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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sertraline
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Accession:CHEBI:9123 term browser browse the term
Definition:A member of the class of tetralins that is tetralin which is substituted at positions 1 and 4 by a methylamino and a 3,4-dichlorophenyl group, respectively (the S,S diastereoisomer). A selective serotonin-reuptake inhibitor (SSRI), it is administered orally as the hydrochloride salt as an antidepressant for the treatment of depression, obsessive-compulsive disorder, panic disorder and post-traumatic stress disorder.
Synonyms:exact_synonym: (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine
 related_synonym: (1S,4S)-sertraline;   (1S-cis)-1,2,3,4-tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-1-naphthalenamine;   CP 51974;   Formula=C17H17Cl2N;   InChI=1S/C17H17Cl2N/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3/t12-,17-/m0/s1;   InChIKey=VGKDLMBJGBXTGI-SJCJKPOMSA-N;   SMILES=[H][C@]1(CC[C@H](NC)c2ccccc12)c1ccc(Cl)c(Cl)c1;   cis-(+)-sertraline;   sertralina;   sertralinum
 xref: Beilstein:5753709;   CAS:79617-96-2;   DrugBank:DB01104;   Drug_Central:2436;   HMDB:HMDB0005010;   KEGG:C07246;   KEGG:D02360;   LINCS:LSM-3843
 xref_mesh: MESH:D020280
 xref: PDBeChem:SRE;   PMID:19502000;   PMID:21823671;   Patent:US4536518;   Reaxys:5753709;   Wikipedia:Sertraline
 cyclic_relationship: is_conjugate_base_of CHEBI:64214


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sertraline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases activity ISO Sertraline results in increased activity of ABCB1 protein CTD PMID:23273999 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Sertraline inhibits the reaction [INS protein results in increased phosphorylation of and results in increased activity of AKT1 protein] CTD PMID:17728140 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin affects binding ISO Sertraline binds to ALB protein CTD PMID:26471709 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Sertraline results in increased expression of ASAH1 mRNA CTD PMID:15342952 NCBI chr16:53,998,604...54,030,006
Ensembl chr16:53,998,560...54,040,836
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Sertraline results in increased expression of ASNS mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Atf2 activating transcription factor 2 increases expression ISO Sertraline results in increased expression of ATF2 mRNA CTD PMID:24865413 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Sertraline results in increased expression of ATF4 protein CTD PMID:24865413 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression
decreases expression
ISO Sertraline affects the expression of BCL2 protein
Sertraline results in decreased expression of BCL2 protein
CTD PMID:18403212 PMID:24194395 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression ISO Sertraline results in increased expression of BDNF protein CTD PMID:18403212 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO 4-phenylbutyric acid inhibits the reaction [Sertraline results in increased activity of CASP3 protein]; Sertraline results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:24194395 PMID:24865413 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp4 caspase 4 increases cleavage
multiple interactions
ISO Sertraline results in increased cleavage of CASP4 protein
MAP4K4 mutant form inhibits the reaction [Sertraline results in increased cleavage of CASP4 protein]
CTD PMID:24865413 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO 4-phenylbutyric acid inhibits the reaction [Sertraline results in increased activity of CASP7 protein] CTD PMID:24865413 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Sertraline results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:24194395 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions EXP Nitric Oxide promotes the reaction [Sertraline inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]]; Sertraline inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein] CTD PMID:20305041 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cd14 CD14 molecule decreases expression ISO Sertraline results in decreased expression of CD14 mRNA CTD PMID:24865413 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression EXP Sertraline results in increased expression of CREB1 mRNA CTD PMID:8601816 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cryaa crystallin, alpha A increases expression ISO Sertraline results in increased expression of CRYAA mRNA CTD PMID:24865413 NCBI chr20:10,438,444...10,442,189
Ensembl chr20:10,438,444...10,442,187
JBrowse link
G Cul1 cullin 1 decreases expression ISO Sertraline results in decreased expression of CUL1 mRNA CTD PMID:24865413 NCBI chr 4:77,211,814...77,283,369
Ensembl chr 4:77,211,692...77,280,250
