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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:senecionine
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Accession:CHEBI:9107 term browser browse the term
Definition:A pyrrolizidine alkaloid isolated from the plant species of the genus Senecio.
Synonyms:exact_synonym: 12-hydroxysenecionan-11,16-dione
 related_synonym: Formula=C18H25NO5;   InChI=1S/C18H25NO5/c1-4-12-9-11(2)18(3,22)17(21)23-10-13-5-7-19-8-6-14(15(13)19)24-16(12)20/h4-5,11,14-15,22H,6-10H2,1-3H3/b12-4-/t11-,14-,15-,18-/m1/s1;   InChIKey=HKODIGSRFALUTA-JTLQZVBZSA-N;   SMILES=[H]\\C(C)=C1/C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@]([H])(OC1=O)[C@@]23[H];   Senecionin;   aureine
 xref: Beilstein:8162955;   Beilstein:934445;   Beilstein:94450;   CAS:130-01-8;   KEGG:C06176;   KNApSAcK:C00002116
 xref_mesh: MESH:C009237
 xref: PMID:15202562;   PMID:17260281;   PMID:21710732;   Reaxys:94450
 cyclic_relationship: is_conjugate_base_of CHEBI:77617


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senecionine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression ISO senecionine results in decreased expression of ABCB11 mRNA CTD PMID:26100227, PMID:31606820 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression ISO senecionine results in decreased expression of ABCB1 mRNA CTD PMID:31606820 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases expression EXP senecionine results in increased expression of ABCB1B mRNA CTD PMID:32419051 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression ISO senecionine results in decreased expression of ABCB4 mRNA CTD PMID:31606820 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO senecionine results in increased expression of ABCC1 mRNA CTD PMID:31606820 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression ISO senecionine results in decreased expression of ABCC2 mRNA CTD PMID:26100227, PMID:31606820 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
decreases expression
EXP
ISO
senecionine results in increased expression of ABCC3 mRNA
senecionine results in decreased expression of ABCC3 mRNA
CTD PMID:24641316, PMID:26100227, PMID:31606820 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 decreases expression ISO senecionine results in decreased expression of ABCC4 mRNA CTD PMID:31606820 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 decreases expression ISO senecionine results in decreased expression of ABCC6 mRNA CTD PMID:26100227 NCBI chr 1:101,954,786...102,013,252
Ensembl chr 1:101,959,540...102,013,243
JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 decreases expression ISO senecionine results in decreased expression of ACSL3 mRNA CTD PMID:26100227 NCBI chr 9:84,569,601...84,593,565
Ensembl chr 9:84,569,597...84,593,565
JBrowse link
G Acsm3 acyl-CoA synthetase medium-chain family member 3 decreases expression ISO senecionine results in decreased expression of ACSM3 mRNA CTD PMID:26100227 NCBI chr 1:189,514,504...189,541,233
Ensembl chr 1:189,514,553...189,541,224
JBrowse link
G Adam8 ADAM metallopeptidase domain 8 increases expression EXP senecionine results in increased expression of ADAM8 mRNA CTD PMID:32419051 NCBI chr 1:212,317,510...212,332,895
Ensembl chr 1:212,317,848...212,330,349
JBrowse link
G Aff3 AF4/FMR2 family, member 3 decreases expression ISO senecionine results in decreased expression of AFF3 mRNA CTD PMID:26100227 NCBI chr 9:44,837,979...45,291,964
Ensembl chr 9:44,839,960...45,292,047
JBrowse link
G Agxt alanine--glyoxylate and serine--pyruvate aminotransferase decreases expression ISO senecionine results in decreased expression of AGXT mRNA CTD PMID:26100227 NCBI chr 9:100,281,339...100,291,292
Ensembl chr 9:100,281,339...100,291,291
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP senecionine results in increased expression of ALDH1A1 mRNA CTD PMID:32419051 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 increases expression ISO senecionine results in increased expression of ALDH6A1 mRNA CTD PMID:26100227 NCBI chr 6:108,146,552...108,167,185
Ensembl chr 6:108,146,582...108,167,185
JBrowse link
G Aldh8a1 aldehyde dehydrogenase 8 family, member A1 decreases expression ISO senecionine results in decreased expression of ALDH8A1 mRNA CTD PMID:26100227 NCBI chr 1:16,910,043...16,929,465
Ensembl chr 1:16,910,069...16,930,481
JBrowse link
