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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:GABAA receptor agonist
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Accession:CHEBI:91016 term browser browse the term
Definition:A GABA receptor agonist specific for GABAA receptors, ligand-gated ion channels (also known as ionotropic receptors).
Synonyms:related_synonym: GABAA receptor agonists


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1-hydroxymidazolam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases chemical synthesis ISO CYP3A5 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam CTD PMID:18191104, PMID:26958860 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Tspo translocator protein affects binding EXP 1-hydroxymethylmidazolam binds to TSPO protein; 1-hydroxymethylmidazolam metabolite binds to TSPO protein CTD PMID:7603229 NCBI chr 7:124,460,358...124,470,610
Ensembl chr 7:124,460,358...124,470,609
JBrowse link
4-hydroxymidazolam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases chemical synthesis
multiple interactions
ISO CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam
diosmetin inhibits the reaction [CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam]; Luteolin inhibits the reaction [CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam]
CTD PMID:18191104 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
flunitrazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO Flunitrazepam results in decreased activity of AKR1C4 protein CTD PMID:11995921 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Flunitrazepam results in decreased activity of AKR1C2 protein CTD PMID:11995921 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Flunitrazepam results in decreased activity of AKR1C3 protein CTD PMID:11995921 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Casp3 caspase 3 multiple interactions ISO CYP3A4 protein affects the reaction [Flunitrazepam results in increased activity of CASP3 protein] CTD PMID:19005028 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO CYP3A4 protein affects the reaction [Flunitrazepam results in increased activity of CASP7 protein] CTD PMID:19005028 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Crp C-reactive protein multiple interactions ISO [bromperidol co-treated with Flunitrazepam] results in increased expression of CRP protein CTD PMID:15298663 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases metabolic processing ISO CYP2C19 protein results in increased metabolism of Flunitrazepam CTD PMID:10911933 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases hydroxylation ISO CYP3A5 protein results in increased hydroxylation of Flunitrazepam CTD PMID:15383492 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions
affects binding
ISO
EXP
2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol promotes the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Flunitrazepam binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]; Propofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]
Flunitrazepam binds to GABRA1 protein
alphaxalone promotes the reaction [Flunitrazepam binds to GABRA1 protein]; Pentobarbital promotes the reaction [Flunitrazepam binds to GABRA1 protein]
CTD PMID:8397295, PMID:8632757, PMID:22029276 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 affects binding
multiple interactions
EXP Flunitrazepam binds to GABRA2 protein
alphaxalone promotes the reaction [Flunitrazepam binds to GABRA2 protein]; Pentobarbital promotes the reaction [Flunitrazepam binds to GABRA2 protein]
CTD PMID:8397295 NCBI chr14:39,662,411...39,801,082
Ensembl chr14:39,661,968...39,798,302
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 multiple interactions
affects binding
ISO 2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol promotes the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Flunitrazepam binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]; Propofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]] CTD PMID:8632757, PMID:22029276 NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions
affects binding
ISO 2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol promotes the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Flunitrazepam binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]; Propofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]] CTD PMID:8632757, PMID:22029276 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Sstr3 somatostatin receptor 3 affects expression EXP Flunitrazepam affects the expression of SSTR3 mRNA CTD PMID:16162846 NCBI chr 7:119,760,881...119,768,082
Ensembl chr 7:119,760,888...119,768,082
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 decreases activity ISO Flunitrazepam results in decreased activity of UGT1A1 protein CTD PMID:15334623 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 decreases activity ISO Flunitrazepam results in decreased activity of UGT1A3 protein CTD PMID:15334623 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
flurazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 affects response to substance ISO GABRA1 protein affects the susceptibility to Flurazepam CTD PMID:12490572 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 affects response to substance ISO GABRB2 protein affects the susceptibility to Flurazepam CTD PMID:12490572 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Flurazepam results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Trh thyrotropin releasing hormone multiple interactions EXP Flurazepam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 4:124,110,716...124,113,242
