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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ixazomib
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Accession:CHEBI:90942 term browser browse the term
Definition:A glycine derivative that is the amide obtained by formal condensation of the carboxy group of N-(2,5-dichlorobenzoyl)glycine with the amino group of [(1R)-1-amino-3-methylbutyl]boronic acid. The active metabolite of ixazomib citrate, it is used in combination therapy for treatment of multiple myeloma.
Synonyms:exact_synonym: N-[(1R)-1-borono-3-methylbutyl]-N(2)-(2,5-dichlorobenzoyl)glycinamide
 related_synonym: Formula=C14H19BCl2N2O4;   InChI=1S/C14H19BCl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12,22-23H,5,7H2,1-2H3,(H,18,21)(H,19,20)/t12-/m0/s1;   InChIKey=MXAYKZJJDUDWDS-LBPRGKRZSA-N;   MLN 2238;   MLN2238;   SMILES=C(NCC(=O)N[C@@H](CC(C)C)B(O)O)(C1=CC(=CC=C1Cl)Cl)=O
 xref: CAS:1072833-77-2;   Drug_Central:5067;   KEGG:D10130;   LINCS:LSM-4944
 xref_mesh: MESH:C548400
 xref: PMID:23514361;   PMID:24239172;   PMID:24292417;   PMID:24467634;   PMID:24904120;   PMID:24920586;   PMID:25124778;   PMID:25302026;   PMID:25325301;   PMID:25377318;   PMID:25456369;   PMID:25777468;   PMID:25832873;   PMID:25919767;   PMID:26141494;   PMID:26275080;   PMID:26337806;   PMID:26588946;   PMID:26634271;   PMID:26667773;   PMID:26709701;   Reaxys:18302358;   Wikipedia:Ixazomib



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ixazomib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lat2 linker for activation of T cells family, member 2 multiple interactions ISO ixazomib inhibits the reaction [10-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphate results in decreased expression of LAT2 protein]; ixazomib inhibits the reaction [perifosine results in decreased expression of LAT2 protein] CTD PMID:23001822 NCBI chr12:22,104,163...22,118,294
Ensembl chr12:22,104,219...22,118,288
JBrowse link
G Zfand2a zinc finger AN1-type containing 2A increases expression ISO ixazomib results in increased expression of ZFAND2A protein CTD PMID:31540997 NCBI chr12:15,161,601...15,172,679
Ensembl chr12:15,161,639...15,172,677
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19659
    role 19634
      biological role 19633
        biochemical role 19388
          apoptosis inducer 13431
            ixazomib 2
              ixazomib citrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19659
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19700
                atom 19658
                  main group element atom 19607
                    p-block element atom 19607
                      carbon group element atom 19550
                        carbon atom 19547
                          organic molecular entity 19588
                            organic group 18752
                              organic divalent group 18771
                                organodiyl group 18737
                                  carbonyl group 18704
                                    carbonyl compound 18738
                                      carboxylic acid 18409
                                        carboacyl group 17570
                                          univalent carboacyl group 17599
                                            carbamoyl group 17407
                                              carboxamide 17407
                                                monocarboxylic acid amide 15526
                                                  arenecarboxamide 7306
                                                    benzamides 7313
                                                      ixazomib 2
                                                        ixazomib citrate 0
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