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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sildenafil
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Accession:CHEBI:9139 term browser browse the term
Definition:A pyrazolo[4,3-d]pyrimidin-7-one having a methyl substituent at the 1-position, a propyl substituent at the 3-position and a 2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl group at the 5-position.
Synonyms:exact_synonym: 5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
 related_synonym: 1-((3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine;   Formula=C22H30N6O4S;   InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29);   InChIKey=BNRNXUUZRGQAQC-UHFFFAOYSA-N;   SMILES=CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1
 alt_id: CHEBI:46436;   CHEBI:600437
 xref: Beilstein:7673458;   CAS:139755-83-2;   DrugBank:DB00203;   Drug_Central:2441;   FooDB:FDB023606;   HMDB:HMDB0005039;   KEGG:C07259;   KEGG:D08514;   LINCS:LSM-3797
 xref_mesh: MESH:C101426
 xref: PDBeChem:VIA;   Patent:EP463756;   Patent:US5250534;   Wikipedia:Sildenafil


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sildenafil citrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle decreases expression EXP Sildenafil Citrate results in decreased expression of ACTA2 protein CTD PMID:14996430 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO Sildenafil Citrate results in increased expression of ADIPOQ mRNA CTD PMID:20471953 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Agt angiotensinogen increases expression
multiple interactions
ISO Sildenafil Citrate results in increased expression of AGT protein modified form
PRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of CCN2 mRNA]]; PRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of COL1A1 mRNA]]; PRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of FN1 mRNA]]; PRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of TGFB1 mRNA]]; Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of CCN2 mRNA]; Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of COL1A1 mRNA]; Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of FN1 mRNA]; Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of TGFB1 mRNA]
CTD PMID:15613622, PMID:25139994 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr1b angiotensin II receptor, type 1b multiple interactions EXP Sildenafil Citrate inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of AGTR1B protein] CTD PMID:32479886 NCBI chr 2:105,149,020...105,224,335
Ensembl chr 2:105,149,020...105,224,295
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation EXP Sildenafil Citrate results in increased phosphorylation of AKT1 protein CTD PMID:18373738 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Angpt1 angiopoietin 1 increases expression EXP Sildenafil Citrate results in increased expression of ANGPT1 mRNA; Sildenafil Citrate results in increased expression of ANGPT1 protein CTD PMID:18373738 NCBI chr 7:81,338,327...81,592,459
Ensembl chr 7:81,342,280...81,592,206
JBrowse link
G Arg1 arginase 1 decreases expression ISO Sildenafil Citrate results in decreased expression of ARG1 protein CTD PMID:17101732 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO Sildenafil Citrate promotes the reaction [Doxorubicin results in decreased phosphorylation of BAD protein] CTD PMID:20884855 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Sildenafil Citrate inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Sildenafil Citrate inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]; Sildenafil Citrate promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]; Tadalafil promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]; Testosterone promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]; Testosterone promotes the reaction [Sildenafil Citrate promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]]; Testosterone promotes the reaction [Tadalafil promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]] CTD PMID:19152827, PMID:20574430 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
ISO
EXP
Sildenafil Citrate inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]
Sildenafil Citrate results in increased expression of BCL2
Sildenafil Citrate inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]; Sildenafil Citrate promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]; Tadalafil promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]; Testosterone promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]; Testosterone promotes the reaction [Sildenafil Citrate promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]]; Testosterone promotes the reaction [Tadalafil promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]]
CTD PMID:15811867, PMID:18373738, PMID:20574430 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
affects response to substance
