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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Sodium salicylate
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Accession:CHEBI:9180 term browser browse the term
Definition:An organic molecular entity that has formula C7H5O3.Na.
Synonyms:related_synonym: Formula=C7H5O3.Na;   InChI=1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1;   InChIKey=ABBQHOQBGMUPJH-UHFFFAOYSA-M;   SMILES=[Na+].Oc1ccccc1C([O-])=O
 xref: CAS:54-21-7;   KEGG:C07587;   KEGG:D00566
 xref_mesh: MESH:D012980


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Sodium salicylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa5 annexin A5 increases activity ISO Sodium Salicylate results in increased activity of ANXA5 protein CTD PMID:10090950 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369 		JBrowse link
G Casp1 caspase 1 increases activity
multiple interactions		 EXP Sodium Salicylate results in increased activity of CASP1 protein
Sodium Salicylate inhibits the reaction [Paraquat results in decreased activity of CASP1 protein]		 CTD PMID:17561093 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression		 EXP
ISO		 Sodium Salicylate inhibits the reaction [Paraquat results in increased activity of CASP3 protein]
Sodium Salicylate results in increased activity of CASP3 protein
Sodium Salicylate promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of CASP3 mRNA]; Sodium Salicylate promotes the reaction [Metformin results in increased expression of CASP3 mRNA]
Sodium Salicylate results in increased expression of CASP3 mRNA		 CTD PMID:10090950 PMID:17561093 PMID:29117515 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions		 EXP Sodium Salicylate results in increased activity of CASP8 protein
Sodium Salicylate inhibits the reaction [Paraquat results in increased activity of CASP8 protein]		 CTD PMID:17561093 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases activity ISO Sodium Salicylate results in decreased activity of CDKN1A protein CTD PMID:15190207 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO Sodium Salicylate promotes the reaction [[EGF protein co-treated with IGF1 protein] results in increased phosphorylation of and results in increased activity of RPS6KB1 protein] CTD PMID:10993886 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Foxo3 forkhead box O3 decreases phosphorylation
increases expression		 ISO Sodium Salicylate results in decreased phosphorylation of FOXO3 protein
Sodium Salicylate results in increased expression of FOXO3 protein		 CTD PMID:21303813 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Gsn gelsolin increases cleavage ISO Sodium Salicylate results in increased cleavage of GSN protein CTD PMID:10090950 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO Sodium Salicylate results in increased expression of H2AX mRNA CTD PMID:29117515 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Sodium Salicylate results in increased activity of HSF1 protein CTD PMID:10328874 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B affects expression ISO Sodium Salicylate affects the expression of HSPA1B protein CTD PMID:16184763 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA] CTD PMID:10328874 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma decreases expression ISO Sodium Salicylate results in decreased expression of IFNG protein CTD PMID:21303813 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Sodium Salicylate promotes the reaction [[EGF protein co-treated with IGF1 protein] results in increased phosphorylation of and results in increased activity of RPS6KB1 protein] CTD PMID:10993886 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta decreases expression
multiple interactions		 ISO Sodium Salicylate results in decreased expression of IKBKB protein modified form
Sodium Salicylate inhibits the reaction [Palmitates results in increased phosphorylation of IKBKB protein]		 CTD PMID:21303813 PMID:23504962 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA] CTD PMID:10328874 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression		 ISO Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL1B protein]; Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
Sodium Salicylate results in decreased expression of IL1B mRNA
Sodium Salicylate results in decreased expression of IL1B protein		 CTD PMID:10328874 PMID:21303813 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO Sodium Salicylate affects the reaction [IL4 results in increased activity of STAT6 protein]; Sodium Salicylate inhibits the reaction [IL4 results in increased phosphorylation of STAT6 protein] CTD PMID:19767084 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions		 ISO Sodium Salicylate results in decreased expression of IL6 protein
Sodium Salicylate inhibits the reaction [Palmitates results in increased secretion of IL6 protein]		 CTD PMID:21303813 PMID:23504962 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO Sodium Salicylate inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased chemical synthesis of Nitric Oxide]]; Sodium Salicylate inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]; Sodium Salicylate inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] CTD PMID:23504962 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO Sodium Salicylate inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]; Sodium Salicylate inhibits the reaction [Palmitates results in increased phosphorylation of IRS1 protein] CTD PMID:23504962 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression		 EXP Sodium Salicylate inhibits the reaction [Paraquat results in increased expression of JUN protein]
