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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:90933 term browser browse the term
Definition:An N-alkylpiperazine that is N,N-dimethyl-N'-{trans-4-[2-(piperazin-1-yl)ethyl]cyclohexyl}urea substituted at position 4 on the piperazine ring by a 2,3-dichlorophenyl group. Used (as the hydrochloride salt) for treatment of schizophrenia and bipolar disorder.
Synonyms:exact_synonym: N'-(trans-4-{2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl}cyclohexyl)-N,N-dimethylurea
 related_synonym: Formula=C21H32Cl2N4O;   InChI=1S/C21H32Cl2N4O/c1-25(2)21(28)24-17-8-6-16(7-9-17)10-11-26-12-14-27(15-13-26)19-5-3-4-18(22)20(19)23/h3-5,16-17H,6-15H2,1-2H3,(H,24,28)/t16-,17-;   InChIKey=KPWSJANDNDDRMB-QAQDUYKDSA-N;   RGH 188;   SMILES=C1[C@H](CC[C@@H](C1)CCN2CCN(CC2)C=3C(=C(C=CC3)Cl)Cl)NC(N(C)C)=O
 xref: CAS:839712-12-8;   DrugBank:DB06016;   Drug_Central:5037;   KEGG:D09997
 xref_mesh: MESH:C533287
 xref: PMID:22537450;   PMID:23138433;   PMID:23966785;   PMID:24048386;   PMID:24229617;   PMID:24412468;   PMID:24975932;   PMID:25056368;   PMID:25083572;   PMID:25532076;   PMID:25562205;   PMID:25692006;   PMID:26044980;   PMID:26075487;   PMID:26160196;   PMID:26419293;   PMID:26472602;   PMID:26510944;   PMID:26541814;   PMID:26586950;   PMID:26655189;   PMID:26655732;   PMID:26717533;   PMID:26723167;   Reaxys:18784658;   Wikipedia:Cariprazine
 cyclic_relationship: is_conjugate_base_of CHEBI:90934

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cariprazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhcr7 7-dehydrocholesterol reductase decreases activity ISO cariprazine results in decreased activity of DHCR7 protein CTD PMID:29698737 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20072
    role 20024
      application 19760
        agrochemical 15391
          fertilizer 12820
            urea 5145
              ureas 5142
                cariprazine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20072
    subatomic particle 20071
      composite particle 20071
        hadron 20071
          baryon 20071
            nucleon 20071
              atomic nucleus 20071
                atom 20071
                  main group element atom 19971
                    p-block element atom 19971
                      carbon group element atom 19894
                        carbon atom 19887
                          organic molecular entity 19887
                            organic group 18965
                              organic divalent group 18951
                                organodiyl group 18951
                                  carbonyl group 18903
                                    carbonyl compound 18903
                                      carboxylic acid 18601
                                        carboacyl group 17713
                                          univalent carboacyl group 17713
                                            carbamoyl group 17552
                                              carboxamide 17552
                                                monocarboxylic acid amide 15537
                                                  urea 5145
                                                    ureas 5142
                                                      cariprazine 1
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