Ensembl chr 4:124,110,716...124,113,242
JBrowse link
G Trhr thyrotropin releasing hormone receptor multiple interactions EXP Flurazepam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 7:83,113,641...83,153,520
Ensembl chr 7:83,113,672...83,153,519
JBrowse link
midazolam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
ISO Midazolam results in decreased activity of ABCB11 protein
Midazolam inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:20829430, PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO Midazolam results in increased expression of ABCB1 protein CTD PMID:8632764 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb6 ATP binding cassette subfamily B member 6 multiple interactions
decreases metabolic processing
ISO [ABCB6 gene mutant form results in decreased expression of CYP3A11 mRNA] inhibits the reaction [CYP3A11 protein results in increased metabolism of Midazolam]; [ABCB6 gene mutant form results in decreased expression of CYP3A11 protein] inhibits the reaction [CYP3A11 protein results in increased metabolism of Midazolam]
ABCB6 gene mutant form results in decreased metabolism of Midazolam
CTD PMID:25623066 NCBI chr 9:82,373,950...82,382,228
Ensembl chr 9:82,373,946...82,382,272
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Midazolam results in increased expression of BCL2 CTD PMID:17715682 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Midazolam results in decreased activity of CYP1A1 protein CTD PMID:18420780 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Midazolam results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity ISO Midazolam results in decreased activity of CYP2B10 protein CTD PMID:18420780 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Midazolam results in decreased activity of CYP2C29 protein CTD PMID:18420780 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Midazolam results in decreased activity of CYP2D6 protein CTD PMID:18420780 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing ISO CYP2E1 protein results in increased metabolism of Midazolam CTD PMID:17590308 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases hydroxylation
affects metabolic processing
multiple interactions
EXP CYP3A2 protein results in increased hydroxylation of Midazolam
CYP3A4 protein affects the metabolism of Midazolam
shikonin inhibits the reaction [CYP3A2 protein results in increased hydroxylation of Midazolam]
CTD PMID:11911841, PMID:15801540, PMID:28941798 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases hydroxylation EXP CYP3A23-3A1 protein results in increased hydroxylation of Midazolam CTD PMID:11911841 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects metabolic processing
increases metabolic processing
multiple interactions
increases hydroxylation
ISO
EXP
CYP3A5 gene polymorphism affects the metabolism of Midazolam; CYP3A5 protein affects the metabolism of Midazolam
CYP3A5 protein results in increased metabolism of Midazolam
fructus schizandrae, radix ginseng, radix ophiopogonis drug combination affects the reaction [CYP3A5 protein affects the metabolism of Midazolam]
CYP3A5 protein results in increased hydroxylation of Midazolam
CTD PMID:15383492, PMID:15499178, PMID:15801540, PMID:15900284, PMID:19557931, PMID:26958860 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 increases expression ISO Midazolam results in increased expression of GABRA4 mRNA CTD PMID:16733821 NCBI chr14:39,154,072...39,230,994
Ensembl chr14:39,154,529...39,231,695
JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 decreases response to substance ISO GABRA6 protein mutant form results in decreased susceptibility to Midazolam CTD PMID:12031754 NCBI chr10:27,847,447...27,862,896
Ensembl chr10:27,847,439...27,862,868
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 increases response to substance ISO GABRB3 protein results in increased susceptibility to Midazolam CTD PMID:9523823 NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364
JBrowse link
G Gabre gamma-aminobutyric acid type A receptor subunit epsilon decreases response to substance EXP GABRE protein results in decreased susceptibility to Midazolam CTD PMID:11691872 NCBI chr  X:152,220,180...152,237,347
Ensembl chr  X:152,218,707...152,237,361
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 affects response to substance
affects binding
ISO GABRG2 protein alternative form affects the susceptibility to Midazolam
GABRG2 protein mutant form binds to Midazolam
CTD PMID:10880692 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Gast gastrin multiple interactions EXP [fluanisone co-treated with Fentanyl co-treated with Midazolam] inhibits the reaction [GAST protein results in increased secretion of Histamine] CTD PMID:10864877 NCBI chr10:88,245,532...88,248,485
Ensembl chr10:88,245,532...88,248,484
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A affects response to substance ISO GRIN2A protein affects the susceptibility to Midazolam CTD PMID:15731593 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO Midazolam results in increased activity of NR1I2 protein
NR1I2 gene promotes the reaction [Rifampin results in increased metabolism of Midazolam]
