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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:silibinin
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Accession:CHEBI:9144 term browser browse the term
Definition:A flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities.
Synonyms:exact_synonym: (2R,3R)-3,5,7-trihydroxy-2-[(2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydro-4H-chromen-4-one
 related_synonym: Flavobin;   Formula=C25H22O10;   InChI=1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3/t20-,23+,24-,25-/m1/s1;   InChIKey=SEBFKMXJBCUCAI-HKTJVKLFSA-N;   Karsil;   SMILES=[H][C@@]1(Oc2cc(ccc2O[C@@H]1CO)[C@@]1([H])Oc2cc(O)cc(O)c2C(=O)[C@@H]1O)c1ccc(O)c(OC)c1;   Silibinine;   Silybin;   Silymarin;   silibinina;   silibininum
 xref: CAS:22888-70-6;   HMDB:HMDB0030583;   KEGG:C07610;   KEGG:D08515;   KNApSAcK:C00001003
 xref_mesh: MESH:C440975
 xref: PMID:22086675;   PMID:22555054;   PMID:22899727;   PMID:23073223;   PMID:23357565;   PMID:23402882;   Patent:CN102727484;   Reaxys:1632852;   Wikipedia:Silibinin



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silibinin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO Silybin results in increased expression of ABCA1 protein CTD PMID:26729088 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions EXP Silybin affects the localization of and affects the activity of ABCB11 protein CTD PMID:15763547 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Silybin inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; Silybin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]] CTD PMID:34217736 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions
increases phosphorylation
ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased phosphorylation of ACACA protein]
Silybin results in increased phosphorylation of ACACA protein
CTD PMID:25294820 PMID:25559859 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acly ATP citrate lyase decreases phosphorylation ISO Silybin results in decreased phosphorylation of ACLY protein CTD PMID:25294820 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions EXP Silybin inhibits the reaction [ferric ammonium citrate results in increased expression of ACP5 protein] CTD PMID:36087815 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
JBrowse link
G Adipor2 adiponectin receptor 2 increases expression EXP silymarin (silibinin) increases expression of adipor2 mRNA and protein in epididymal white adipose tissue of alcohol fed rats RGD PMID:26115886 RGD:25330099 NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355
JBrowse link
G Agpat3 1-acylglycerol-3-phosphate O-acyltransferase 3 multiple interactions EXP Silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in increased expression of AGPAT3 mRNA] CTD PMID:28619387 NCBI chr20:10,330,960...10,415,358
Ensembl chr20:10,384,507...10,415,358
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Silybin results in decreased activity of AKR1C3 protein CTD PMID:19007764 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of AKT1 protein] CTD PMID:25559859 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO Silybin inhibits the reaction [ferric ammonium citrate results in decreased expression of and results in decreased activity of ALPL protein] CTD PMID:36087815 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Amacr alpha-methylacyl-CoA racemase decreases expression ISO Silybin results in decreased expression of AMACR protein CTD PMID:25294820 NCBI chr 2:59,946,158...59,958,255
Ensembl chr 2:59,946,153...59,958,255
JBrowse link
G Apoa5 apolipoprotein A5 multiple interactions EXP Silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of APOA5 mRNA] CTD PMID:28619387 NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816
JBrowse link
G Asl argininosuccinate lyase multiple interactions EXP Silybin inhibits the reaction [[Isoniazid co-treated with Zidovudine] results in increased activity of ASL protein] CTD PMID:28619387 NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662
JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO Silybin results in increased phosphorylation of and results in increased activity of ATM protein CTD PMID:16777994 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Silybin inhibits the reaction [Acetaldehyde results in increased expression of BAX protein]; Silybin inhibits the reaction [Ethanol results in increased expression of BAX protein]; Silybin inhibits the reaction [Mitomycin affects the localization of BAX protein]; Silybin inhibits the reaction [Staurosporine promotes the reaction [Acetaldehyde results in increased expression of BAX protein]] CTD PMID:19834285 PMID:35158046 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO Silybin results in decreased expression of BCL2 mRNA
[Silybin co-treated with Arsenic Trioxide] results in decreased expression of BCL2 mRNA; Silybin inhibits the reaction [Acetaldehyde results in decreased expression of BCL2 protein]; Silybin inhibits the reaction [Ethanol results in decreased expression of BCL2 protein]; Silybin inhibits the reaction [Mitomycin affects the expression of BCL2]; Silybin inhibits the reaction [Staurosporine promotes the reaction [Acetaldehyde results in decreased expression of BCL2 protein]]
CTD PMID:19834285 PMID:21969006 PMID:35158046 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
affects localization
increases cleavage
ISO benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Silybin results in increased cleavage of BID protein]; Caffeine inhibits the reaction [Silybin results in increased cleavage of BID protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of BID protein]
Silybin affects the localization of BID protein modified form
