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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:SU6656
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Accession:CHEBI:91462 term browser browse the term
Definition:A member of the class of oxindoles that is 3-methyleneoxindole in which the hydrogeh at position 5 has been replaced by a dimethylaminosulfonyl group and in which one of the hydrogens of the methylene group has been replaced by a 4,5,6,7-tetrahydro-indol-2-yl group. It is a specific inhibitor of Src family kinase.
Synonyms:exact_synonym: N,N-dimethyl-2-oxo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)indoline-5-sulfonamide
 related_synonym: Formula=C19H21N3O3S;   InChI=1S/C19H21N3O3S/c1-22(2)26(24,25)14-7-8-18-15(11-14)16(19(23)21-18)10-13-9-12-5-3-4-6-17(12)20-13/h7-11,20H,3-6H2,1-2H3,(H,21,23);   InChIKey=LOGJQOUIVKBFGH-UHFFFAOYSA-N;   SMILES=N1C(C(C2=C1C=CC(=C2)S(N(C)C)(=O)=O)=CC=3NC4=C(C3)CCCC4)=O;   SU-6656
 alt_id: CHEBI:131826;   MESH:C416927
 xref: CAS:330161-87-0;   LINCS:LSM-1219
 xref_mesh: MESH:C416927
 xref: PMID:11074000;   PMID:15677565;   PMID:15985613;   PMID:16504759;   PMID:22034098;   PMID:22102627;   PMID:22244830;   PMID:23386415;   PMID:24093774;   PMID:24275091



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SU6656 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Areg amphiregulin decreases secretion ISO SU 6656 results in decreased secretion of AREG protein CTD PMID:15615697 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
JBrowse link
G Ctnnb1 catenin beta 1 affects localization ISO SU 6656 affects the localization of CTNNB1 protein CTD PMID:23527294 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO SU 6656 inhibits the reaction [alpha-naphthoflavone results in increased expression of CYP1A1 mRNA] CTD PMID:30508555 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO SU 6656 inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein] CTD PMID:30508555 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A decreases activity ISO SU 6656 results in decreased activity of DYRK1A protein CTD PMID:12534346 NCBI chr11:33,890,706...34,009,420
Ensembl chr11:33,890,490...34,009,420
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO SU 6656 inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of EGFR protein]
[[RTKI cpd results in decreased activity of EGFR protein] co-treated with [SU 6656 results in decreased activity of SRC protein]] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein]; [SU 6656 results in decreased activity of SRC protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of EGFR protein]
CTD PMID:15504454 PMID:23376140 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO SU 6656 inhibits the reaction [lead acetate results in increased activity of HRAS protein] CTD PMID:19133285 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions ISO SU 6656 inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein] CTD PMID:16963453 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
JBrowse link
G Krt18 keratin 18 increases expression ISO SU 6656 results in increased expression of KRT18 protein CTD PMID:23527294 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
JBrowse link
G Krt8 keratin 8 increases expression ISO SU 6656 results in increased expression of KRT8 protein CTD PMID:23527294 NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase decreases activity ISO SU 6656 results in decreased activity of LCK protein CTD PMID:12534346 NCBI chr 5:141,888,319...141,916,992
Ensembl chr 5:141,888,326...141,903,794
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO SU 6656 inhibits the reaction [lead acetate results in increased phosphorylation of MAPK1 protein]; SU 6656 inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of MAPK1 protein]
[SU 6656 results in decreased activity of SRC protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SU 6656 inhibits the reaction [alpha-naphthoflavone results in increased phosphorylation of MAPK1 protein]
CTD PMID:15504454 PMID:19133285 PMID:23376140 PMID:30508555 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO SU 6656 inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; SU 6656 inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of MAPK3 protein]
[SU 6656 results in decreased activity of SRC protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SU 6656 inhibits the reaction [alpha-naphthoflavone results in increased phosphorylation of MAPK3 protein]
CTD PMID:15504454 PMID:19133285 PMID:23376140 PMID:30508555 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [SU 6656 results in decreased activity of SRC protein] inhibits the reaction [Cadmium Chloride results in increased expression of MT2 protein] CTD PMID:23376140 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO SU 6656 inhibits the reaction [afimoxifene results in increased expression of MYC mRNA]; SU 6656 inhibits the reaction [Estradiol results in increased expression of MYC mRNA] CTD PMID:15528270 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO SU 6656 results in decreased expression of POU5F1 protein CTD PMID:23527294 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO SU 6656 inhibits the reaction [lead acetate results in increased activity of PRKCA protein] CTD PMID:19133285 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO SU 6656 inhibits the reaction [lead acetate results in increased phosphorylation of RAF1 protein] CTD PMID:19133285 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family multiple interactions ISO SU 6656 inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein] CTD PMID:16963453 NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501
JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 decreases activity ISO SU 6656 results in decreased activity of RPS6KA1 protein CTD PMID:12534346 NCBI chr 5:146,079,018...146,118,272
Ensembl chr 5:146,079,021...146,118,272
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions
decreases activity
ISO [[RTKI cpd results in decreased activity of EGFR protein] co-treated with [SU 6656 results in decreased activity of SRC protein]] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein]; [SU 6656 results in decreased activity of SRC protein] inhibits the reaction [Cadmium Chloride results in increased expression of MT2 protein]; [SU 6656 results in decreased activity of SRC protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of EGFR protein]; [SU 6656 results in decreased activity of SRC protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [SU 6656 results in decreased activity of SRC protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:23376140 PMID:23527294 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [[RTKI cpd results in decreased activity of EGFR protein] co-treated with [SU 6656 results in decreased activity of SRC protein]] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein] CTD PMID:23376140 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tff1 trefoil factor 1 multiple interactions ISO SU 6656 inhibits the reaction [afimoxifene results in increased expression of TFF1 mRNA]; SU 6656 inhibits the reaction [Estradiol results in increased expression of TFF1 mRNA] CTD PMID:15528270 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
JBrowse link

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  CHEBI ontology 20056
    role 20008
      application 19745
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            antineoplastic agent 17639
              SU6656 23
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  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
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              atomic nucleus 20054
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                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic group 18961
                              organic divalent group 18947
                                organodiyl group 18947
                                  carbonyl group 18900
                                    carbonyl compound 18900
                                      carboxylic acid 18594
                                        carboacyl group 17706
                                          univalent carboacyl group 17706
                                            carbamoyl group 17546
                                              carboxamide 17546
                                                lactam 8343
                                                  gamma-lactam 6606
                                                    oxindoles 5864
                                                      SU6656 23
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