G Areg amphiregulin increases expression ISO senecionine results in increased expression of AREG mRNA CTD PMID:26100227 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Arhgap11a Rho GTPase activating protein 11A increases expression EXP senecionine results in increased expression of ARHGAP11A mRNA CTD PMID:32419051 NCBI chr 3:105,281,827...105,298,108
Ensembl chr 3:105,281,827...105,298,108
JBrowse link
G Atad2 ATPase family, AAA domain containing 2 increases expression EXP senecionine results in increased expression of ATAD2 mRNA CTD PMID:32419051 NCBI chr 7:97,984,754...98,027,379
Ensembl chr 7:97,984,862...98,026,052
JBrowse link
G Axin2 axin 2 decreases expression ISO senecionine results in decreased expression of AXIN2 mRNA CTD PMID:31606820 NCBI chr10:97,212,483...97,238,824
Ensembl chr10:97,212,432...97,239,642
JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase decreases expression EXP
ISO
senecionine results in decreased expression of BAAT mRNA CTD PMID:24641316, PMID:26100227 NCBI chr 5:64,768,397...64,777,368
Ensembl chr 5:64,768,401...64,777,368
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO senecionine results in decreased expression of BCL2L1 protein CTD PMID:29458164 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp12 caspase 12 increases expression EXP senecionine results in increased expression of CASP12 mRNA CTD PMID:32419051 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp3 caspase 3 multiple interactions ISO senecionine results in increased activity of and results in increased cleavage of CASP3 protein CTD PMID:29458164 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO senecionine results in increased activity of and results in increased cleavage of CASP8 protein CTD PMID:29458164 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity ISO senecionine results in increased activity of CASP9 protein CTD PMID:29458164 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccna2 cyclin A2 increases expression EXP senecionine results in increased expression of CCNA2 mRNA CTD PMID:32419051 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccne2 cyclin E2 increases expression EXP senecionine results in increased expression of CCNE2 mRNA CTD PMID:32419051 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Ccng1 cyclin G1 increases expression EXP senecionine results in increased expression of CCNG1 mRNA CTD PMID:32419051 NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP senecionine results in increased expression of CDKN1A mRNA CTD PMID:32419051 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cenpq centromere protein Q increases expression EXP senecionine results in increased expression of CENPQ mRNA CTD PMID:32419051 NCBI chr 9:23,352,271...23,368,774 JBrowse link
G Cenpw centromere protein W increases expression EXP senecionine results in increased expression of CENPW mRNA CTD PMID:32419051 NCBI chr 1:29,915,443...29,920,598
Ensembl chr 1:29,915,443...29,920,598
JBrowse link
G Ckap2 cytoskeleton associated protein 2 increases expression EXP senecionine results in increased expression of CKAP2 mRNA CTD PMID:32419051 NCBI chr16:74,752,655...74,779,184
Ensembl chr16:74,752,655...74,779,184
JBrowse link
G Clec4f C-type lectin domain family 4, member F decreases expression EXP senecionine results in decreased expression of CLEC4F mRNA CTD PMID:32419051 NCBI chr 4:115,322,300...115,332,021
Ensembl chr 4:115,322,291...115,332,052
JBrowse link
G Csf1r colony stimulating factor 1 receptor decreases expression EXP senecionine results in decreased expression of CSF1R mRNA CTD PMID:32419051 NCBI chr18:56,414,493...56,458,300
Ensembl chr18:56,414,488...56,458,300
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression ISO senecionine results in increased expression of CYP11A1 mRNA CTD PMID:26100227 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO senecionine results in increased expression of CYP1A1 mRNA CTD PMID:26100227 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases expression
ISO senecionine results in increased expression of CYP1A2 mRNA
senecionine results in decreased expression of CYP1A2 mRNA
CTD PMID:26100227, PMID:31606820 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO senecionine results in increased expression of CYP1B1 mRNA CTD PMID:26100227 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 affects expression ISO senecionine affects the expression of CYP2B10 mRNA CTD PMID:31606820 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO senecionine results in increased expression of CYP2B6 mRNA CTD PMID:26100227 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 decreases expression ISO senecionine results in decreased expression of CYP2C18 mRNA CTD PMID:26100227 NCBI chr 1:258,074,797...258,139,176
