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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sibutramine
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Accession:CHEBI:9137 term browser browse the term
Definition:A tertiary amino compound that has formula C17H26ClN.
Synonyms:exact_synonym: 1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine
 related_synonym: BTS 54524;   Butramin;   Formula=C17H26ClN;   InChI=1S/C17H26ClN/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14/h6-9,13,16H,5,10-12H2,1-4H3;   InChIKey=UNAANXDKBXWMLN-UHFFFAOYSA-N;   Medaria;   Meridia;   Reductil;   SMILES=CC(C)CC(N(C)C)C1(CCC1)c1ccc(Cl)cc1;   didemethyl sibutramine HCl;   didemethyl sibutramine hydrochloride;   didesmethylsibutramine;   racemic sibutramine;   sibutramine HCl;   sibutramine hydrochloride;   sibutramine hydrochloride hydrate
 xref: CAS:106650-56-0;   DrugBank:DB01105;   Drug_Central:2440;   HMDB:HMDB0015237;   KEGG:C07247;   KEGG:D08513;   LINCS:LSM-5000
 xref_mesh: MESH:C058254
 xref: PMID:22830954;   PMID:23406184;   PMID:23543553;   PMID:23576325;   PMID:23625194;   PMID:23677499;   PMID:23776614;   PMID:23777987;   Patent:CN101890017;   Patent:CN101897685;   Wikipedia:Sibutramine


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sibutramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO sibutramine results in increased expression of BAX protein CTD PMID:27838152 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO sibutramine results in decreased expression of BCL2 protein CTD PMID:27838152 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases activity ISO sibutramine results in increased activity of CASP3 protein CTD PMID:27838152 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity
multiple interactions		 ISO sibutramine results in decreased activity of CYP2B6 protein
sibutramine inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]		 CTD PMID:23777987 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO sibutramine results in decreased activity of CYP2C19 protein CTD PMID:23777987 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO sibutramine results in decreased activity of CYP2D6 protein CTD PMID:23777987 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects response to substance
affects metabolic processing		 ISO CYP3A4 protein affects the susceptibility to sibutramine
CYP3A4 protein affects the metabolism of sibutramine		 CTD PMID:27838152 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO sibutramine results in increased expression of DDIT3 mRNA; sibutramine results in increased expression of DDIT3 protein CTD PMID:27838152 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO sibutramine results in decreased expression of and affects the phosphorylation of NOS3 protein CTD PMID:27838152 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Psmb5 proteasome 20S subunit beta 5 decreases expression ISO sibutramine results in decreased expression of PSMB5 protein CTD PMID:27838152 NCBI chr15:28,072,772...28,077,367
Ensembl chr15:28,072,781...28,077,440 		JBrowse link
G Psmb8 proteasome 20S subunit beta 8 decreases expression ISO sibutramine results in decreased expression of PSMB8 protein CTD PMID:27838152 NCBI chr20:4,652,159...4,655,122
Ensembl chr20:4,652,159...4,655,283 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19659
    role 19634
      biological role 19633
        pharmacological role 18933
          anti-obesity agent 461
            sibutramine 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19659
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19700
                atom 19658
                  main group element atom 19607
                    main group molecular entity 19649
                      s-block molecular entity 19457
                        hydrogen molecular entity 19450
                          hydrides 18928
                            inorganic hydride 17765
                              pnictogen hydride 17748
                                nitrogen hydride 17633
                                  azane 17403
                                    ammonia 17402
                                      organic amino compound 17402
                                        tertiary amino compound 9087
                                          sibutramine 11
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