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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester
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Accession:CHEBI:91834 term browser browse the term
Definition:A thiophenecarboxylic acid that has formula C13H20N2O3S.
Synonyms:related_synonym: Formula=C13H20N2O3S;   InChI=1S/C13H20N2O3S/c1-5-6-14-9(3)12(16)15-10-8(2)7-19-11(10)13(17)18-4/h7,9,14H,5-6H2,1-4H3,(H,15,16);   InChIKey=QTGIAADRBBLJGA-UHFFFAOYSA-N;   SMILES=CCCNC(C)C(=O)NC1=C(SC=C1C)C(=O)OC;   articaine HCl;   articaine hydrochloride;   carticaine
 xref: CAS:23964-58-1;   Drug_Central:3070;   LINCS:LSM-1750
 xref_mesh: MESH:D002355


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4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Carticaine inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein] CTD PMID:32687258 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Carticaine inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein] CTD PMID:32687258 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Calca calcitonin-related polypeptide alpha increases secretion ISO Carticaine results in increased secretion of CALCA protein CTD PMID:18172555 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Casp1 caspase 1 multiple interactions ISO Carticaine inhibits the reaction [Lipopolysaccharides results in increased expression of CASP1 protein] CTD PMID:32687258 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Carticaine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:32687258 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Carticaine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:32687258 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Carticaine inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein] CTD PMID:32687258 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO Carticaine inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein] CTD PMID:32687258 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Carticaine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:32687258 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Carticaine inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein] CTD PMID:32687258 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Carticaine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:32687258 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Carticaine inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein] CTD PMID:32687258 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Carticaine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:32687258 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases activity EXP Carticaine results in increased activity of TRPV1 protein CTD PMID:18172555 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      chemical role 19288
        donor 18421
          Bronsted acid 18289
            oxoacid 18241
              carbon oxoacid 18126
                carboxylic acid 18114
                  thiophenecarboxylic acid 14
                    4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        thiophenecarboxylic acid 14
                                          4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester 14
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