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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:90908 term browser browse the term
Definition:An azaspiro compound that is 1,7-diazaspiro[4.5]decan-2-one carrying additional phenyl and 1-{[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl substituents at position 8. Used (in the form of the hydrochloride hydrate) for the prevention of delayed nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy.
Synonyms:exact_synonym: (5S,8S)-8-({(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-8-phenyl-1,7-diazaspiro[4.5]decan-2-one
 related_synonym: Formula=C25H26F6N2O2;   InChI=1S/C25H26F6N2O2/c1-16(17-11-19(24(26,27)28)13-20(12-17)25(29,30)31)35-15-23(18-5-3-2-4-6-18)10-9-22(14-32-23)8-7-21(34)33-22/h2-6,11-13,16,32H,7-10,14-15H2,1H3,(H,33,34)/t16-,22-,23-/m1/s1;   InChIKey=FIVSJYGQAIEMOC-ZGNKEGEESA-N;   SCH 619734;   SMILES=C1=C(C=C(C=C1C(F)(F)F)C(F)(F)F)[C@H](OC[C@@]2(NC[C@]3(CC2)CCC(N3)=O)C4=CC=CC=C4)C
 xref: CAS:552292-08-7;   Drug_Central:5027;   KEGG:D10742;   PMID:22497992;   PMID:24874107;   PMID:25755107;   PMID:25856052;   PMID:25940030;   PMID:26272768;   PMID:26272769;   PMID:26366937;   PMID:26442475;   PMID:26467681;   PMID:26694923;   PMID:26699406;   Reaxys:15570068
 cyclic_relationship: is_conjugate_base_of CHEBI:90913

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