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression EXP Sertraline results in decreased expression of CYP11A1 mRNA CTD PMID:29850907 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression EXP Sertraline results in decreased expression of CYP17A1 mRNA CTD PMID:29850907 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Sertraline results in decreased activity of CYP19A1 protein CTD PMID:26162595 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 decreases expression EXP Sertraline results in decreased expression of CYP21A1 mRNA CTD PMID:29850907 NCBI chr20:4,486,213...4,489,358
Ensembl chr20:4,486,219...4,489,550
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
decreases activity
ISO [Sertraline results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion; CYP2B6 protein results in decreased methylation of and results in increased metabolism of Sertraline CTD PMID:15547048 PMID:26599973 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 affects metabolic processing
increases metabolic processing
decreases methylation
multiple interactions
ISO CYP2C19 gene polymorphism affects the metabolism of Sertraline
CYP2C19 protein results in increased metabolism of Sertraline
CYP2C19 protein results in decreased methylation of Sertraline
CYP2C19 protein results in decreased amination of and results in increased metabolism of Sertraline; CYP2C19 protein results in decreased methylation of and results in increased metabolism of Sertraline
CTD PMID:11452243 PMID:15547048 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO CYP2D6 protein results in decreased methylation of and results in increased metabolism of Sertraline CTD PMID:15547048 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Dbh dopamine beta-hydroxylase increases response to substance ISO DBH protein results in increased susceptibility to Sertraline CTD PMID:15148402 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO 4-phenylbutyric acid inhibits the reaction [Sertraline results in increased expression of DDIT3 protein]; MAP4K4 mutant form inhibits the reaction [Sertraline results in increased expression of DDIT3 protein]
Sertraline results in increased expression of DDIT3 mRNA; Sertraline results in increased expression of DDIT3 protein
CTD PMID:24865413 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Depp1 DEPP1, autophagy regulator increases expression ISO Sertraline results in increased expression of DEPP1 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 4:148,780,330...148,784,566
Ensembl chr 4:148,782,479...148,784,562
JBrowse link
G Dnajc5 DnaJ heat shock protein family (Hsp40) member C5 increases expression ISO Sertraline results in increased expression of DNAJC5 mRNA; Sertraline results in increased expression of DNAJC5 protein CTD PMID:11257428 NCBI chr 3:177,012,714...177,047,787
Ensembl chr 3:177,013,604...177,043,902
JBrowse link
G Drd1 dopamine receptor D1 increases expression EXP Sertraline results in increased expression of DRD1 mRNA CTD PMID:16499906 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression ISO Sertraline results in increased expression of DUSP1 mRNA CTD PMID:24865413 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Dusp10 dual specificity phosphatase 10 increases expression ISO Sertraline results in increased expression of DUSP10 mRNA CTD PMID:24865413 NCBI chr13:104,284,660...104,321,455
Ensembl chr13:104,284,660...104,321,455
JBrowse link
G Dusp14 dual specificity phosphatase 14 increases expression ISO Sertraline results in increased expression of DUSP14 mRNA CTD PMID:24865413 NCBI chr10:71,363,688...71,383,602
Ensembl chr10:71,363,688...71,383,602
JBrowse link
G Dusp16 dual specificity phosphatase 16 increases expression ISO Sertraline results in increased expression of DUSP16 mRNA CTD PMID:24865413 NCBI chr 4:168,470,141...168,551,346
Ensembl chr 4:168,472,412...168,517,177
JBrowse link
G Dusp8 dual specificity phosphatase 8 increases expression ISO Sertraline results in increased expression of DUSP8 mRNA CTD PMID:24865413 NCBI chr 1:215,030,429...215,043,111
Ensembl chr 1:215,030,429...215,033,460
JBrowse link
G Egfr epidermal growth factor receptor increases expression ISO Sertraline results in increased expression of EGFR mRNA CTD PMID:24865413 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases expression
ISO MAP4K4 mutant form inhibits the reaction [Sertraline results in increased phosphorylation of EIF2AK3 protein]; Sertraline results in increased expression of and results in increased phosphorylation of EIF2AK3 protein
Sertraline results in increased expression of EIF2AK3 mRNA
CTD PMID:24865413 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO Sertraline results in increased phosphorylation of EIF2S1 protein CTD PMID:24865413 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO Sertraline results in increased expression of ERN1 mRNA CTD PMID:24865413 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Sertraline results in increased expression of FABP1 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Fndc4 fibronectin type III domain containing 4 increases expression ISO Sertraline results in increased expression of FNDC4 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 6:26,387,284...26,389,524 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression
