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ONTOLOGY REPORT - ANNOTATIONS


Term:WLL-vs
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Accession:CHEBI:91210 term browser browse the term
Definition:A dipeptide that is L-tryptophyl-L-leucinamide in which the N-terminal amino group has been converted to the corresponding (morpholin-4-yl)acetamide and in which one of the hydrogens attached to the nitrogen of the C-terminal amide has been replaced by a (1E)-5-methyl-1-(methylsulfonyl)hex-1-en-3-yl group. It is a selective proteasome inhibitor.
Synonyms:exact_synonym: N-(morpholin-4-ylacetyl)-L-tryptophyl-N-[(1E,3S)-5-methyl-1-(methylsulfonyl)hex-1-en-3-yl]-L-leucinamide
 related_synonym: Formula=C31H47N5O6S;   InChI=1S/C31H47N5O6S/c1-21(2)16-24(10-15-43(5,40)41)33-30(38)27(17-22(3)4)35-31(39)28(34-29(37)20-36-11-13-42-14-12-36)18-23-19-32-26-9-7-6-8-25(23)26/h6-10,15,19,21-22,24,27-28,32H,11-14,16-18,20H2,1-5H3,(H,33,38)(H,34,37)(H,35,39)/b15-10+/t24-,27+,28+/m1/s1;   InChIKey=DKBAFRHAWTVKAD-ODGLJRBPSA-N;   SMILES=C(\\[C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CC=1C2=CC=CC=C2NC1)NC(=O)CN3CCOCC3)=O)=O)=C/S(C)(=O)=O
 xref: PMID:26863983


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  CHEBI ontology 23948
    role 23836
      application 23245
        pharmaceutical 22803
          drug 22803
            proteasome inhibitor 1321
              WLL-vs 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 23948
    subatomic particle 23899
      composite particle 23899
        hadron 23899
          baryon 23899
            nucleon 23899
              atomic nucleus 23899
                atom 23899
                  main group element atom 23720
                    p-block element atom 23720
                      carbon group element atom 23436
                        carbon atom 23392
                          organic molecular entity 23392
                            organic group 22058
                              organic divalent group 22032
                                organodiyl group 22032
                                  carbonyl group 22007
                                    carbonyl compound 22007
                                      carboxylic acid 21059
                                        carboacyl group 19095
                                          univalent carboacyl group 19095
                                            carbamoyl group 18453
                                              carboxamide 18453
                                                peptide 9817
                                                  oligopeptide 1182
                                                    dipeptide 370
                                                      Trp-Leu 0
                                                        WLL-vs 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.