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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:KN-93
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Accession:CHEBI:91460 term browser browse the term
Definition:A sulfonamide resulting from the formal condensation of p-methoxybenzenesulfonic acid with the anilino nitrogen of 2-(aminomethyl)-N-(2-hydroxyethyl)aniline in which the hydrogens of the primary amino group have been replaced by methyl and p-chlorocinnamyl groups. KN-93 is a selective inhibitor of Ca(2+)/calmodulin-dependent protein kinase II.
Synonyms:exact_synonym: N-[2-({[(2E)-3-(4-chlorophenyl)prop-2-en-1-yl](methyl)amino}methyl)phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide
 related_synonym: Formula=C26H29ClN2O4S;   KN93;   N-[2-[[3-(4-chlorophenyl)prop-2-enyl-methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide
 xref: CAS:139298-40-1;   LINCS:LSM-42804
 xref_mesh: MESH:C072105
 xref: PMID:10712242;   PMID:16368898;   PMID:1662507;   PMID:17457979;   PMID:22363408;   PMID:23983471;   PMID:24142712;   PMID:24829059;   PMID:24836181;   PMID:25206480;   PMID:25498987;   PMID:25937575;   PMID:26024774;   PMID:26463508;   PMID:9864285;   Reaxys:8359108



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KN-93 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO KN 93 inhibits the reaction [Digoxin results in increased expression of ABCB1 protein]; KN 93 inhibits the reaction [Ouabain results in increased expression of ABCB1 protein] CTD PMID:19647009 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Aco1 aconitase 1 multiple interactions EXP KN 93 inhibits the reaction [Cadmium Chloride affects the localization of ACO1 protein] CTD PMID:25106854 NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391
JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO KN 93 affects the reaction [[Cadmium co-treated with TNFSF11 protein co-treated with CSF1R protein] affects the expression of ACP5 protein] CTD PMID:32522522 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO KN 93 inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of AHR protein] CTD PMID:18089838 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor multiple interactions ISO KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHRR mRNA] CTD PMID:18089838 NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO KN 93 inhibits the reaction [Cadmium Chloride affects the localization of AIFM1 protein] CTD PMID:18506790 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP
ISO
KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]
KN 93 inhibits the reaction [rutacarpine results in increased phosphorylation of AKT1 protein]
CTD PMID:19233221 PMID:21933187 PMID:28025122 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions EXP KN 93 inhibits the reaction [cadmium acetate results in increased expression of ATF4 protein] CTD PMID:29883672 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atf6 activating transcription factor 6 increases expression
multiple interactions
ISO KN 93 results in increased expression of ATF6 protein
KN 93 inhibits the reaction [Silicon Dioxide results in increased expression of ATF6 protein]
CTD PMID:37075931 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO KN 93 inhibits the reaction [Vincristine results in increased expression of BAX mRNA]; KN 93 inhibits the reaction [Vincristine results in increased expression of BAX protein] CTD PMID:34286406 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO KN 93 inhibits the reaction [Vincristine results in decreased expression of BCL2 mRNA]; KN 93 inhibits the reaction [Vincristine results in decreased expression of BCL2 protein] CTD PMID:34286406 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H multiple interactions ISO KN 93 inhibits the reaction [Vincristine results in increased expression of CACNA1H mRNA]; KN 93 inhibits the reaction [Vincristine results in increased expression of CACNA1H protein] CTD PMID:34286406 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376
JBrowse link
G Calcr calcitonin receptor multiple interactions ISO KN 93 inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA] CTD PMID:21869564 NCBI chr 4:31,661,270...31,736,392
Ensembl chr 4:31,661,273...31,736,392
JBrowse link
G Camk1 calcium/calmodulin-dependent protein kinase I decreases activity ISO KN 93 results in decreased activity of CAMK1 protein CTD PMID:12193581 NCBI chr 4:146,481,196...146,492,039
Ensembl chr 4:146,481,196...146,492,081
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions ISO
EXP
[KN 93 co-treated with Losartan] inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein]; KN 93 inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein]
KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of CAMK2A protein]; KN 93 inhibits the reaction [Cocaine promotes the reaction [DRD3 protein binds to CAMK2A protein]]; KN 93 inhibits the reaction [Excitatory Amino Acid Agents promotes the reaction [CAMK2A protein binds to DRD3 protein]]; KN 93 inhibits the reaction [Ionomycin promotes the reaction [CAMK2A protein binds to DRD3 protein]]; KN 93 inhibits the reaction [Ionomycin promotes the reaction [CAMK2A protein modified form binds to DRD3 protein]]
KN 93 inhibits the reaction [rutacarpine results in increased phosphorylation of CAMK2A protein]
CTD PMID:19217379 PMID:21933187 PMID:25103225 PMID:28025122 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta multiple interactions EXP KN 93 inhibits the reaction [Cadmium affects the localization of CAMK2D protein] CTD PMID:22553113 NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178
JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV multiple interactions EXP KN 93 inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CAMK4 protein] CTD PMID:17973980 NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487
JBrowse link
G Casp12 caspase 12 multiple interactions EXP KN 93 inhibits the reaction [cadmium acetate results in increased cleavage of CASP12 protein] CTD PMID:29883672 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
KN 93 inhibits the reaction [cadmium acetate results in increased cleavage of CASP3 protein]; KN 93 inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; KN 93 promotes the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]
KN 93 inhibits the reaction [bisphenol A results in increased expression of and results in increased cleavage of CASP3 protein]; KN 93 inhibits the reaction [GW 7845 results in increased activity of CASP3 protein]; KN 93 inhibits the reaction [Vincristine results in increased cleavage of CASP3 protein]
KN 93 inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]]
CTD PMID:19233221 PMID:20810541 PMID:26096086 PMID:26923100 PMID:28025122 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccl1 C-C motif chemokine ligand 1 multiple interactions ISO KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CCL1 mRNA] CTD PMID:18089838 NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO KN 93 results in decreased expression of CCND1 protein CTD PMID:15958590 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP KN 93 inhibits the reaction [Capsaicin results in increased phosphorylation of CREB1 protein]; KN 93 inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein] CTD PMID:15385614 PMID:15631885 PMID:21113126 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Csf1r colony stimulating factor 1 receptor multiple interactions ISO KN 93 affects the reaction [[Cadmium co-treated with TNFSF11 protein co-treated with CSF1R protein] affects the expression of ACP5 protein]; KN 93 affects the reaction [[Cadmium co-treated with TNFSF11 protein co-treated with CSF1R protein] affects the expression of NFATC1 protein] CTD PMID:32522522 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions ISO KN 93 inhibits the reaction [Vincristine results in increased expression of CXCL12 mRNA] CTD PMID:34286406 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO KN 93 inhibits the reaction [GW 7845 affects the localization of CYCS protein] CTD PMID:20810541 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 multiple interactions ISO KN 93 inhibits the reaction [Potassium results in increased expression of CYP11B2 mRNA] CTD PMID:12193581 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO
EXP
KN 93 inhibits the reaction [STO 609 results in increased activity of CYP1A1 protein]; KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] CTD PMID:18089838 PMID:18755850 PMID:23298284 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA] CTD PMID:18089838 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
decreases expression
EXP
ISO
KN 93 inhibits the reaction [cadmium acetate results in increased expression of DDIT3 protein]
KN 93 results in decreased expression of DDIT3 protein
CTD PMID:29883672 PMID:37075931 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Drd3 dopamine receptor D3 multiple interactions EXP KN 93 inhibits the reaction [Cocaine promotes the reaction [DRD3 protein binds to CAMK2A protein]]; KN 93 inhibits the reaction [Excitatory Amino Acid Agents promotes the reaction [CAMK2A protein binds to DRD3 protein]]; KN 93 inhibits the reaction [Ionomycin promotes the reaction [CAMK2A protein binds to DRD3 protein]]; KN 93 inhibits the reaction [Ionomycin promotes the reaction [CAMK2A protein modified form binds to DRD3 protein]]; KN 93 inhibits the reaction [Ionomycin results in increased phosphorylation of DRD3 protein] CTD PMID:19217379 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP
ISO
KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EGFR protein]
KN 93 inhibits the reaction [carvacrol results in increased phosphorylation of EGFR protein]