increases expression
EXP
ISO
Sertraline results in decreased expression of FOS mRNA
Sertraline results in increased expression of FOS mRNA
CTD PMID:7612155 PMID:24865413 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Sertraline results in increased expression of GADD45A mRNA CTD PMID:24865413 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression ISO Sertraline results in increased expression of GADD45B mRNA CTD PMID:24865413 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322
JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Sertraline results in increased expression of GDPD3 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 1:198,199,032...198,209,178
Ensembl chr 1:198,199,622...198,209,150
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression ISO Sertraline results in increased expression of HERPUD1 mRNA CTD PMID:24865413 NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254
JBrowse link
G Hpn hepsin increases expression ISO Sertraline results in increased expression of HPN mRNA CTD PMID:15342952 NCBI chr 1:89,534,112...89,549,575
Ensembl chr 1:89,534,106...89,543,967
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression EXP Sertraline results in decreased expression of HSD3B1 mRNA CTD PMID:29850907
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO Sertraline results in increased expression of HSPA1A mRNA CTD PMID:24865413 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO Sertraline results in increased expression of HSPA1B mRNA CTD PMID:24865413 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression
decreases expression
EXP
ISO
Sertraline results in increased expression of HSPA8 mRNA alternative form; Sertraline results in increased expression of HSPA8 protein alternative form
Sertraline results in decreased expression of HSPA8 mRNA
CTD PMID:10425221 PMID:24865413 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions
increases expression
EXP [Estradiol co-treated with Sertraline] affects the expression of HTR1A mRNA
Sertraline results in increased expression of HTR1A mRNA
CTD PMID:18650020 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions
increases expression
EXP [Estradiol co-treated with Sertraline] affects the expression of HTR2A mRNA; Estradiol promotes the reaction [Sertraline results in increased expression of HTR2A mRNA] CTD PMID:18650020 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C multiple interactions
increases expression
EXP [Estradiol co-treated with Sertraline] affects the expression of HTR2C mRNA; Estradiol promotes the reaction [Sertraline results in increased expression of HTR2C mRNA] CTD PMID:18650020 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039
JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Sertraline results in increased expression of INHBE mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 7:70,641,423...70,642,848
Ensembl chr 7:70,640,075...70,643,169
JBrowse link
G Ins2 insulin 2 multiple interactions EXP Sertraline affects the reaction [INS protein affects the phosphorylation of IRS1 protein]; Sertraline inhibits the reaction [INS protein results in increased phosphorylation of and results in increased activity of AKT1 protein] CTD PMID:17728140 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions
decreases activity
EXP Sertraline affects the reaction [INS protein affects the phosphorylation of IRS1 protein]
Sertraline results in decreased activity of IRS1 protein
CTD PMID:17728140 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO Sertraline results in increased expression of and results in increased phosphorylation of JUN protein
Sertraline results in increased expression of JUN mRNA
CTD PMID:24194395 PMID:24865413 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit increases expression ISO Sertraline results in increased expression of JUND mRNA CTD PMID:24865413 NCBI chr16:20,485,028...20,486,707
Ensembl chr16:20,485,029...20,486,707
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Sertraline results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO Sertraline inhibits the reaction [Ethanol results in increased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA]]; Sertraline results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA]; Sertraline results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr 3:41,019,898...41,181,070
Ensembl chr 3:41,019,898...41,181,070
JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 multiple interactions ISO Sertraline results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA] CTD PMID:22164246 NCBI chr 8:33,435,493...33,463,410
Ensembl chr 8:33,433,905...33,463,467
JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 multiple interactions ISO Sertraline inhibits the reaction [Ethanol results in increased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA]]; Sertraline results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr11:35,011,007...35,262,362
Ensembl chr11:35,024,196...35,099,383