CTD PMID:16777994 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO [Silybin co-treated with Arsenic Trioxide] results in decreased expression of BIRC5 mRNA CTD PMID:21969006 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Car9 carbonic anhydrase 9 decreases expression
multiple interactions
ISO Silybin results in decreased expression of CA9 mRNA
Arsenic Trioxide promotes the reaction [Silybin results in decreased expression of CA9 mRNA]
CTD PMID:21969006 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
JBrowse link
G Casp2 caspase 2 multiple interactions ISO benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP2 protein]; Caffeine inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP2 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP2 protein]; Silybin results in increased cleavage of and results in increased activity of CASP2 protein CTD PMID:16777994 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Casp3 caspase 3 increases expression
increases activity
multiple interactions
ISO Silybin results in increased expression of CASP3 mRNA
Silybin results in increased activity of CASP3 protein
Arsenic Trioxide promotes the reaction [Silybin results in increased activity of CASP3 protein]; benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP3 protein]; Caffeine inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP3 protein]; Silybin inhibits the reaction [Acetaldehyde results in increased cleavage of CASP3 protein]; Silybin inhibits the reaction [Ethanol results in increased cleavage of CASP3 protein]; Silybin promotes the reaction [Arsenic Trioxide results in increased expression of CASP3 mRNA]; Silybin results in increased cleavage of and results in increased activity of CASP3 protein
CTD PMID:16777994 PMID:21969006 PMID:35158046 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP8 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP8 protein]; Silybin results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:16777994 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions ISO benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP9 protein]; Caffeine inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP9 protein]; Silybin results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:16777994 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions EXP Silybin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased activity of CAT protein]; Silybin inhibits the reaction [Arsenic results in decreased activity of CAT protein] CTD PMID:22229868 PMID:35752206 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccna1 cyclin A1 decreases expression ISO Silybin results in decreased expression of CCNA1 protein CTD PMID:18435416 NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157
JBrowse link
G Ccna2 cyclin A2 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCNA2 protein] CTD PMID:25559859 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 multiple interactions
decreases expression
ISO Silybin inhibits the reaction [Arsenic results in increased expression of CCNB1]
Silybin results in decreased expression of CCNB1 protein
CTD PMID:18435416 PMID:25868784 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCND1 protein]
[Silybin co-treated with Arsenic] results in decreased expression of CCND1 protein
Silybin results in decreased expression of CCND1 protein
CTD PMID:16788158 PMID:18435416 PMID:25559859 PMID:25868784 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd3 cyclin D3 multiple interactions
decreases expression
ISO [Silybin co-treated with Arsenic] results in decreased expression of CCND3 protein
Silybin results in decreased expression of CCND3 protein
CTD PMID:18435416 PMID:25868784 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO Silybin results in decreased expression of CCNE1 protein CTD PMID:18435416 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cdc25a cell division cycle 25A decreases expression ISO Silybin results in decreased expression of CDC25A protein CTD PMID:18435416 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
JBrowse link
G Cdc25b cell division cycle 25B decreases expression ISO Silybin results in decreased expression of CDC25B protein CTD PMID:18435416 NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272
JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO Silybin results in decreased expression of CDC25C protein CTD PMID:18435416 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions
decreases expression
ISO Silybin inhibits the reaction [Arsenic results in increased expression of CDK1 protein]
Silybin results in decreased expression of CDK1 protein
CTD PMID:18435416 PMID:25868784 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions
decreases expression
ISO [Silybin co-treated with Arsenic] results in decreased expression of CDK2 protein
Silybin results in decreased expression of CDK2 protein
CTD PMID:18435416 PMID:25868784 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions
decreases expression
ISO [Silybin co-treated with Arsenic] results in decreased expression of CDK4 protein
Silybin results in decreased expression of CDK4 protein
CTD PMID:18435416 PMID:25868784 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions ISO [Silybin co-treated with Arsenic] results in decreased expression of CDK6 protein CTD PMID:25868784 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases cleavage
ISO [Silybin co-treated with Arsenic] results in increased expression of CDKN1A protein; benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Silybin results in increased cleavage of CDKN1A protein] CTD PMID:16777994 PMID:25868784 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
increases expression
ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CDKN1B protein]
[Silybin co-treated with Arsenic] results in increased expression of CDKN1B protein
