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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Sodium salicylate
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Accession:CHEBI:9180 term browser browse the term
Definition:An organic molecular entity that has formula C7H5O3.Na.
Synonyms:related_synonym: Formula=C7H5O3.Na;   InChI=1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1;   InChIKey=ABBQHOQBGMUPJH-UHFFFAOYSA-M;   SMILES=[Na+].Oc1ccccc1C([O-])=O
 xref: CAS:54-21-7;   KEGG:C07587;   KEGG:D00566
 xref_mesh: MESH:D012980


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Sodium salicylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa5 annexin A5 increases activity ISO Sodium Salicylate results in increased activity of ANXA5 protein CTD PMID:10090950 NCBI chr 2:123,162,477...123,194,730
Ensembl chr 2:123,162,461...123,193,130
JBrowse link
G Casp1 caspase 1 increases activity
multiple interactions
EXP Sodium Salicylate results in increased activity of CASP1 protein
Sodium Salicylate inhibits the reaction [Paraquat results in decreased activity of CASP1 protein]
CTD PMID:17561093 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
EXP
ISO
Sodium Salicylate inhibits the reaction [Paraquat results in increased activity of CASP3 protein]
Sodium Salicylate results in increased expression of CASP3 mRNA
Sodium Salicylate promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of CASP3 mRNA]; Sodium Salicylate promotes the reaction [Metformin results in increased expression of CASP3 mRNA]
Sodium Salicylate results in increased activity of CASP3 protein
CTD PMID:10090950, PMID:17561093, PMID:29117515 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
EXP Sodium Salicylate results in increased activity of CASP8 protein
Sodium Salicylate inhibits the reaction [Paraquat results in increased activity of CASP8 protein]
CTD PMID:17561093 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases activity ISO Sodium Salicylate results in decreased activity of CDKN1A protein CTD PMID:15190207 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Egf epidermal growth factor multiple interactions ISO Sodium Salicylate promotes the reaction [[EGF protein co-treated with IGF1 protein] results in increased phosphorylation of and results in increased activity of RPS6KB1 protein] CTD PMID:10993886 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Foxo3 forkhead box O3 decreases phosphorylation
increases expression
ISO Sodium Salicylate results in decreased phosphorylation of FOXO3 protein
Sodium Salicylate results in increased expression of FOXO3 protein
CTD PMID:21303813 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Gsn gelsolin increases cleavage ISO Sodium Salicylate results in increased cleavage of GSN protein CTD PMID:10090950 NCBI chr 3:14,456,106...14,508,922
Ensembl chr 3:14,467,330...14,508,911
JBrowse link
G H2ax H2A.X variant histone increases expression ISO Sodium Salicylate results in increased expression of H2AX mRNA CTD PMID:29117515 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Sodium Salicylate results in increased activity of HSF1 protein CTD PMID:10328874 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B affects expression ISO Sodium Salicylate affects the expression of HSPA1B protein CTD PMID:16184763 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA] CTD PMID:10328874 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma decreases expression ISO Sodium Salicylate results in decreased expression of IFNG protein CTD PMID:21303813 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Sodium Salicylate promotes the reaction [[EGF protein co-treated with IGF1 protein] results in increased phosphorylation of and results in increased activity of RPS6KB1 protein] CTD PMID:10993886 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta decreases expression
multiple interactions
ISO Sodium Salicylate results in decreased expression of IKBKB protein modified form
Sodium Salicylate inhibits the reaction [Palmitates results in increased phosphorylation of IKBKB protein]
CTD PMID:21303813, PMID:23504962 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA] CTD PMID:10328874 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL1B protein]; Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
Sodium Salicylate results in decreased expression of IL1B protein
Sodium Salicylate results in decreased expression of IL1B mRNA
CTD PMID:10328874, PMID:21303813 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il4 interleukin 4 multiple interactions ISO Sodium Salicylate affects the reaction [IL4 results in increased activity of STAT6 protein]; Sodium Salicylate inhibits the reaction [IL4 results in increased phosphorylation of STAT6 protein] CTD PMID:19767084 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
ISO Sodium Salicylate results in decreased expression of IL6 protein
Sodium Salicylate inhibits the reaction [Palmitates results in increased secretion of IL6 protein]
CTD PMID:21303813, PMID:23504962 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions ISO Sodium Salicylate inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased chemical synthesis of Nitric Oxide]]; Sodium Salicylate inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]; Sodium Salicylate inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] CTD PMID:23504962 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO Sodium Salicylate inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]; Sodium Salicylate inhibits the reaction [Palmitates results in increased phosphorylation of IRS1 protein] CTD PMID:23504962 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
EXP Sodium Salicylate inhibits the reaction [Paraquat results in increased expression of JUN protein]
Sodium Salicylate results in decreased expression of JUN protein
CTD PMID:17561093 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO
Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Sodium Salicylate results in decreased phosphorylation of and results in decreased activity of MAPK1 protein
CTD PMID:10357911, PMID:10993886 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
