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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions decreases phosphorylation |
ISO |
osimertinib affects the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; osimertinib inhibits the reaction [Derp2 allergen, Dermatophagoides pteronyssinus results in increased phosphorylation of AKT1 protein]; osimertinib results in decreased expression of and results in decreased phosphorylation of AKT1 protein osimertinib decreases phosphorylation of AKT1 protein in lung |
CTD RGD |
PMID:30145802 PMID:30623574 PMID:30993382 PMID:32276600 |
RGD:151357000 |
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Casp3 |
caspase 3 |
multiple interactions increases expression |
ISO |
[ginsenoside Rg3 co-treated with osimertinib] results in increased cleavage of CASP3 protein; Acetylcysteine inhibits the reaction [osimertinib results in increased expression of CASP3 protein modified form]; CAT protein inhibits the reaction [osimertinib results in increased expression of CASP3 protein modified form]; Vitamin E inhibits the reaction [osimertinib results in increased expression of CASP3 protein modified form] |
CTD |
PMID:28237877 PMID:31916386 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Cat |
catalase |
multiple interactions decreases response to substance |
ISO |
CAT protein inhibits the reaction [osimertinib results in increased abundance of Hydrogen Peroxide]; CAT protein inhibits the reaction [osimertinib results in increased expression of CASP3 protein modified form]; CAT protein inhibits the reaction [osimertinib results in increased expression of PARP1 protein modified form] CAT protein results in decreased susceptibility to osimertinib |
CTD |
PMID:28237877 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cftr |
CF transmembrane conductance regulator |
multiple interactions |
ISO |
osimertinib inhibits the reaction [Dronabinol results in decreased expression of and results in decreased activity of CFTR protein] |
CTD |
PMID:29928919 |
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NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
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G |
Egf |
epidermal growth factor |
multiple interactions |
ISO |
osimertinib affects the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; osimertinib affects the reaction [EGF protein results in increased phosphorylation of EGFR protein]; osimertinib affects the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; osimertinib affects the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; osimertinib affects the reaction [EGF protein results in increased phosphorylation of STAT3 protein] |
CTD |
PMID:30623574 |
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NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
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G |
Egfr |
epidermal growth factor receptor |
multiple interactions decreases activity decreases phosphorylation |
ISO |
osimertinib affects the reaction [EGF protein results in increased phosphorylation of EGFR protein]; osimertinib inhibits the reaction [EGFR protein mutant form results in decreased susceptibility to Gefitinib]; osimertinib promotes the reaction [Derp2 allergen, Dermatophagoides pteronyssinus results in increased phosphorylation of EGFR protein]; osimertinib results in decreased expression of and results in decreased phosphorylation of EGFR protein osimertinib results in decreased activity of EGFR protein osimertinib decreases phosphorylation of EGFR protein in lung |
CTD RGD |
PMID:28237877 PMID:30145802 PMID:30623574 PMID:30993382 PMID:32276600 |
RGD:151357000 |
NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Gpt |
glutamic--pyruvic transaminase |
increases secretion |
ISO |
osimertinib results in increased secretion of GPT protein |
CTD |
PMID:29655783 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
osimertinib inhibits the reaction [Derp2 allergen, Dermatophagoides pteronyssinus results in increased expression of IL6 mRNA]; osimertinib inhibits the reaction [Derp2 allergen, Dermatophagoides pteronyssinus results in increased secretion of IL6 protein] |
CTD |
PMID:30623574 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
osimertinib affects the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; osimertinib inhibits the reaction [Dronabinol results in increased phosphorylation of MAPK1 protein]; osimertinib results in decreased expression of and results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:29928919 PMID:30623574 PMID:30993382 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
osimertinib affects the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; osimertinib inhibits the reaction [Dronabinol results in increased phosphorylation of MAPK3 protein]; osimertinib results in decreased expression of and results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:29928919 PMID:30623574 PMID:30993382 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
decreases expression |
ISO |
osimertinib decreases expression of MCL1 protein in lung |
RGD |
PMID:31301315 PMID:32276600 |
RGD:151356917, RGD:151357000 |
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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G |
Mki67 |
marker of proliferation Ki-67 |
multiple interactions |
ISO |
[ginsenoside Rg3 co-treated with osimertinib] results in decreased expression of MKI67 protein |
CTD |
PMID:31916386 |
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NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases expression multiple interactions increases cleavage |
ISO |
osimertinib results in increased expression of PARP1 protein modified form [ginsenoside Rg3 co-treated with osimertinib] results in increased cleavage of PARP1 protein; [TWIST1 protein results in decreased susceptibility to osimertinib] which results in decreased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [osimertinib results in increased expression of PARP1 protein modified form]; CAT protein inhibits the reaction [osimertinib results in increased expression of PARP1 protein modified form]; TWIST1 protein inhibits the reaction [osimertinib results in increased cleavage of PARP1 protein]; Vitamin E inhibits the reaction [osimertinib results in increased expression of PARP1 protein modified form] |
CTD |
PMID:28237877 PMID:30171258 PMID:31916386 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Sqstm1 |
sequestosome 1 |
decreases expression |
ISO |
osimertinib results in decreased expression of SQSTM1 protein |
CTD |
PMID:30145802 |
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NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
ISO |
osimertinib affects the reaction [EGF protein results in increased phosphorylation of STAT3 protein]; osimertinib inhibits the reaction [Derp2 allergen, Dermatophagoides pteronyssinus results in increased phosphorylation of STAT3 protein] |
CTD |
PMID:30623574 |
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Twist1 |
twist family bHLH transcription factor 1 |
decreases response to substance affects response to substance multiple interactions |
ISO |
TWIST1 protein results in decreased susceptibility to osimertinib TWIST1 protein affects the susceptibility to osimertinib [TWIST1 protein results in decreased susceptibility to osimertinib] which results in decreased cleavage of PARP1 protein; TWIST1 protein inhibits the reaction [osimertinib results in increased cleavage of PARP1 protein] |
CTD |
PMID:30171258 PMID:30993382 |
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NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
multiple interactions decreases activity |
ISO |
osimertinib inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone] osimertinib results in decreased activity of UGT1A1 protein |
CTD |
PMID:34044055 |
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NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a2 |
UDP glucuronosyltransferase 1 family, polypeptide A2 |
decreases activity |
ISO |
osimertinib results in decreased activity of UGT1A3 protein |
CTD |
PMID:34044055 |
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NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a6 |
UDP glucuronosyltransferase family 1 member A6 |
decreases activity |
ISO |
osimertinib results in decreased activity of UGT1A6 protein |
CTD |
PMID:34044055 |
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NCBI chr 9:88,747,229...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt2b7 |
UDP glucuronosyltransferase family 2 member B7 |
decreases activity |
ISO |
osimertinib results in decreased activity of UGT2B7 protein |
CTD |
PMID:34044055 |
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NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
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