Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:TGFbeta receptor antagonist
go back to main search page
Accession:CHEBI:91202 term browser browse the term
Definition:An antagonist that binds to and deactivates TGFbeta receptors.
Synonyms:related_synonym: TGFR antagonist;   TGFR antagonists;   TGFbeta receptor antagonists;   transforming growth factor receptor antagonist;   transforming growth factor receptor antagonists
 xref: Wikipedia:TGF_beta_receptors


show annotations for term's descendants           Sort by:
 
LY 364947 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of ACTA2 mRNA] CTD PMID:25566828 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Ly-364947 inhibits the reaction [arsenic trioxide results in increased expression of BAX protein] CTD PMID:23542815 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Ly-364947 inhibits the reaction [arsenic trioxide results in decreased expression of BCL2 protein] CTD PMID:23542815 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions EXP Ly-364947 inhibits the reaction [arsenic trioxide results in increased activity of CASP3 protein] CTD PMID:23542815 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of CCN2 mRNA] CTD PMID:25566828 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
decreases expression
ISO [Ly-364947 co-treated with Carbon Tetrachloride] results in increased expression of CDKN1A protein; Ly-364947 inhibits the reaction [Carbon Tetrachloride results in increased expression of CDKN1A mRNA]
Ly-364947 results in decreased expression of CDKN1A protein
CTD PMID:25566828 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Ly-364947 promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA] CTD PMID:25566828 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression
ISO Ly-364947 inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]; Ly-364947 inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein]
Ly-364947 results in increased expression of CYP2E1 mRNA
CTD PMID:25566828 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Ly-364947 inhibits the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:23542815 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Ly-364947 inhibits the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:23542815 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Ly-364947 promotes the reaction [Carbon Tetrachloride results in increased expression of PCNA protein] CTD PMID:25566828 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO Ly-364947 affects the reaction [TGFB3 protein results in increased expression of SERPINE1 mRNA] CTD PMID:25566828 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Smad2 SMAD family member 2 multiple interactions
decreases expression
ISO Ly-364947 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]
Ly-364947 results in decreased expression of SMAD2 protein modified form
Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of SMAD2 protein modified form]
CTD PMID:24727557 PMID:25566828 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of SMAD3 protein modified form] CTD PMID:25566828 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases activity
multiple interactions
EXP
ISO
Ly-364947 results in decreased activity of TGFB1 protein
Ly-364947 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]
CTD PMID:23542815 PMID:24727557 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfb3 transforming growth factor, beta 3 multiple interactions ISO Ly-364947 affects the reaction [TGFB3 protein results in increased expression of SERPINE1 mRNA]; Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of ACTA2 mRNA]; Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of CCN2 mRNA]; Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of SMAD2 protein modified form]; Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of SMAD3 protein modified form] CTD PMID:25566828 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
JBrowse link
LY-2157299 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of COL1A1 mRNA; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of CTNNB1 protein; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of FN1 protein; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of LAMC2 protein; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of TGFB1 mRNA; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the phosphorylation of SMAD2 protein CTD PMID:29808285 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Acan aggrecan decreases expression EXP LY-2157299 results in decreased expression of ACAN mRNA CTD PMID:29660438 NCBI chr 1:132,981,034...133,044,416
Ensembl chr 1:132,981,582...133,043,627
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of COL1A1 mRNA CTD PMID:29808285 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col2a1 collagen type II alpha 1 chain decreases expression EXP LY-2157299 results in decreased expression of COL2A1 mRNA CTD PMID:29660438 NCBI chr 7:129,098,489...129,127,620
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of CTNNB1 protein CTD PMID:29808285 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of FN1 protein CTD PMID:29808285 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Lamc2 laminin subunit gamma 2 multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of LAMC2 protein CTD PMID:29808285 NCBI chr13:65,284,664...65,344,200
Ensembl chr13:65,284,664...65,344,200
JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the phosphorylation of SMAD2 protein CTD PMID:29808285 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of TGFB1 mRNA CTD PMID:29808285 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        pharmacological role 18847
          antagonist 16277
            TGFbeta receptor antagonist 22
              LY 364947 16
              LY-2157299 9
              SB 505124 0
              aspirin-triggered resolvin D1 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        inhibitor 18592
          enzyme inhibitor 18398
            EC 2.* (transferase) inhibitor 13899
              EC 2.7.* (P-containing group transferase) inhibitor 13535
                protein kinase inhibitor 13061
                  EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8192
                    EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitor 22
                      TGFbeta receptor antagonist 22
                        LY 364947 16
                        LY-2157299 9
                        SB 505124 0
                        aspirin-triggered resolvin D1 0
paths to the root