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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:collagen cross-linking inhibitor
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Accession:CHEBI:91085 term browser browse the term
Definition:Any compound that inhibits collagen cross-linking.
Synonyms:related_synonym: collagen cross-linking inhibitors



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beta-aminopropionitrile term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Aminopropionitrile results in decreased expression of BCL2 protein CTD PMID:24614111 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Eln elastin multiple interactions
decreases expression
EXP Aminopropionitrile results in increased expression of and results in increased degradation of ELN protein modified form
Aminopropionitrile results in decreased expression of ELN mRNA
CTD PMID:1680324 NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928
JBrowse link
G Lox lysyl oxidase decreases activity
multiple interactions
EXP
ISO
Aminopropionitrile results in decreased activity of LOX protein
Aminopropionitrile inhibits the reaction [cupric chloride results in increased activity of LOX protein]
CTD PMID:16023247 PMID:19524603 PMID:22367676 PMID:25044713 NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477
JBrowse link
G Mmp14 matrix metallopeptidase 14 decreases activity ISO Aminopropionitrile results in decreased activity of MMP14 protein CTD PMID:24014025 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
increases expression
EXP Propylthiouracil inhibits the reaction [Aminopropionitrile results in increased expression of MMP2 protein] CTD PMID:33462684 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases expression
EXP Propylthiouracil inhibits the reaction [Aminopropionitrile results in increased expression of MMP9 protein] CTD PMID:33462684 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO Aminopropionitrile results in decreased expression of PCNA protein CTD PMID:24614111 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Smad2 SMAD family member 2 increases phosphorylation
multiple interactions
EXP Aminopropionitrile results in increased phosphorylation of SMAD2 protein
Propylthiouracil inhibits the reaction [Aminopropionitrile results in increased phosphorylation of SMAD2 protein]
CTD PMID:33462684 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19887
      biological role 19885
        inhibitor 18944
          collagen cross-linking inhibitor 8
            beta-aminopropionitrile + 8
            beta-aminopropionitrile hemifumarate 0
paths to the root