ISO BCL2L1 protein inhibits the reaction [Sildenafil Citrate results in increased activity of Doxorubicin]; Sildenafil Citrate promotes the reaction [Doxorubicin results in decreased expression of BCL2L1 protein]
BCL2L1 protein affects the susceptibility to Sildenafil Citrate
CTD PMID:20884855 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
CASP3 protein promotes the reaction [Sildenafil Citrate results in increased susceptibility to Doxorubicin]; Sildenafil Citrate promotes the reaction [Doxorubicin results in increased activity of CASP3 protein]
5-hydroxydecanoic acid inhibits the reaction [Sildenafil Citrate inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]]; Sildenafil Citrate inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]
Sildenafil Citrate inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]
CTD PMID:15811867, PMID:19152827, PMID:20155316, PMID:20884855 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 affects response to substance
multiple interactions
ISO CASP9 protein affects the susceptibility to Sildenafil Citrate
CASP9 protein mutant form inhibits the reaction [Sildenafil Citrate results in increased activity of Doxorubicin]; Sildenafil Citrate promotes the reaction [Doxorubicin results in increased activity of CASP9 protein]
CTD PMID:20884855 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase increases expression EXP Sildenafil Citrate results in increased expression of CAT protein CTD PMID:18265987 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO PRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of CCN2 mRNA]]; Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of CCN2 mRNA] CTD PMID:25139994 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression ISO Sildenafil Citrate results in increased expression of CEBPA mRNA; Sildenafil Citrate results in increased expression of CEBPA protein CTD PMID:20471953 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions
increases expression
ISO 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate inhibits the reaction [Sildenafil Citrate results in increased expression of CEBPB protein]
Sildenafil Citrate results in increased expression of CEBPB mRNA; Sildenafil Citrate results in increased expression of CEBPB protein
CTD PMID:20471953 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cftr CF transmembrane conductance regulator affects localization
multiple interactions
increases activity
ISO Sildenafil Citrate affects the localization of CFTR protein mutant form
Sildenafil Citrate promotes the reaction [CFTR protein affects the secretion of Chlorides]
Sildenafil Citrate results in increased activity of CFTR protein
CTD PMID:12714375, PMID:15618584 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO PRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of COL1A1 mRNA]]; Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of COL1A1 mRNA] CTD PMID:25139994 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation
ISO atosiban inhibits the reaction [Sildenafil Citrate results in increased phosphorylation of CREB1 protein] CTD PMID:27220266 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP Sildenafil Citrate inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CYBB protein] CTD PMID:32479886 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Des desmin multiple interactions ISO Sildenafil Citrate inhibits the reaction [Doxorubicin affects the localization of DES protein] CTD PMID:15811867 NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Sildenafil Citrate inhibits the reaction [EDN1 protein results in increased expression of TRPC1 mRNA] CTD PMID:18818482 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions
increases expression
ISO 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate inhibits the reaction [Sildenafil Citrate results in increased expression of FABP4 protein]
Sildenafil Citrate results in increased expression of FABP4 mRNA; Sildenafil Citrate results in increased expression of FABP4 protein
CTD PMID:20471953 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fasn fatty acid synthase increases expression ISO Sildenafil Citrate results in increased expression of FASN mRNA CTD PMID:20471953 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression EXP Sildenafil Citrate results in increased expression of FGF1 mRNA CTD PMID:20583517 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 increases expression EXP Sildenafil Citrate results in increased expression of FGFR3 mRNA CTD PMID:20583517 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO PRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of FN1 mRNA]]; Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of FN1 mRNA] CTD PMID:25139994 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO Sildenafil Citrate inhibits the reaction [Streptozocin results in decreased expression of FSHB protein] CTD PMID:30365938 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
