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ONTOLOGY REPORT - ANNOTATIONS


Term:PF-00477736
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Accession:CHEBI:91385 term browser browse the term
Definition:A diazepinoindole that is 8-amino-4,5-dihydro-6H-[1,2]diazepino[4,5,6-cd]indol-6-one which is substituted at position 2 by a 1-methylpyrazol-4-yl group and in which the amino group at position 8 has undergone condensation with the carboxy group of (2R)-2-cyclohexylglycine to give the corresponding carboxamide. It is an inhibitor of checkpoint kinase 1 (Chk 1).
Synonyms:exact_synonym: (2R)-2-amino-2-cyclohexyl-N-[2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-5,6-dihydro-4H-[1,2]diazepino[4,5,6-cd]indol-8-yl]acetamide
 related_synonym: Formula=C22H25N7O2;   InChI=1S/C22H25N7O2/c1-29-11-13(9-25-29)20-16-10-24-28-21(30)15-7-14(8-17(27-20)18(15)16)26-22(31)19(23)12-5-3-2-4-6-12/h7-12,19,24H,2-6,23H2,1H3,(H,26,31)(H,28,30)/t19-/m1/s1;   InChIKey=YFNWWNRZJGMDBR-LJQANCHMSA-N;   PF-477736;   SMILES=CN1C=C(C=N1)C2=NC3=C4C2=CNNC(=O)C4=CC(=C3)NC(=O)[C@@H](C5CCCCC5)N
 xref: CAS:952021-60-2 "ChemIDplus";   LINCS:LSM-1112
 xref_mesh: MESH:C532366
 xref: PMID:18694366 "Europe PMC";   PMID:19584159 "Europe PMC";   PMID:23820871 "Europe PMC";   PMID:24838526 "Europe PMC";   PMID:25104095 "Europe PMC";   PMID:25428911 "Europe PMC";   PMID:25465126 "Europe PMC";   PMID:26439697 "Europe PMC";   PMID:26542114 "Europe PMC"


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PF-00477736 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdk1 cyclin-dependent kinase 1 JBrowse link 20 20,576,341 20,591,510 RGD:6480464
G Chek1 checkpoint kinase 1 JBrowse link 8 39,181,162 39,201,588 RGD:6480464

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  CHEBI ontology 19662
    role 19606
      application 19232
        pharmaceutical 19094
          drug 19094
            antineoplastic agent 16568
              PF-00477736 2
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  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic group 18340
                              organic divalent group 18330
                                organodiyl group 18330
                                  carbonyl group 18217
                                    carbonyl compound 18217
                                      carboxylic acid 17921
                                        carboacyl group 16944
                                          univalent carboacyl group 16944
                                            carbamoyl group 16623
                                              carboxamide 16623
                                                amino acid amide 873
                                                  PF-00477736 2
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