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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:SU6656
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Accession:CHEBI:91462 term browser browse the term
Definition:A member of the class of oxindoles that is 3-methyleneoxindole in which the hydrogeh at position 5 has been replaced by a dimethylaminosulfonyl group and in which one of the hydrogens of the methylene group has been replaced by a 4,5,6,7-tetrahydro-indol-2-yl group. It is a specific inhibitor of Src family kinase.
Synonyms:exact_synonym: N,N-dimethyl-2-oxo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)indoline-5-sulfonamide
 related_synonym: Formula=C19H21N3O3S;   InChI=1S/C19H21N3O3S/c1-22(2)26(24,25)14-7-8-18-15(11-14)16(19(23)21-18)10-13-9-12-5-3-4-6-17(12)20-13/h7-11,20H,3-6H2,1-2H3,(H,21,23);   InChIKey=LOGJQOUIVKBFGH-UHFFFAOYSA-N;   SMILES=N1C(C(C2=C1C=CC(=C2)S(N(C)C)(=O)=O)=CC=3NC4=C(C3)CCCC4)=O;   SU-6656
 alt_id: CHEBI:131826;   MESH:C416927
 xref: CAS:330161-87-0;   LINCS:LSM-1219
 xref_mesh: MESH:C416927
 xref: PMID:11074000;   PMID:15677565;   PMID:15985613;   PMID:16504759;   PMID:22034098;   PMID:22102627;   PMID:22244830;   PMID:23386415;   PMID:24093774;   PMID:24275091


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SU6656 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Areg amphiregulin decreases secretion ISO SU 6656 results in decreased secretion of AREG protein CTD PMID:15615697 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Ctnnb1 catenin beta 1 affects localization ISO SU 6656 affects the localization of CTNNB1 protein CTD PMID:23527294 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO SU 6656 inhibits the reaction [alpha-naphthoflavone results in increased expression of CYP1A1 mRNA] CTD PMID:30508555 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO SU 6656 inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein] CTD PMID:30508555 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A decreases activity ISO SU 6656 results in decreased activity of DYRK1A protein CTD PMID:12534346 NCBI chr11:34,858,339...34,958,733
Ensembl chr11:34,865,532...34,956,536
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO SU 6656 inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of EGFR protein]
[[RTKI cpd results in decreased activity of EGFR protein] co-treated with [SU 6656 results in decreased activity of SRC protein]] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein]; [SU 6656 results in decreased activity of SRC protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of EGFR protein]
CTD PMID:15504454 PMID:23376140 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO SU 6656 inhibits the reaction [lead acetate results in increased activity of HRAS protein] CTD PMID:19133285 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions ISO SU 6656 inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein] CTD PMID:16963453 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
JBrowse link
G Krt18 keratin 18 increases expression ISO SU 6656 results in increased expression of KRT18 protein CTD PMID:23527294 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Krt8 keratin 8 increases expression ISO SU 6656 results in increased expression of KRT8 protein CTD PMID:23527294 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase decreases activity ISO SU 6656 results in decreased activity of LCK protein CTD PMID:12534346 NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO SU 6656 inhibits the reaction [lead acetate results in increased phosphorylation of MAPK1 protein]; SU 6656 inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of MAPK1 protein]
[SU 6656 results in decreased activity of SRC protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SU 6656 inhibits the reaction [alpha-naphthoflavone results in increased phosphorylation of MAPK1 protein]
CTD PMID:15504454 PMID:19133285 PMID:23376140 PMID:30508555 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO SU 6656 inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; SU 6656 inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of MAPK3 protein]
[SU 6656 results in decreased activity of SRC protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SU 6656 inhibits the reaction [alpha-naphthoflavone results in increased phosphorylation of MAPK3 protein]
CTD PMID:15504454 PMID:19133285 PMID:23376140 PMID:30508555 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [SU 6656 results in decreased activity of SRC protein] inhibits the reaction [Cadmium Chloride results in increased expression of MT2 protein] CTD PMID:23376140 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO SU 6656 inhibits the reaction [afimoxifene results in increased expression of MYC mRNA]; SU 6656 inhibits the reaction [Estradiol results in increased expression of MYC mRNA] CTD PMID:15528270 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO SU 6656 results in decreased expression of POU5F1 protein CTD PMID:23527294 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO SU 6656 inhibits the reaction [lead acetate results in increased activity of PRKCA protein] CTD PMID:19133285 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO SU 6656 inhibits the reaction [lead acetate results in increased phosphorylation of RAF1 protein] CTD PMID:19133285 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family multiple interactions ISO SU 6656 inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein] CTD PMID:16963453 NCBI chr 2:208,193,950...208,215,186
Ensembl chr 2:208,193,954...208,215,187
JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 decreases activity ISO SU 6656 results in decreased activity of RPS6KA1 protein CTD PMID:12534346 NCBI chr 5:152,078,217...152,122,684
Ensembl chr 5:152,078,220...152,122,684
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions
decreases activity
ISO [[RTKI cpd results in decreased activity of EGFR protein] co-treated with [SU 6656 results in decreased activity of SRC protein]] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein]; [SU 6656 results in decreased activity of SRC protein] inhibits the reaction [Cadmium Chloride results in increased expression of MT2 protein]; [SU 6656 results in decreased activity of SRC protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of EGFR protein]; [SU 6656 results in decreased activity of SRC protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [SU 6656 results in decreased activity of SRC protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:23376140 PMID:23527294 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [[RTKI cpd results in decreased activity of EGFR protein] co-treated with [SU 6656 results in decreased activity of SRC protein]] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein] CTD PMID:23376140 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tff1 trefoil factor 1 multiple interactions ISO SU 6656 inhibits the reaction [afimoxifene results in increased expression of TFF1 mRNA]; SU 6656 inhibits the reaction [Estradiol results in increased expression of TFF1 mRNA] CTD PMID:15528270 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link

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  CHEBI ontology 19883
    role 19833
      application 19505
        pharmaceutical 19375
          drug 19375
            antineoplastic agent 17034
              SU6656 23
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  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    p-block element atom 19771
                      carbon group element atom 19679
                        carbon atom 19668
                          organic molecular entity 19668
                            organic group 18580
                              organic divalent group 18571
                                organodiyl group 18571
                                  carbonyl group 18479
                                    carbonyl compound 18479
                                      carboxylic acid 18153
                                        carboacyl group 17410
                                          univalent carboacyl group 17410
                                            carbamoyl group 17192
                                              carboxamide 17192
                                                lactam 8049
                                                  gamma-lactam 6278
                                                    oxindoles 5838
                                                      SU6656 23
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