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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:SL-327
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Accession:CHEBI:92211 term browser browse the term
Definition:A nitrile that is acrylonitrile in which the hydrogen attached to the same carbon as the cyano group has been replaced by an o-(trifluoromethyl)phenyl group, while the remaining hydrogens of the ethenyl group have been replaced by amino and (4-aminophenyl)sulfanyl groups. The configuration of the double bond is not specified. It is an inhibitor of MEK1 and MEK2.
Synonyms:exact_synonym: 3-amino-3-[(4-aminophenyl)sulfanyl]-2-[2-(trifluoromethyl)phenyl]acrylonitrile
 related_synonym: 3-amino-3-[(4-aminophenyl)thio]-2-[2-(trifluoromethyl)phenyl]-2-propenenitrile;   Formula=C16H12F3N3S;   InChI=1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2;   InChIKey=JLOXTZFYJNCPIS-UHFFFAOYSA-N;   SL327;   SMILES=C1(=CC=CC=C1C(F)(F)F)C(C#N)=C(N)SC2=CC=C(C=C2)N;   alpha-{amino[(4-aminophenyl)thio]methylene}-2-(trifluoromethyl)benzeneacetonitrile
 alt_id: MESH:C424127
 xref: CAS:305350-87-2;   LINCS:LSM-2253
 xref_mesh: MESH:C424127
 xref: PMID:10969080;   PMID:12490588;   PMID:18766328;   PMID:21074569;   PMID:21312031;   Reaxys:9423720


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SL-327 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions
increases expression		 ISO SL 327 promotes the reaction [Tetrachlorodibenzodioxin affects the localization of AHR protein]
SL 327 results in increased expression of AHR protein		 CTD PMID:15572374 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Bdnf brain-derived neurotrophic factor increases response to substance
multiple interactions		 ISO BDNF gene mutant form results in increased susceptibility to SL 327
SL 327 inhibits the reaction [Dronabinol results in increased expression of BDNF mRNA]		 CTD PMID:12657697 PMID:16945347 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
decreases secretion		 EXP SL 327 results in decreased expression of CCL2 mRNA
SL 327 results in decreased secretion of CCL2 protein		 CTD PMID:20050970 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO SL 327 inhibits the reaction [Cocaine results in increased phosphorylation of CREB1 protein] CTD PMID:16339038 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Egr1 early growth response 1 multiple interactions ISO SL 327 inhibits the reaction [Chenodeoxycholic Acid results in increased expression of EGR1 mRNA]; SL 327 inhibits the reaction [Chenodeoxycholic Acid results in increased expression of EGR1 protein]; SL 327 inhibits the reaction [Deoxycholic Acid results in increased expression of EGR1 mRNA]; SL 327 inhibits the reaction [Deoxycholic Acid results in increased expression of EGR1 protein]; SL 327 inhibits the reaction [Dronabinol results in increased expression of EGR1 mRNA]; SL 327 inhibits the reaction [Dronabinol results in increased expression of EGR1 protein] CTD PMID:11553284 PMID:12657697 PMID:19931294 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions ISO SL 327 inhibits the reaction [Dronabinol results in increased phosphorylation of and results in increased activity of ELK1 protein]; SL 327 inhibits the reaction [Haloperidol results in increased phosphorylation of ELK1 protein] CTD PMID:11553284 PMID:12871586 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO
EXP		 SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOS protein]; SL 327 inhibits the reaction [Cocaine results in increased activity of FOS protein]; SL 327 inhibits the reaction [Cocaine results in increased expression of FOS mRNA]; SL 327 inhibits the reaction [Cocaine results in increased expression of FOS protein]; SL 327 inhibits the reaction [Dronabinol results in increased expression of FOS protein]
SL 327 inhibits the reaction [Amphetamine results in increased expression of FOS mRNA]; SL 327 inhibits the reaction [Naloxone results in increased expression of FOS protein]		 CTD PMID:11553284 PMID:12657697 PMID:15056714 PMID:15447667 PMID:16263220 More... NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSB protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOSB protein]; SL 327 inhibits the reaction [Cocaine results in increased expression of FOSB protein alternative form] CTD PMID:15056714 PMID:16263220 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit multiple interactions ISO SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSL2 protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOSL2 protein] CTD PMID:15056714 NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]] CTD PMID:25550330 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]] CTD PMID:25550330 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions ISO SL 327 inhibits the reaction [Cocaine results in increased phosphorylation of GRIA1 protein] CTD PMID:16473939 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Il1b interleukin 1 beta decreases expression EXP SL 327 results in decreased expression of IL1B CTD PMID:20050970 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO SL 327 inhibits the reaction [Cocaine results in increased expression of JUNB protein] CTD PMID:16263220 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Kl Klotho multiple interactions ISO SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]] CTD PMID:25550330 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation		 ISO