Ensembl chr 1:258,074,860...258,139,176
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression
decreases expression
ISO senecionine results in increased expression of CYP2E1 mRNA
senecionine results in decreased expression of CYP2E1 mRNA
CTD PMID:26100227, PMID:31606820 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 increases expression ISO senecionine results in increased expression of CYP3A43 mRNA CTD PMID:26100227 NCBI chr12:10,636,294...10,684,273
Ensembl chr12:10,636,275...10,684,278
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases expression ISO senecionine results in decreased expression of CYP3A5 mRNA CTD PMID:26100227 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 decreases expression ISO senecionine results in decreased expression of CYP4F12 mRNA CTD PMID:26100227 NCBI chr 7:15,179,472...15,191,113
Ensembl chr 7:15,179,467...15,190,796
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression EXP
ISO
senecionine results in decreased expression of CYP7A1 mRNA CTD PMID:24641316, PMID:26100227, PMID:31606820 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression ISO senecionine results in decreased expression of CYP8B1 mRNA CTD PMID:26100227 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388
JBrowse link
G Cyria CYFIP related Rac1 interactor A increases expression EXP senecionine results in increased expression of CYRIA mRNA CTD PMID:32419051 NCBI chr 6:37,555,167...37,661,196
Ensembl chr 6:37,555,182...37,665,064
JBrowse link
G Ddias DNA damage-induced apoptosis suppressor increases expression EXP senecionine results in increased expression of DDIAS mRNA CTD PMID:32419051 NCBI chr 1:157,675,754...157,700,064
Ensembl chr 1:157,675,765...157,700,064
JBrowse link
G Dhrs2 dehydrogenase/reductase 2 increases expression ISO senecionine results in increased expression of DHRS2 mRNA CTD PMID:26100227 NCBI chr15:33,876,701...33,891,559
Ensembl chr15:33,885,106...33,891,539
JBrowse link
G Dhrs9 dehydrogenase/reductase 9 increases expression ISO senecionine results in increased expression of DHRS9 mRNA CTD PMID:26100227 NCBI chr 3:55,623,671...55,645,883
Ensembl chr 3:55,623,634...55,648,325
JBrowse link
G Diaph3 diaphanous-related formin 3 increases expression EXP senecionine results in increased expression of DIAPH3 mRNA CTD PMID:32419051 NCBI chr15:69,928,507...70,400,077
Ensembl chr15:70,039,424...70,399,924
JBrowse link
G Dlgap5 DLG associated protein 5 increases expression EXP senecionine results in increased expression of DLGAP5 mRNA CTD PMID:32419051 NCBI chr15:24,167,484...24,199,417
Ensembl chr15:24,167,486...24,199,341
JBrowse link
G Dpyd dihydropyrimidine dehydrogenase decreases expression ISO senecionine results in decreased expression of DPYD mRNA CTD PMID:26100227 NCBI chr 2:221,823,692...222,694,627
Ensembl chr 2:221,823,687...222,694,627
JBrowse link
G Dtl denticleless E3 ubiquitin protein ligase homolog increases expression EXP senecionine results in increased expression of DTL mRNA CTD PMID:32419051 NCBI chr13:110,219,276...110,257,345
Ensembl chr13:110,220,283...110,257,367
JBrowse link
G Eda2r ectodysplasin A2 receptor increases expression EXP senecionine results in increased expression of EDA2R mRNA CTD PMID:32419051 NCBI chr  X:66,560,200...66,602,509
Ensembl chr  X:66,561,286...66,602,506
JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression ISO senecionine results in decreased expression of EPHX2 mRNA CTD PMID:26100227 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
JBrowse link
G Esco2 establishment of sister chromatid cohesion N-acetyltransferase 2 increases expression EXP senecionine results in increased expression of ESCO2 mRNA CTD PMID:32419051 NCBI chr15:42,500,929...42,519,019
Ensembl chr15:42,500,929...42,518,855
JBrowse link
G Ethe1 ETHE1, persulfide dioxygenase decreases expression EXP senecionine results in decreased expression of ETHE1 mRNA CTD PMID:32419051 NCBI chr 1:81,457,008...81,472,061
Ensembl chr 1:81,456,984...81,472,097
JBrowse link
G Fancd2 FA complementation group D2 increases expression EXP senecionine results in increased expression of FANCD2 mRNA CTD PMID:32419051 NCBI chr 4:145,489,869...145,551,479