CTD PMID:19233221 PMID:32535744 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions EXP KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:21933187 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO KN 93 inhibits the reaction [Cadmium Chloride results in decreased activity of FOXO3 protein]; KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein] CTD PMID:23673518 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP
ISO
KN 93 inhibits the reaction [diphenylditelluride results in increased phosphorylation of GFAP protein]
KN 93 inhibits the reaction [Vincristine results in increased expression of GFAP protein]
CTD PMID:21879721 PMID:34286406 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO KN 93 inhibits the reaction [Vincristine results in increased expression of GJA1 mRNA]; KN 93 inhibits the reaction [Vincristine results in increased expression of GJA1 protein] CTD PMID:34286406 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression ISO KN 93 results in decreased expression of GPX4 protein CTD PMID:37075931 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions EXP KN 93 inhibits the reaction [Capsaicin results in increased phosphorylation of GRIA1 protein] CTD PMID:12019337 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
JBrowse link
G Hdac5 histone deacetylase 5 multiple interactions ISO KN 93 inhibits the reaction [Potassium Chloride results in increased phosphorylation of HDAC5 protein] CTD PMID:17988634 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235
JBrowse link
G Hexb hexosaminidase subunit beta multiple interactions EXP KN 93 inhibits the reaction [Ionomycin results in increased secretion of HEXB protein] CTD PMID:14499669 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO KN 93 inhibits the reaction [Digoxin affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Digoxin results in increased phosphorylation of HIF1A protein]; KN 93 inhibits the reaction [Ouabain affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Ouabain results in increased phosphorylation of HIF1A protein] CTD PMID:19647009 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO KN 93 inhibits the reaction [rutacarpine results in increased expression of HMOX1 mRNA]; KN 93 inhibits the reaction [rutacarpine results in increased expression of HMOX1 protein] CTD PMID:28025122 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP KN 93 inhibits the reaction [cadmium acetate results in increased expression of HSPA5 protein] CTD PMID:29883672 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IL1B mRNA]
KN 93 inhibits the reaction [Vincristine results in increased expression of IL1B mRNA]
CTD PMID:18089838 PMID:34286406 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions ISO KN 93 inhibits the reaction [Cannabinol promotes the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL2 protein]] CTD PMID:11809870 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il6 interleukin 6 multiple interactions ISO KN 93 inhibits the reaction [Vincristine results in increased expression of IL6 mRNA] CTD PMID:34286406 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itgb7 integrin subunit beta 7 multiple interactions ISO KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ITGB7 mRNA] CTD PMID:18089838 NCBI chr 7:133,347,927...133,364,955
Ensembl chr 7:133,347,960...133,364,876
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions EXP KN 93 inhibits the reaction [Phenylephrine results in increased activity of MAP3K5 protein] CTD PMID:15629441 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
KN 93 inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein]; KN 93 promotes the reaction [wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein]]; wortmannin promotes the reaction [KN 93 inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein]]
KN 93 inhibits the reaction [cadmium acetate results in increased phosphorylation of MAPK1 protein]; KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]; KN 93 inhibits the reaction [diphenylditelluride results in increased phosphorylation of MAPK1 protein]; KN 93 inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased phosphorylation of MAPK1 protein]
KN 93 affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK1 protein]
CTD PMID:15086530 PMID:15355987 PMID:19233221 PMID:21879721 PMID:21933187 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK14 protein] CTD PMID:21933187 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
KN 93 inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein]; KN 93 promotes the reaction [wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein]]; wortmannin promotes the reaction [KN 93 inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein]]
KN 93 inhibits the reaction [cadmium acetate results in increased phosphorylation of MAPK3 protein]; KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; KN 93 inhibits the reaction [diphenylditelluride results in increased phosphorylation of MAPK3 protein]; KN 93 inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased phosphorylation of MAPK3 protein]
