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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sibutramine
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Accession:CHEBI:9137 term browser browse the term
Definition:A tertiary amino compound that has formula C17H26ClN.
Synonyms:exact_synonym: 1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine
 related_synonym: BTS 54524;   Butramin;   Formula=C17H26ClN;   InChI=1S/C17H26ClN/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14/h6-9,13,16H,5,10-12H2,1-4H3;   InChIKey=UNAANXDKBXWMLN-UHFFFAOYSA-N;   Medaria;   Meridia;   Reductil;   SMILES=CC(C)CC(N(C)C)C1(CCC1)c1ccc(Cl)cc1;   didemethyl sibutramine HCl;   didemethyl sibutramine hydrochloride;   didesmethylsibutramine;   racemic sibutramine;   sibutramine HCl;   sibutramine hydrochloride;   sibutramine hydrochloride hydrate
 xref: CAS:106650-56-0;   DrugBank:DB01105;   Drug_Central:2440;   HMDB:HMDB0015237;   KEGG:C07247;   KEGG:D08513;   LINCS:LSM-5000
 xref_mesh: MESH:C058254
 xref: PMID:22830954;   PMID:23406184;   PMID:23543553;   PMID:23576325;   PMID:23625194;   PMID:23677499;   PMID:23776614;   PMID:23777987;   Patent:CN101890017;   Patent:CN101897685;   Wikipedia:Sibutramine

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sibutramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO sibutramine results in increased expression of BAX protein CTD PMID:27838152 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO sibutramine results in decreased expression of BCL2 protein CTD PMID:27838152 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Casp3 caspase 3 increases activity ISO sibutramine results in increased activity of CASP3 protein CTD PMID:27838152 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity
multiple interactions		 ISO sibutramine results in decreased activity of CYP2B6 protein
sibutramine inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]		 CTD PMID:23777987 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO sibutramine results in decreased activity of CYP2C19 protein CTD PMID:23777987 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO sibutramine results in decreased activity of CYP2D6 protein CTD PMID:23777987 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO sibutramine results in increased expression of DDIT3 mRNA; sibutramine results in increased expression of DDIT3 protein CTD PMID:27838152 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO sibutramine results in decreased expression of and affects the phosphorylation of NOS3 protein CTD PMID:27838152 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Psmb5 proteasome 20S subunit beta 5 decreases expression ISO sibutramine results in decreased expression of PSMB5 protein CTD PMID:27838152 NCBI chr15:33,259,039...33,263,634
Ensembl chr15:33,259,043...33,263,659 		JBrowse link
G Psmb8 proteasome 20S subunit beta 8 decreases expression ISO sibutramine results in decreased expression of PSMB8 protein CTD PMID:27838152 NCBI chr20:3,990,809...3,993,772
Ensembl chr20:3,990,613...3,993,769 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        pharmacological role 18797
          anti-obesity agent 169
            sibutramine 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            inorganic hydride 17411
                              pnictogen hydride 17383
                                nitrogen hydride 17224
                                  azane 16941
                                    ammonia 16940
                                      organic amino compound 16939
                                        tertiary amino compound 8630
                                          sibutramine 10
paths to the root

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