMID:10751552 PMID:16330492 PMID:16963249 PMID:21684301 More... NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp2g1 cytochrome P450, family 2, subfamily g, polypeptide 1 decreases expression EXP Chlormethiazole results in decreased expression of CYP2G1 protein CTD PMID:10751552 NCBI chr 1:82,145,635...82,156,862
Ensembl chr 1:82,145,073...82,156,828 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions ISO Chlormethiazole promotes the reaction [Ethanol results in increased expression of DGAT2 protein] CTD PMID:24892905 NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428 		JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO Chlormethiazole inhibits the reaction [Ethanol results in decreased expression of EP300 protein] CTD PMID:24892905 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO Chlormethiazole inhibits the reaction [Ethanol results in decreased expression of FASN protein] CTD PMID:24892905 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO Chlormethiazole inhibits the reaction [Ethanol results in decreased phosphorylation of GSK3B protein] CTD PMID:24892905 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Chlormethiazole inhibits the reaction [Ethanol results in decreased phosphorylation of MAPK1 protein] CTD PMID:24892905 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Chlormethiazole inhibits the reaction [Ethanol results in decreased phosphorylation of MAPK3 protein] CTD PMID:24892905 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO Chlormethiazole inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA]; Chlormethiazole inhibits the reaction [Ethanol results in decreased expression of PPARA protein]; Chlormethiazole inhibits the reaction [Ethanol results in increased expression of PPARA protein] CTD PMID:24892905 PMID:25162931 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO Chlormethiazole affects the reaction [Ethanol results in decreased expression of PPARGC1A mRNA]; Chlormethiazole inhibits the reaction [Ethanol results in decreased acetylation of PPARGC1A protein] CTD PMID:24892905 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO Chlormethiazole affects the reaction [Ethanol affects the expression of RXRA mRNA] CTD PMID:24892905 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
G Sirt1 sirtuin 1 decreases expression
multiple interactions		 ISO Chlormethiazole results in decreased expression of SIRT1 protein
Chlormethiazole inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein]		 CTD PMID:24892905 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO Chlormethiazole inhibits the reaction [Methamphetamine results in decreased activity of TH protein] CTD PMID:1381816 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Chlormethiazole inhibits the reaction [Ethanol results in increased expression of TNF protein] CTD PMID:24892905 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Chlormethiazole inhibits the reaction [Acetaminophen results in increased degradation of TP53 protein] CTD PMID:16330492 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    chemical entity 19840
      atom 19809
        nonmetal atom 19747
          sulfur atom 17687
            sulfur molecular entity 17715
              organosulfur compound 17334
                organosulfur heterocyclic compound 10025
                  thiazoles 1787
                    5-(2-chloroethyl)-4-methylthiazole 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            organic molecule 19658
                              organic cyclic compound 19471
                                organic heterocyclic compound 18862
                                  heteroarene 17114
                                    monocyclic heteroarene 14850
                                      azole 14355
                                        thiazoles 1787
                                          5-(2-chloroethyl)-4-methylthiazole 21
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