Silybin results in increased expression of CDKN1B protein
CTD PMID:18435416 PMID:25559859 PMID:25868784 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CEBPA protein] CTD PMID:25559859 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Chek2 checkpoint kinase 2 increases phosphorylation
multiple interactions
ISO Silybin results in increased phosphorylation of CHEK2 protein
Caffeine inhibits the reaction [Silybin results in increased phosphorylation of CHEK2 protein]
CTD PMID:16777994 PMID:18435416 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP [Silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of COL1A1 mRNA] CTD PMID:16169303 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Ctsb cathepsin B multiple interactions ISO [Arsenic Trioxide co-treated with Silybin] results in decreased expression of CTSB mRNA CTD PMID:21969006 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
JBrowse link
G Cyb5a cytochrome b5 type A multiple interactions EXP Silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of CYB5A mRNA] CTD PMID:28619387 NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP Silybin inhibits the reaction [sodium arsenite results in increased expression of CYBB] CTD PMID:24062023 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Silybin results in decreased activity of CYP2C8 protein CTD PMID:28457856
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO Silybin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]
Silybin results in decreased activity of CYP3A4 protein
CTD PMID:15155549 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO DDIT3 affects the reaction [Silybin results in increased expression of TNFRSF10B] CTD PMID:19939880 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of DLK1 mRNA] CTD PMID:25559859 NCBI chr 6:128,410,216...128,417,518
Ensembl chr 6:128,410,316...128,417,522
JBrowse link
G Dnm1l dynamin 1-like multiple interactions ISO Silybin inhibits the reaction [Acetaldehyde results in increased expression of DNM1L protein]; Silybin inhibits the reaction [Ethanol results in increased expression of DNM1L protein] CTD PMID:35158046 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
JBrowse link
G Egr1 early growth response 1 increases expression
multiple interactions
ISO Silybin results in increased expression of EGR1 protein
EGR1 mutant form inhibits the reaction [Silybin results in increased expression of GDF15 protein]
CTD PMID:24440808 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions EXP
ISO
Silybin results in increased activity of [ESR1 protein binds to ESR2 protein] CTD PMID:16076518 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO
EXP
Silybin results in increased activity of [ESR1 protein binds to ESR2 protein] CTD PMID:16076518 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Faah fatty acid amide hydrolase multiple interactions
decreases activity
EXP Silybin inhibits the reaction [FAAH protein results in increased metabolism of and results in decreased activity of anandamide]
Silybin results in decreased activity of FAAH protein
CTD PMID:37245739 NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of FABP4 protein] CTD PMID:25559859 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Fasn fatty acid synthase multiple interactions
decreases expression
ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of FASN protein]
Silybin results in decreased expression of FASN protein
CTD PMID:25294820 PMID:25559859 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO Silybin inhibits the reaction [Urethane results in increased secretion of FGF2 protein] CTD PMID:16788158 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO Silybin inhibits the reaction [Acetaldehyde results in decreased expression of FTH1 mRNA]; Silybin inhibits the reaction [Acetaldehyde results in decreased expression of FTH1 protein]; Silybin inhibits the reaction [Ethanol results in decreased expression of FTH1 mRNA]; Silybin inhibits the reaction [Ethanol results in decreased expression of FTH1 protein] CTD PMID:35595033 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP Silybin inhibits the reaction [Arsenic results in decreased activity of G6PD protein] CTD PMID:22229868 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression
multiple interactions
ISO Silybin results in increased expression of GDF15 mRNA; Silybin results in increased expression of GDF15 protein
EGR1 mutant form inhibits the reaction [Silybin results in increased expression of GDF15 protein]; GDF15 mutant form inhibits the reaction [Silybin results in increased cleavage of PARP1 protein]; pyrazolanthrone promotes the reaction [Silybin results in increased expression of GDF15 protein]; SB 203580 inhibits the reaction [Silybin results in increased expression of GDF15 protein]
CTD PMID:24440808 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO
Silybin inhibits the reaction [Isoniazid promotes the reaction [Zidovudine results in increased activity of GPT protein]]
Silybin inhibits the reaction [Acetaldehyde results in increased activity of GPT protein]; Silybin inhibits the reaction [Ethanol results in increased activity of and results in increased secretion of GPT protein]
CTD PMID:28619387 PMID:35158046 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Silybin inhibits the reaction [Arsenic results in decreased activity of GSR protein] CTD PMID:22229868 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases phosphorylation
