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Term:tenofovir alafenamide
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Accession:CHEBI:90926 term browser browse the term
Definition:An L-alanine derivative that is isopropyl L-alaninate in which one of the amino hydrogens is replaced by an (S)-({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)(phenoxy)phosphoryl group. A prodrug for tenofovir, it is used (as the fumarate salt) in combination therapy for the treatment of HIV-1 infection.
Synonyms:exact_synonym: propan-2-yl N-[(S)-({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)(phenoxy)phosphoryl]-L-alaninate
 related_synonym: Formula=C21H29N6O5P;   GS-7340;   InChI=1S/C21H29N6O5P/c1-14(2)31-21(28)16(4)26-33(29,32-17-8-6-5-7-9-17)13-30-15(3)10-27-12-25-18-19(22)23-11-24-20(18)27/h5-9,11-12,14-16H,10,13H2,1-4H3,(H,26,29)(H2,22,23,24)/t15-,16+,33+/m1/s1;   InChIKey=LDEKQSIMHVQZJK-CAQYMETFSA-N;   SMILES=N1=CN=C2C(=C1N)N=CN2C[C@H](OC[P@](N[C@H](C(OC(C)C)=O)C)(=O)OC3=CC=CC=C3)C;   TAF
 xref: CAS:379270-37-8 "ChemIDplus";   CAS:379270-37-8 "KEGG DRUG";   DrugBank:DB09299;   Drug_Central:4944 "DrugCentral";   KEGG:D10428;   Reaxys:8948831 "Reaxys";   Wikipedia:Tenofovir_alafenamide
 cyclic_relationship: is_conjugate_base_of CHEBI:90927

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  CHEBI ontology 19754
    role 19701
      application 19353
        pro-agent 8831
          prodrug 8620
            tenofovir alafenamide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19754
    subatomic particle 19752
      composite particle 19752
        hadron 19752
          baryon 19752
            nucleon 19752
              atomic nucleus 19752
                atom 19752
                  main group element atom 19637
                    p-block element atom 19637
                      carbon group element atom 19528
                        carbon atom 19517
                          organic molecular entity 19517
                            organic group 18422
                              organic divalent group 18414
                                organodiyl group 18414
                                  carbonyl group 18303
                                    carbonyl compound 18303
                                      carboxylic acid 17971
                                        monocarboxylic acid 17286
                                          fatty acid 15829
                                            saturated fatty acid 15795
                                              propionic acid 3659
                                                alanine 104
                                                  L-alanine 96
                                                    L-alanine derivative 94
                                                      tenofovir alafenamide 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.