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP Sertraline results in increased expression of LHB protein CTD PMID:29850907 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G LOC299277 similar to serine (or cysteine) peptidase inhibitor, clade A, member 3B increases expression ISO Sertraline results in increased expression of SERPINA3 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 6:127,871,895...127,888,287
Ensembl chr 6:127,872,666...127,886,540
JBrowse link
G LOC686035 similar to heat shock 70kDa protein 6 (HSP70B) increases expression ISO Sertraline results in increased expression of HSPA6 mRNA CTD PMID:24865413 NCBI chr13:89,408,703...89,411,500 JBrowse link
G Lss lanosterol synthase increases expression ISO Sertraline results in increased expression of LSS mRNA CTD PMID:15342952 PMID:17567588 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497
JBrowse link
G Maoa monoamine oxidase A multiple interactions ISO MAOA protein results in decreased amination of and results in increased metabolism of Sertraline CTD PMID:15547048 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Maob monoamine oxidase B multiple interactions ISO MAOB protein results in decreased amination of and results in increased metabolism of Sertraline CTD PMID:15547048 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Map3k13 mitogen-activated protein kinase kinase kinase 13 increases expression ISO Sertraline results in increased expression of MAP3K13 mRNA CTD PMID:24865413 NCBI chr11:82,744,391...82,938,357
Ensembl chr11:82,745,735...82,938,357
JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 increases expression ISO Sertraline results in increased expression of MAP3K8 mRNA CTD PMID:24865413 NCBI chr17:56,109,403...56,129,925
Ensembl chr17:56,109,549...56,129,919
JBrowse link
G Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 multiple interactions
decreases expression
ISO MAP4K4 mutant form inhibits the reaction [Sertraline results in increased cleavage of CASP4 protein]; MAP4K4 mutant form inhibits the reaction [Sertraline results in increased expression of DDIT3 protein]; MAP4K4 mutant form inhibits the reaction [Sertraline results in increased phosphorylation of EIF2AK3 protein]
Sertraline results in decreased expression of MAP4K4 mRNA
CTD PMID:24865413 NCBI chr 9:46,657,444...46,782,545
Ensembl chr 9:46,657,575...46,782,545
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
EXP
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Sertraline results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Sertraline results in increased phosphorylation of and results in increased activity of MAPK1 protein
Sertraline results in increased phosphorylation of MAPK1 protein
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Sertraline results in increased phosphorylation of MAPK1 protein]
CTD PMID:17728140 PMID:24194395 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
EXP
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Sertraline results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Sertraline results in increased phosphorylation of and results in increased activity of MAPK3 protein
Sertraline results in increased phosphorylation of MAPK3 protein
CTD PMID:17728140 PMID:24194395 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP pyrazolanthrone inhibits the reaction [Sertraline results in increased phosphorylation of and results in increased activity of MAPK8 protein]; Sertraline results in increased phosphorylation of and results in increased activity of MAPK8 protein CTD PMID:17728140 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 increases expression ISO Sertraline results in increased expression of MAPK8IP3 mRNA CTD PMID:24865413 NCBI chr10:14,259,394...14,299,276
Ensembl chr10:14,260,787...14,299,167
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO Sertraline results in decreased expression of MCL1 protein CTD PMID:24194395 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO Sertraline results in increased expression of MYC mRNA CTD PMID:24865413 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression ISO Sertraline results in increased expression of NFE2L2 mRNA CTD PMID:24865413 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression ISO Sertraline results in increased expression of NFKB1 mRNA CTD PMID:24865413 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 increases expression ISO Sertraline results in increased expression of NFKB2 mRNA CTD PMID:24865413 NCBI chr 1:266,050,634...266,059,277
Ensembl chr 1:266,053,002...266,059,256
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Sertraline results in increased expression of NR0B2 mRNA CTD PMID:15342952 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Sertraline results in increased expression of NUPR1 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 decreases expression ISO Sertraline results in decreased expression of PECAM1 protein CTD PMID:15932816 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Pf4 platelet factor 4 decreases expression ISO Sertraline results in decreased expression of PF4 protein CTD PMID:15932816 NCBI chr14:18,848,549...18,849,258