CTD PMID:18799805, PMID:20080160 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 decreases metabolic processing ISO NR1I3 gene mutant form results in decreased metabolism of Midazolam CTD PMID:27434302 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Star steroidogenic acute regulatory protein increases expression ISO Midazolam results in increased expression of STAR protein CTD PMID:19857560 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Syn1 synapsin I decreases expression EXP Midazolam results in decreased expression of SYN1 protein CTD PMID:21920406 NCBI chr  X:1,321,315...1,379,202
Ensembl chr  X:1,321,315...1,379,198
JBrowse link
G Trh thyrotropin releasing hormone multiple interactions EXP Midazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 4:124,110,716...124,113,242
Ensembl chr 4:124,110,716...124,113,242
JBrowse link
G Trhr thyrotropin releasing hormone receptor multiple interactions EXP Midazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 7:83,113,641...83,153,520
Ensembl chr 7:83,113,672...83,153,519
JBrowse link
G Tspo translocator protein increases expression
affects binding
ISO
EXP
Midazolam results in increased expression of TSPO protein
Midazolam binds to TSPO protein
CTD PMID:7603229, PMID:19857560 NCBI chr 7:124,460,358...124,470,610
Ensembl chr 7:124,460,358...124,470,609
JBrowse link
pentobarbital term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO ABCB1A protein affects the susceptibility to [Pentobarbital co-treated with Cyclosporine]; ABCB1A protein affects the susceptibility to [Pentobarbital co-treated with Ketamine] CTD PMID:17959987 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Pentobarbital results in decreased activity of and results in decreased phosphorylation of AKT1 protein CTD PMID:19346066 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 decreases expression EXP Pentobarbital results in decreased expression of APAF1 mRNA CTD PMID:16978161 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G App amyloid beta precursor protein affects expression
multiple interactions
EXP Pentobarbital affects the expression of APP mRNA
Pentobarbital inhibits the reaction [Pentylenetetrazole results in increased expression of APP mRNA]
CTD PMID:1306490, PMID:9720974 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bcl10 BCL10, immune signaling adaptor decreases expression EXP Pentobarbital results in decreased expression of BCL10 mRNA CTD PMID:16978161 NCBI chr 2:251,805,392...251,814,957
Ensembl chr 2:251,805,392...251,814,957
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Pentobarbital results in increased expression of BCL2 CTD PMID:17715682 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
decreases expression
EXP [Diazepam co-treated with Pentobarbital] promotes the reaction [Pilocarpine results in increased expression of BDNF mRNA]; [Pilocarpine co-treated with Diazepam co-treated with Pentobarbital] results in increased expression of BDNF protein; Pentobarbital inhibits the reaction [Dizocilpine Maleate affects the expression of BDNF mRNA]
Pentobarbital results in decreased expression of BDNF mRNA
CTD PMID:8247360, PMID:8405262, PMID:11259499 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Blk BLK proto-oncogene, Src family tyrosine kinase decreases expression EXP Pentobarbital results in decreased expression of BLK mRNA CTD PMID:16978161 NCBI chr15:46,555,552...46,593,778
Ensembl chr15:46,555,188...46,593,653
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression EXP Pentobarbital results in increased expression of BNIP3 mRNA CTD PMID:16978161 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I affects response to substance EXP CACNA1I protein affects the susceptibility to Pentobarbital CTD PMID:15644869 NCBI chr 7:121,521,787...121,619,300
Ensembl chr 7:121,511,097...121,619,283
JBrowse link
G Casp14 caspase 14 decreases expression EXP Pentobarbital results in decreased expression of CASP14 mRNA CTD PMID:16978161 NCBI chr 7:13,938,376...13,944,286
Ensembl chr 7:13,938,302...13,945,130
JBrowse link
G Casp7 caspase 7 increases expression EXP Pentobarbital results in increased expression of CASP7 mRNA CTD PMID:16978161 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 decreases expression EXP Pentobarbital results in decreased expression of CASP8 mRNA CTD PMID:16978161 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Ccnd1 cyclin D1 decreases expression EXP Pentobarbital results in decreased expression of CCND1 protein CTD PMID:19346066 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd3 cyclin D3 decreases expression EXP Pentobarbital results in decreased expression of CCND3 protein CTD PMID:19346066 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Cd27 CD27 molecule decreases expression EXP Pentobarbital results in decreased expression of CD27 mRNA CTD PMID:16978161 NCBI chr 4:157,744,881...157,751,609
Ensembl chr 4:157,744,882...157,750,088
JBrowse link
G Cd40lg CD40 ligand decreases expression EXP Pentobarbital results in decreased expression of CD40LG mRNA CTD PMID:16978161 NCBI chr  X:159,703,703...159,714,886
Ensembl chr  X:159,703,578...159,716,562
