Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:neocuproine
go back to main search page
Accession:CHEBI:91222 term browser browse the term
Definition:A member of the class of phenanthrolines that is 1,10-phenanthroline bearing two methyl substituents at positions 2 and 9.
Synonyms:exact_synonym: 2,9-dimethyl-1,10-phenanthroline
 related_synonym: 2,9-Dimethyl-o-phenanthroline;   2,9-Dimethylphenanthroline;   DMPHEN;   Formula=C14H12N2;   InChI=1S/C14H12N2/c1-9-3-5-11-7-8-12-6-4-10(2)16-14(12)13(11)15-9/h3-8H,1-2H3;   InChIKey=IYRGXJIJGHOCFS-UHFFFAOYSA-N;   Neocuproin;   SMILES=N1=C(C=CC2=CC=C3C=CC(=NC3=C12)C)C
 xref: CAS:484-11-7;   LINCS:LSM-19991
 xref_mesh: MESH:C002701
 xref: PMID:25151036;   Reaxys:153179;   Wikipedia:Neocuproine



show annotations for term's descendants           Sort by:
 
neocuproine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha multiple interactions ISO neocuproine inhibits the reaction [ATP7A protein mutant form promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL1 protein]]; neocuproine promotes the reaction [ATP7A protein mutant form inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein]]; neocuproine promotes the reaction [ATP7A protein mutant form inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL7 protein]]; neocuproine promotes the reaction [ATP7A protein mutant form inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNG protein]]; neocuproine promotes the reaction [ATP7A protein mutant form inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of VEGFA protein]] CTD PMID:23604539 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO neocuproine inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of BAX protein] CTD PMID:29803612 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
EXP
ISO
[Copper binds to neocuproine] which results in increased activity of CASP3 protein; bathocuproine sulfonate inhibits the reaction [[Copper binds to neocuproine] which results in increased activity of CASP3 protein]
neocuproine inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased activity of CASP3 protein]
neocuproine results in increased activity of CASP3 protein
CTD PMID:18056745 PMID:29803612 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions EXP CAT protein results in decreased susceptibility to [Copper binds to neocuproine] CTD PMID:18056745 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO neocuproine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein]; neocuproine promotes the reaction [ATP7A protein mutant form inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein]] CTD PMID:23604539 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO neocuproine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL4 protein] CTD PMID:23604539 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO neocuproine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL5 protein] CTD PMID:23604539 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 multiple interactions ISO neocuproine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL7 protein]; neocuproine promotes the reaction [ATP7A protein mutant form inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL7 protein]] CTD PMID:23604539 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO neocuproine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL2 protein] CTD PMID:23604539 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO neocuproine inhibits the reaction [ATP7A protein mutant form promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL1 protein]]; neocuproine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL1 protein] CTD PMID:23604539 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP [Copper binds to neocuproine] which affects the localization of CYCS protein; bathocuproine sulfonate inhibits the reaction [[Copper binds to neocuproine] which affects the localization of CYCS protein] CTD PMID:18056745 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO [Copper binds to neocuproine] which results in increased phosphorylation of EGFR protein CTD PMID:18346929 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Fgf9 fibroblast growth factor 9 multiple interactions ISO neocuproine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of FGF9 protein] CTD PMID:23604539 NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO [neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; [neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:12633744 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma multiple interactions ISO neocuproine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNG protein]; neocuproine promotes the reaction [ATP7A protein mutant form inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNG protein]] CTD PMID:23604539 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il12a interleukin 12A multiple interactions ISO neocuproine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12A protein] CTD PMID:23604539 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO neocuproine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1A protein] CTD PMID:23604539 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il2 interleukin 2 multiple interactions ISO neocuproine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL2 protein] CTD PMID:23604539 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il3 interleukin 3 multiple interactions ISO neocuproine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL3 protein] CTD PMID:23604539 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
JBrowse link
G Il4 interleukin 4 multiple interactions ISO neocuproine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL4 protein] CTD PMID:23604539 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions ISO neocuproine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein] CTD PMID:23604539 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [[Copper binds to neocuproine] which results in increased activity of MAPK8 protein] which results in increased phosphorylation of JUN protein CTD PMID:18056745 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP [[Copper binds to neocuproine] which results in increased activity of MAPK3 protein] which results in increased phosphorylation of MBP protein; [Copper binds to neocuproine] which results in increased activity of MAPK3 protein CTD PMID:18056745 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP [[Copper binds to neocuproine] which results in increased activity of MAPK8 protein] which results in increased phosphorylation of JUN protein; [Copper binds to neocuproine] which results in increased activity of MAPK8 protein; bathocuproine sulfonate inhibits the reaction [[Copper binds to neocuproine] which results in increased activity of MAPK8 protein] CTD PMID:18056745 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mbp myelin basic protein multiple interactions EXP [[Copper binds to neocuproine] which results in increased activity of MAPK3 protein] which results in increased phosphorylation of MBP protein CTD PMID:18056745 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
JBrowse link
G Sele selectin E multiple interactions ISO [neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; [neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:12633744 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO [neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased activity of SP1 protein] CTD PMID:12633744 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased activity of SP1 protein]; [neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; [neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; [neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased expression of SELE protein]; [neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; [neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
neocuproine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]
CTD PMID:12633744 PMID:23604539 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO neocuproine inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of TP53 protein] CTD PMID:29803612 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO [neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; [neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:12633744 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO neocuproine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of VEGFA protein]; neocuproine promotes the reaction [ATP7A protein mutant form inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of VEGFA protein]] CTD PMID:23604539 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      chemical role 19320
        ligand 5825
          chelator 5811
            neocuproine 31
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic heterocyclic compound 18584
                                  organic heteropolycyclic compound 18043
                                    organic heterotricyclic compound 14639
                                      phenanthrolines 181
                                        neocuproine 31
paths to the root