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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sporidesmin A
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Accession:CHEBI:9243 term browser browse the term
Definition:An organic heteropentacyclic compound that has formula C18H20ClN3O6S2, produced by the saprophyte fungus Pithomyces chartarum. It is a mycotoxin responsible for the hepatogenous photosensitisation disease facial eczema in ruminants.
Synonyms:exact_synonym: (3R,5aR,10bS,11R,11aR)-9-chloro-10b,11-dihydroxy-7,8-dimethoxy-2,3,6-trimethyl-2,3,5a,6,10b,11-hexahydro-3,11a-epidithiopyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione
 related_synonym: (3R,5aR,10bS,11R,11aR)-9-Chloro-2,3,5a,6,10b,11-hexahydro-10b,11-dihydroxy-7,8-dimethoxy-2,3,6-trimethyl-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione;   Formula=C18H20ClN3O6S2;   InChI=1S/C18H20ClN3O6S2/c1-16-14(24)22-13-17(26,12(23)18(22,30-29-16)15(25)21(16)3)7-6-8(19)10(27-4)11(28-5)9(7)20(13)2/h6,12-13,23,26H,1-5H3/t12-,13-,16-,17-,18-/m1/s1;   InChIKey=QTONANGUNATZOU-ICTVWZTPSA-N;   SMILES=[H][C@]12N(C)C3=C(C=C(Cl)C(OC)=C3OC)[C@@]1(O)[C@@H](O)[C@@]13SS[C@@](C)(N(C)C1=O)C(=O)N23;   hydroxysporidesmin B;   sporidesmin
 xref: AGR:IND93006948;   CAS:1456-55-9;   Chemspider:89980;   HMDB:HMDB0258439;   KEGG:C10618;   KNApSAcK:C00002363
 xref_mesh: MESH:C001873
 xref: PMID:10947103;   PMID:11410239;   PMID:16005584;   PMID:16031618;   PMID:16031836;   PMID:16032061;   PMID:16032063;   PMID:16032149;   PMID:16032159;   PMID:16032308;   PMID:16315666;   PMID:16846241;   PMID:19032699;   PMID:24280939;   PMID:27079671;   PMID:28193462;   PMID:29706850;   PMID:29949719;   PMID:30016827;   PMID:30145942;   PMID:31747528;   PMID:32054403;   PMID:32981484;   PMID:33670922;   PMID:3611593;   PMID:5071863;   PMID:8307980;   PMID:9489029



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sporidesmin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 affects localization ISO sporidesmin affects the localization of CTNNB1 protein CTD PMID:28193462 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects expression ISO sporidesmin affects the expression of CYP1A2 mRNA CTD PMID:28193462 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 multiple interactions
increases expression
ISO MIR21 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA]; MIR31 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA]
sporidesmin results in increased expression of CYP2C18 mRNA; sporidesmin results in increased expression of CYP2C18 protein
CTD PMID:28193462 NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects expression
multiple interactions
ISO sporidesmin affects the expression of CYP2C8 mRNA
MIR21 mRNA affects the reaction [sporidesmin affects the expression of CYP2C8 mRNA]
CTD PMID:28193462
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 decreases expression ISO sporidesmin results in decreased expression of DKK3 mRNA CTD PMID:28193462 NCBI chr 1:166,237,969...166,281,271
Ensembl chr 1:166,238,238...166,280,590
JBrowse link
G Mir132 microRNA 132 increases expression ISO sporidesmin results in increased expression of MIR132 mRNA CTD PMID:28193462 NCBI chr10:60,023,696...60,023,796
Ensembl chr10:60,023,696...60,023,796
JBrowse link
G Mir138-2 microRNA 138-2 increases expression ISO sporidesmin results in increased expression of MIR138-2 mRNA alternative form CTD PMID:28193462 NCBI chr19:10,674,193...10,674,274
Ensembl chr19:10,674,193...10,674,274
JBrowse link
G Mir139 microRNA 139 increases expression ISO sporidesmin results in increased expression of MIR139 mRNA CTD PMID:28193462 NCBI chr 1:155,878,828...155,878,895
Ensembl chr 1:155,878,825...155,878,902
JBrowse link
G Mir150 microRNA 150 increases expression ISO sporidesmin results in increased expression of MIR150 mRNA CTD PMID:28193462 NCBI chr 1:95,605,024...95,605,108