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression EXP Pentobarbital results in decreased expression of CDK2 protein CTD PMID:19346066 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression EXP Pentobarbital results in decreased expression of CDKN1A mRNA CTD PMID:16978161 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Chek2 checkpoint kinase 2 increases expression EXP Pentobarbital results in increased expression of CHEK2 mRNA CTD PMID:16978161 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Cnr1 cannabinoid receptor 1 affects response to substance ISO CNR1 protein affects the susceptibility to Pentobarbital CTD PMID:17442049 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain increases expression EXP Pentobarbital results in increased expression of CRADD mRNA CTD PMID:16978161 NCBI chr 7:36,395,665...36,408,588
Ensembl chr 7:36,395,665...36,408,588
JBrowse link
G Crh corticotropin releasing hormone affects expression EXP Pentobarbital affects the expression of CRH mRNA CTD PMID:18819432 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 multiple interactions EXP Pentobarbital inhibits the reaction [Corticotropin-Releasing Hormone results in decreased activity of CRHR1 protein]; Pentobarbital inhibits the reaction [Corticotropin-Releasing Hormone results in increased expression of CRHR1 mRNA] CTD PMID:12093084 NCBI chr10:92,191,473...92,233,662
Ensembl chr10:92,191,718...92,232,645
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO Pentobarbital results in increased expression of CYP1A2 mRNA CTD PMID:10064569 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP Pentobarbital results in increased expression of CYP2B1 mRNA; Pentobarbital results in increased expression of CYP2B1 protein CTD PMID:8205533, PMID:15655285 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Pentobarbital results in increased expression of CYP2B2 mRNA CTD PMID:15655285 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Dffa DNA fragmentation factor subunit alpha decreases expression EXP Pentobarbital results in decreased expression of DFFA mRNA CTD PMID:16978161 NCBI chr 5:165,922,893...165,935,822
Ensembl chr 5:165,922,915...165,935,821
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO [Haloperidol results in increased expression of DRD2 protein] which results in decreased susceptibility to Pentobarbital CTD PMID:2945998 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Faslg Fas ligand decreases expression EXP Pentobarbital results in decreased expression of FASLG mRNA CTD PMID:16978161 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Folh1 folate hydrolase 1 increases response to substance ISO FOLH1 protein results in increased susceptibility to Pentobarbital CTD PMID:15387974 NCBI chr 1:150,323,768...150,395,415
Ensembl chr 1:150,323,768...150,395,415
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
decreases expression
affects expression
ISO
EXP
Pentobarbital inhibits the reaction [Pentylenetetrazole results in increased expression of FOS mRNA]
Pentobarbital results in increased expression of FOS mRNA; Pentobarbital results in increased expression of FOS protein
Pentobarbital results in decreased expression of FOS mRNA; Pentobarbital results in decreased expression of FOS protein
Pentobarbital affects the expression of FOS protein
Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; Pentobarbital promotes the reaction [Naloxone results in increased expression of FOS protein]
Pentobarbital affects the expression of FOS mRNA
CTD PMID:1527597, PMID:2114646, PMID:2176705, PMID:3037702, PMID:3427445, PMID:7970238, PMID:8417141, PMID:8510500, PMID:8635557, PMID:9041360, PMID:9332719, PMID:10781476, PMID:17136530 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression
multiple interactions
EXP Pentobarbital results in decreased expression of FSHB protein
Pentobarbital inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Gonadotropins, Equine] results in increased expression of FSHB protein]
CTD PMID:12606454, PMID:17638707 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Fst follistatin multiple interactions EXP Pentobarbital inhibits the reaction [Estrogens results in increased expression of FST mRNA] CTD PMID:8612495 NCBI chr 2:46,537,589...46,544,813
Ensembl chr 2:46,538,700...46,544,457
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions
decreases expression
affects expression
ISO
EXP
[Propofol co-treated with Pentobarbital] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]; Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]; Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Pentobarbital results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]; Pentobarbital results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]; Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]
Pentobarbital results in decreased expression of GABRA1 mRNA
Pentobarbital promotes the reaction [Flunitrazepam binds to GABRA1 protein]; Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]; Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; Pentobarbital results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB1 protein]
Pentobarbital affects the expression of GABRA1 mRNA
Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]
CTD PMID:1712603, PMID:1977069, PMID:2165521, PMID:8207435, PMID:8397295, PMID:8787126, PMID:9316872, PMID:10049148, PMID:12939268 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 affects response to substance
multiple interactions
ISO
EXP
GABRA2 protein affects the susceptibility to Pentobarbital
Pentobarbital promotes the reaction [Flunitrazepam binds to GABRA2 protein]
