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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:serpentine
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Accession:CHEBI:9119 term browser browse the term
Definition:An indole alkaloid that is 18-oxayohimban dehydrogenated at positions 3, 4, 5, 6, 16 and 17 and substituted by a methyl group at the 19alpha position and by a methoxycarbonyl group at position 16.
Synonyms:exact_synonym: methyl (19alpha)-19-methyl-3,4,5,6,16,17-hexadehydro-18-oxayohimban-4-ium-1-ide-16-carboxylate
 related_synonym: (19alpha)-3,4,5,6,16,17-hexadehydro-16-(methoxycarbonyl)-19-methyloxayohimbanium;   (4S,4aR,14aS)-4-methyl-1-[(methyloxy)carbonyl]-4a,5,14,14a-tetrahydro-4H-indolo[2,3-a]pyrano[3,4-g]quinolizin-6-ium-13-ide;   Formula=C21H20N2O3;   InChI=1S/C21H20N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-8,11-12,15-16H,9-10H2,1-2H3/t12-,15-,16+/m0/s1;   InChIKey=WYTGDNHDOZPMIW-VBNZEHGJSA-N;   SMILES=[C@]12([C@@H](OC=C([C@]1(CC=3[N+](C2)=CC=C4C5=CC=CC=C5[N-]C34)[H])C(=O)OC)C)[H];   Serpentine (alkaloid);   methyl (19alpha)-19-methyl-3,4,5,6,16,17-hexadehydrooxayohimban-4-ium-1-ide-16-carboxylate
 xref: Beilstein:5421116;   CAS:18786-24-8;   KEGG:C09241;   KNApSAcK:C00001769
 xref_mesh: MESH:C009244
 cyclic_relationship: is_conjugate_base_of CHEBI:142531



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serpentine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity
multiple interactions
ISO serpentine (alkaloid) results in decreased activity of CYP2D6 protein
serpentine (alkaloid) inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan]
CTD PMID:15930738 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20057
    role 20023
      biological role 20010
        biochemical role 19662
          metabolite 19645
            alkaloid 5715
              indole alkaloid 1885
                serpentine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20057
    subatomic particle 20056
      composite particle 20068
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19971
                    main group molecular entity 19959
                      s-block molecular entity 19758
                        hydrogen molecular entity 19764
                          hydrides 19134
                            inorganic hydride 17935
                              pnictogen hydride 17901
                                nitrogen hydride 17789
                                  ammonium 8314
                                    ammonium ion derivative 8310
                                      quaternary ammonium ion 5215
                                        quaternary nitrogen compound 760
                                          iminium betaine 50
                                            serpentine 1
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