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ONTOLOGY REPORT - ANNOTATIONS
Term:N-butyl-N-(4-hydroxybutyl)nitrosamine
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Accession:CHEBI:91275 term browser browse the term
Definition:A nitrosamine that has butyl and 4-hydroxybutyl substituents. In mice, it causes high-grade, invasive cancers in the urinary bladder, but not in any other tissues.
Synonyms:exact_synonym: N-butyl-N-(4-hydroxybutyl)nitrous amide
 related_synonym: 4-(butylnitrosamino)-1-butanol;   4-(butylnitrosoamino)butanol;   4-hydroxybutylbutylnitrosamine;   BBN;   Formula=C8H18N2O2;   InChI=1S/C8H18N2O2/c1-2-3-6-10(9-12)7-4-5-8-11/h11H,2-8H2,1H3;   InChIKey=DIKPQFXYECAYPC-UHFFFAOYSA-N;   N-butyl-(4-hydroxybutyl)nitrosamine;   N-nitroso-N-butyl-(4-hydroxybutyl)amine;   N-nitroso-N-butyl-N-(4-carboxypropyl)amine;   N-nitrosobutylbutanolamine;   SMILES=C(O)CCCN(CCCC)N=O;   butyl(4-hydroxybutyl)nitrosamine;   butylbutanolnitrosamine;   butylhydroxybutylnitrosamine
 xref: CAS:3817-11-6 "ChemIDplus";   CAS:3817-11-6 "NIST Chemistry WebBook"
 xref_mesh: MESH:D002085
 xref: PMID:16886626 "Europe PMC";   PMID:22095756 "Europe PMC";   PMID:22155125 "Europe PMC";   PMID:26782701 "Europe PMC";   PMID:8065076 "Europe PMC";   Reaxys:2080574 "Reaxys"

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N-butyl-N-(4-hydroxybutyl)nitrosamine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Birc5 baculoviral IAP repeat-containing 5 JBrowse link 10 106,856,097 106,864,419 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit JBrowse link 1 123,897,341 124,039,263 RGD:6480464
G Gstm1 glutathione S-transferase mu 1 JBrowse link 2 210,803,869 210,809,461 RGD:6480464
G Gsto1 glutathione S-transferase omega 1 JBrowse link 1 267,607,437 267,617,387 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6480464
G Krt15 keratin 15 JBrowse link 10 88,046,803 88,050,622 RGD:6480464
G Krt18 keratin 18 JBrowse link 7 143,629,455 143,633,131 RGD:6480464
G Krt8 keratin 8 JBrowse link 7 143,596,511 143,603,745 RGD:6480464
G Ldhb lactate dehydrogenase B JBrowse link 4 176,701,980 176,719,999 RGD:6480464
G Mki67 marker of proliferation Ki-67 JBrowse link 1 207,993,895 208,020,454 RGD:6480464
G Mt-co1 mitochondrially encoded cytochrome c oxidase I JBrowse link MT 5,323 6,867 RGD:6480464
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6480464
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:6480464
G Pmp22 peripheral myelin protein 22 JBrowse link 10 49,538,588 49,568,583 RGD:6480464
G Sp1 Sp1 transcription factor JBrowse link 7 144,014,173 144,044,635 RGD:6480464
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6480464
G Top2a DNA topoisomerase II alpha JBrowse link 10 86,901,467 86,930,947 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 JBrowse link 9 95,241,609 95,302,822 RGD:6480464
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 JBrowse link 9 95,161,157 95,302,822 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19679
    role 19623
      biological role 19621
        aetiopathogenetic role 18776
          carcinogenic agent 17773
            N-butyl-N-(4-hydroxybutyl)nitrosamine 24
              N-butyl-N-(3-carboxypropyl)nitrosamine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19679
    subatomic particle 19675
      composite particle 19675
        hadron 19675
          baryon 19675
            nucleon 19675
              atomic nucleus 19675
                atom 19675
                  main group element atom 19555
                    p-block element atom 19555
                      chalcogen 19242
                        oxygen atom 19196
                          oxygen molecular entity 19196
                            hydroxides 18973
                              organic hydroxy compound 18516
                                alcohol 14919
                                  primary alcohol 13792
                                    N-butyl-N-(4-hydroxybutyl)nitrosamine 24
                                      N-butyl-N-(3-carboxypropyl)nitrosamine 0
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