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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:streptonigrin
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Accession:CHEBI:9287 term browser browse the term
Definition:Complex cytotoxic antibiotic obtained from Streptomyces flocculus or S. rufochronmogenus. It is used in advanced carcinoma and causes leukopenia.
Synonyms:exact_synonym: 5-amino-6-(7-amino-6-methoxy-5,8-dioxo-5,8-dihydroquinolin-2-yl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpyridine-2-carboxylic acid
 related_synonym: 5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic acid;   Formula=C25H22N4O8;   InChI=1S/C25H22N4O8/c1-9-14(10-6-8-13(35-2)23(36-3)20(10)30)15(26)19(29-17(9)25(33)34)12-7-5-11-18(28-12)22(32)16(27)24(37-4)21(11)31/h5-8,30H,26-27H2,1-4H3,(H,33,34);   InChIKey=PVYJZLYGTZKPJE-UHFFFAOYSA-N;   SMILES=COc1ccc(c(O)c1OC)-c1c(C)c(nc(c1N)-c1ccc2C(=O)C(OC)=C(N)C(=O)c2n1)C(O)=O;   Streptonigran;   rufocromomicina;   rufocromomycin;   rufocromomycine;   rufocromomycinum
 alt_id: CHEBI:108632
 xref: Beilstein:599390;   CAS:3930-19-6;   Gmelin:1240693;   KEGG:C02081;   KEGG:D05931;   KNApSAcK:C00026485
 xref_mesh: MESH:D013308
 xref: PMID:10328288;   PMID:10465544;   PMID:1905760;   PMID:2738877



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streptonigrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases response to substance
ISO [Dicumarol results in decreased activity of NQO1 protein] which results in decreased susceptibility to Streptonigrin; [Dimethyl Fumarate results in increased activity of NQO1 protein] which results in increased susceptibility to Streptonigrin
NQO1 protein results in increased susceptibility to Streptonigrin
CTD PMID:8615901 PMID:10368308 PMID:15655414 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      biological role 19892
        antimicrobial agent 18166
          streptonigrin 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic molecule 19758
                              organic cyclic compound 19565
                                organic heterocyclic compound 18906
                                  organonitrogen heterocyclic compound 18192
                                    quinolines 2657
                                      quinolone 333
                                        streptonigrin 1
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