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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dilazep
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Accession:CHEBI:92842 term browser browse the term
Definition:A member of the class of diazepanes that is 1,4-diazepane substituted by 3-[(3,4,5-trimethoxybenzoyl)oxy]propyl groups at positions 1 and 4. It is a potent adenosine uptake inhibitor that exhibits antiplatelet, antianginal and vasodilator properties.
Synonyms:exact_synonym: 1,4-diazepane-1,4-diyldipropane-3,1-diyl bis(3,4,5-trimethoxybenzoate)
 related_synonym: Formula=C31H44N2O10;   InChI=1S/C31H44N2O10/c1-36-24-18-22(19-25(37-2)28(24)40-5)30(34)42-16-8-12-32-10-7-11-33(15-14-32)13-9-17-43-31(35)23-20-26(38-3)29(41-6)27(21-23)39-4/h18-21H,7-17H2,1-6H3;   InChIKey=QVZCXCJXTMIDME-UHFFFAOYSA-N;   N,N'-bis[3-(3,4,5-trimethoxybenzoyloxy)propyl]homopiperazine;   SMILES=COC1=CC(=CC(OC)=C1OC)C(=O)OCCCN1CCCN(CCCOC(=O)C2=CC(OC)=C(OC)C(OC)=C2)CC1;   dilazepum;   tetrahydro-1H-1,4-diazepine-1,4(5H)-dipropanediyl-3,4,5-trimethoxybenzoate
 xref: CAS:35898-87-4;   Chemspider:2965;   DrugBank:DB13715;   Drug_Central:893;   KEGG:D07843;   LINCS:LSM-3068
 xref_mesh: MESH:D004109
 xref: PDBeChem:8DZ;   PMID:12358150;   PMID:12627880;   PMID:12954370;   PMID:14551048;   PMID:15386824;   PMID:15456541;   PMID:18360052;   PMID:20424118;   PMID:20647687;   PMID:22562044;   PMID:23318848;   PMID:25091947;   PMID:31235912;   PMID:6136584;   PMID:7630041;   PMID:8531061;   PMID:9824428;   Wikipedia:Dilazep
 cyclic_relationship: is_conjugate_base_of CHEBI:170000


show annotations for term's descendants           Sort by:
dilazep term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Dilazep results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Slc29a1 solute carrier family 29 member 1 multiple interactions ISO Dilazep inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine] CTD PMID:9353301 PMID:9396714 PMID:11085929 NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      application 19622
        pharmaceutical 19499
          drug 19499
            cardiovascular drug 8502
              vasodilator agent 5853
                dilazep 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            organic group 18905
                              organic divalent group 18887
                                organodiyl group 18887
                                  carbonyl group 18853
                                    carbonyl compound 18853
                                      carboxylic acid 18569
                                        aromatic carboxylic acid 11830
                                          benzoic acids 11805
                                            benzoate ester 5138
                                              dilazep 2
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