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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol
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Accession:CHEBI:91704 term browser browse the term
Definition:An aromatic ether that has formula C15H23NO3.
Synonyms:related_synonym: (+/-)-Oxprenolol;   Formula=C15H23NO3;   InChI=1S/C15H23NO3/c1-4-9-18-14-7-5-6-8-15(14)19-11-13(17)10-16-12(2)3/h4-8,12-13,16-17H,1,9-11H2,2-3H3;   InChIKey=CEMAWMOMDPGJMB-UHFFFAOYSA-N;   SMILES=CC(C)NCC(COC1=CC=CC=C1OCC=C)O;   dl-Oxprenolol;   oxprenolol HCl;   oxprenolol hydrochloride
 xref: CAS:6452-71-7;   Drug_Central:2027;   HMDB:HMDB0015520;   LINCS:LSM-1554
 xref_mesh: MESH:D010096



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1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions ISO Oxprenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP] CTD PMID:15060759 NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO [Oxprenolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP; [Oxprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Oxprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein CTD PMID:17925438 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions ISO Oxprenolol binds to and results in increased activity of ADRB3 protein CTD PMID:1682311 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552
JBrowse link
G Avp arginine vasopressin decreases expression ISO Oxprenolol results in decreased expression of AVP protein CTD PMID:6367368 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Oxprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein CTD PMID:17925438 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Oxprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein CTD PMID:17925438 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Ren renin multiple interactions
decreases activity
ISO [Oxprenolol co-treated with Indomethacin] results in decreased activity of REN protein
Oxprenolol results in decreased activity of REN protein
CTD PMID:6173514 PMID:6344036 PMID:7023672 PMID:7049707 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20072
    chemical entity 20071
      group 20002
        polyatomic entity 20000
          molecule 19859
            organic molecule 19835
              organic cyclic compound 19589
                organic aromatic compound 19430
                  aromatic ether 16335
                    1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 20072
    subatomic particle 20071
      composite particle 20071
        hadron 20071
          baryon 20071
            nucleon 20071
              atomic nucleus 20071
                atom 20071
                  main group element atom 19971
                    main group molecular entity 19971
                      p-block molecular entity 19971
                        carbon group molecular entity 19894
                          organic molecular entity 19887
                            heteroorganic entity 19577
                              organochalcogen compound 19339
                                organooxygen compound 19239
                                  ether 17003
                                    aromatic ether 16335
                                      1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol 7
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