CTD PMID:8397295, PMID:18313124 NCBI chr14:39,662,411...39,801,082
Ensembl chr14:39,661,968...39,798,302
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 increases expression ISO Pentobarbital results in increased expression of GABRA4 mRNA CTD PMID:16733821 NCBI chr14:39,154,072...39,230,994
Ensembl chr14:39,154,529...39,231,695
JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 increases expression EXP Pentobarbital results in increased expression of GABRA6 mRNA CTD PMID:8787126 NCBI chr10:27,847,447...27,862,896
Ensembl chr10:27,847,439...27,862,868
JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions
increases expression
ISO
EXP
Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]; Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]; Pentobarbital results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]; Pentobarbital results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]
Pentobarbital results in increased expression of GABRB1 mRNA
Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]
Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]; Pentobarbital results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB1 protein]
CTD PMID:1712603, PMID:1977069, PMID:2165521, PMID:9661255, PMID:10049148 NCBI chr14:38,631,192...39,112,598
Ensembl chr14:38,643,385...39,112,600
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 affects response to substance
affects expression
multiple interactions
EXP GABRB2 protein affects the susceptibility to Pentobarbital
Pentobarbital affects the expression of GABRB2 mRNA
Pentobarbital affects the reaction [GABRB2 protein binds to Muscimol]; Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Pentobarbital promotes the reaction [Muscimol binds to GABRB2 protein]; Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]
CTD PMID:8397295, PMID:10591412, PMID:12939268 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 multiple interactions EXP
ISO
Pentobarbital promotes the reaction [Muscimol binds to GABRB3 protein]
[Propofol co-treated with Pentobarbital] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]
CTD PMID:8397295, PMID:9316872 NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364
JBrowse link
G Gabrd gamma-aminobutyric acid type A receptor subunit delta affects response to substance
increases expression
ISO GABRD protein affects the susceptibility to Pentobarbital
Pentobarbital results in increased expression of GABRD mRNA
CTD PMID:8848253, PMID:15201633 NCBI chr 5:172,797,478...172,809,374
Ensembl chr 5:172,797,450...172,809,353
JBrowse link
G Gabre gamma-aminobutyric acid type A receptor subunit epsilon multiple interactions
decreases response to substance
ISO
EXP
Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]; Pentobarbital results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]
GABRE protein results in decreased susceptibility to Pentobarbital
CTD PMID:9039914, PMID:10049148 NCBI chr  X:152,220,180...152,237,347
Ensembl chr  X:152,218,707...152,237,361
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions
decreases expression
affects expression
ISO
EXP
[Propofol co-treated with Pentobarbital] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]; Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Pentobarbital results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]; Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]
Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; Pentobarbital results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB1 protein]
Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]
Pentobarbital results in decreased expression of GABRG2 mRNA
Pentobarbital affects the expression of GABRG2 mRNA
CTD PMID:1712603, PMID:2165521, PMID:8412506, PMID:8787126, PMID:9316872, PMID:9336343, PMID:10049148, PMID:12939268 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Gal galanin and GMAP prepropeptide decreases expression
multiple interactions
EXP Pentobarbital results in decreased expression of GAL mRNA
Pentobarbital inhibits the reaction [[Estrogens co-treated with Progesterone] results in increased expression of GAL mRNA]
CTD PMID:7512492, PMID:7537244 NCBI chr 1:218,653,059...218,657,922
Ensembl chr 1:218,652,917...218,657,925
JBrowse link
G Gap43 growth associated protein 43 multiple interactions EXP Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of GAP43 mRNA] CTD PMID:8774942 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914
JBrowse link
G Gast gastrin multiple interactions EXP Pentobarbital inhibits the reaction [GAST protein results in increased secretion of Histamine] CTD PMID:10864877, PMID:12190085 NCBI chr10:88,245,532...88,248,485
Ensembl chr10:88,245,532...88,248,484
JBrowse link
G Ghrl ghrelin and obestatin prepropeptide multiple interactions EXP [Pentobarbital co-treated with L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide] results in increased expression of GHRL protein; Atropine inhibits the reaction [[Pentobarbital co-treated with L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide] results in increased expression of GHRL protein] CTD PMID:16959836 NCBI chr 4:145,674,157...145,678,066
Ensembl chr 4:145,674,157...145,678,066
JBrowse link
G Gjb1 gap junction protein, beta 1 decreases expression EXP Pentobarbital results in decreased expression of GJB1 protein CTD PMID:8205533 NCBI chr  X:71,272,030...71,279,973