Ensembl chr 4:145,489,869...145,551,479
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO
EXP
senecionine metabolite results in increased expression of FAS mRNA
senecionine results in increased expression of FAS mRNA
CTD PMID:30465738, PMID:32419051 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fmo4 flavin containing dimethylaniline monoxygenase 4 decreases expression ISO senecionine results in decreased expression of FMO4 mRNA CTD PMID:26100227 NCBI chr13:80,685,385...80,703,575
Ensembl chr13:80,685,325...80,703,615
JBrowse link
G Fmo5 flavin containing dimethylaniline monoxygenase 5 decreases expression ISO senecionine results in decreased expression of FMO5 mRNA CTD PMID:26100227 NCBI chr 2:199,796,870...199,823,927
Ensembl chr 2:199,796,881...199,823,927
JBrowse link
G Gem GTP binding protein overexpressed in skeletal muscle increases expression ISO senecionine results in increased expression of GEM mRNA CTD PMID:26100227 NCBI chr 5:25,339,479...25,353,661
Ensembl chr 5:25,349,928...25,353,661
JBrowse link
G Gls glutaminase increases expression ISO senecionine results in increased expression of GLS mRNA CTD PMID:26100227 NCBI chr 9:54,212,622...54,284,879
Ensembl chr 9:54,212,767...54,284,872
JBrowse link
G Glyat glycine-N-acyltransferase decreases expression ISO senecionine results in decreased expression of GLYAT mRNA CTD PMID:26100227 NCBI chr 1:229,060,125...229,081,113
Ensembl chr 1:229,063,714...229,080,410
JBrowse link
G Gnmt glycine N-methyltransferase increases expression ISO senecionine results in increased expression of GNMT mRNA CTD PMID:26100227 NCBI chr 9:16,565,274...16,568,626
Ensembl chr 9:16,565,225...16,568,627
JBrowse link
G Gphn gephyrin decreases expression ISO senecionine results in decreased expression of GPHN mRNA CTD PMID:26100227 NCBI chr 6:101,327,874...101,859,169
Ensembl chr 6:101,532,518...101,859,164
JBrowse link
G Gprc5a G protein-coupled receptor, class C, group 5, member A increases expression ISO senecionine results in increased expression of GPRC5A mRNA CTD PMID:26100227 NCBI chr 4:168,832,937...168,851,650
Ensembl chr 4:168,832,910...168,851,652
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity
increases expression
multiple interactions
EXP
ISO
senecionine results in increased activity of GPT protein
senecionine results in increased expression of GPT protein
POR protein affects the reaction [senecionine results in increased expression of GPT protein]
CTD PMID:24641316, PMID:31606820 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 increases expression EXP senecionine results in increased expression of GRIA3 mRNA CTD PMID:32419051 NCBI chr  X:127,561,843...127,829,763
Ensembl chr  X:127,562,660...127,829,753
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 decreases expression ISO senecionine results in decreased expression of GSTA4 mRNA CTD PMID:26100227 NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879
JBrowse link
G Gstt1 glutathione S-transferase theta 1 decreases expression ISO senecionine results in decreased expression of GSTT1 mRNA CTD PMID:26100227 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G Gzma granzyme A decreases expression EXP senecionine results in decreased expression of GZMA mRNA CTD PMID:32419051 NCBI chr 2:44,968,846...44,981,436
Ensembl chr 2:44,968,765...44,981,458
JBrowse link
G Herc6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 increases expression EXP senecionine results in increased expression of HERC6 mRNA CTD PMID:32419051 NCBI chr 4:88,606,851...88,649,424
Ensembl chr 4:88,607,518...88,649,216
JBrowse link
G Hmmr hyaluronan-mediated motility receptor increases expression EXP senecionine results in increased expression of HMMR mRNA CTD PMID:32419051 NCBI chr10:25,861,490...25,890,639
Ensembl chr10:25,861,490...25,890,639
JBrowse link
G Hnmt histamine N-methyltransferase decreases expression ISO senecionine results in decreased expression of HNMT mRNA CTD PMID:26100227 NCBI chr 3:905,111...937,038
Ensembl chr 3:904,765...937,102
JBrowse link
G Ifit2 interferon-induced protein with tetratricopeptide repeats 2 increases expression EXP senecionine results in increased expression of IFIT2 mRNA CTD PMID:32419051 NCBI chr 1:252,894,663...252,900,727
Ensembl chr 1:252,894,663...252,900,726
JBrowse link
G Il11 interleukin 11 increases expression ISO senecionine metabolite results in increased expression of IL11 mRNA CTD PMID:30465738 NCBI chr 1:72,636,959...72,643,255