Sodium Salicylate results in decreased expression of JUN protein		 CTD PMID:17561093 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO		 Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Sodium Salicylate results in decreased phosphorylation of and results in decreased activity of MAPK1 protein		 CTD PMID:10357911 PMID:10993886 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP		 Sodium Salicylate results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAPK3 protein]		 CTD PMID:10357911 PMID:10993886 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases expression ISO Sodium Salicylate results in increased expression of MCL1 protein CTD PMID:10090950 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases localization
multiple interactions		 EXP
ISO		 Sodium Salicylate results in decreased localization of NFKB1 protein
Sodium Salicylate inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]		 CTD PMID:9281604 PMID:17259377 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein] CTD PMID:16936242 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions		 ISO Sodium Salicylate results in decreased expression of NOS2 protein
[Sodium Salicylate results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide		 CTD PMID:10860828 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 increases phosphorylation
multiple interactions		 ISO Sodium Salicylate results in increased phosphorylation of NOS3 protein
Sodium Salicylate inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]]		 CTD PMID:21303813 PMID:23504962 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
increases expression		 ISO Sodium Salicylate results in increased cleavage of PARP1 protein
Sodium Salicylate inhibits the reaction [epothilone A results in increased expression of PARP1 mRNA]; Sodium Salicylate promotes the reaction [Metformin results in increased expression of PARP1 mRNA]
Sodium Salicylate results in increased expression of PARP1 mRNA		 CTD PMID:9694730 PMID:10090950 PMID:29117515 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pepd peptidase D decreases activity ISO Sodium Salicylate results in decreased activity of PEPD protein CTD PMID:16991207 NCBI chr 1:87,536,650...87,681,233
Ensembl chr 1:87,536,609...87,681,231 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
decreases activity		 ISO Sodium Salicylate results in increased expression of PTGS2 mRNA; Sodium Salicylate results in increased expression of PTGS2 protein
12-HPETE inhibits the reaction [Sodium Salicylate inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]]; 12-HPETE inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS2 protein]; [PTGS2 protein results in increased abundance of prostaglandin G2] inhibits the reaction [Sodium Salicylate inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]]; [PTGS2 protein results in increased abundance of prostaglandin G2] inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS2 protein]; Hydrogen Peroxide affects the reaction [Sodium Salicylate results in decreased activity of PTGS2 protein]; Sodium Salicylate inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]		 CTD PMID:12538810 PMID:14742690 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases localization		 ISO
EXP		 Sodium Salicylate inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]
Sodium Salicylate results in decreased localization of RELA protein
Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]; Sodium Salicylate inhibits the reaction [Palmitates results in increased phosphorylation of RELA protein]		 CTD PMID:9281604 PMID:10328874 PMID:17259377 PMID:23504962 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO Sodium Salicylate inhibits the reaction [SB 203580 promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]]; Sodium Salicylate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; Sodium Salicylate promotes the reaction [[EGF protein co-treated with IGF1 protein] results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; Sodium Salicylate results in decreased phosphorylation of and results in decreased activity of RPS6KB1 protein CTD PMID:10993886 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression
increases expression		 ISO Sodium Salicylate results in decreased expression of SCARB1 protein
Sodium Salicylate results in increased expression of SCARB1 protein		 CTD PMID:16816107 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647 		JBrowse link
G Slc26a5 solute carrier family 26 member 5 increases expression EXP Sodium Salicylate results in increased expression of SLC26A5 mRNA; Sodium Salicylate results in increased expression of SLC26A5 protein CTD PMID:19173110 NCBI chr 4:13,210,260...13,249,289
Ensembl chr 4:13,210,260...13,249,289 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO Sodium Salicylate results in increased expression of SOD2 protein CTD PMID:21303813 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions ISO Sodium Salicylate affects the reaction [IL4 results in increased activity of STAT6 protein]; Sodium Salicylate inhibits the reaction [IL4 results in increased phosphorylation of STAT6 protein] CTD PMID:19767084 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 ISO
EXP		 Sodium Salicylate inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]; Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Sodium Salicylate results in decreased expression of TNF protein
Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]
Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Sodium Salicylate inhibits the reaction [Palmitates results in increased secretion of TNF protein]		 CTD PMID:9281604 PMID:10328874 PMID:10357911 PMID:17568627 PMID:21303813 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Sodium Salicylate inhibits the reaction [Paraquat results in increased expression of TP53 protein] CTD PMID:17561093 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 19922
    chemical entity 19920
      atom 19892
        nonmetal atom 19849
          carbon atom 19802
            organic molecular entity 19775
              Sodium salicylate 40
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19805
                        carbon atom 19802
                          organic molecular entity 19775
                            Sodium salicylate 40
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