Sodium Salicylate results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:10357911, PMID:10993886 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases expression ISO Sodium Salicylate results in increased expression of MCL1 protein CTD PMID:10090950 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases localization
multiple interactions
EXP
ISO
Sodium Salicylate results in decreased localization of NFKB1 protein
Sodium Salicylate inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]
CTD PMID:9281604, PMID:17259377 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein] CTD PMID:16936242 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
ISO Sodium Salicylate results in decreased expression of NOS2 protein
[Sodium Salicylate results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide
CTD PMID:10860828 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 increases phosphorylation
multiple interactions
ISO Sodium Salicylate results in increased phosphorylation of NOS3 protein
Sodium Salicylate inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]]
CTD PMID:21303813, PMID:23504962 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
increases expression
multiple interactions
ISO Sodium Salicylate results in increased cleavage of PARP1 protein
Sodium Salicylate results in increased expression of PARP1 mRNA
Sodium Salicylate inhibits the reaction [epothilone A results in increased expression of PARP1 mRNA]; Sodium Salicylate promotes the reaction [Metformin results in increased expression of PARP1 mRNA]
CTD PMID:9694730, PMID:10090950, PMID:29117515 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pepd peptidase D decreases activity ISO Sodium Salicylate results in decreased activity of PEPD protein CTD PMID:16991207 NCBI chr 1:90,820,670...91,285,128 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
decreases activity
multiple interactions
ISO Sodium Salicylate results in increased expression of PTGS2 mRNA; Sodium Salicylate results in increased expression of PTGS2 protein
Sodium Salicylate results in decreased activity of PTGS2 protein
12-HPETE inhibits the reaction [Sodium Salicylate inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]]; 12-HPETE inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS2 protein]; [PTGS2 protein results in increased abundance of prostaglandin G2] inhibits the reaction [Sodium Salicylate inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]]; [PTGS2 protein results in increased abundance of prostaglandin G2] inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS2 protein]; Hydrogen Peroxide affects the reaction [Sodium Salicylate results in decreased activity of PTGS2 protein]; Sodium Salicylate inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]
CTD PMID:12538810, PMID:14742690 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases localization
ISO
EXP
Sodium Salicylate inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]
Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]; Sodium Salicylate inhibits the reaction [Palmitates results in increased phosphorylation of RELA protein]
Sodium Salicylate results in decreased localization of RELA protein
CTD PMID:9281604, PMID:10328874, PMID:17259377, PMID:23504962 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO Sodium Salicylate inhibits the reaction [SB 203580 promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]]; Sodium Salicylate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; Sodium Salicylate promotes the reaction [[EGF protein co-treated with IGF1 protein] results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; Sodium Salicylate results in decreased phosphorylation of and results in decreased activity of RPS6KB1 protein CTD PMID:10993886 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression
increases expression
ISO Sodium Salicylate results in decreased expression of SCARB1 protein
Sodium Salicylate results in increased expression of SCARB1 protein
CTD PMID:16816107 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
JBrowse link
G Slc26a5 solute carrier family 26 member 5 increases expression EXP Sodium Salicylate results in increased expression of SLC26A5 mRNA; Sodium Salicylate results in increased expression of SLC26A5 protein CTD PMID:19173110 NCBI chr 4:9,795,811...9,860,904
Ensembl chr 4:9,821,541...9,860,571
JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO Sodium Salicylate results in increased expression of SOD2 protein CTD PMID:21303813 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions ISO Sodium Salicylate affects the reaction [IL4 results in increased activity of STAT6 protein]; Sodium Salicylate inhibits the reaction [IL4 results in increased phosphorylation of STAT6 protein] CTD PMID:19767084 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
Sodium Salicylate inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]; Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Sodium Salicylate inhibits the reaction [Palmitates results in increased secretion of TNF protein]
Sodium Salicylate results in decreased expression of TNF protein
CTD PMID:9281604, PMID:10328874, PMID:10357911, PMID:17568627, PMID:21303813, PMID:23504962 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Sodium Salicylate inhibits the reaction [Paraquat results in increased expression of TP53 protein] CTD PMID:17561093 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

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  CHEBI ontology 19810
    chemical entity 19810
      atom 19808
        nonmetal atom 19683
          carbon atom 19588
            organic molecular entity 19588
              Sodium salicylate 40
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  CHEBI ontology 19810
    subatomic particle 19808
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          baryon 19808
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              atomic nucleus 19808
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                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            Sodium salicylate 40
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.