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ONTOLOGY REPORT - ANNOTATIONS


Term:CHIR 99021
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Accession:CHEBI:91091 term browser browse the term
Definition:A member of the class of aminopyrimidines that is 2-aminopyrimidine substituted at positions N2, 5 and 6 by (5-cyanopyridin-2-yl)ethyl, 4-methylimidazol-2-yl and 2,4-dichlorophenyl groups respectively.
Synonyms:exact_synonym: 6-[(2-{[4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino}ethyl)amino]pyridine-3-carbonitrile
 related_synonym: 6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile;   CHIR-911;   CHIR99021;   CT-99021;   Formula=C22H18Cl2N8;   InChI=1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32);   InChIKey=AQGNHMOJWBZFQQ-UHFFFAOYSA-N;   SMILES=N1=C(C=CC(=C1)C#N)NCCNC2=NC=C(C(=N2)C3=CC=C(C=C3Cl)Cl)C4=NC=C(N4)C
 xref: CAS:252917-06-9;   LINCS:LSM-1181
 xref_mesh: MESH:C473711
 xref: PMID:26565809;   Reaxys:25763160


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CHIR 99021 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acadvl acyl-CoA dehydrogenase, very long chain JBrowse link 10 56,619,321 56,624,468 RGD:6480464
G Acan aggrecan JBrowse link 1 140,762,758 140,824,441 RGD:6480464
G Afp alpha-fetoprotein JBrowse link 14 19,141,755 19,159,919 RGD:6480464
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:6480464
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 JBrowse link 8 77,640,234 77,719,488 RGD:6480464
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:6480464
G Bglap bone gamma-carboxyglutamate protein JBrowse link 2 187,741,770 187,748,445 RGD:6480464
G Cdx1 caudal type homeo box 1 JBrowse link 18 56,337,485 56,355,477 RGD:6480464
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:6480464
G Eif2b5 eukaryotic translation initiation factor 2B subunit epsilon JBrowse link 11 84,080,273 84,090,259 RGD:6480464
G Esrra estrogen related receptor, alpha JBrowse link 1 222,168,729 222,178,842 RGD:6480464
G Eya1 EYA transcriptional coactivator and phosphatase 1 JBrowse link 5 4,275,728 4,495,525 RGD:6480464
G Fbxo32 F-box protein 32 JBrowse link 7 98,065,664 98,098,071 RGD:6480464
G Fgf8 fibroblast growth factor 8 JBrowse link 1 265,492,949 265,498,965 RGD:6480464
G Foxa1 forkhead box A1 JBrowse link 6 78,516,579 78,549,669 RGD:6480464
G Foxc2 forkhead box C2 JBrowse link 19 53,044,379 53,047,081 RGD:6480464
G Gata6 GATA binding protein 6 JBrowse link 18 2,415,821 2,447,087 RGD:6480464
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6480464
G Hes5 hes family bHLH transcription factor 5 JBrowse link 5 172,364,421 172,365,188 RGD:6480464
G Hes7 hes family bHLH transcription factor 7 JBrowse link 10 55,704,485 55,710,523 RGD:6480464
G Hoxb1 homeo box B1 JBrowse link 10 84,214,358 84,215,812 RGD:6480464
G Hoxb3 homeo box B3 JBrowse link 10 84,170,629 84,196,823 RGD:6480464
G Hoxb5 homeo box B5 JBrowse link 10 84,152,152 84,154,360 RGD:6480464
G Hoxb7 homeo box B7 JBrowse link 10 84,135,224 84,138,642 RGD:6480464
G Hoxb9 homeo box B9 JBrowse link 10 84,119,772 84,124,963 RGD:6480464
G Ihh Indian hedgehog signaling molecule JBrowse link 9 82,208,223 82,214,440 RGD:6480464
G Lamp1 lysosomal-associated membrane protein 1 JBrowse link 16 81,689,576 81,714,341 RGD:6480464
G Lgr5 leucine rich repeat containing G protein coupled receptor 5 JBrowse link 7 58,447,097 58,587,787 RGD:6480464
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha JBrowse link 3 150,801,289 150,802,935 RGD:6480464
G Meox1 mesenchyme homeobox 1 JBrowse link 10 89,797,011 89,817,009 RGD:6480464
G Mesp2 mesoderm posterior bHLH transcription factor 2 JBrowse link 1 141,550,633 141,553,239 RGD:6480464
G Mpp1 membrane palmitoylated protein 1 JBrowse link 1 148,450,213 148,458,945 RGD:6480464