Ensembl chr 1:72,635,267...72,643,255
JBrowse link
G Il17rd interleukin 17 receptor D increases expression EXP senecionine results in increased expression of IL17RD mRNA CTD PMID:32419051 NCBI chr16:2,670,471...2,737,271
Ensembl chr16:2,670,618...2,731,808
JBrowse link
G Il1b interleukin 1 beta increases expression ISO senecionine metabolite results in increased expression of IL1B mRNA CTD PMID:30465738 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Inmt indolethylamine N-methyltransferase decreases expression EXP senecionine results in decreased expression of INMT mRNA CTD PMID:32419051 NCBI chr 4:85,381,907...85,386,203
Ensembl chr 4:85,381,889...85,386,231
JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 increases expression ISO senecionine results in increased expression of ISG20 mRNA CTD PMID:26100227 NCBI chr 1:140,602,553...140,608,892
Ensembl chr 1:140,601,791...140,608,946
JBrowse link
G Jam3 junctional adhesion molecule 3 increases expression EXP senecionine results in increased expression of JAM3 mRNA CTD PMID:32419051 NCBI chr 8:28,147,110...28,208,466
Ensembl chr 8:28,147,111...28,208,466
JBrowse link
G Kif11 kinesin family member 11 increases expression EXP senecionine results in increased expression of KIF11 mRNA CTD PMID:32419051 NCBI chr 1:256,035,866...256,088,299
Ensembl chr 1:256,035,866...256,088,299
JBrowse link
G Kif18a kinesin family member 18A increases expression EXP senecionine results in increased expression of KIF18A mRNA CTD PMID:32419051 NCBI chr 3:100,366,168...100,426,867
Ensembl chr 3:100,366,168...100,427,030
JBrowse link
G Kntc1 kinetochore associated 1 increases expression EXP senecionine results in increased expression of KNTC1 mRNA CTD PMID:32419051 NCBI chr12:38,200,463...38,274,162
Ensembl chr12:38,200,463...38,274,036
JBrowse link
G Kyat1 kynurenine aminotransferase 1 decreases expression ISO senecionine results in decreased expression of KYAT1 mRNA CTD PMID:26100227 NCBI chr 3:8,752,289...8,785,617
Ensembl chr 3:8,752,625...8,766,433
JBrowse link
G Lbp lipopolysaccharide binding protein increases expression EXP senecionine results in increased expression of LBP mRNA CTD PMID:32419051 NCBI chr 3:154,786,232...154,812,910
Ensembl chr 3:154,786,215...154,813,464
JBrowse link
G Lcn2 lipocalin 2 increases expression ISO senecionine results in increased expression of LCN2 mRNA CTD PMID:31606820 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Lgr5 leucine rich repeat containing G protein coupled receptor 5 decreases expression ISO senecionine results in decreased expression of LGR5 mRNA CTD PMID:31606820 NCBI chr 7:58,447,097...58,587,787
Ensembl chr 7:58,448,277...58,587,787
JBrowse link
G LOC100911204 protein CASC5-like increases expression EXP senecionine results in increased expression of KNL1 mRNA CTD PMID:32419051 NCBI chr 3:112,531,429...112,560,698
Ensembl chr 3:112,531,703...112,560,634
JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 increases expression EXP senecionine results in increased expression of MAD2L1 mRNA CTD PMID:32419051 NCBI chr 4:97,530,993...97,543,179
Ensembl chr 4:97,531,083...97,537,086
JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO senecionine results in increased expression of MAFF mRNA CTD PMID:26100227 NCBI chr 7:120,580,743...120,592,095
Ensembl chr 7:120,580,743...120,592,095
JBrowse link
G Maoa monoamine oxidase A decreases expression ISO senecionine results in decreased expression of MAOA mRNA CTD PMID:26100227 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Mastl microtubule associated serine/threonine kinase-like increases expression EXP senecionine results in increased expression of MASTL mRNA CTD PMID:32419051 NCBI chr17:89,839,562...89,875,855
Ensembl chr17:89,742,140...89,876,825
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression EXP senecionine results in increased expression of MCM3 mRNA CTD PMID:32419051 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201
JBrowse link
G Mcm5 minichromosome maintenance complex component 5 increases expression EXP senecionine results in increased expression of MCM5 mRNA CTD PMID:32419051 NCBI chr19:14,523,482...14,561,281
Ensembl chr19:14,523,554...14,561,278
