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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(-)-selegiline
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Accession:CHEBI:9086 term browser browse the term
Definition:A selegiline that has formula C13H17N.
Synonyms:exact_synonym: N-methyl-N-[(2R)-1-phenylpropan-2-yl]prop-2-yn-1-amine
 related_synonym: EmSam;   Formula=C13H17N;   InChI=1S/C13H17N/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13/h1,5-9,12H,10-11H2,2-3H3/t12-/m1/s1;   InChIKey=MEZLKOACVSPNER-GFCCVEGCSA-N;   L-Deprenalin;   SMILES=C[C@H](Cc1ccccc1)N(C)CC#C;   selegilina;   selegilinum
 xref: Beilstein:5863318;   CAS:14611-51-9;   Chemspider:24930;   DrugBank:DB01037;   Drug_Central:2429;   KEGG:C07245;   KEGG:D03731;   LINCS:LSM-5920
 xref_mesh: MESH:D012642
 xref: PMID:8423709;   Patent:NL6605956;   Patent:US4564706;   Wikipedia:Selegiline
 cyclic_relationship: is_conjugate_base_of CHEBI:50350



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(-)-selegiline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO [Clorgyline co-treated with Selegiline] inhibits the reaction [Norepinephrine results in increased expression of ACTA2 mRNA] CTD PMID:34609854 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium affects the localization of AIFM1 protein]; Selegiline inhibits the reaction [Oxidopamine affects the localization of AIFM1 protein]; Selegiline inhibits the reaction [Rotenone affects the localization of AIFM1 protein] CTD PMID:12880480 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Selegiline co-treated with 1-Methyl-4-phenylpyridinium] results in increased phosphorylation of AKT1 protein]; [Selegiline co-treated with 1-Methyl-4-phenylpyridinium] results in increased phosphorylation of AKT1 protein
Selegiline results in increased phosphorylation of AKT1 protein
CTD PMID:22019741 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bach1 BTB domain and CNC homolog 1 multiple interactions ISO Selegiline inhibits the reaction [Smoke analog affects the localization of BACH1 protein] CTD PMID:28108387 NCBI chr11:26,939,429...26,974,876
Ensembl chr11:26,939,480...26,972,447
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Selegiline inhibits the reaction [linsidomine results in increased expression of BAX protein] CTD PMID:12880480 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Selegiline inhibits the reaction [linsidomine results in decreased expression of BCL2 protein] CTD PMID:12880480 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 mRNA]; Selegiline inhibits the reaction [linsidomine results in increased expression of CASP3 mRNA]; Selegiline inhibits the reaction [linsidomine results in increased expression of CASP3 protein]
Selegiline promotes the reaction [Hydroxyurea results in increased cleavage of CASP3 protein]
CTD PMID:12880480 PMID:14724376 PMID:23696560 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions EXP
ISO
Selegiline promotes the reaction [Rotenone results in increased activity of CAT protein]
Selegiline inhibits the reaction [Smoke analog results in decreased activity of CAT protein]
CTD PMID:16490285 PMID:28108387 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO [Clorgyline co-treated with Selegiline] inhibits the reaction [Norepinephrine results in increased expression of COL1A1 mRNA] CTD PMID:34609854 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO [Clorgyline co-treated with Selegiline] inhibits the reaction [Norepinephrine results in increased expression of COL3A1 mRNA] CTD PMID:34609854 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO Selegiline inhibits the reaction [linsidomine affects the localization of CYCS protein] CTD PMID:12880480 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing ISO CYP1A2 protein affects the metabolism of Selegiline CTD PMID:16198659 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
decreases activity
ISO Selegiline inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]
Selegiline results in decreased activity of CYP2B6 protein
CTD PMID:25656918 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of FOS mRNA] CTD PMID:14724376 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO
EXP
Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of GAPDH mRNA]
Selegiline inhibits the reaction [Hydroxyurea affects the localization of GAPDH protein]
Selegiline inhibits the reaction [Paraquat affects the localization of GAPDH protein]
CTD PMID:14724376 PMID:20478973 PMID:23696560 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Selegiline inhibits the reaction [Smoke analog results in increased expression of HMOX1 protein] CTD PMID:28108387 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of JUN mRNA]
Selegiline results in increased expression of JUN protein
CTD PMID:14724376 PMID:16099847 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Maoa monoamine oxidase A decreases activity ISO Selegiline results in decreased activity of MAOA protein CTD PMID:31323226 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593
JBrowse link
G Maob monoamine oxidase B affects binding
multiple interactions
decreases activity
ISO
EXP
Selegiline binds to MAOB protein
Selegiline inhibits the reaction [MAOB protein results in decreased amination of Dopamine]; Selegiline inhibits the reaction [MAOB protein results in increased degradation of Dopamine]; Selegiline inhibits the reaction [Smoke analog results in increased activity of MAOB protein]
Selegiline results in decreased activity of MAOB protein
[Selegiline results in decreased activity of MAOB protein] which results in increased susceptibility to Methamphetamine; zonisamide inhibits the reaction [Selegiline binds to MAOB protein]