Ensembl chr  X:71,272,042...71,279,977
JBrowse link
G Gnai1 G protein subunit alpha i1 affects expression EXP Pentobarbital affects the expression of GNAI1 mRNA CTD PMID:12199159 NCBI chr 4:13,405,136...13,486,866
Ensembl chr 4:13,405,136...13,485,883
JBrowse link
G Gnao1 G protein subunit alpha o1 affects expression EXP Pentobarbital affects the expression of GNAO1 mRNA CTD PMID:12199159 NCBI chr19:11,513,201...11,669,578
Ensembl chr19:11,513,201...11,669,578
JBrowse link
G Gnas GNAS complex locus affects expression EXP Pentobarbital affects the expression of GNAS mRNA CTD PMID:12199159 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483
JBrowse link
G Gnrhr gonadotropin releasing hormone receptor decreases expression EXP Pentobarbital results in decreased expression of GNRHR mRNA CTD PMID:7867555 NCBI chr14:23,480,462...23,498,450
Ensembl chr14:23,480,462...23,498,450
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 affects response to substance ISO GRIA2 protein affects the susceptibility to Pentobarbital CTD PMID:10551584 NCBI chr 2:179,584,302...179,704,629
Ensembl chr 2:179,584,308...179,704,629
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 affects expression EXP Pentobarbital affects the expression of GRIN1 mRNA CTD PMID:10717408 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A affects response to substance
affects expression
ISO
EXP
GRIN2A protein affects the susceptibility to Pentobarbital
Pentobarbital affects the expression of GRIN2A mRNA
CTD PMID:9814547, PMID:15731593 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B affects expression EXP Pentobarbital affects the expression of GRIN2B mRNA CTD PMID:9814547 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C affects expression EXP Pentobarbital affects the expression of GRIN2C mRNA CTD PMID:9814547 NCBI chr10:103,798,290...103,816,923
Ensembl chr10:103,798,291...103,816,287
JBrowse link
G Hcrtr1 hypocretin receptor 1 decreases expression EXP Pentobarbital results in decreased expression of HCRTR1 mRNA CTD PMID:17638707 NCBI chr 5:148,346,029...148,355,404
Ensembl chr 5:148,346,031...148,355,406
JBrowse link
G Hcrtr2 hypocretin receptor 2 decreases expression EXP Pentobarbital results in decreased expression of HCRTR2 mRNA CTD PMID:17638707 NCBI chr 8:83,307,684...83,421,612
Ensembl chr 8:83,307,684...83,421,612
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions EXP Pentobarbital inhibits the reaction [Arginine Vasopressin results in increased expression of HSPB1 mRNA]; Pentobarbital inhibits the reaction [Arginine Vasopressin results in increased expression of HSPB1 protein]; Pentobarbital inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HSPB1 protein] CTD PMID:10839933 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO Pentobarbital results in increased expression of ICAM1 mRNA CTD PMID:17414419 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
ISO
EXP
Pentobarbital results in increased expression of IL1B mRNA
Ozone promotes the reaction [Pentobarbital results in increased expression of IL1B mRNA]
CTD PMID:15207037, PMID:15207038, PMID:17414419 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 increases expression ISO
EXP
Pentobarbital results in increased expression of IL6 protein
Pentobarbital results in increased expression of IL6 mRNA
CTD PMID:15207037, PMID:15207038, PMID:17414419 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgae integrin subunit alpha E increases expression EXP Pentobarbital results in increased expression of ITGAE mRNA CTD PMID:28717108 NCBI chr10:59,652,324...59,711,885
Ensembl chr10:59,539,405...59,711,874
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
affects expression
decreases activity
ISO
EXP
Pentobarbital inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of JUN mRNA]
Pentobarbital results in decreased expression of JUN protein
Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of JUN protein]; Pentobarbital results in decreased activity of and results in decreased phosphorylation of JUN protein
Pentobarbital affects the expression of JUN mRNA
Pentobarbital results in decreased activity of JUN protein
Pentobarbital inhibits the reaction [Lipopolysaccharides results in increased activity of JUN protein]
CTD PMID:1572316, PMID:8417141, PMID:8510500, PMID:9332719, PMID:10781476, PMID:15263067, PMID:17545946, PMID:19346066 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Pentobarbital results in decreased expression of JUNB protein CTD PMID:8510500 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Pentobarbital results in decreased expression of JUND protein CTD PMID:8510500 NCBI chr16:20,485,028...20,486,707
Ensembl chr16:20,485,029...20,486,707
JBrowse link
G Kcne1 potassium voltage-gated channel subfamily E regulatory subunit 1 decreases activity ISO Pentobarbital results in decreased activity of KCNE1 protein CTD PMID:11862331 NCBI chr11:32,498,260...32,511,202
Ensembl chr11:32,498,261...32,508,420
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Pentobarbital results in decreased activity of KCNH2 protein CTD PMID:11862331 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions ISO Pentobarbital inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased activity of KRAS protein] CTD PMID:15263067 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions
decreases expression