EXP Curcumin promotes the reaction [Sildenafil Citrate results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [Sildenafil Citrate results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Sildenafil Citrate results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [Sildenafil Citrate results in increased expression of HMOX1 protein]
Sildenafil Citrate results in increased expression of HMOX1; Sildenafil Citrate results in increased expression of HMOX1 mRNA; Sildenafil Citrate results in increased expression of HMOX1 protein
CTD PMID:17627722, PMID:18373738 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il4 interleukin 4 multiple interactions ISO Sildenafil Citrate inhibits the reaction [4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone results in decreased expression of IL4 protein] CTD PMID:15169552 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il4r interleukin 4 receptor decreases expression ISO Sildenafil Citrate results in decreased expression of IL4RA protein CTD PMID:17101732 NCBI chr 1:196,942,343...196,967,221
Ensembl chr 1:196,942,364...196,967,220
JBrowse link
G Il5 interleukin 5 multiple interactions ISO Sildenafil Citrate inhibits the reaction [4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone results in decreased expression of IL5 protein] CTD PMID:15169552 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions ISO Sildenafil Citrate inhibits the reaction [Streptozocin results in decreased expression of LHB protein] CTD PMID:30365938 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Sildenafil Citrate inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:16113693 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
increases expression
EXP [Sildenafil Citrate co-treated with Resveratrol] inhibits the reaction [Streptozocin results in decreased expression of NOS1 protein]; [Sildenafil Citrate co-treated with zinc protoporphyrin] results in increased expression of NOS1 mRNA; Curcumin promotes the reaction [Sildenafil Citrate results in increased expression of NOS1 mRNA] CTD PMID:17627722, PMID:26006044 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
ISO
EXP
Sildenafil Citrate results in decreased expression of NOS2 protein
[Cisplatin co-treated with Sildenafil Citrate] results in increased expression of NOS2 mRNA; [Cisplatin co-treated with Sildenafil Citrate] results in increased expression of NOS2 protein
CTD PMID:17101732, PMID:19152827 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 increases activity
increases phosphorylation
increases expression
multiple interactions
ISO
EXP
Sildenafil Citrate results in increased activity of NOS3 protein
Sildenafil Citrate results in increased phosphorylation of NOS3 protein
Sildenafil Citrate results in increased expression of NOS3 protein
[Cisplatin co-treated with Sildenafil Citrate] results in increased expression of NOS3 mRNA; [Cisplatin co-treated with Sildenafil Citrate] results in increased expression of NOS3 protein; [Sildenafil Citrate co-treated with Resveratrol] inhibits the reaction [Streptozocin results in decreased expression of NOS3 protein]; [Sildenafil Citrate results in increased expression of NOS3 protein] which results in increased secretion of Nitric Oxide; Sildenafil Citrate inhibits the reaction [alpha-naphthyl thiourea results in decreased expression of NOS3 mRNA]; Sildenafil Citrate inhibits the reaction [alpha-naphthyl thiourea results in decreased expression of NOS3 protein]; Sildenafil Citrate inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of NOS3 protein]
CTD PMID:18373738, PMID:19152827, PMID:19845545, PMID:23650378, PMID:26006044, PMID:30974023, PMID:32479886 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP Sildenafil Citrate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:18790048 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nppb natriuretic peptide B affects expression
multiple interactions
ISO
EXP
Sildenafil Citrate affects the expression of NPPB protein
Sildenafil Citrate inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]
CTD PMID:18790048, PMID:19179780 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Pde5a phosphodiesterase 5A decreases activity
multiple interactions
ISO
EXP
Sildenafil Citrate results in decreased activity of PDE5A protein
[Sildenafil Citrate co-treated with resveratrol] inhibits the reaction [Streptozocin results in increased expression of PDE5A protein]
CTD PMID:8858389, PMID:10422958, PMID:15934858, PMID:16368379, PMID:17138653, PMID:18778098, PMID:19374906, PMID:26006044 NCBI chr 2:226,899,604...227,044,916
Ensembl chr 2:226,900,619...227,041,576
JBrowse link
G Pde8b phosphodiesterase 8B multiple interactions ISO Sildenafil Citrate inhibits the reaction [PDE8B protein results in increased metabolism of Cyclic AMP] CTD PMID:12681444 NCBI chr 2:24,718,548...24,955,533
Ensembl chr 2:24,719,976...24,923,128
