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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sibutramine
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Accession:CHEBI:9137 term browser browse the term
Definition:A tertiary amino compound that has formula C17H26ClN.
Synonyms:exact_synonym: 1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine
 related_synonym: BTS 54524;   Butramin;   Formula=C17H26ClN;   InChI=1S/C17H26ClN/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14/h6-9,13,16H,5,10-12H2,1-4H3;   InChIKey=UNAANXDKBXWMLN-UHFFFAOYSA-N;   Medaria;   Meridia;   Reductil;   SMILES=CC(C)CC(N(C)C)C1(CCC1)c1ccc(Cl)cc1;   didemethyl sibutramine HCl;   didemethyl sibutramine hydrochloride;   didesmethylsibutramine;   racemic sibutramine;   sibutramine HCl;   sibutramine hydrochloride;   sibutramine hydrochloride hydrate
 xref: CAS:106650-56-0;   DrugBank:DB01105;   Drug_Central:2440;   HMDB:HMDB0015237;   KEGG:C07247;   KEGG:D08513;   LINCS:LSM-5000
 xref_mesh: MESH:C058254
 xref: PMID:22830954;   PMID:23406184;   PMID:23543553;   PMID:23576325;   PMID:23625194;   PMID:23677499;   PMID:23776614;   PMID:23777987;   Patent:CN101890017;   Patent:CN101897685;   Wikipedia:Sibutramine


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sibutramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO sibutramine results in increased expression of BAX protein CTD PMID:27838152 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO sibutramine results in decreased expression of BCL2 protein CTD PMID:27838152 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Casp3 caspase 3 increases activity ISO sibutramine results in increased activity of CASP3 protein CTD PMID:27838152 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity
multiple interactions 		ISO sibutramine results in decreased activity of CYP2B6 protein
sibutramine inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion] 		CTD PMID:23777987 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity ISO sibutramine results in decreased activity of CYP2C19 protein CTD PMID:23777987 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO sibutramine results in decreased activity of CYP2D6 protein CTD PMID:23777987 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects response to substance
affects metabolic processing 		ISO CYP3A4 protein affects the susceptibility to sibutramine
CYP3A4 protein affects the metabolism of sibutramine 		CTD PMID:27838152 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO sibutramine results in increased expression of DDIT3 mRNA; sibutramine results in increased expression of DDIT3 protein CTD PMID:27838152 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO sibutramine results in decreased expression of and affects the phosphorylation of NOS3 protein CTD PMID:27838152 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664 		JBrowse link
G Psmb5 proteasome 20S subunit beta 5 decreases expression ISO sibutramine results in decreased expression of PSMB5 protein CTD PMID:27838152 NCBI chr15:32,042,784...32,047,379
Ensembl chr15:32,042,787...32,047,379 		JBrowse link
G Psmb8 proteasome 20S subunit beta 8 decreases expression ISO sibutramine results in decreased expression of PSMB8 protein CTD PMID:27838152 NCBI chr20:4,654,068...4,657,049
Ensembl chr20:4,654,068...4,657,031 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        pharmacological role 19911
          anti-obesity agent 536
            sibutramine 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    main group molecular entity 20781
                      s-block molecular entity 20574
                        hydrogen molecular entity 20558
                          hydrides 19693
                            inorganic hydride 18602
                              pnictogen hydride 18589
                                nitrogen hydride 18502
                                  azane 18262
                                    ammonia 18261
                                      organic amino compound 18261
                                        tertiary amino compound 11023
                                          sibutramine 11
paths to the root