G Msgn1 mesogenin 1 JBrowse link 6 36,876,165 36,876,805 RGD:6480464
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6480464
G Nanog Nanog homeobox JBrowse link 4 155,531,906 155,539,268 RGD:6480464
G Nes nestin JBrowse link 2 187,343,109 187,352,972 RGD:6480464
G Neurog2 neurogenin 2 JBrowse link 2 231,962,517 231,963,441 RGD:6480464
G Nodal nodal growth differentiation factor JBrowse link 20 31,035,729 31,044,096 RGD:6480464
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464
G Nrf1 nuclear respiratory factor 1 JBrowse link 4 57,335,732 57,445,317 RGD:6480464
G Olig3 oligodendrocyte transcription factor 3 JBrowse link 1 14,797,766 14,799,835 RGD:6480464
G Pax3 paired box 3 JBrowse link 9 84,004,004 84,101,226 RGD:6480464
G Pax6 paired box 6 JBrowse link 3 95,700,241 95,728,682 RGD:6480464
G Perm1 PPARGC1 and ESRR induced regulator, muscle 1 JBrowse link 5 173,640,780 173,646,073 RGD:6480464
G Pou5f1 POU class 5 homeobox 1 JBrowse link 20 3,747,231 3,751,994 RGD:6480464
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 7 126,618,872 126,687,282 RGD:6480464
G Ppard peroxisome proliferator-activated receptor delta JBrowse link 20 7,818,289 7,883,482 RGD:6480464
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6480464
G Rictor RPTOR independent companion of MTOR, complex 2 JBrowse link 2 56,013,898 56,105,818 RGD:6480464
G Runx2 RUNX family transcription factor 2 JBrowse link 9 18,564,743 18,773,092 RGD:6480464
G Sox17 SRY-box transcription factor 17 JBrowse link 5 14,890,318 14,895,907 RGD:6480464
G Sox2 SRY-box transcription factor 2 JBrowse link 2 121,165,137 121,167,545 RGD:6480464
G Sox9 SRY-box transcription factor 9 JBrowse link 10 101,288,528 101,294,030 RGD:6480464
G Sp7 Sp7 transcription factor JBrowse link 7 143,957,316 143,967,488 RGD:6480464
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:6480464
G Syp synaptophysin JBrowse link X 15,694,699 15,709,244 RGD:6480464
G Tbx1 T-box transcription factor 1 JBrowse link 11 86,552,022 86,561,647 RGD:6480464
G Tbx6 T-box transcription factor 6 JBrowse link 1 198,214,797 198,218,706 RGD:6480464
G Tcf15 transcription factor 15 JBrowse link 3 147,643,250 147,649,511 RGD:6480464
G Tfeb transcription factor EB JBrowse link 9 15,208,141 15,264,101 RGD:6480464
G Tubb3 tubulin, beta 3 class III JBrowse link 19 56,220,759 56,229,813 RGD:6480464
G Uncx UNC homeobox JBrowse link 12 17,182,158 17,186,679 RGD:6480464
G Vim vimentin JBrowse link 17 80,882,715 80,891,200 RGD:6480464
G Wnt3a Wnt family member 3A JBrowse link 10 45,598,898 45,643,151 RGD:6480464
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:6480464
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta JBrowse link 6 43,463,294 43,493,816 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19790
    chemical entity 19789
      group 19698
        pseudohalo group 2878
          cyano group 2878
            nitrile 2878
              cyanopyridine 73
                CHIR 99021 68
Path 2
Term Annotations click to browse term
  CHEBI ontology 19790
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19674
                    main group molecular entity 19674
                      s-block molecular entity 19416
                        hydrogen molecular entity 19407
                          hydrides 18389
                            inorganic hydride 17221
                              pnictogen hydride 17184
                                nitrogen hydride 17018
                                  azane 16713
                                    ammonia 16712
                                      organic amino compound 16711
                                        polyamine 8108
                                          diamine 8035
                                            CHIR 99021 68
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.