CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: sibutramine
Accession: CHEBI:9137
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Definition: A tertiary amino compound that has formula C17H26ClN.
Synonyms: exact_synonym: 1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine
related_synonym: BTS 54524; Butramin; Formula=C17H26ClN; InChI=1S/C17H26ClN/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14/h6-9,13,16H,5,10-12H2,1-4H3; InChIKey=UNAANXDKBXWMLN-UHFFFAOYSA-N; Medaria; Meridia; Reductil; SMILES=CC(C)CC(N(C)C)C1(CCC1)c1ccc(Cl)cc1; didemethyl sibutramine HCl; didemethyl sibutramine hydrochloride; didesmethylsibutramine; racemic sibutramine; sibutramine HCl; sibutramine hydrochloride; sibutramine hydrochloride hydrate
xref: CAS:106650-56-0; DrugBank:DB01105; Drug_Central:2440; HMDB:HMDB0015237; KEGG:C07247; KEGG:D08513; LINCS:LSM-5000
xref_mesh: MESH:C058254
xref: PMID:22830954; PMID:23406184; PMID:23543553; PMID:23576325; PMID:23625194; PMID:23677499; PMID:23776614; PMID:23777987; Patent:CN101890017; Patent:CN101897685; Wikipedia:Sibutramine
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
sibutramine results in increased expression of BAX protein
CTD
PMID:27838152
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
sibutramine results in decreased expression of BCL2 protein
CTD
PMID:27838152
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
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Casp3
caspase 3
increases activity
ISO
sibutramine results in increased activity of CASP3 protein
CTD
PMID:27838152
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
decreases activity multiple interactions
ISO
sibutramine results in decreased activity of CYP2B6 protein sibutramine inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]
CTD
PMID:23777987
NCBI chr 1:90,780,468...90,859,852
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
decreases activity
ISO
sibutramine results in decreased activity of CYP2C19 protein
CTD
PMID:23777987
NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
decreases activity
ISO
sibutramine results in decreased activity of CYP2D6 protein
CTD
PMID:23777987
NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
affects response to substance affects metabolic processing
ISO
CYP3A4 protein affects the susceptibility to sibutramine CYP3A4 protein affects the metabolism of sibutramine
CTD
PMID:27838152
NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
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Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
sibutramine results in increased expression of DDIT3 mRNA; sibutramine results in increased expression of DDIT3 protein
CTD
PMID:27838152
NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509
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Nos3
nitric oxide synthase 3
multiple interactions
ISO
sibutramine results in decreased expression of and affects the phosphorylation of NOS3 protein
CTD
PMID:27838152
NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664
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Psmb5
proteasome 20S subunit beta 5
decreases expression
ISO
sibutramine results in decreased expression of PSMB5 protein
CTD
PMID:27838152
NCBI chr15:32,042,784...32,047,379
Ensembl chr15:32,042,787...32,047,379
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Psmb8
proteasome 20S subunit beta 8
decreases expression
ISO
sibutramine results in decreased expression of PSMB8 protein
CTD
PMID:27838152
NCBI chr20:4,654,068...4,657,049
Ensembl chr20:4,654,068...4,657,031
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