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression EXP senecionine results in increased expression of MGMT mRNA CTD PMID:32419051 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression EXP senecionine results in increased expression of MKI67 mRNA CTD PMID:32419051 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mmp1 matrix metallopeptidase 1 increases expression ISO senecionine results in increased expression of MMP1 mRNA CTD PMID:26100227 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mt2A metallothionein 2A increases expression ISO senecionine results in increased expression of MT2 mRNA CTD PMID:31606820 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Mybl1 MYB proto-oncogene like 1 increases expression EXP senecionine results in increased expression of MYBL1 mRNA CTD PMID:32419051 NCBI chr 5:9,279,756...9,315,112
Ensembl chr 5:9,279,970...9,315,114
JBrowse link
G Mybl2 MYB proto-oncogene like 2 increases expression EXP senecionine results in increased expression of MYBL2 mRNA CTD PMID:32419051 NCBI chr 3:159,421,638...159,450,087
Ensembl chr 3:159,421,671...159,450,086
JBrowse link
G Ncaph non-SMC condensin I complex, subunit H increases expression EXP senecionine results in increased expression of NCAPH mRNA CTD PMID:32419051 NCBI chr 3:119,583,798...119,611,148
Ensembl chr 3:119,583,648...119,611,136
JBrowse link
G Ndc80 NDC80 kinetochore complex component increases expression EXP senecionine results in increased expression of NDC80 mRNA CTD PMID:32419051 NCBI chr 9:119,837,857...119,871,435
Ensembl chr 9:119,839,016...119,871,382
JBrowse link
G Neb nebulin decreases expression ISO senecionine results in decreased expression of NEB mRNA CTD PMID:26100227 NCBI chr 3:37,658,081...37,855,843
Ensembl chr 3:37,658,563...37,854,561
JBrowse link
G Nnmt nicotinamide N-methyltransferase decreases expression ISO senecionine results in decreased expression of NNMT mRNA CTD PMID:26100227 NCBI chr 8:52,918,437...52,938,172
Ensembl chr 8:52,925,175...52,937,972
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO senecionine results in increased expression of NQO1 mRNA CTD PMID:26100227 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression EXP
ISO
senecionine results in decreased expression of NR0B2 mRNA CTD PMID:24641316, PMID:31606820 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression EXP senecionine results in decreased expression of NR1H4 mRNA CTD PMID:24641316 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 decreases expression ISO senecionine results in decreased expression of NR1I3 mRNA CTD PMID:31606820 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases expression EXP senecionine results in decreased expression of NR3C1 mRNA CTD PMID:32419051 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nrcam neuronal cell adhesion molecule increases expression EXP senecionine results in increased expression of NRCAM mRNA CTD PMID:32419051 NCBI chr 6:64,297,843...64,867,408
Ensembl chr 6:64,297,888...64,864,996
JBrowse link
G Nrg1 neuregulin 1 increases expression EXP senecionine results in increased expression of NRG1 mRNA CTD PMID:32419051 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434
JBrowse link
G Nusap1 nucleolar and spindle associated protein 1 increases expression EXP senecionine results in increased expression of NUSAP1 mRNA CTD PMID:32419051 NCBI chr 3:111,422,267...111,452,600
Ensembl chr 3:111,422,267...111,452,971
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases expression ISO senecionine results in decreased expression of PARP1 protein CTD PMID:29458164 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pclaf PCNA clamp associated factor increases expression EXP senecionine results in increased expression of PCLAF mRNA CTD PMID:32419051 NCBI chr 8:71,514,281...71,526,182
Ensembl chr 8:71,514,281...71,526,182
JBrowse link
G Plk4 polo-like kinase 4 increases expression EXP senecionine results in increased expression of PLK4 mRNA CTD PMID:32419051 NCBI chr 2:127,686,911...127,705,518
Ensembl chr 2:127,686,925...127,705,518
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
affects response to substance
ISO POR protein affects the reaction [senecionine results in increased expression of GPT protein]
POR protein affects the susceptibility to senecionine
CTD PMID:31606820 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Prc1 protein regulator of cytokinesis 1 increases expression EXP senecionine results in increased expression of PRC1 mRNA CTD PMID:32419051 NCBI chr 1:142,087,181...142,108,746
Ensembl chr 1:142,087,208...142,108,746
JBrowse link
