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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ixazomib
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Accession:CHEBI:90942 term browser browse the term
Definition:A glycine derivative that is the amide obtained by formal condensation of the carboxy group of N-(2,5-dichlorobenzoyl)glycine with the amino group of [(1R)-1-amino-3-methylbutyl]boronic acid. The active metabolite of ixazomib citrate, it is used in combination therapy for treatment of multiple myeloma.
Synonyms:exact_synonym: N-[(1R)-1-borono-3-methylbutyl]-N(2)-(2,5-dichlorobenzoyl)glycinamide
 related_synonym: Formula=C14H19BCl2N2O4;   InChI=1S/C14H19BCl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12,22-23H,5,7H2,1-2H3,(H,18,21)(H,19,20)/t12-/m0/s1;   InChIKey=MXAYKZJJDUDWDS-LBPRGKRZSA-N;   MLN 2238;   MLN2238;   SMILES=C(NCC(=O)N[C@@H](CC(C)C)B(O)O)(C1=CC(=CC=C1Cl)Cl)=O
 xref: CAS:1072833-77-2;   Drug_Central:5067;   KEGG:D10130;   LINCS:LSM-4944
 xref_mesh: MESH:C548400
 xref: PMID:23514361;   PMID:24239172;   PMID:24292417;   PMID:24467634;   PMID:24904120;   PMID:24920586;   PMID:25124778;   PMID:25302026;   PMID:25325301;   PMID:25377318;   PMID:25456369;   PMID:25777468;   PMID:25832873;   PMID:25919767;   PMID:26141494;   PMID:26275080;   PMID:26337806;   PMID:26588946;   PMID:26634271;   PMID:26667773;   PMID:26709701;   Reaxys:18302358;   Wikipedia:Ixazomib


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ixazomib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lat2 linker for activation of T cells family, member 2 multiple interactions ISO ixazomib inhibits the reaction [10-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphate results in decreased expression of LAT2 protein]; ixazomib inhibits the reaction [perifosine results in decreased expression of LAT2 protein] CTD PMID:23001822 NCBI chr12:22,104,163...22,118,294
Ensembl chr12:22,104,219...22,118,288
JBrowse link
G Zfand2a zinc finger AN1-type containing 2A increases expression ISO ixazomib results in increased expression of ZFAND2A protein CTD PMID:31540997 NCBI chr12:15,161,601...15,172,679
Ensembl chr12:15,161,639...15,172,677
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        biochemical role 19389
          apoptosis inducer 13236
            ixazomib 2
              ixazomib citrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        carboacyl group 17485
                                          univalent carboacyl group 17485
                                            carbamoyl group 17299
                                              carboxamide 17299
                                                monocarboxylic acid amide 15008
                                                  arenecarboxamide 7262
                                                    benzamides 7262
                                                      ixazomib 2
                                                        ixazomib citrate 0
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