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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:spiroxamine
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Accession:CHEBI:9242 term browser browse the term
Definition:The spiroketal resulting from the formal condensation of 4-tert-butylcyclohexanone with 3-[ethyl(propyl)amino]propane-1,2-diol. An inhibitor of ergosterol synthesis, it is a broad spectrum agricultural fungicide used particularly against powdery mildew in the production of cereals, bananas and grapes.
Synonyms:exact_synonym: N-[(8-tert-butyl-1,4-dioxaspiro[4.5]dec-2-yl)methyl]-N-ethylpropan-1-amine
 related_synonym: (8-tert-Butyl-1,4-dioxa-spiro[4.5]dec-2-ylmethyl)-ethyl-propyl-amine;   8-(1,1-dimethylethyl)-N-ethyl-N-propyl-1,4-dioxaspiro(4.5)decane-2-methanamine;   Formula=C18H35NO2;   Impulse;   InChI=1S/C18H35NO2/c1-6-12-19(7-2)13-16-14-20-18(21-16)10-8-15(9-11-18)17(3,4)5/h15-16H,6-14H2,1-5H3;   InChIKey=PUYXTUJWRLOUCW-UHFFFAOYSA-N;   KWG4168;   Prosper;   SMILES=CCCN(CC)CC1COC2(CCC(CC2)C(C)(C)C)O1
 alt_id: CHEBI:546779
 xref: AGR:IND43667533;   CAS:118134-30-8;   KEGG:C11124
 xref_mesh: MESH:C510887
 xref: PMID:16366700;   PMID:16526469;   PMID:17804411;   PMID:19733892;   PMID:20060629;   PPDB:599;   Patent:DE3735555;   Patent:US4851405;   Pesticides:spiroxamine;   Reaxys:11342560


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spiroxamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 increases expression ISO spiroxamine results in increased expression of ALDH1A2 mRNA CTD PMID:34737147 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107 		JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 increases expression ISO spiroxamine results in increased expression of CYP26A1 mRNA CTD PMID:34737147 NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression ISO spiroxamine results in increased expression of MSMO1 mRNA CTD PMID:34737147 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016 		JBrowse link
G Myh14 myosin heavy chain 14 decreases expression ISO spiroxamine results in decreased expression of MYH14 protein CTD PMID:34737147 NCBI chr 1:95,096,266...95,158,861
Ensembl chr 1:95,096,266...95,158,836 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases activity ISO spiroxamine results in increased activity of NR3C1 protein CTD PMID:20143881 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Tfap2a transcription factor AP-2 alpha increases expression ISO spiroxamine results in increased expression of TFAP2A protein CTD PMID:34737147 NCBI chr17:24,028,716...24,047,507
Ensembl chr17:24,024,432...24,047,507 		JBrowse link
G Tubb3 tubulin, beta 3 class III increases expression ISO spiroxamine results in increased expression of TUBB3 mRNA CTD PMID:34737147 NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        xenobiotic 18732
          spiroxamine 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    main group molecular entity 19849
                      s-block molecular entity 19681
                        hydrogen molecular entity 19662
                          hydrides 19167
                            inorganic hydride 18182
                              pnictogen hydride 18172
                                nitrogen hydride 18085
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17888
                                        tertiary amino compound 10155
                                          spiroxamine 7
paths to the root