Ensembl chr14:18,848,549...18,849,258
JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase increases expression ISO Sertraline results in increased expression of PHYH mRNA CTD PMID:15342952 NCBI chr17:77,287,580...77,304,482
Ensembl chr17:77,287,188...77,304,530
JBrowse link
G Ppbp pro-platelet basic protein decreases expression ISO Sertraline results in decreased expression of PPBP protein CTD PMID:12912814 NCBI chr14:18,852,433...18,853,237
Ensembl chr14:18,851,954...18,853,315
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO Sertraline results in increased expression of PPP1R15A mRNA CTD PMID:24865413 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Sertraline results in decreased expression of PTGS2 mRNA; Sertraline results in decreased expression of PTGS2 protein CTD PMID:17499975 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rbx1 ring-box 1 decreases expression ISO Sertraline results in decreased expression of RBX1 mRNA CTD PMID:24865413 NCBI chr 7:122,700,849...122,710,907
Ensembl chr 7:122,700,854...122,709,935
JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit increases expression ISO Sertraline results in increased expression of RELB mRNA CTD PMID:24865413 NCBI chr 1:80,517,081...80,545,019
Ensembl chr 1:80,517,411...80,544,825
JBrowse link
G Rnf103 ring finger protein 103 increases expression EXP Sertraline results in increased expression of RNF103 mRNA CTD PMID:11071867 NCBI chr 4:99,398,479...99,415,193
Ensembl chr 4:99,398,494...99,421,164
JBrowse link
G Rps6ka3 ribosomal protein S6 kinase A3 decreases expression ISO Sertraline results in decreased expression of RPS6KA3 mRNA CTD PMID:24865413 NCBI chr  X:37,469,736...37,576,055
Ensembl chr  X:37,469,937...37,575,624
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions EXP Sertraline results in increased phosphorylation of and results in increased activity of RPS6KB1 protein; Sirolimus inhibits the reaction [Sertraline results in increased phosphorylation of and results in increased activity of RPS6KB1 protein] CTD PMID:17728140 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Sec61g SEC61 translocon subunit gamma decreases expression ISO Sertraline results in decreased expression of SEC61G mRNA CTD PMID:24865413 NCBI chr14:99,774,589...99,780,964
Ensembl chr14:99,774,589...99,780,964
JBrowse link
G Sele selectin E decreases expression ISO Sertraline results in decreased expression of SELE protein CTD PMID:12912814 PMID:15932816 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Selenos selenoprotein S increases expression ISO Sertraline results in increased expression of SELS mRNA CTD PMID:24865413 NCBI chr 1:126,979,579...126,989,344
Ensembl chr 1:126,979,575...126,989,344
JBrowse link
G Selp selectin P decreases expression ISO Sertraline results in decreased expression of SELP protein CTD PMID:12912814 PMID:15932816 NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628
JBrowse link
G Serpini1 serpin family I member 1 increases expression EXP Sertraline results in increased expression of SERPINI1 mRNA CTD PMID:16637596 NCBI chr 2:174,013,058...174,111,693
Ensembl chr 2:174,013,288...174,111,752
JBrowse link
G Skp1 S-phase kinase-associated protein 1 decreases expression ISO Sertraline results in decreased expression of SKP1 mRNA CTD PMID:24865413 NCBI chr10:37,594,578...37,609,498
Ensembl chr10:37,594,578...37,609,498
JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Sertraline results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856
Ensembl chr 4:155,408,233...155,631,856
JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions
increases expression
decreases expression
affects response to substance
increases response to substance
ISO
EXP
Sertraline inhibits the reaction [Monocrotaline results in increased expression of SLC6A4 mRNA]
Sertraline results in increased expression of SLC6A4 mRNA
Sertraline results in decreased expression of SLC6A4 protein
SLC6A4 protein affects the susceptibility to Sertraline
[Estradiol co-treated with Sertraline] affects the expression of SLC6A4 mRNA; [Sertraline results in decreased expression of SLC6A4 protein] which results in decreased metabolism of Serotonin Uptake Inhibitors; Estradiol promotes the reaction [Sertraline results in increased expression of SLC6A4 mRNA]
SLC6A4 promoter polymorphism results in increased susceptibility to Sertraline
CTD PMID:12151556 PMID:12955294 PMID:17042913 PMID:18650020 PMID:18923402 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link
G Ssr2 signal sequence receptor subunit 2 increases expression ISO Sertraline results in increased expression of SSR2 mRNA CTD PMID:24865413 NCBI chr 2:187,951,316...187,960,067
Ensembl chr 2:187,951,344...187,960,063
