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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:spinosyn A
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Accession:CHEBI:9230 term browser browse the term
Definition:A spinosyn in which the sugar amino and hydroxy groups are globally methylated. One of the two active ingredients of spinosad.
Synonyms:exact_synonym: (2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bR)-13-{[(2R,5S,6R)-5-(dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl]oxy}-9-ethyl-14-methyl-7,15-dioxo-2,3,3a,5a,5b,6,7,9,10,11,12,13,14,15,16a,16b-hexadecahydro-1H-as-indaceno[3,2-d]oxacyclododecin-2-yl 6-deoxy-2,3,4-tri-O-methyl-alpha-L-mannopyranoside
 related_synonym: A 83543A;   Formula=C41H65NO10;   InChI=1S/C41H65NO10/c1-10-26-12-11-13-34(52-36-17-16-33(42(5)6)23(3)48-36)22(2)37(44)32-20-30-28(31(32)21-35(43)50-26)15-14-25-18-27(19-29(25)30)51-41-40(47-9)39(46-8)38(45-7)24(4)49-41/h14-15,20,22-31,33-34,36,38-41H,10-13,16-19,21H2,1-9H3/t22-,23-,24+,25-,26+,27-,28-,29-,30-,31+,33+,34+,36+,38+,39-,40-,41+/m1/s1;   InChIKey=SRJQTHAZUNRMPR-UYQKXTDMSA-N;   SMILES=[H][C@@]12C[C@H](C[C@@]1([H])[C@]1([H])C=C3C(=O)[C@H](C)[C@H](CCC[C@H](CC)OC(=O)C[C@@]3([H])[C@]1([H])C=C2)O[C@H]1CC[C@@H]([C@@H](C)O1)N(C)C)O[C@@H]1O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]1OC;   Spinosad factor A;   lepicidin A
 xref: Beilstein:6838034;   CAS:131929-60-7;   KEGG:C11054;   MetaCyc:CPD-13385;   PMID:21544146;   PMID:21834600;   PMID:22097790;   PMID:22200799;   PMID:22686274;   PMID:22885939;   Patent:WO2004095926;   Patent:WO2006127322;   Reaxys:6838034;   Wikipedia:Spinosad


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spinosad term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions
decreases activity		 EXP spinosad inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; spinosad inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; spinosad inhibits the reaction [ABCB1 protein results in increased transport of Ivermectin]
spinosad results in decreased activity of ABCB1 protein		 CTD PMID:21321059 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit decreases response to substance EXP CHRNA7 protein mutant form results in decreased susceptibility to spinosad CTD PMID:23016960 NCBI chr15:32,030,483...32,173,018
Ensembl chr15:31,923,438...32,173,018 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26041
    role 25957
      application 25179
        pesticide 20539
          insecticide 18758
            pediculicide 827
              spinosyn A 2
                spinosad 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  main group element atom 25841
                    p-block element atom 25841
                      carbon group element atom 25441
                        carbon atom 25399
                          organic molecular entity 25399
                            heteroorganic entity 24773
                              organochalcogen compound 24384
                                organooxygen compound 24061
                                  ester 18759
                                    carboxylic ester 17841
                                      lactone 12966
                                        macrocyclic lactone 6094
                                          macrolide 6018
                                            macrolide antibiotic 772
                                              macrolide pesticide 57
                                                macrolide insecticide 57
                                                  spinosyn insecticide 2
                                                    spinosyn A 2
                                                      spinosad 2
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