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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one
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Accession:CHEBI:91215 term browser browse the term
Definition:A member of the class of oxadiazoloquinoxalines that is 1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline substituted at position 1 by an oxo group.
Synonyms:related_synonym: Formula=C9H5N3O2;   InChI=1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H;   InChIKey=LZMHWZHOZLVYDL-UHFFFAOYSA-N;   ODQ;   SMILES=N12C3=C(N=CC1=NOC2=O)C=CC=C3
 alt_id: MESH:C095284
 xref: LINCS:LSM-2568
 xref_mesh: MESH:C095284
 xref: PMID:25023422;   PMID:26510967;   PMID:26619941;   PMID:26732984;   PMID:26764324;   Reaxys:1109587


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1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adnp activity-dependent neuroprotector homeobox decreases expression EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in decreased expression of ADNP mRNA; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in decreased expression of ADNP protein CTD PMID:18375135 NCBI chr 3:156,886,921...156,921,500
Ensembl chr 3:156,891,381...156,917,312 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Quercetin inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] CTD PMID:18001288 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased expression of BAX protein CTD PMID:16288207 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein decreases expression ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in decreased expression of BGLAP mRNA CTD PMID:22543296 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495 		JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [S-nitro-N-acetylpenicillamine results in decreased expression of BNIP3 mRNA] CTD PMID:11592958 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO
EXP		 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased activity of CASP3 protein
1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one inhibits the reaction [Nitric Oxide Donors results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one inhibits the reaction [[Nitric Oxide Donors results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]]		 CTD PMID:9388267 PMID:16288207 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased expression of CDKN1A protein CTD PMID:16288207 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions
decreases expression		 ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [NOC 18 results in increased expression of COL1A2 mRNA]
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in decreased expression of COL1A2 mRNA		 CTD PMID:22543296 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867 		JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased expression of COX4I1 protein]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of COX4I1 protein] CTD PMID:24041027 NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Quercetin inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] CTD PMID:18001288 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Dusp10 dual specificity phosphatase 10 multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [andrographolide results in increased expression of DUSP10 mRNA]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [andrographolide results in increased expression of DUSP10 protein] CTD PMID:29165873 NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 multiple interactions EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroprusside results in decreased expression of ENPP1 protein] CTD PMID:21414308 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715 		JBrowse link
G Gabpa GA binding protein transcription factor subunit alpha multiple interactions EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of GABPA protein] CTD PMID:17179207 NCBI chr11:23,888,586...23,917,612
Ensembl chr11:23,888,815...23,917,605 		JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 multiple interactions EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein] CTD PMID:17110411 NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased activity of GSK3B protein] CTD PMID:19135050 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions
increases degradation		 ISO
EXP		 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one affects the folding of [Nitric Oxide binds to [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [1,1-diethyl-2-hydroxy-2-nitrosohydrazine results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one promotes the reaction [dicyanocobinamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; [BAY 58-2667 co-treated with 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one] results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [3-(2-(2,2-dimethylpropylsulfanyl)pyridin-3-yl)-N-(3-hydroxycyclohexyl)acrylamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [3-(2-(4-chlorophenylsulfanyl)phenyl)-N-(4-dimethylaminobutyl)acrylamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroprusside results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one promotes the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one promotes the reaction [BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1A1 protein]		 CTD PMID:11744065 PMID:12495780 PMID:17050951 PMID:19466990 PMID:22171090 NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671 		JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 multiple interactions
increases degradation		 ISO
EXP		 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one affects the folding of [Nitric Oxide binds to [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [1,1-diethyl-2-hydroxy-2-nitrosohydrazine results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one promotes the reaction [dicyanocobinamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; [BAY 58-2667 co-treated with 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one] results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [3-(2-(2,2-dimethylpropylsulfanyl)pyridin-3-yl)-N-(3-hydroxycyclohexyl)acrylamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [3-(2-(4-chlorophenylsulfanyl)phenyl)-N-(4-dimethylaminobutyl)acrylamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroprusside results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one promotes the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one promotes the reaction [BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1B1 protein		 CTD PMID:11744065 PMID:12495780 PMID:17050951 PMID:19466990 PMID:22171090 NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Resveratrol results in increased expression of HMOX1 mRNA]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Resveratrol results in increased expression of HMOX1 protein] CTD PMID:24041027 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Ibsp integrin-binding sialoprotein multiple interactions
decreases expression		 ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroprusside results in increased expression of IBSP mRNA]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [NOC 18 results in increased expression of IBSP mRNA]
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in decreased expression of IBSP mRNA		 CTD PMID:22543296 NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693 		JBrowse link
G Il12rb2 interleukin 12 receptor subunit beta 2 multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [NOC 18 results in increased expression of IL12RB2 mRNA] CTD PMID:12451176 NCBI chr 4:96,426,396...96,515,251
Ensembl chr 4:96,426,842...96,515,289 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased expression of MDM2 protein CTD PMID:16288207 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased expression of NDUFB8 protein] CTD PMID:24041027 NCBI chr 1:243,408,656...243,413,715
Ensembl chr 1:243,408,619...243,413,817 		JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions EXP
ISO		 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of NRF1 protein]
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased expression of NRF1 mRNA]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of NRF1 mRNA]		 CTD PMID:17179207 PMID:24041027 NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO
EXP		 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased expression of PPARGC1A mRNA]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of PPARGC1A mRNA]
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of PPARGC1A protein]		 CTD PMID:17179207 PMID:24041027 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Mevinphos results in increased expression of PRKG1 protein] CTD PMID:15617736 NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions EXP ODQ inhibits the reaction [SNAP increases activity of Ptpn1 protein in aortic smooth muscle cells] RGD PMID:10484424 RGD:401965470 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [[2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased abundance of Nitric Oxide] which results in increased expression of and results in increased activity of SOD2 protein]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [[2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased abundance of Nitric Oxide] which results in increased expression of SOD2 mRNA] CTD PMID:14996425 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions
decreases expression		 ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroprusside results in increased expression of SPP1 mRNA]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [NOC 18 results in increased expression of SPP1 mRNA]
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in decreased expression of SPP1 mRNA		 CTD PMID:22543296 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions ISO
EXP		 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Resveratrol results in increased expression of TFAM mRNA]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of TFAM mRNA]
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of TFAM protein]		 CTD PMID:17179207 PMID:24041027 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased stability of and results in increased expression of and results in increased phosphorylation of TP53 protein CTD PMID:16288207 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased expression of UQCRC1 protein] CTD PMID:24041027 NCBI chr 8:109,589,735...109,601,481
Ensembl chr 8:109,589,706...109,601,480 		JBrowse link
G Vasp vasodilator-stimulated phosphoprotein multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroglycerin results in increased phosphorylation of VASP protein]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Resveratrol results in increased phosphorylation of VASP protein] CTD PMID:17868048 NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061 		JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases activity ISO XIAP protein results in decreased activity of 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one CTD PMID:16288207 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 19921
    role 19893
      biological role 19891
        inhibitor 18966
          enzyme inhibitor 18792
            EC 4.* (lyase) inhibitor 7401
              EC 4.6.* (P-O lyase) inhibitor 75
                EC 4.6.1.2 (guanylate cyclase) inhibitor 70
                  1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one 33
Path 2
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  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19865
                    p-block element atom 19865
                      carbon group element atom 19804
                        carbon atom 19801
                          organic molecular entity 19801
                            organic molecule 19754
                              organic cyclic compound 19544
                                organic heterocyclic compound 18909
                                  organic heteropolycyclic compound 18316
                                    organic heterotricyclic compound 15655
                                      oxadiazoloquinoxaline 33
                                        1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one 33
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