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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:streptonigrin
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Accession:CHEBI:9287 term browser browse the term
Definition:Complex cytotoxic antibiotic obtained from Streptomyces flocculus or S. rufochronmogenus. It is used in advanced carcinoma and causes leukopenia.
Synonyms:exact_synonym: 5-amino-6-(7-amino-6-methoxy-5,8-dioxo-5,8-dihydroquinolin-2-yl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpyridine-2-carboxylic acid
 related_synonym: 5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic acid;   Formula=C25H22N4O8;   InChI=1S/C25H22N4O8/c1-9-14(10-6-8-13(35-2)23(36-3)20(10)30)15(26)19(29-17(9)25(33)34)12-7-5-11-18(28-12)22(32)16(27)24(37-4)21(11)31/h5-8,30H,26-27H2,1-4H3,(H,33,34);   InChIKey=PVYJZLYGTZKPJE-UHFFFAOYSA-N;   SMILES=COc1ccc(c(O)c1OC)-c1c(C)c(nc(c1N)-c1ccc2C(=O)C(OC)=C(N)C(=O)c2n1)C(O)=O;   Streptonigran;   rufocromomicina;   rufocromomycin;   rufocromomycine;   rufocromomycinum
 alt_id: CHEBI:108632
 xref: Beilstein:599390;   CAS:3930-19-6;   Gmelin:1240693;   KEGG:C02081;   KEGG:D05931;   KNApSAcK:C00026485
 xref_mesh: MESH:D013308
 xref: PMID:10328288;   PMID:10465544;   PMID:1905760;   PMID:2738877


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streptonigrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases response to substance
ISO [Dicumarol results in decreased activity of NQO1 protein] which results in decreased susceptibility to Streptonigrin; [Dimethyl Fumarate results in increased activity of NQO1 protein] which results in increased susceptibility to Streptonigrin
NQO1 protein results in increased susceptibility to Streptonigrin
CTD PMID:8615901, PMID:10368308, PMID:15655414 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        antimicrobial agent 17312
          streptonigrin 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  organonitrogen heterocyclic compound 17461
                                    quinolines 2562
                                      quinolone 304
                                        streptonigrin 1
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