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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ketotifen
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Accession:CHEBI:92511 term browser browse the term
Definition:An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.
Synonyms:exact_synonym: 4-(1-methylpiperidin-4-ylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one
 related_synonym: 10-(1-methyl-4-piperidinylidene)-5H-benzo[1,2]cyclohepta[3,4-b]thiophen-4-one;   Formula=C19H19NOS;   InChI=1S/C19H19NOS/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19/h2-5,8,11H,6-7,9-10,12H2,1H3;   InChIKey=ZCVMWBYGMWKGHF-UHFFFAOYSA-N;   SMILES=CN1CCC(=C2C3=C(C(=O)CC4=CC=CC=C42)SC=C3)CC1;   ketotifene;   ketotifeno;   ketotifenum
 xref: CAS:34580-13-7;   DrugBank:DB00920;   Drug_Central:1530;   HMDB:HMDB0015056;   KEGG:D08105;   LINCS:LSM-2637
 xref_mesh: MESH:D007665
 xref: Patent:DE2111071;   Patent:US3682930;   Wikipedia:Ketotifen
 cyclic_relationship: is_conjugate_base_of CHEBI:140417



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ketotifen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 multiple interactions ISO Ketotifen inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Isoproterenol] CTD PMID:10226872 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Fcer1g Fc epsilon receptor Ig decreases expression EXP Ketotifen results in decreased expression of FCER1G protein CTD PMID:1834581 NCBI chr13:83,649,447...83,654,248
Ensembl chr13:83,649,449...83,671,443
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO [Ketotifen co-treated with nimesulide] results in decreased expression of ICAM1 protein CTD PMID:12121561 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO
EXP
[Ketotifen co-treated with nimesulide] results in decreased expression of IL1B protein
Ketotifen results in increased expression of IL1B protein
CTD PMID:12121561 PMID:15265675 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Ketotifen inhibits the reaction [Capsaicin results in increased expression of IL6 protein] CTD PMID:15265675 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ngf nerve growth factor multiple interactions EXP Ketotifen inhibits the reaction [Capsaicin results in increased expression of NGF protein] CTD PMID:15265675 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Ketotifen results in increased expression of PPARGC1A mRNA CTD PMID:27089845 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Sele selectin E multiple interactions ISO [Ketotifen co-treated with nimesulide] results in decreased expression of SELE protein CTD PMID:12121561 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Ketotifen inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression ISO Ketotifen results in increased expression of SREBF1 mRNA CTD PMID:27089845 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
[Ketotifen co-treated with nimesulide] results in decreased expression of TNF protein
Ketotifen inhibits the reaction [Capsaicin results in increased expression of TNF protein]
CTD PMID:12121561 PMID:15265675 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO [Ketotifen co-treated with nimesulide] results in decreased expression of VCAM1 protein CTD PMID:12121561 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19904
    role 19880
      application 19715
        anti-asthmatic agent 9307
          anti-asthmatic drug 8684
            ketotifen 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19904
    subatomic particle 19902
      composite particle 19902
        hadron 19902
          baryon 19902
            nucleon 19902
              atomic nucleus 19902
                atom 19902
                  main group element atom 19852
                    p-block element atom 19852
                      carbon group element atom 19797
                        carbon atom 19792
                          organic molecular entity 19792
                            organic group 18983
                              organic divalent group 18958
                                organodiyl group 18958
                                  carbonyl group 18911
                                    carbonyl compound 18911
                                      ketone 17206
                                        cyclic ketone 15715
                                          ketotifen 12
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