[Selegiline results in decreased activity of MAOB protein] which results in decreased abundance of 3,4-Dihydroxyphenylacetic Acid; [Selegiline results in decreased activity of MAOB protein] which results in decreased abundance of Homovanillic Acid; [Selegiline results in decreased activity of MAOB protein] which results in increased abundance of Dopamine
CTD PMID:1905457 PMID:15178694 PMID:15545290 PMID:16012872 PMID:16252076 More... NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Selegiline results in increased phosphorylation of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Selegiline co-treated with 1-Methyl-4-phenylpyridinium] results in increased phosphorylation of MAPK1 protein]; [Selegiline co-treated with 1-Methyl-4-phenylpyridinium] results in increased phosphorylation of MAPK1 protein
CTD PMID:16099847 PMID:22019741 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO
EXP
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Selegiline results in increased phosphorylation of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Selegiline co-treated with 1-Methyl-4-phenylpyridinium] results in increased phosphorylation of MAPK3 protein]; [Selegiline co-treated with 1-Methyl-4-phenylpyridinium] results in increased phosphorylation of MAPK3 protein
CTD PMID:16099847 PMID:22019741 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases phosphorylation
multiple interactions
ISO Selegiline results in increased phosphorylation of MYC protein
MYC protein affects the reaction [Selegiline results in increased expression of TXN]
CTD PMID:16099847 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases localization
EXP
ISO
NFE2L2 mutant form inhibits the reaction [Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of NQO1 protein]]; NFE2L2 mutant form inhibits the reaction [Selegiline results in increased activity of NQO1 protein]; Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased localization of NFE2L2 protein]
Selegiline results in increased localization of NFE2L2 protein
Selegiline inhibits the reaction [Smoke analog affects the localization of NFE2L2 protein]
CTD PMID:22019741 PMID:28108387 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases activity
EXP
ISO
NFE2L2 mutant form inhibits the reaction [Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of NQO1 protein]]; NFE2L2 mutant form inhibits the reaction [Selegiline results in increased activity of NQO1 protein]; Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of NQO1 protein]
Selegiline inhibits the reaction [Smoke analog results in increased expression of NQO1 protein]
CTD PMID:22019741 PMID:28108387 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Selegiline inhibits the reaction [linsidomine results in decreased expression of PARP1 protein] CTD PMID:12880480 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO Selegiline inhibits the reaction [linsidomine results in increased expression of PRKN protein] CTD PMID:12880480 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Selegiline inhibits the reaction [Smoke analog affects the localization of RELA protein] CTD PMID:28108387 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Siah1 siah E3 ubiquitin protein ligase 1 multiple interactions EXP Selegiline inhibits the reaction [Paraquat affects the localization of SIAH1A protein] CTD PMID:20478973 NCBI chr19:20,378,908...20,402,512
Ensembl chr19:20,378,439...20,403,808
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Selegiline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Snca synuclein alpha multiple interactions ISO Selegiline inhibits the reaction [1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline results in increased expression of SNCA protein]; Selegiline inhibits the reaction [linsidomine results in increased expression of SNCA protein] CTD PMID:12880480 PMID:15114628 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [Clorgyline co-treated with Selegiline] inhibits the reaction [Norepinephrine results in increased phosphorylation of STAT3 protein] CTD PMID:34609854 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Th tyrosine hydroxylase multiple interactions
decreases expression
EXP Selegiline inhibits the reaction [Rotenone results in decreased expression of TH protein]
Selegiline results in decreased expression of TH mRNA
CTD PMID:11862330 PMID:16490285 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Txn1 thioredoxin 1 multiple interactions
increases expression
affects response to substance
ISO Dinitrochlorobenzene inhibits the reaction [Selegiline results in increased expression of TXN]; Dinitrochlorobenzene inhibits the reaction [TXN protein affects the susceptibility to Selegiline]; MYC protein affects the reaction [Selegiline results in increased expression of TXN]
Selegiline results in increased expression of TXN protein
CTD PMID:16099847 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link

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                          hydrides 18928
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                              pnictogen hydride 17748
                                nitrogen hydride 17633
                                  azane 17403
                                    ammonia 17402
                                      organic amino compound 17402
                                        tertiary amino compound 9087
                                          tertiary amine 628
                                            selegiline 33
                                              (-)-selegiline 33
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