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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:LY 364947
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Accession:CHEBI:91198 term browser browse the term
Definition:A member of the class of pyrazoles carrying pyridin-2-yl and quinolin-4-yl substituents at positions 3 and 4 respectively.
Synonyms:exact_synonym: 4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline
 related_synonym: Formula=C17H12N4;   HTS 466284;   InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21);   InChIKey=IBCXZJCWDGCXQT-UHFFFAOYSA-N;   LY364947;   SMILES=N1=C2C(C=CC=C2)=C(C=C1)C3=CNN=C3C=4N=CC=CC4
 xref_mesh: MESH:C520284
 xref: PMID:23721184;   PMID:24535220;   PMID:24742493;   PMID:25155999;   PMID:25566828;   PMID:26047759;   PMID:26751819;   Reaxys:9492522


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LY 364947 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of ACTA2 mRNA] CTD PMID:25566828 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Ly-364947 inhibits the reaction [arsenic trioxide results in increased expression of BAX protein] CTD PMID:23542815 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Ly-364947 inhibits the reaction [arsenic trioxide results in decreased expression of BCL2 protein] CTD PMID:23542815 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions EXP Ly-364947 inhibits the reaction [arsenic trioxide results in increased activity of CASP3 protein] CTD PMID:23542815 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of CCN2 mRNA] CTD PMID:25566828 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
decreases expression
ISO [Ly-364947 co-treated with Carbon Tetrachloride] results in increased expression of CDKN1A protein; Ly-364947 inhibits the reaction [Carbon Tetrachloride results in increased expression of CDKN1A mRNA]
Ly-364947 results in decreased expression of CDKN1A protein
CTD PMID:25566828 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Ly-364947 promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA] CTD PMID:25566828 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression
ISO Ly-364947 inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]; Ly-364947 inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein]
Ly-364947 results in increased expression of CYP2E1 mRNA
CTD PMID:25566828 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Ly-364947 inhibits the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:23542815 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Ly-364947 inhibits the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:23542815 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Ly-364947 promotes the reaction [Carbon Tetrachloride results in increased expression of PCNA protein] CTD PMID:25566828 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO Ly-364947 affects the reaction [TGFB3 protein results in increased expression of SERPINE1 mRNA] CTD PMID:25566828 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Smad2 SMAD family member 2 multiple interactions
decreases expression
ISO Ly-364947 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]
Ly-364947 results in decreased expression of SMAD2 protein modified form
Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of SMAD2 protein modified form]
CTD PMID:24727557, PMID:25566828 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of SMAD3 protein modified form] CTD PMID:25566828 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases activity
multiple interactions
EXP
ISO
Ly-364947 results in decreased activity of TGFB1 protein
Ly-364947 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]
CTD PMID:23542815, PMID:24727557 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb3 transforming growth factor, beta 3 multiple interactions ISO Ly-364947 affects the reaction [TGFB3 protein results in increased expression of SERPINE1 mRNA]; Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of ACTA2 mRNA]; Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of CCN2 mRNA]; Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of SMAD2 protein modified form]; Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of SMAD3 protein modified form] CTD PMID:25566828 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        pharmacological role 18797
          antagonist 16197
            TGFbeta receptor antagonist 22
              LY 364947 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  heteroarene 16447
                                    monocyclic heteroarene 13303
                                      azole 12471
                                        diazole 8126
                                          pyrazoles 1294
                                            LY 364947 16
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.