G Ptgis prostaglandin I2 synthase decreases expression ISO senecionine metabolite results in decreased expression of PTGIS mRNA; senecionine metabolite results in decreased expression of PTGIS protein CTD PMID:30465738 NCBI chr 3:163,950,746...163,986,129 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO senecionine metabolite results in increased expression of PTGS2 mRNA; senecionine metabolite results in increased expression of PTGS2 protein CTD PMID:30465738 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptprd protein tyrosine phosphatase, receptor type, D decreases expression ISO senecionine results in decreased expression of PTPRD mRNA CTD PMID:26100227 NCBI chr 5:92,862,229...93,514,071
Ensembl chr 5:92,862,267...93,244,202
JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor 4 decreases expression ISO senecionine results in decreased expression of RAPGEF4 mRNA CTD PMID:26100227 NCBI chr 3:58,632,338...58,925,127
Ensembl chr 3:58,632,476...58,924,038
JBrowse link
G Rrad RRAD, Ras related glycolysis inhibitor and calcium channel regulator increases expression ISO senecionine results in increased expression of RRAD mRNA CTD PMID:26100227 NCBI chr19:561,696...564,929
Ensembl chr19:561,727...564,930
JBrowse link
G Rrm1 ribonucleotide reductase catalytic subunit M1 increases expression EXP senecionine results in increased expression of RRM1 mRNA CTD PMID:32419051 NCBI chr 1:167,538,387...167,562,688
Ensembl chr 1:167,538,263...167,562,688
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 increases expression ISO senecionine results in increased expression of SAT1 mRNA CTD PMID:26100227 NCBI chr  X:43,626,480...43,629,767
Ensembl chr  X:43,625,169...43,629,765
JBrowse link
G Sgcb sarcoglycan, beta increases expression EXP senecionine results in increased expression of SGCB mRNA CTD PMID:32419051 NCBI chr14:37,113,194...37,128,623
Ensembl chr14:37,113,210...37,128,737
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP
ISO
senecionine results in decreased expression of SLC10A1 mRNA CTD PMID:24641316, PMID:31606820 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases expression ISO senecionine results in decreased expression of SLC22A1 mRNA CTD PMID:31606820 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a25 solute carrier family 22, member 25 decreases expression ISO senecionine results in decreased expression of SLC22A9 mRNA CTD PMID:26100227 NCBI chr 1:224,596,886...224,698,512
Ensembl chr 1:224,596,887...224,698,514
JBrowse link
G Slc22a7 solute carrier family 22 member 7 decreases expression ISO senecionine results in decreased expression of SLC22A7 mRNA CTD PMID:26100227, PMID:31606820 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 decreases expression EXP senecionine results in decreased expression of SLCO1A2 mRNA CTD PMID:24641316 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression EXP
ISO
senecionine results in decreased expression of SLCO1B2 mRNA
senecionine results in decreased expression of SLCO1B3 mRNA
CTD PMID:24641316, PMID:26100227, PMID:31606820 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Smc2 structural maintenance of chromosomes 2 increases expression EXP senecionine results in increased expression of SMC2 mRNA CTD PMID:32419051 NCBI chr 5:68,717,509...68,764,080
Ensembl chr 5:68,717,519...68,763,850
JBrowse link
G Smc4 structural maintenance of chromosomes 4 increases expression EXP senecionine results in increased expression of SMC4 mRNA CTD PMID:32419051 NCBI chr 2:165,600,934...165,629,415
Ensembl chr 2:165,601,007...165,629,415
JBrowse link
G Stac3 SH3 and cysteine rich domain 3 decreases expression EXP senecionine results in decreased expression of STAC3 mRNA CTD PMID:32419051 NCBI chr 7:70,807,427...70,815,271
Ensembl chr 7:70,807,867...70,815,270
JBrowse link
G Stil STIL, centriolar assembly protein increases expression EXP senecionine results in increased expression of STIL mRNA CTD PMID:32419051 NCBI chr 5:133,819,302...133,851,362
Ensembl chr 5:133,819,726...133,851,416
JBrowse link
G Stmn1 stathmin 1 increases expression EXP senecionine results in increased expression of STMN1 mRNA CTD PMID:32419051 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 decreases expression ISO senecionine results in decreased expression of SULT1E1 mRNA CTD PMID:26100227 NCBI chr14:22,070,861...22,089,264
Ensembl chr14:22,072,024...22,089,248