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
ISO 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate inhibits the reaction [Sildenafil Citrate results in increased expression of PPARG protein]
Sildenafil Citrate results in increased expression of PPARG mRNA; Sildenafil Citrate results in increased expression of PPARG protein
CTD PMID:20471953 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions
increases response to substance
ISO PRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of CCN2 mRNA]]; PRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of COL1A1 mRNA]]; PRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of FN1 mRNA]]; PRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of TGFB1 mRNA]]
PRKG1 protein results in increased susceptibility to Sildenafil Citrate
CTD PMID:25139994 NCBI chr 1:248,982,039...250,300,952 JBrowse link
G Ren renin increases activity ISO Sildenafil Citrate results in increased activity of REN protein CTD PMID:15613622 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Sildenafil Citrate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression ISO Sildenafil Citrate results in increased expression of SLC2A4 mRNA; Sildenafil Citrate results in increased expression of SLC2A4 protein CTD PMID:20471953 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP Sildenafil Citrate inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of STAR protein] CTD PMID:32479886 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO PRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of TGFB1 mRNA]]; Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of TGFB1 mRNA] CTD PMID:25139994 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Sildenafil Citrate inhibits the reaction [4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone results in decreased expression of TNF protein] CTD PMID:15169552 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO TP53 protein inhibits the reaction [Sildenafil Citrate results in increased susceptibility to Doxorubicin] CTD PMID:20155316 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 multiple interactions ISO Sildenafil Citrate inhibits the reaction [EDN1 protein results in increased expression of TRPC1 mRNA] CTD PMID:18818482 NCBI chr 8:103,503,982...103,554,905
Ensembl chr 8:103,503,985...103,554,468
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 increases phosphorylation ISO Sildenafil Citrate results in increased phosphorylation of TRPC6 protein CTD PMID:20177073 NCBI chr 8:6,811,543...6,917,534
Ensembl chr 8:6,811,543...6,917,535
JBrowse link
G Tuba1a tubulin, alpha 1A increases expression ISO Sildenafil Citrate results in increased expression of TUBA1A mRNA CTD PMID:27015953 NCBI chr 7:140,637,287...140,640,953
Ensembl chr 7:140,637,287...140,640,953
JBrowse link
G Txn1 thioredoxin 1 increases expression EXP Sildenafil Citrate results in increased expression of TXN1 CTD PMID:18373738 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions
EXP Sildenafil Citrate results in increased expression of VEGFA mRNA; Sildenafil Citrate results in increased expression of VEGFA protein
Sildenafil Citrate inhibits the reaction [alpha-naphthyl thiourea results in increased expression of VEGFA mRNA]; Sildenafil Citrate inhibits the reaction [alpha-naphthyl thiourea results in increased expression of VEGFA protein]
CTD PMID:18373738, PMID:20583517, PMID:30974023 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vegfb vascular endothelial growth factor B increases expression EXP Sildenafil Citrate results in increased expression of VEGFB mRNA CTD PMID:20583517 NCBI chr 1:222,237,000...222,242,786
Ensembl chr 1:222,239,022...222,242,644
JBrowse link
G Vegfc vascular endothelial growth factor C increases expression EXP Sildenafil Citrate results in increased expression of VEGFC mRNA CTD PMID:20583517 NCBI chr16:40,440,371...40,555,178
Ensembl chr16:40,440,207...40,555,576
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      application 19420
        pharmaceutical 19293
          drug 19293
            cardiovascular drug 7618
              vasodilator agent 5733
                sildenafil 58
                  sildenafil citrate 58
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      chalcogen 19391
                        oxygen atom 19353
                          oxygen molecular entity 19353
                            hydroxides 19103
                              oxoacid 18235
                                chalcogen oxoacid 11493
                                  sulfur oxoacid 11097
                                    sulfonic acid 7344
                                      sulfonic acid derivative 7344
                                        sulfonamide 3178
                                          sildenafil 58
                                            sildenafil citrate 58
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.