ISO Caffeine inhibits the reaction [Silybin results in increased phosphorylation of H2AX protein] CTD PMID:16777994 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression ISO Silybin results in decreased expression of HMGCR protein CTD PMID:25294820 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Silybin inhibits the reaction [sodium arsenite results in decreased expression of HMOX1] CTD PMID:24062023 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Ifng interferon gamma multiple interactions ISO Silybin inhibits the reaction [IL1B protein results in increased expression of IFNG mRNA]; Silybin inhibits the reaction [IL1B protein results in increased secretion of IFNG protein] CTD PMID:28914761 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Silybin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein] CTD PMID:33839235 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Silybin inhibits the reaction [IL1B protein results in increased expression of IFNG mRNA]; Silybin inhibits the reaction [IL1B protein results in increased expression of TNF mRNA]; Silybin inhibits the reaction [IL1B protein results in increased secretion of IFNG protein]; Silybin inhibits the reaction [IL1B protein results in increased secretion of IL2 protein]; Silybin inhibits the reaction [IL1B protein results in increased secretion of TNF protein] CTD PMID:28914761 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions ISO Silybin inhibits the reaction [IL1B protein results in increased secretion of IL2 protein] CTD PMID:28914761 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Silybin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:33839235 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins1 insulin 1 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CDKN1B protein]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of DLK1 mRNA]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of KLF2 mRNA]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased phosphorylation of ACACA protein]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCNA2 protein]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCND1 protein]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CEBPA protein]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of FABP4 protein]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of FASN protein]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of KLF4 mRNA]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of KLF5 mRNA]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LPIN1 protein]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of AKT1 protein]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK1 protein]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK3 protein]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of RB1 protein]; Silybin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein]; Silybin inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose] CTD PMID:18591783 PMID:25559859 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO silibinin decreases expression and phosphorylation of JAK2 protein in breast epithelium RGD PMID:28440514 RGD:149735360 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions EXP Silybin inhibits the reaction [sodium arsenite results in increased expression of KEAP1] CTD PMID:24062023 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Klf2 KLF transcription factor 2 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of KLF2 mRNA] CTD PMID:25559859 NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944
JBrowse link
G Klf4 KLF transcription factor 4 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of KLF4 mRNA]
silibinin inhibits the reaction [angiotensin II increases expression of KLF4 protein in vascular smooth muscle cells]
CTD
RGD
PMID:25559859 PMID:29127880 RGD:155230825 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
JBrowse link
G Klf5 KLF transcription factor 5 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of KLF5 mRNA] CTD PMID:25559859 NCBI chr15:76,060,320...76,079,445
Ensembl chr15:76,064,258...76,079,445
JBrowse link
G Lpin1 lipin 1 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LPIN1 protein] CTD PMID:25559859 NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK1 protein] CTD PMID:25559859 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK3 protein] CTD PMID:25559859 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
ISO Silybin results in increased phosphorylation of MAPK8 protein
pifithrin inhibits the reaction [Silybin results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Silybin results in increased phosphorylation of MAPK8 protein]
CTD PMID:16777994 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation
ISO pifithrin inhibits the reaction [Silybin results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Silybin results in increased phosphorylation of MAPK9 protein] CTD PMID:16777994 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mfn1 mitofusin 1 multiple interactions ISO Silybin inhibits the reaction [Acetaldehyde results in decreased expression of MFN1 protein]; Silybin inhibits the reaction [Ethanol results in decreased expression of MFN1 protein] CTD PMID:35158046 NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase multiple interactions ISO Silybin results in increased expression of and results in increased activity of MGMT protein CTD PMID:16950796 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
JBrowse link
G Mmp14 matrix metallopeptidase 14 multiple interactions ISO [Arsenic Trioxide co-treated with Silybin] results in decreased expression of MMP14 mRNA; Arsenic Trioxide inhibits the reaction [Silybin results in increased expression of MMP14 mRNA] CTD PMID:21969006 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression
multiple interactions
ISO
EXP
Silybin results in increased expression of MMP2 mRNA