EXP Pentobarbital inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Gonadotropins, Equine] results in increased expression of LHB protein]
Pentobarbital results in decreased expression of LHB protein
CTD PMID:12606454, PMID:17638707 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Ltbr lymphotoxin beta receptor decreases expression EXP Pentobarbital results in decreased expression of LTBR mRNA CTD PMID:16978161 NCBI chr 4:157,822,838...157,829,291
Ensembl chr 4:157,822,840...157,829,241
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions
ISO
EXP
Pentobarbital results in decreased phosphorylation of MAPK1 protein
Pentobarbital results in decreased activity of and results in decreased phosphorylation of MAPK1 protein
CTD PMID:15263067, PMID:19346066 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
ISO
EXP
Pentobarbital results in decreased phosphorylation of MAPK3 protein
Pentobarbital results in decreased activity of and results in decreased phosphorylation of MAPK3 protein
CTD PMID:15263067, PMID:19346066 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression EXP Pentobarbital results in decreased expression of MCL1 mRNA CTD PMID:16978161 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Med1 mediator complex subunit 1 multiple interactions ISO MED1 protein affects the localization of [Pentobarbital binds to NR1I3 protein] CTD PMID:16828057 NCBI chr10:86,101,560...86,145,271
Ensembl chr10:86,103,600...86,144,880
JBrowse link
G Mpo myeloperoxidase increases activity EXP Pentobarbital results in increased activity of MPO protein CTD PMID:15564938 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor increases expression EXP Pentobarbital results in increased expression of MYD88 mRNA CTD PMID:16978161 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Nppa natriuretic peptide A decreases expression EXP Pentobarbital results in decreased expression of NPPA protein CTD PMID:8464334 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Npy neuropeptide Y increases response to substance
multiple interactions
ISO NPY protein results in increased susceptibility to Pentobarbital
NPY1R protein affects the reaction [NPY protein results in increased susceptibility to Pentobarbital]
CTD PMID:11454027 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Npy1r neuropeptide Y receptor Y1 multiple interactions
increases response to substance
ISO NPY1R protein affects the reaction [NPY protein results in increased susceptibility to Pentobarbital]
NPY1R protein results in increased susceptibility to Pentobarbital
CTD PMID:11454027 NCBI chr16:24,779,480...24,789,131
Ensembl chr16:24,779,477...24,788,740
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Pentobarbital binds to and results in increased activity of NR1I2 protein CTD PMID:15039302 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
affects binding
ISO MED1 protein affects the localization of [Pentobarbital binds to NR1I3 protein] CTD PMID:16828057 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions
decreases expression
EXP Chorionic Gonadotropin inhibits the reaction [Pentobarbital results in decreased expression of NR4A1 mRNA] CTD PMID:11416027 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 decreases expression EXP Pentobarbital results in decreased expression of NTRK3 mRNA CTD PMID:9191102 NCBI chr 1:139,890,537...140,262,503
Ensembl chr 1:139,890,560...140,262,503
JBrowse link
G Obp3 alpha-2u globulin PGCL4 increases expression EXP Pentobarbital results in increased expression of OBP3 mRNA CTD PMID:28717108 NCBI chr 5:77,313,357...77,316,875 JBrowse link
G Pdyn prodynorphin multiple interactions EXP Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of PDYN mRNA] CTD PMID:8417141 NCBI chr 3:122,194,327...122,206,671
Ensembl chr 3:122,194,329...122,206,671
JBrowse link
G Penk proenkephalin multiple interactions EXP Pentobarbital inhibits the reaction [Estradiol results in increased expression of PENK mRNA]; Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of PENK mRNA] CTD PMID:8417141, PMID:8717366 NCBI chr 5:17,056,412...17,061,762
Ensembl chr 5:17,056,419...17,061,837
JBrowse link
G Pgr progesterone receptor decreases expression EXP Pentobarbital results in decreased expression of PGR mRNA CTD PMID:1840636 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pomc proopiomelanocortin multiple interactions
decreases expression
EXP Muscimol promotes the reaction [Pentobarbital results in decreased expression of POMC mRNA]; Pentobarbital inhibits the reaction [Acetylcholine results in increased expression of POMC protein] CTD PMID:7588217, PMID:7937335 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Por cytochrome p450 oxidoreductase increases export
affects response to substance
increases metabolic processing
ISO POR protein results in increased export of Pentobarbital
POR protein affects the susceptibility to Pentobarbital
POR protein results in increased metabolism of Pentobarbital
CTD PMID:12566435, PMID:12697746, PMID:15328377 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Prl prolactin decreases expression EXP Pentobarbital results in decreased expression of PRL protein CTD PMID:17638707 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO Pentobarbital inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of RAC1 protein] CTD PMID:15263067 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression EXP Pentobarbital results in decreased expression of RB1 protein modified form CTD PMID:19346066 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Ren renin increases activity EXP Pentobarbital results in increased activity of REN protein CTD PMID:3512818 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Slc13a3 solute carrier family 13 member 3 increases expression EXP Pentobarbital results in increased expression of SLC13A3 mRNA CTD PMID:28717108 NCBI chr 3:162,084,336...162,147,398