EXP		 SL 327 inhibits the reaction [[benserazide, levodopa drug combination co-treated with Oxidopamine] results in increased phosphorylation of MAPK1 protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSB protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSL2 protein]; SL 327 inhibits the reaction [Chenodeoxycholic Acid results in increased phosphorylation of MAPK1 protein]; SL 327 inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SL 327 inhibits the reaction [Deoxycholic Acid results in increased phosphorylation of MAPK1 protein]; SL 327 inhibits the reaction [Dronabinol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SL 327 inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK1 protein]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]]; SL 327 inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK1 protein]
SL 327 results in decreased phosphorylation of MAPK1 protein
SL 327 inhibits the reaction [HU 211 results in increased phosphorylation of MAPK1 protein]; SL 327 inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK1 protein]; SL 327 results in decreased phosphorylation of and results in decreased activity of MAPK1 protein		 CTD PMID:12657697 PMID:12871586 PMID:15056714 PMID:16473939 PMID:17596448 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation		 ISO
EXP		 SL 327 inhibits the reaction [[benserazide, levodopa drug combination co-treated with Oxidopamine] results in increased phosphorylation of MAPK3 protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOS protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOSB protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOSL2 protein]; SL 327 inhibits the reaction [Chenodeoxycholic Acid results in increased phosphorylation of MAPK3 protein]; SL 327 inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SL 327 inhibits the reaction [Deoxycholic Acid results in increased phosphorylation of MAPK3 protein]; SL 327 inhibits the reaction [Dronabinol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SL 327 inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK3 protein]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]]; SL 327 inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK3 protein]
SL 327 inhibits the reaction [HU 211 results in increased phosphorylation of MAPK3 protein]; SL 327 inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK3 protein]; SL 327 results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
SL 327 results in decreased phosphorylation of MAPK3 protein		 CTD PMID:12657697 PMID:12871586 PMID:15056714 PMID:16473939 PMID:17596448 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]] CTD PMID:25550330 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Pdyn prodynorphin multiple interactions EXP SL 327 inhibits the reaction [Dextroamphetamine results in increased expression of PDYN mRNA] CTD PMID:16459022 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Penk proenkephalin multiple interactions EXP SL 327 inhibits the reaction [Dextroamphetamine results in increased expression of PENK mRNA] CTD PMID:16459022 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129 		JBrowse link
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 multiple interactions EXP SL 327 inhibits the reaction [Isoproterenol results in increased expression of PTPN5 protein] CTD PMID:17623046 NCBI chr 1:97,620,638...97,681,186
Ensembl chr 1:97,620,642...97,679,882 		JBrowse link
G Rnd3 Rho family GTPase 3 multiple interactions ISO SL 327 inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of RND3 mRNA] CTD PMID:17196187 NCBI chr 3:35,571,929...35,589,283
Ensembl chr 3:35,571,143...35,589,327 		JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 multiple interactions ISO SL 327 inhibits the reaction [[benserazide, levodopa drug combination co-treated with Oxidopamine] results in increased phosphorylation of RPS6KA5 protein]; SL 327 inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of RPS6KA5 protein] CTD PMID:16339038 PMID:17596448 NCBI chr 6:119,828,823...120,006,190
Ensembl chr 6:119,828,846...120,006,224 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    chemical entity 19872
      group 19825
        pseudohalo group 4580
          cyano group 4580
            nitrile 4580
              SL-327 23
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    main group molecular entity 19811
                      s-block molecular entity 19647
                        hydrogen molecular entity 19628
                          hydrides 19139
                            organic hydride 18687
                              organic fundamental parent 18687
                                hydrocarbon 18438
                                  halohydrocarbon 15850
                                    haloalkane 12898
                                      fluoroalkane 9223
                                        fluoromethanes 6772
                                          tetrafluoromethane 6772
                                            trifluoromethyl group 6772
                                              (trifluoromethyl)benzenes 6772
                                                SL-327 23
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