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression EXP Sertraline results in decreased expression of STAR mRNA CTD PMID:29850907 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases expression ISO Sertraline results in decreased expression of STAT3 mRNA; Sertraline results in decreased expression of STAT3 protein CTD PMID:17499975 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Stmn1 stathmin 1 decreases expression ISO Sertraline results in decreased expression of STMN1 mRNA CTD PMID:24865413 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Syvn1 synoviolin 1 increases expression ISO Sertraline results in increased expression of SYVN1 mRNA CTD PMID:24865413 NCBI chr 1:221,409,281...221,416,229
Ensembl chr 1:221,409,271...221,417,886
JBrowse link
G Tagln transgelin decreases expression ISO Sertraline results in decreased expression of TAGLN mRNA CTD PMID:15342952 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357
JBrowse link
G Taok2 TAO kinase 2 increases expression ISO Sertraline results in increased expression of TAOK2 mRNA CTD PMID:24865413 NCBI chr 1:198,301,789...198,354,601
Ensembl chr 1:198,301,938...198,320,075
JBrowse link
G Tfap2a transcription factor AP-2 alpha increases expression ISO Sertraline results in increased expression of TFAP2A protein CTD PMID:28844482 NCBI chr17:24,653,342...24,670,457
Ensembl chr17:24,654,902...24,670,457
JBrowse link
G Tnf tumor necrosis factor decreases secretion
increases expression
ISO Sertraline results in decreased secretion of TNF protein
Sertraline results in increased expression of TNF mRNA
CTD PMID:17499975 PMID:24194395 PMID:24865413 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tph2 tryptophan hydroxylase 2 multiple interactions
increases expression
increases activity
EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Sertraline results in increased expression of TPH2 mRNA]
Sertraline results in increased expression of TPH2 mRNA; Sertraline results in increased expression of TPH2 protein
Sertraline results in increased activity of TPH2 protein
CTD PMID:11901216 NCBI chr 7:58,042,279...58,149,220
Ensembl chr 7:58,042,281...58,149,061
JBrowse link
G Txndc5 thioredoxin domain containing 5 decreases expression ISO Sertraline results in decreased expression of TXNDC5 mRNA CTD PMID:24865413 NCBI chr17:26,925,828...26,953,981
Ensembl chr17:26,925,828...26,953,970
JBrowse link
G Ube2d4 ubiquitin-conjugating enzyme E2D 4 (putative) decreases expression ISO Sertraline results in decreased expression of UBE2D4 mRNA CTD PMID:24865413 NCBI chr14:2,933,097...2,934,571
Ensembl chr14:2,933,100...2,934,571
JBrowse link
G Ube2g1 ubiquitin-conjugating enzyme E2G 1 decreases expression ISO Sertraline results in decreased expression of UBE2G1 mRNA CTD PMID:24865413 NCBI chr10:59,173,268...59,254,458
Ensembl chr10:59,173,268...59,254,453
JBrowse link
G Ube4b ubiquitination factor E4B decreases expression ISO Sertraline results in decreased expression of UBE4B mRNA CTD PMID:24865413 NCBI chr 5:166,156,033...166,259,069
Ensembl chr 5:166,156,033...166,259,069
JBrowse link
G Ubqln1 ubiquilin 1 increases expression ISO Sertraline results in increased expression of UBQLN1 mRNA CTD PMID:24865413 NCBI chr17:6,840,441...6,878,842
Ensembl chr17:6,840,463...6,878,844
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO UGT2B7 protein results in increased glucuronidation of and results in increased metabolism of Sertraline CTD PMID:15547048 NCBI chr14:22,597,103...22,619,968 JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression ISO Sertraline results in increased expression of VCAM1 protein CTD PMID:15932816 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Sertraline results in increased expression of WIPI1 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr10:97,859,730...97,896,949
Ensembl chr10:97,859,727...97,896,525
JBrowse link
G Xbp1 X-box binding protein 1 increases splicing ISO Sertraline results in increased splicing of XBP1 mRNA CTD PMID:24865413 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19781
    role 19726
      chemical role 19270
        environmental contaminant 18600
          naphthalene 2356
            tetralin 147
              sertraline 121
Path 2
Term Annotations click to browse term
  CHEBI ontology 19781
    subatomic particle 19779
      composite particle 19779
        hadron 19779
          baryon 19779
            nucleon 19779
              atomic nucleus 19779
                atom 19779
                  main group element atom 19669
                    main group molecular entity 19669
                      s-block molecular entity 19434
                        hydrogen molecular entity 19429
                          hydrides 18757
                            organic hydride 18355
                              organic fundamental parent 18355
                                hydrocarbon 18074
                                  cyclic hydrocarbon 17090
                                    arene 17086
                                      polycyclic arene 16907
                                        ortho-fused polycyclic arene 9665
                                          ortho-fused bicyclic arene 2411
                                            naphthalene 2356
                                              tetralin 147
                                                sertraline 121
paths to the root