Ensembl chr 3:162,084,315...162,147,393
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions
decreases activity
ISO Pentobarbital inhibits the reaction [SLC2A1 protein results in increased uptake of 3-O-Methylglucose]; Pentobarbital promotes the reaction [SLC2A1 gene polymorphism results in decreased uptake of 3-O-Methylglucose]
Pentobarbital results in decreased activity of SLC2A1 protein
CTD PMID:10590023 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Sumo1 small ubiquitin-like modifier 1 multiple interactions
increases expression
ISO Chorionic Gonadotropin inhibits the reaction [Pentobarbital results in increased expression of SUMO1 protein]; Pentobarbital inhibits the reaction [Gonadotropins results in decreased expression of SUMO1 protein] CTD PMID:14500579 NCBI chr 9:66,453,428...66,483,614
Ensembl chr 9:66,453,438...66,483,614
JBrowse link
G Tnf tumor necrosis factor decreases activity
multiple interactions
increases expression
ISO
EXP
Pentobarbital results in decreased activity of TNF protein
Pentobarbital inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Pentobarbital results in increased expression of TNF mRNA; Pentobarbital results in increased expression of TNF protein
Pentobarbital inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Pentobarbital inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD PMID:17414419, PMID:17545946 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A decreases expression EXP Pentobarbital results in decreased expression of TNFRSF11A mRNA CTD PMID:16978161 NCBI chr13:25,778,306...25,835,802
Ensembl chr13:25,778,317...25,835,957
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression EXP Pentobarbital results in increased expression of TNFRSF11B mRNA CTD PMID:16978161 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A decreases expression EXP Pentobarbital results in decreased expression of TNFRSF1A mRNA CTD PMID:16978161 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression EXP Pentobarbital results in decreased expression of TNFSF11 mRNA CTD PMID:16978161 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Tnfsf12 TNF superfamily member 12 decreases expression EXP Pentobarbital results in decreased expression of TNFSF12 mRNA CTD PMID:16978161 NCBI chr10:56,290,780...56,300,137
Ensembl chr10:56,290,780...56,300,077
JBrowse link
G Tnfsf13 TNF superfamily member 13 decreases expression EXP Pentobarbital results in decreased expression of TNFSF13 mRNA CTD PMID:16978161 NCBI chr10:56,286,964...56,290,680
Ensembl chr10:56,286,887...56,289,952
JBrowse link
G Tnfsf14 TNF superfamily member 14 decreases expression EXP Pentobarbital results in decreased expression of TNFSF14 mRNA CTD PMID:16978161 NCBI chr 9:9,761,363...9,765,461
Ensembl chr 9:9,761,536...9,765,186
JBrowse link
G Tnfsf4 TNF superfamily member 4 decreases expression EXP Pentobarbital results in decreased expression of TNFSF4 mRNA CTD PMID:16978161 NCBI chr13:79,269,973...79,293,775
Ensembl chr13:79,269,973...79,293,778
JBrowse link
G Traf2 Tnf receptor-associated factor 2 decreases expression EXP Pentobarbital results in decreased expression of TRAF2 mRNA CTD PMID:16978161 NCBI chr 3:2,746,061...2,770,690
Ensembl chr 3:2,746,075...2,770,620
JBrowse link
G Traf3 Tnf receptor-associated factor 3 decreases expression EXP Pentobarbital results in decreased expression of TRAF3 mRNA CTD PMID:16978161 NCBI chr 6:135,610,698...135,720,247
Ensembl chr 6:135,610,743...135,718,564
JBrowse link
G Upp1 uridine phosphorylase 1 affects response to substance
multiple interactions
ISO UPP1 protein affects the susceptibility to Pentobarbital
[UPP1 protein results in increased metabolism of Uridine] which affects the susceptibility to Pentobarbital
CTD PMID:15772079 NCBI chr14:89,314,234...89,334,060
Ensembl chr14:89,314,176...89,334,276
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression EXP Pentobarbital results in decreased expression of XIAP mRNA CTD PMID:16978161 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        pharmacological role 18825
          neurotransmitter agent 16439
            GABA agent 15429
              GABA agonist 3817
                GABAA receptor agonist 136
                  didesethylflurazepam 0
                  flunitrazepam 15
                  flurazepam + 5
                  midazolam + 27
                  midazolam hydrochloride 0
                  pentobarbital 112
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        pharmaceutical 19301
          drug 19301
            neurotransmitter agent 16439
              GABA agent 15429
                GABA agonist 3817
                  GABAA receptor agonist 136
                    didesethylflurazepam 0
                    flunitrazepam 15
                    flurazepam + 5
                    midazolam + 27
                    midazolam hydrochloride 0
                    pentobarbital 112
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.