Ensembl chr 1:95,605,024...95,605,108
JBrowse link
G Mir184 microRNA 184 increases expression ISO sporidesmin results in increased expression of MIR184 mRNA CTD PMID:28193462 NCBI chr 8:90,343,134...90,343,210
Ensembl chr 8:90,343,134...90,343,210
JBrowse link
G Mir21 microRNA 21 increases expression
multiple interactions
ISO sporidesmin results in increased expression of MIR21 mRNA
MIR21 mRNA affects the reaction [sporidesmin affects the expression of CYP2C8 mRNA]; MIR21 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA]
CTD PMID:28193462 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Mir290 microRNA 290 increases expression ISO sporidesmin results in increased expression of MIR371A mRNA CTD PMID:28193462 NCBI chr 1:65,964,648...65,964,728
Ensembl chr 1:65,964,648...65,964,728
JBrowse link
G Mir295-1 microRNA 295-1 increases expression ISO sporidesmin results in increased expression of MIR372 mRNA CTD PMID:28193462 NCBI chr 1:65,962,566...65,962,646
Ensembl chr 1:65,962,566...65,962,646
JBrowse link
G Mir31 microRNA 31 multiple interactions
increases expression
ISO MIR31 mRNA affects the reaction [sporidesmin affects the expression of WIF1 mRNA]; MIR31 mRNA affects the reaction [sporidesmin results in decreased expression of SFRP1 mRNA]; MIR31 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA]
sporidesmin results in increased expression of MIR31 mRNA
CTD PMID:28193462 NCBI chr 5:103,599,038...103,599,143 JBrowse link
G Mir375 microRNA 375 increases expression ISO sporidesmin results in increased expression of MIR375 mRNA CTD PMID:28193462 NCBI chr 9:76,457,911...76,457,985
Ensembl chr 9:76,457,911...76,457,985
JBrowse link
G Mir409 microRNA 409 increases expression ISO sporidesmin results in increased expression of MIR409 mRNA CTD PMID:28193462 NCBI chr 6:128,757,780...128,757,856
Ensembl chr 6:128,757,779...128,757,858
JBrowse link
G Mir487b microRNA 487b increases expression ISO sporidesmin results in increased expression of MIR487B mRNA CTD PMID:28193462 NCBI chr 6:128,741,485...128,741,566
Ensembl chr 6:128,741,485...128,741,566
JBrowse link
G Sfrp1 secreted frizzled-related protein 1 decreases expression
multiple interactions
ISO sporidesmin results in decreased expression of SFRP1 mRNA
MIR31 mRNA affects the reaction [sporidesmin results in decreased expression of SFRP1 mRNA]
CTD PMID:28193462 NCBI chr16:68,575,763...68,613,905
Ensembl chr16:68,575,763...68,614,286
JBrowse link
G Wif1 Wnt inhibitory factor 1 multiple interactions
affects expression
ISO MIR31 mRNA affects the reaction [sporidesmin affects the expression of WIF1 mRNA] CTD PMID:28193462 NCBI chr 7:56,548,058...56,618,364
Ensembl chr 7:56,548,053...56,618,360
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20039
    role 19990
      biological role 19989
        biochemical role 19612
          Wnt signalling activator 22
            sporidesmin A 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 20039
    subatomic particle 20037
      composite particle 20037
        hadron 20037
          baryon 20037
            nucleon 20037
              atomic nucleus 20037
                atom 20037
                  main group element atom 19938
                    p-block element atom 19938
                      carbon group element atom 19861
                        carbon atom 19852
                          organic molecular entity 19852
                            organic group 18932
                              organic divalent group 18916
                                organodiyl group 18916
                                  carbonyl group 18865
                                    carbonyl compound 18865
                                      ketone 17087
                                        cyclic ketone 15642
                                          sporidesmin A 19
paths to the root