[Arsenic Trioxide co-treated with Silybin] results in decreased activity of MMP2 protein; [Arsenic Trioxide co-treated with Silybin] results in decreased expression of MMP2 mRNA; [Silybin co-treated with Arsenic] results in decreased expression of MMP2; Silybin promotes the reaction [Arsenic Trioxide results in decreased expression of MMP2 mRNA]
[Silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of MMP2 mRNA]
CTD PMID:16169303 PMID:21969006 PMID:25868784 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
decreases activity
multiple interactions
ISO Silybin results in decreased expression of MMP9 mRNA
Silybin results in decreased activity of MMP9 protein
[Arsenic Trioxide co-treated with Silybin] results in decreased expression of MMP9 mRNA; [Silybin co-treated with Arsenic Trioxide] results in decreased activity of MMP9 protein
CTD PMID:21969006 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO Silybin results in decreased expression of MYC protein CTD PMID:27746612 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nat2 N-acetyltransferase 2 multiple interactions EXP Silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of NAT2 mRNA] CTD PMID:28619387 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Ncoa4 nuclear receptor coactivator 4 multiple interactions ISO Silybin inhibits the reaction [Acetaldehyde results in increased expression of NCOA4 mRNA]; Silybin inhibits the reaction [Ethanol results in increased expression of NCOA4 mRNA] CTD PMID:35595033 NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641
Ensembl chr16:7,366,542...7,409,641
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Silybin inhibits the reaction [sodium arsenite results in decreased expression of NFE2L2] CTD PMID:24062023 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression ISO Silybin results in decreased expression of NOS2 protein CTD PMID:16788158 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP Silybin inhibits the reaction [sodium arsenite results in increased expression of NOX4] CTD PMID:24062023 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression
multiple interactions
IEP
ISO
Silymarin decreases Nqo1 mRNA in liver
Silybin inhibits the reaction [cyfluthrin results in decreased activity of NQO1 protein]
CTD
RGD
PMID:31330490 PMID:31432116 RGD:25823187 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases expression EXP silymarin increases Nr1h4 mRNA expression in rat kidney and liver RGD PMID:30308196 RGD:15042865 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression ISO Silybin results in increased expression of NR1I2 mRNA CTD PMID:29933105 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions ISO Silybin inhibits the reaction [Acetaldehyde results in decreased expression of OPA1 protein]; Silybin inhibits the reaction [Ethanol results in decreased expression of OPA1 protein] CTD PMID:35158046 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
increases expression
ISO Silybin results in increased cleavage of PARP1 protein
benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Silybin results in increased cleavage of PARP1 protein]; GDF15 mutant form inhibits the reaction [Silybin results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of PARP1 protein]; Silybin inhibits the reaction [Acetaldehyde results in increased cleavage of PARP1 protein]; Silybin inhibits the reaction [Ethanol results in increased cleavage of PARP1 protein]; Silybin inhibits the reaction [Staurosporine promotes the reaction [Acetaldehyde results in increased cleavage of PARP1 protein]]; Silybin results in increased cleavage of and results in increased activity of PARP1 protein
Silybin results in increased expression of PARP1 protein
CTD PMID:16777994 PMID:24440808 PMID:27402681 PMID:35158046 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO Silybin results in decreased expression of PCNA protein CTD PMID:16788158 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 decreases expression ISO Silybin results in decreased expression of PECAM1 protein CTD PMID:16788158 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
JBrowse link
G Pf4 platelet factor 4 multiple interactions ISO Silybin inhibits the reaction [Adenosine Diphosphate results in increased secretion of PF4 protein] CTD PMID:29439388 NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365
JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions ISO Silybin inhibits the reaction [Acetaldehyde results in decreased expression of PINK1 mRNA]; Silybin inhibits the reaction [Acetaldehyde results in decreased expression of PINK1 protein]; Silybin inhibits the reaction [Ethanol results in decreased expression of PINK1 mRNA]; Silybin inhibits the reaction [Ethanol results in decreased expression of PINK1 protein] CTD PMID:35595033 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
JBrowse link
G Plau plasminogen activator, urokinase multiple interactions
decreases expression
ISO [Silybin co-treated with Arsenic Trioxide] results in decreased expression of PLAU mRNA; Arsenic Trioxide promotes the reaction [Silybin results in decreased expression of PLAU mRNA]; Silybin promotes the reaction [Arsenic Trioxide results in decreased expression of PLAU mRNA] CTD PMID:21969006 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions EXP Silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of POR mRNA] CTD PMID:28619387 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein]
Silybin results in increased expression of PPARG protein
