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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:lesinurad
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Accession:CHEBI:90929 term browser browse the term
Definition:A member of the class of triazoles that is [(3-bromo-1,2,4-triazol-5-yl)sulfanyl]acetic acid substituted at position 1 of the triazole ring by a 4-cyclopropylnaphthalen-1-yl group. Used for treatment of gout.
Synonyms:exact_synonym: {[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetic acid
 related_synonym: Formula=C17H14BrN3O2S;   InChI=1S/C17H14BrN3O2S/c18-16-19-20-17(24-9-15(22)23)21(16)14-8-7-11(10-5-6-10)12-3-1-2-4-13(12)14/h1-4,7-8,10H,5-6,9H2,(H,22,23);   InChIKey=FGQFOYHRJSUHMR-UHFFFAOYSA-N;   RDEA 594;   RDEA594;   SMILES=C=1C=C(C2=C(C1N3C(=NN=C3Br)SCC(O)=O)C=CC=C2)C4CC4;   Zurampic
 xref: CAS:878672-00-5;   Drug_Central:5075;   KEGG:D09921
 xref_mesh: MESH:C000593471
 xref: PMID:24509406;   PMID:24703353;   PMID:25603039;   PMID:26073200;   PMID:26165106;   PMID:26170627;   PMID:26742777;   Reaxys:12932464;   Wikipedia:Lesinurad


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lesinurad term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ces1d carboxylesterase 1D decreases activity ISO lesinurad results in decreased activity of CES1 protein CTD PMID:38670244 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Ces2h carboxylesterase 2H decreases activity ISO lesinurad results in decreased activity of CES2 protein CTD PMID:38670244 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    role 19904
      application 19741
        pharmaceutical 19579
          drug 19579
            renal agent 424
              uricosuric drug 409
                lesinurad 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    p-block element atom 19876
                      carbon group element atom 19816
                        carbon atom 19812
                          organic molecular entity 19812
                            organic molecule 19764
                              organic cyclic compound 19553
                                organic heterocyclic compound 18905
                                  heteroarene 17172
                                    monocyclic heteroarene 14997
                                      azole 14521
                                        triazoles 8441
                                          lesinurad 2
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