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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ketotifen
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Accession:CHEBI:92511 term browser browse the term
Definition:An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.
Synonyms:exact_synonym: 4-(1-methylpiperidin-4-ylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one
 related_synonym: 10-(1-methyl-4-piperidinylidene)-5H-benzo[1,2]cyclohepta[3,4-b]thiophen-4-one;   Formula=C19H19NOS;   InChI=1S/C19H19NOS/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19/h2-5,8,11H,6-7,9-10,12H2,1H3;   InChIKey=ZCVMWBYGMWKGHF-UHFFFAOYSA-N;   SMILES=CN1CCC(=C2C3=C(C(=O)CC4=CC=CC=C42)SC=C3)CC1;   ketotifene;   ketotifeno;   ketotifenum
 xref: CAS:34580-13-7;   DrugBank:DB00920;   Drug_Central:1530;   HMDB:HMDB0015056;   KEGG:D08105;   LINCS:LSM-2637
 xref_mesh: MESH:D007665
 xref: Patent:DE2111071;   Patent:US3682930;   Wikipedia:Ketotifen
 cyclic_relationship: is_conjugate_base_of CHEBI:140417


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ketotifen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 multiple interactions ISO Ketotifen inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Isoproterenol] CTD PMID:10226872 NCBI chr18:57,912,760...57,914,802
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Fcer1g Fc epsilon receptor Ig decreases expression EXP Ketotifen results in decreased expression of FCER1G protein CTD PMID:1834581 NCBI chr13:86,181,908...86,186,766
Ensembl chr13:83,649,449...83,671,443 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO [Ketotifen co-treated with nimesulide] results in decreased expression of ICAM1 protein CTD PMID:12121561 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 ISO
EXP		 [Ketotifen co-treated with nimesulide] results in decreased expression of IL1B protein
Ketotifen results in increased expression of IL1B protein		 CTD PMID:12121561 PMID:15265675 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Ketotifen inhibits the reaction [Capsaicin results in increased expression of IL6 protein] CTD PMID:15265675 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ngf nerve growth factor multiple interactions EXP Ketotifen inhibits the reaction [Capsaicin results in increased expression of NGF protein] CTD PMID:15265675 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Ketotifen results in increased expression of PPARGC1A mRNA CTD PMID:27089845 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Sele selectin E multiple interactions ISO [Ketotifen co-treated with nimesulide] results in decreased expression of SELE protein CTD PMID:12121561 NCBI chr13:78,935,997...78,945,905
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Ketotifen inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression ISO Ketotifen results in increased expression of SREBF1 mRNA CTD PMID:27089845 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 [Ketotifen co-treated with nimesulide] results in decreased expression of TNF protein
Ketotifen inhibits the reaction [Capsaicin results in increased expression of TNF protein]		 CTD PMID:12121561 PMID:15265675 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO [Ketotifen co-treated with nimesulide] results in decreased expression of VCAM1 protein CTD PMID:12121561 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19909
    role 19880
      application 19720
        anti-asthmatic agent 9321
          anti-asthmatic drug 8693
            ketotifen 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19909
    subatomic particle 19907
      composite particle 19907
        hadron 19907
          baryon 19907
            nucleon 19907
              atomic nucleus 19907
                atom 19907
                  main group element atom 19846
                    main group molecular entity 19846
                      s-block molecular entity 19679
                        hydrogen molecular entity 19661
                          hydrides 19163
                            inorganic hydride 18182
                              pnictogen hydride 18172
                                nitrogen hydride 18079
                                  azane 17889
                                    ammonia 17888
                                      organic amino compound 17888
                                        tertiary amino compound 10171
                                          ketotifen 12
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