Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tianeptine
go back to main search page
Accession:CHEBI:91749 term browser browse the term
Definition:A racemate comprising of equimolar amounts of (R)- and (S)-tianeptine. It is an atypical antidepressant used in Europe to treat patients who respond poorly to selective serotonin reuptake inhibitors (SSRIs).
Synonyms:exact_synonym: rac-7-[(3-chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid
 related_synonym: (+-)-7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide;   7-{[(11RS)-3-chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl]amino}heptanoic acid;   Formula=C21H25ClN2O4S;   rac-tianeptine;   racemic tianeptine;   tianeptina;   tianeptinum
 xref: CAS:72797-41-2;   Chemspider:62102;   Drug_Central:2650;   HMDB:HMDB0042038;   KEGG:D02575;   LINCS:LSM-1626
 xref_mesh: MESH:C050504
 xref: PMID:27693216;   PMID:30550394;   PMID:30612921;   PMID:31160227;   PMID:31425465;   PMID:31924532;   PMID:32122858;   PMID:32134888;   PMID:32552075;   PMID:33065230;   PMID:33154348;   PMID:33410462;   PMID:33433378;   PMID:33608048;   PMID:33909525;   PMID:34134575;   PMID:34195969;   PMID:34464676;   PMID:34493757;   PMID:34593976;   PMID:34819526;   PMID:34966012;   PMID:35211768;   PMID:3771709;   Wikipedia:Tianeptine


show annotations for term's descendants           Sort by:
tianeptine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP tianeptine results in increased expression of ABCC2 mRNA CTD PMID:27765674 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression EXP tianeptine results in increased expression of ABCG5 mRNA CTD PMID:27765674 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563 		JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression EXP tianeptine results in increased expression of ABCG8 mRNA CTD PMID:27765674 NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912 		JBrowse link
G Angptl3 angiopoietin-like 3 decreases expression ISO tianeptine results in decreased expression of ANGPTL3 mRNA CTD PMID:27089845 NCBI chr 5:113,703,007...113,710,044
Ensembl chr 5:113,703,012...113,709,957 		JBrowse link
G Cat catalase multiple interactions EXP tianeptine inhibits the reaction [Indomethacin results in increased activity of CAT protein] CTD PMID:19497431 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cnr2 cannabinoid receptor 2 increases expression EXP tianeptine results in increased expression of CNR2 protein CTD PMID:28866072 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548 		JBrowse link
G Drd2 dopamine receptor D2 decreases expression EXP tianeptine results in decreased expression of DRD2 mRNA CTD PMID:11981225 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression ISO tianeptine results in increased expression of IGFBP1 mRNA CTD PMID:27089845 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP tianeptine inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:19497431 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Oprm1 opioid receptor, mu 1 increases activity ISO tianeptine results in increased activity of OPRM1 protein CTD PMID:32734307 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP tianeptine results in decreased expression of SLC10A1 mRNA CTD PMID:27765674 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions ISO tianeptine binds to and results in decreased activity of SLC6A4 protein CTD PMID:16272152 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 decreases expression EXP tianeptine results in decreased expression of SLCO1A1 mRNA CTD PMID:27765674 NCBI chr 4:174,877,045...174,950,900
Ensembl chr 4:174,876,593...174,950,873 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression ISO tianeptine results in increased expression of SREBF1 mRNA CTD PMID:27089845 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20845
    chemical entity 20843
      chemical substance 14567
        mixture 13885
          racemate 12274
            tianeptine 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 20845
    subatomic particle 20843
      composite particle 20843
        hadron 20843
          baryon 20843
            nucleon 20843
              atomic nucleus 20843
                atom 20843
                  main group element atom 20766
                    p-block element atom 20766
                      carbon group element atom 20699
                        carbon atom 20693
                          organic molecular entity 20693
                            heteroorganic entity 20202
                              organochalcogen compound 19890
                                organooxygen compound 19792
                                  carbon oxoacid 19137
                                    carboxylic acid 19134
                                      monocarboxylic acid 18281
                                        7-[(3-chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid 14
                                          (S)-tianeptine 14
                                            tianeptine 14
paths to the root