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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide
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Accession:CHEBI:92070 term browser browse the term
Definition:A salicylamide that has formula C15H20Cl2N2O3.
Synonyms:related_synonym: Formula=C15H20Cl2N2O3;   InChI=1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m0/s1;   InChIKey=WAOQONBSWFLFPE-VIFPVBQESA-N;   SMILES=CCN1CCC[C@H]1CNC(=O)C2=C(C(=CC(=C2OC)Cl)Cl)O
 alt_id: MESH:D020891
 xref: LINCS:LSM-2064
 xref_mesh: MESH:D020891


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3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions ISO Clozapine promotes the reaction [Raclopride promotes the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]]; Raclopride inhibits the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]; Raclopride promotes the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]] CTD PMID:11549694 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Raclopride inhibits the reaction [Dextroamphetamine results in increased expression of CALCA protein] CTD PMID:11398184 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV decreases expression EXP Raclopride results in decreased expression of CAMK4 protein CTD PMID:19289156 NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487 		JBrowse link
G Camkk1 calcium/calmodulin-dependent protein kinase kinase 1 decreases expression EXP Raclopride results in decreased expression of CAMKK1 protein CTD PMID:19289156 NCBI chr10:57,637,335...57,660,498
Ensembl chr10:57,637,391...57,660,498 		JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 decreases expression EXP Raclopride results in decreased expression of CAMKK2 protein CTD PMID:19289156 NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279 		JBrowse link
G Crh corticotropin releasing hormone decreases expression ISO Raclopride results in decreased expression of CRH mRNA CTD PMID:16205782 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression		 EXP DRD2 protein affects the reaction [Raclopride results in increased expression of CTNNB1 protein] CTD PMID:16144542 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Drd1 dopamine receptor D1 multiple interactions ISO Raclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole] CTD PMID:8103921 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
affects binding
increases response to substance		 ISO
EXP		 [Dopamine co-treated with Raclopride] promotes the reaction [Dopamine binds to DRD2 protein]; Cocaine affects the reaction [Raclopride binds to DRD2]
Raclopride binds to DRD2; Raclopride binds to DRD2 protein
DRD2 protein alternative form results in increased susceptibility to Raclopride
Raclopride binds to DRD2 protein; Raclopride binds to DRD2 protein alternative form
Amlodipine inhibits the reaction [Raclopride binds to DRD2 protein]; bisphenol A promotes the reaction [Raclopride binds to DRD2 protein]; Diltiazem inhibits the reaction [Raclopride binds to DRD2 protein]; Flunarizine inhibits the reaction [Raclopride binds to DRD2 protein]; manidipine inhibits the reaction [Raclopride binds to DRD2 protein]; Raclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]; Verapamil inhibits the reaction [Raclopride binds to DRD2 protein]
[Raclopride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Methylphenidate; [Raclopride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Nicotine; [Raclopride binds to and results in decreased activity of DRD2 protein] which results in increased abundance of Dopamine; DRD2 protein affects the reaction [Raclopride results in increased expression of CTNNB1 protein]; DRD2 protein affects the reaction [Raclopride results in increased expression of GSK3A protein]; Raclopride binds to and results in decreased activity of DRD2 protein; Saponins inhibits the reaction [Raclopride binds to DRD2 protein]		 CTD PMID:1833784 PMID:7901417 PMID:8103921 PMID:8804920 PMID:9533112 More... NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Drd3 dopamine receptor D3 multiple interactions EXP [Raclopride binds to and results in decreased activity of DRD3 protein] which results in increased abundance of Dopamine; Raclopride binds to and results in decreased activity of DRD3 protein CTD PMID:15341276 PMID:19289156 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596 		JBrowse link
G Fadd Fas associated via death domain multiple interactions EXP Raclopride affects the reaction [Cocaine affects the expression of FADD protein] CTD PMID:18580876 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Raclopride results in increased expression of FOS protein CTD PMID:17913375 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO Raclopride inhibits the reaction [Methamphetamine results in increased expression of GFAP protein] CTD PMID:16088948 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha multiple interactions
increases expression		 EXP DRD2 protein affects the reaction [Raclopride results in increased expression of GSK3A protein] CTD PMID:16144542 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Raclopride inhibits the reaction [Dronabinol results in increased activity of MAPK1 protein] CTD PMID:11553284 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Raclopride inhibits the reaction [Dronabinol results in increased activity of MAPK3 protein] CTD PMID:11553284 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 affects response to substance ISO NR4A1 affects the susceptibility to Raclopride CTD PMID:14603264 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297 		JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO Raclopride inhibits the reaction [Methamphetamine results in increased expression of PLAT mRNA] CTD PMID:15659235 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B increases phosphorylation ISO Raclopride results in increased phosphorylation of PPP1R1B protein CTD PMID:12064480 NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 multiple interactions
increases expression		 EXP Raclopride promotes the reaction [Amphetamine results in increased expression of RGS2 mRNA]
Raclopride results in increased expression of RGS2 mRNA		 CTD PMID:10098858 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO Raclopride inhibits the reaction [Methamphetamine results in decreased expression of TH protein] CTD PMID:16088948 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
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  CHEBI ontology 19811
    role 19818
      biological role 19785
        antimicrobial agent 18104
          antifungal agent 16832
            salicylic acid 1542
              salicylamides 910
                3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide 21
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Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  carbon oxoacid 18597
                                    carboxylic acid 18594
                                      carboacyl group 17675
                                        univalent carboacyl group 17675
                                          carbamoyl group 17524
                                            carboxamide 17547
                                              monocarboxylic acid amide 15660
                                                arenecarboxamide 8245
                                                  benzamides 8250
                                                    salicylamides 910
                                                      3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide 21
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