CTD PMID:25559859 PMID:27746612 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO Silybin inhibits the reaction [Acetaldehyde results in decreased expression of PRKN mRNA]; Silybin inhibits the reaction [Acetaldehyde results in decreased expression of PRKN protein]; Silybin inhibits the reaction [Ethanol results in decreased expression of PRKN mRNA]; Silybin inhibits the reaction [Ethanol results in decreased expression of PRKN protein] CTD PMID:35595033 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Silybin results in decreased expression of PTGS2 protein CTD PMID:16788158 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions ISO Silybin binds to and results in decreased activity of PTPN1 protein CTD PMID:30160205 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of RB1 protein] CTD PMID:25559859 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO Silybin inhibits the reaction [ferric ammonium citrate results in decreased expression of RUNX2 protein] CTD PMID:36087815 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Silybin inhibits the reaction [ferric ammonium citrate results in decreased expression of SIRT1 protein] CTD PMID:36087815 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Skp2 S-phase kinase associated protein 2 decreases expression ISO Silybin results in decreased expression of SKP2 protein CTD PMID:18435416 NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338
JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions ISO Silybin inhibits the reaction [SLC16A1 protein results in increased uptake of Benzoic Acid] CTD PMID:17976262 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO Silybin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein] CTD PMID:18591783 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO
EXP
Silybin inhibits the reaction [ferric ammonium citrate results in decreased expression of SOD2 protein] CTD PMID:36087815 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
decreases response to substance
ISO fatostatin promotes the reaction [Silybin results in decreased cleavage of SREBF1 protein]; Silybin results in decreased cleavage of and results in increased phosphorylation of SREBF1 protein
SREBF1 protein results in decreased susceptibility to Silybin
CTD PMID:25294820 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Tfrc transferrin receptor multiple interactions ISO Silybin inhibits the reaction [Acetaldehyde results in increased expression of TFRC protein]; Silybin inhibits the reaction [Ethanol results in increased expression of TFRC protein] CTD PMID:35595033 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [Silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFB1 mRNA] CTD PMID:16169303 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP [Silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP1 mRNA] CTD PMID:16169303 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
Silybin inhibits the reaction [[Isoniazid co-treated with Zidovudine] results in increased expression of TNF protein]
Silybin inhibits the reaction [IL1B protein results in increased expression of TNF mRNA]; Silybin inhibits the reaction [IL1B protein results in increased secretion of TNF protein]
CTD PMID:28619387 PMID:28914761 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
increases phosphorylation
affects localization
ISO Caffeine inhibits the reaction [Silybin results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Silybin results in increased phosphorylation of TP53 protein]; Silybin inhibits the reaction [Mitomycin results in increased expression of TP53]
Silybin results in increased expression of TP53 protein
Silybin affects the localization of TP53 protein
CTD PMID:16777994 PMID:19834285 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 decreases activity
multiple interactions
EXP
ISO
Silybin metabolite results in decreased activity of UGT1A1 protein
Silybin inhibits the reaction [UGT1A1 protein results in increased glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin]
CTD PMID:15155549 PMID:15921999 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 decreases activity
multiple interactions
EXP
ISO
Silybin metabolite results in decreased activity of UGT1A6 protein
Silybin inhibits the reaction [UGT1A6 protein results in increased glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin]
CTD PMID:15155549 PMID:15921999 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 multiple interactions ISO Silybin inhibits the reaction [UGT1A9 protein results in increased glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin] CTD PMID:15155549 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO Silybin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin] CTD PMID:15155549 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link
G Vasp vasodilator-stimulated phosphoprotein increases phosphorylation ISO Silybin results in increased phosphorylation of VASP protein CTD PMID:29439388 NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression
ISO Silybin promotes the reaction [Lipids deficiency inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]]; Silybin promotes the reaction [Lipids deficiency results in decreased expression of VEGFA protein]
Silybin inhibits the reaction [Urethane results in increased secretion of VEGFA protein]
Silybin results in decreased expression of VEGFA protein
CTD PMID:16788158 PMID:26087400 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vim vimentin multiple interactions ISO [Silybin co-treated with Arsenic] results in decreased expression of VIM CTD PMID:25868784 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      chemical role 19422
        antioxidant 16120
          silibinin 128
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  carbonyl compound 18858
                                    ketone 17163
                                      oxyketone 8906
                                        alpha-oxyketone 8900
                                          alpha-hydroxy ketone 8900
                                            secondary alpha-hydroxy ketone 1037
                                              silibinin 128
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