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ONTOLOGY REPORT - ANNOTATIONS


Term:sibutramine
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Accession:CHEBI:9137 term browser browse the term
Definition:A tertiary amino compound that has formula C17H26ClN.
Synonyms:exact_synonym: 1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine
 related_synonym: BTS 54524;   Butramin;   Formula=C17H26ClN;   InChI=1S/C17H26ClN/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14/h6-9,13,16H,5,10-12H2,1-4H3;   InChIKey=UNAANXDKBXWMLN-UHFFFAOYSA-N;   Medaria;   Meridia;   Reductil;   SMILES=CC(C)CC(N(C)C)C1(CCC1)c1ccc(Cl)cc1;   didemethyl sibutramine HCl;   didemethyl sibutramine hydrochloride;   didesmethylsibutramine;   racemic sibutramine;   sibutramine HCl;   sibutramine hydrochloride;   sibutramine hydrochloride hydrate
 xref: CAS:106650-56-0 "ChemIDplus";   CAS:106650-56-0 "KEGG COMPOUND";   DrugBank:DB01105;   Drug_Central:2440 "DrugCentral";   HMDB:HMDB0015237;   KEGG:C07247;   KEGG:D08513;   LINCS:LSM-5000
 xref_mesh: MESH:C058254
 xref: PMID:22830954 "Europe PMC";   PMID:23406184 "Europe PMC";   PMID:23543553 "Europe PMC";   PMID:23576325 "Europe PMC";   PMID:23625194 "Europe PMC";   PMID:23677499 "Europe PMC";   PMID:23776614 "Europe PMC";   PMID:23777987 "Europe PMC";   Patent:CN101890017;   Patent:CN101897685;   Wikipedia:Sibutramine


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sibutramine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 JBrowse link 1 83,163,103 83,236,615 RGD:6480464
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 JBrowse link 1 147,713,879 147,814,410 RGD:6480464
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 JBrowse link 7 123,599,264 123,608,436 RGD:6480464
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:6480464
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:6480464
G Psmb5 proteasome 20S subunit beta 5 JBrowse link 15 33,259,039 33,263,634 RGD:6480464
G Psmb8 proteasome 20S subunit beta 8 JBrowse link 20 3,990,809 3,993,772 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        pharmacological role 18684
          anti-obesity agent 165
            sibutramine 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    main group molecular entity 19545
                      s-block molecular entity 19329
                        hydrogen molecular entity 19319
                          hydrides 18242
                            inorganic hydride 17104
                              pnictogen hydride 17062
                                nitrogen hydride 16885
                                  azane 16564
                                    ammonia 16561
                                      organic amino compound 16560
                                        tertiary amino compound 8521
                                          sibutramine 10
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.