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 decreases expression ISO senecionine results in decreased expression of SULT2A1 mRNA CTD PMID:31606820 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
JBrowse link
G Tcf19 transcription factor 19 increases expression EXP senecionine results in increased expression of TCF19 mRNA CTD PMID:32419051 NCBI chr20:3,740,454...3,746,964
Ensembl chr20:3,744,395...3,746,964
JBrowse link
G Tenm1 teneurin transmembrane protein 1 decreases expression ISO senecionine results in decreased expression of TENM1 mRNA CTD PMID:26100227 NCBI chr  X:129,034,755...129,336,023
NCBI chr  X:128,923,951...128,951,520
JBrowse link
G Tenm2 teneurin transmembrane protein 2 decreases expression ISO senecionine results in decreased expression of TENM2 mRNA CTD PMID:26100227 NCBI chr10:20,846,091...21,791,771
Ensembl chr10:20,844,899...21,265,026
JBrowse link
G Top2a DNA topoisomerase II alpha increases expression EXP senecionine results in increased expression of TOP2A mRNA CTD PMID:32419051 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Tpmt thiopurine S-methyltransferase increases expression ISO senecionine results in increased expression of TPMT mRNA CTD PMID:26100227 NCBI chr17:18,029,090...18,047,716
Ensembl chr17:18,029,124...18,047,714
JBrowse link
G Tpx2 TPX2, microtubule nucleation factor increases expression EXP senecionine results in increased expression of TPX2 mRNA CTD PMID:32419051 NCBI chr 3:148,327,965...148,370,187
Ensembl chr 3:148,327,965...148,370,187
JBrowse link
G Ttk Ttk protein kinase increases expression EXP senecionine results in increased expression of TTK mRNA CTD PMID:32419051 NCBI chr 8:91,368,065...91,405,995
Ensembl chr 8:91,368,111...91,405,993
JBrowse link
G Tyms thymidylate synthetase increases expression EXP senecionine results in increased expression of TYMS mRNA CTD PMID:32419051 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
G Uchl3 ubiquitin C-terminal hydrolase L3 increases expression ISO senecionine results in increased expression of UCHL3 mRNA CTD PMID:26100227 NCBI chr15:86,153,624...86,198,127
Ensembl chr15:86,153,628...86,198,127
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glycosylation
multiple interactions
ISO UGT1A4 protein results in increased glycosylation of senecionine
[hecogenin results in decreased activity of UGT1A4 protein] which results in decreased glycosylation of senecionine
CTD PMID:20092275 NCBI chr 9:95,256,628...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2a3 UDP glucuronosyltransferase family 2 member A3 decreases expression ISO senecionine results in decreased expression of UGT2A3 mRNA CTD PMID:26100227 NCBI chr14:22,251,507...22,267,899
Ensembl chr14:22,192,970...22,619,968
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 decreases expression ISO senecionine results in decreased expression of UGT2B1 mRNA CTD PMID:31606820 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link
G Vps13b vacuolar protein sorting 13 homolog B decreases expression ISO senecionine results in decreased expression of VPS13B mRNA CTD PMID:26100227 NCBI chr 7:74,118,834...74,722,341 JBrowse link
G Zfp367 zinc finger protein 367 increases expression EXP senecionine results in increased expression of ZFP367 mRNA CTD PMID:32419051 NCBI chr17:1,652,892...1,672,021
Ensembl chr17:1,652,895...1,672,021
JBrowse link
G Zwilch zwilch kinetochore protein increases expression EXP senecionine results in increased expression of ZWILCH mRNA CTD PMID:32419051 NCBI chr 8:69,089,449...69,121,420
Ensembl chr 8:69,091,955...69,121,192
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            alkaloid 5349
              pyrrolizidine alkaloid 308
                senecionine 159
                  dehydrojacoline 0
                  jacoline + 0
                  senecionine N-oxide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  organic heteropolycyclic compound 17820
                                    organic heterobicyclic compound 16742
                                      pyrrolizines 382
                                        pyrrolizine alkaloid 212
                                          senecionan 212
                                            senecionine 159
                                              dehydrojacoline 0
                                              jacoline + 0
                                              senecionine N-oxide 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.