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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tipiracil
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Accession:CHEBI:90879 term browser browse the term
Definition:A member of the class of pyrimidones that is uracil substituted by chloro and (2-iminopyrrolidin-1-yl)methyl groups at positions 5 and 6 respectively. Used (as the hydrochloride salt) in combination with trifluridine, a nucleoside metabolic inhibitor, for treatment of advanced/relapsed unresectable colorectal cancer.
Synonyms:exact_synonym: 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4(1H,3H)-dione
 related_synonym: Formula=C9H11ClN4O2;   InChI=1S/C9H11ClN4O2/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11/h11H,1-4H2,(H2,12,13,15,16);   InChIKey=QQHMKNYGKVVGCZ-UHFFFAOYSA-N;   SMILES=C1(=C(C(NC(N1)=O)=O)Cl)CN2C(CCC2)=N
 xref: CAS:183204-74-2;   Drug_Central:4893;   PMID:24562648;   PMID:25230742;   PMID:25750295;   PMID:25812794;   PMID:25900515;   PMID:25901475;   PMID:25970050;   PMID:26084259;   PMID:26163340;   PMID:26197742;   PMID:26254349;   PMID:26370544;   PMID:26428513;   PMID:26509228;   PMID:26535019;   PMID:26609205;   PMID:26616466;   PMID:26677869;   PMID:26722024;   PMID:26723516;   PMID:26730280;   Reaxys:9272220;   Wikipedia:Tipiracil
 cyclic_relationship: is_conjugate_base_of CHEBI:90880


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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    role 19833
      application 19505
        pro-agent 8876
          prodrug 8631
            uracil 5661
              tipiracil 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    p-block element atom 19771
                      carbon group element atom 19679
                        carbon atom 19668
                          organic molecular entity 19668
                            organic molecule 19596
                              organic cyclic compound 19407
                                organic heterocyclic compound 18517
                                  organic heteromonocyclic compound 16622
                                    diazines 12215
                                      pyrimidines 12036
                                        pyrimidine nucleobase 6199
                                          uracil 5661
                                            tipiracil 0
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