KN 93 affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK3 protein]
CTD PMID:15086530 PMID:15355987 PMID:19233221 PMID:21879721 PMID:21933187 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:21933187 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions EXP Curcumin promotes the reaction [KN 93 inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]]; KN 93 inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; KN 93 promotes the reaction [Curcumin inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]] CTD PMID:25093688 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Nefl neurofilament light chain multiple interactions EXP KN 93 inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFL protein] CTD PMID:21879721 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
JBrowse link
G Nefm neurofilament medium chain multiple interactions EXP KN 93 inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFM protein] CTD PMID:21879721 NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO KN 93 affects the reaction [[Cadmium co-treated with TNFSF11 protein co-treated with CSF1R protein] affects the expression of NFATC1 protein] CTD PMID:32522522 NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028
JBrowse link
G Nfatc2 nuclear factor of activated T-cells 2 decreases expression ISO KN 93 results in decreased expression of NFATC2 protein CTD PMID:37075931 NCBI chr 3:157,195,970...157,328,640
Ensembl chr 3:157,198,872...157,328,325
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP KN 93 inhibits the reaction [Phenylephrine results in increased degradation of NFKBIA protein] CTD PMID:15629441 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO KN 93 inhibits the reaction [Glyburide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]] CTD PMID:27246103 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO KN 93 inhibits the reaction [Vincristine results in increased expression of PTGS2 mRNA]; KN 93 inhibits the reaction [Vincristine results in increased expression of PTGS2 protein] CTD PMID:34286406 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO KN 93 results in decreased phosphorylation of RB1 protein CTD PMID:15958590 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO KN 93 inhibits the reaction [Vincristine results in increased phosphorylation of RELA protein] CTD PMID:34286406 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions EXP KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein] CTD PMID:21933187 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions ISO KN 93 inhibits the reaction [Silicon Dioxide results in decreased expression of SLC7A11 protein] CTD PMID:37075931 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions EXP KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of SRC protein] CTD PMID:19233221 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO KN 93 inhibits the reaction [carvacrol results in increased secretion of TGFA protein] CTD PMID:32535744 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO KN 93 inhibits the reaction [Vincristine results in increased expression of TNF mRNA] CTD PMID:34286406 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO KN 93 affects the reaction [[Cadmium co-treated with TNFSF11 protein co-treated with CSF1R protein] affects the expression of ACP5 protein]; KN 93 affects the reaction [[Cadmium co-treated with TNFSF11 protein co-treated with CSF1R protein] affects the expression of NFATC1 protein]; KN 93 inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA] CTD PMID:21869564 PMID:32522522 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Vim vimentin multiple interactions EXP KN 93 inhibits the reaction [diphenylditelluride results in increased phosphorylation of VIM protein] CTD PMID:21879721 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Wnt5a Wnt family member 5A multiple interactions ISO KN 93 inhibits the reaction [Silicon Dioxide results in increased expression of WNT5A protein] CTD PMID:37075931 NCBI chr16:3,697,032...3,718,230
Ensembl chr16:3,697,032...3,718,234
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      application 19729
        pharmaceutical 19565
          drug 19565
            protective agent 18248
              geroprotector 17409
                KN-93 69
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic molecule 19758
                              organic cyclic compound 19565
                                carbocyclic compound 18616
                                  benzenoid aromatic compound 17993
                                    benzenes 17844
                                      methoxybenzenes 2051
                                        monomethoxybenzene 1853
                                          KN-93 69
paths to the root