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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol
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Accession:CHEBI:91704 term browser browse the term
Definition:An aromatic ether that has formula C15H23NO3.
Synonyms:related_synonym: (+/-)-Oxprenolol;   Formula=C15H23NO3;   InChI=1S/C15H23NO3/c1-4-9-18-14-7-5-6-8-15(14)19-11-13(17)10-16-12(2)3/h4-8,12-13,16-17H,1,9-11H2,2-3H3;   InChIKey=CEMAWMOMDPGJMB-UHFFFAOYSA-N;   SMILES=CC(C)NCC(COC1=CC=CC=C1OCC=C)O;   dl-Oxprenolol;   oxprenolol HCl;   oxprenolol hydrochloride
 xref: CAS:6452-71-7;   Drug_Central:2027;   HMDB:HMDB0015520;   LINCS:LSM-1554
 xref_mesh: MESH:D010096


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1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions ISO Oxprenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP] CTD PMID:15060759 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO [Oxprenolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP; [Oxprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Oxprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein CTD PMID:17925438 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions ISO Oxprenolol binds to and results in increased activity of ADRB3 protein CTD PMID:1682311 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Avp arginine vasopressin decreases expression ISO Oxprenolol results in decreased expression of AVP protein CTD PMID:6367368 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Oxprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein CTD PMID:17925438 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Oxprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein CTD PMID:17925438 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Ren renin multiple interactions
decreases activity
ISO [Oxprenolol co-treated with Indomethacin] results in decreased activity of REN protein
Oxprenolol results in decreased activity of REN protein
CTD PMID:6173514 PMID:6344036 PMID:7023672 PMID:7049707 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link

Term paths to the root
Path 1
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  CHEBI ontology 19771
    chemical entity 19771
      group 19689
        polyatomic entity 19688
          molecule 19527
            organic molecule 19497
              organic cyclic compound 19321
                organic aromatic compound 19146
                  aromatic ether 15632
                    1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    main group molecular entity 19658
                      p-block molecular entity 19658
                        carbon group molecular entity 19574
                          organic molecular entity 19564
                            heteroorganic entity 19199
                              organochalcogen compound 18946
                                organooxygen compound 18873
                                  ether 16633
                                    aromatic ether 15632
                                      1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol 7
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